JP2012512910A5 - - Google Patents
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- JP2012512910A5 JP2012512910A5 JP2011542519A JP2011542519A JP2012512910A5 JP 2012512910 A5 JP2012512910 A5 JP 2012512910A5 JP 2011542519 A JP2011542519 A JP 2011542519A JP 2011542519 A JP2011542519 A JP 2011542519A JP 2012512910 A5 JP2012512910 A5 JP 2012512910A5
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- Prior art keywords
- cell
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- express
- umbilical cord
- medicament according
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- 210000004027 cell Anatomy 0.000 claims description 54
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- 108010017842 Telomerase Proteins 0.000 claims description 14
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- 239000003814 drug Substances 0.000 claims 27
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000028389 Nerve injury Diseases 0.000 claims 6
- 230000008764 nerve damage Effects 0.000 claims 6
- 102100022464 5'-nucleotidase Human genes 0.000 claims 4
- 102100022749 Aminopeptidase N Human genes 0.000 claims 4
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 102000011786 HLA-A Antigens Human genes 0.000 claims 4
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- 108010058597 HLA-DR Antigens Proteins 0.000 claims 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 4
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13930508P | 2008-12-19 | 2008-12-19 | |
| US61/139,305 | 2008-12-19 | ||
| PCT/US2009/068880 WO2010071863A1 (en) | 2008-12-19 | 2009-12-19 | Regeneration and repair of neural tissue following injury |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512910A JP2012512910A (ja) | 2012-06-07 |
| JP2012512910A5 true JP2012512910A5 (cg-RX-API-DMAC7.html) | 2013-05-02 |
| JP6095893B2 JP6095893B2 (ja) | 2017-03-15 |
Family
ID=42097221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542519A Expired - Fee Related JP6095893B2 (ja) | 2008-12-19 | 2009-12-19 | 傷害後の神経組織の再生および修復 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100158880A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2379089B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6095893B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102458425A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009327383B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0923070A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2747758C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010071863A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| PL1641916T3 (pl) | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| CN101611139B (zh) | 2006-11-13 | 2012-07-04 | 伊西康公司 | 利用微载体的产后来源的细胞的体外扩增 |
| CN102036688B (zh) * | 2007-10-05 | 2014-07-02 | 伊西康公司 | 使用人脐带组织来源的细胞进行肾脏组织的修复和再生 |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| EP2237789B1 (en) * | 2007-12-27 | 2017-01-25 | DePuy Synthes Products, Inc. | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| AU2009327384B2 (en) | 2008-12-19 | 2014-07-10 | DePuy Synthes Products, LLC | Treatment of lung and pulmonary diseases and disorders |
| EP2411504B1 (en) * | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
| US8703487B2 (en) * | 2009-12-01 | 2014-04-22 | The Regents Of The University Of California | Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells |
| US9045657B2 (en) * | 2010-03-24 | 2015-06-02 | The Board Of Trustees Of The University Of Illinois | Viscoelastic ink for direct writing of hydrogel structures |
| AU2012358810B2 (en) * | 2011-12-23 | 2018-03-15 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue-derived cells |
| RU2539750C2 (ru) * | 2013-04-09 | 2015-01-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ оценки иммуносупрессивных свойств мезенхимальных стромальных клеток человека |
| WO2015017775A2 (en) * | 2013-08-01 | 2015-02-05 | Parcell Laboratories, Llc | Compositions having early lineage adult stem cells and extracts thereof |
| CA2943088A1 (en) * | 2014-03-20 | 2015-10-01 | Patrick J. Casey | Method for the treatment of damaged tissue |
| CA2995634A1 (en) * | 2015-08-15 | 2017-02-23 | Asterias Biotherapeutics, Inc. | Stem cell-derived oligodendrocyte progenitor cells for the treatment of white matter stroke |
| US10662409B2 (en) | 2015-09-09 | 2020-05-26 | Trustees Of Tufts College | Methods of generating neural stem cells |
| JP6967308B1 (ja) * | 2020-06-30 | 2021-11-17 | 国立大学法人高知大学 | 胎児付属物由来組織細胞培養上清を含む脳神経障害治療剤 |
| WO2022159789A1 (en) * | 2021-01-25 | 2022-07-28 | Biostem Technologies, Inc. | Two-part clotting composition and methods of making and using thereof |
| CN114561355B (zh) * | 2022-01-23 | 2023-04-11 | 四川大学华西医院 | 一种脊髓瘢痕组织细胞急性快速分离方法 |
| WO2024124507A1 (en) * | 2022-12-15 | 2024-06-20 | Center For Excellence In Brain Science And Intelligence Technology, Chinese Academy Of Sciences | Striatal neural progenitors in treatment of hypoxic-ischemic encephalopathy |
| CN118962134A (zh) * | 2023-05-15 | 2024-11-15 | 上海交通大学医学院附属仁济医院 | Ch25h+抑炎型小胶质细胞在缺血性脑卒中治疗中的应用 |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3665061A (en) * | 1969-07-16 | 1972-05-23 | United States Banknote Corp | Process for producing collagen sponges |
| JPS5651747B2 (cg-RX-API-DMAC7.html) * | 1973-05-31 | 1981-12-08 | ||
| US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| US5004681B1 (en) * | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US20030032178A1 (en) * | 1988-08-04 | 2003-02-13 | Williams Robert Lindsay | In vitro propagation of embryonic stem cells |
| US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5286632A (en) * | 1991-01-09 | 1994-02-15 | Jones Douglas H | Method for in vivo recombination and mutagenesis |
| US6399369B1 (en) * | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
| US5320962A (en) * | 1992-07-22 | 1994-06-14 | Duke University | DNA encoding the human A1 adenosine receptor |
| US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| JP3680114B2 (ja) * | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| US6686198B1 (en) * | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US6703017B1 (en) * | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| EP0952792B1 (en) * | 1994-06-06 | 2003-08-27 | Case Western Reserve University | Biomatrix for tissue regeneration |
| US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5906934A (en) * | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| US6358737B1 (en) * | 1996-07-31 | 2002-03-19 | Board Of Regents, The University Of Texas System | Osteocyte cell lines |
| US6787355B1 (en) * | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
| CA2290381A1 (en) * | 1997-05-21 | 1998-11-26 | Sloan-Kettering Institute For Cancer Research | Method for increasing the concentration of ascorbic acid in brain tissues of a subject |
| AU738334B2 (en) * | 1997-05-30 | 2001-09-13 | Osteobiologics, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| US5902598A (en) * | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
| AU1615599A (en) * | 1997-12-02 | 1999-06-16 | Zen Bio, Inc. | Differentiation of adipose stromal cells into osteoblasts and uses thereof |
| US6059968A (en) * | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| AU749675B2 (en) * | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| US6171610B1 (en) * | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
| WO1999056759A1 (en) * | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| US6387367B1 (en) * | 1998-05-29 | 2002-05-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
| US5958767A (en) * | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US20030007954A1 (en) * | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| CA2370330C (en) * | 1999-04-16 | 2009-01-20 | Wm. Marsh Rice University | Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers |
| US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6287340B1 (en) * | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
| US6333029B1 (en) * | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US6555374B1 (en) * | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| US20030129745A1 (en) * | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| JP2003523323A (ja) * | 1999-12-06 | 2003-08-05 | ザ ジェネラル ホスピタル コーポレーション | 膵臓幹細胞および移植におけるその使用 |
| US7544509B2 (en) * | 2000-01-24 | 2009-06-09 | Mcgill University | Method for preparing stem cell preparations |
| AU2001243464B2 (en) * | 2000-03-09 | 2006-04-13 | Saneron Ccel Therapeutics, Inc. | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
| US6673606B1 (en) * | 2000-04-12 | 2004-01-06 | The Children's Hospital Of Philadelphia | Therapeutic uses for mesenchymal stromal cells |
| US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US6759039B2 (en) * | 2000-06-30 | 2004-07-06 | Amcyte, Inc. | Culturing pancreatic stem cells having a specified, intermediate stage of development |
| EP2336299A1 (en) * | 2001-02-14 | 2011-06-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20030022369A1 (en) * | 2001-05-18 | 2003-01-30 | Helen Fillmore | Differentiation of specialized dermal and epidermal cells into neuronal cells |
| JP2005515753A (ja) * | 2001-05-25 | 2005-06-02 | サイセラ，インコーポレイテッド | 幹細胞分化 |
| WO2003018767A2 (en) * | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| US20030104997A1 (en) * | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
| US7129034B2 (en) * | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
| JP3728750B2 (ja) * | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| WO2003054171A1 (en) * | 2001-12-06 | 2003-07-03 | The Regents Of The University Of California | Method for differentiating islet precursor cells into beta cells |
| EP1458854B1 (en) * | 2001-12-21 | 2010-04-14 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| US20030162290A1 (en) * | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
| US20040029269A1 (en) * | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
| AU2003233119A1 (en) * | 2002-05-08 | 2003-11-11 | Neuronova Ab | Modulation of neural stem cells with s1p or lpa receptor agonists |
| KR20050008757A (ko) * | 2002-05-30 | 2005-01-21 | 셀진 코포레이션 | 세포 분화를 조절하고 골수증식성 질환 및 골수형성이상증후군을 치료하기 위하여 ｊｎｋ 또는 ｍｋｋ 저해제를사용하는 방법 |
| US7410797B2 (en) * | 2002-06-11 | 2008-08-12 | Ogle Roy C | Meningeal-derived stem cells |
| US7285415B2 (en) * | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
| US7390659B2 (en) * | 2002-07-16 | 2008-06-24 | The Trustees Of Columbia University In The City Of New York | Methods for inducing differentiation of embryonic stem cells and uses thereof |
| EP1543111A4 (en) * | 2002-08-28 | 2006-09-13 | Univ Florida | NEUROGENESIS FROM HEPATIC STEM CELLS |
| US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| CA2515594A1 (en) * | 2003-02-13 | 2004-08-26 | Anthrogenesis Corporation | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| PL1641916T3 (pl) * | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US20050089513A1 (en) * | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| US7833513B2 (en) * | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| ES2621847T3 (es) * | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| WO2006071778A2 (en) * | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| WO2007016245A2 (en) * | 2005-07-29 | 2007-02-08 | Vivicells International, Llc | Reprogramming of adult or neonic stem cells and methods of use |
| US7923007B2 (en) * | 2005-08-08 | 2011-04-12 | Academia Sinica | Brain tissue damage therapies |
| US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
| DK2078073T3 (da) * | 2006-10-12 | 2013-10-28 | Ethicon Inc | Nyreafledte celler og fremgangsmåder til anvendelse deraf til vævsreparation og -regenerering |
| AU2008266312A1 (en) * | 2007-06-15 | 2008-12-24 | Ethicon, Inc. | Human umbilical tissue-derived cell compositions for the treatment of incontinence |
| CA2630708C (en) * | 2007-09-13 | 2017-08-01 | Clifford L. Librach | Method of isolation and use of cells derived from first trimester umbilical cord tissue |
| CN102036688B (zh) * | 2007-10-05 | 2014-07-02 | 伊西康公司 | 使用人脐带组织来源的细胞进行肾脏组织的修复和再生 |
| EP2411504B1 (en) * | 2009-03-26 | 2017-05-10 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells as therapy for alzheimer's disease |
-
2009
- 2009-12-19 JP JP2011542519A patent/JP6095893B2/ja not_active Expired - Fee Related
- 2009-12-19 AU AU2009327383A patent/AU2009327383B2/en not_active Ceased
- 2009-12-19 WO PCT/US2009/068880 patent/WO2010071863A1/en not_active Ceased
- 2009-12-19 US US12/642,773 patent/US20100158880A1/en not_active Abandoned
- 2009-12-19 EP EP09807662.3A patent/EP2379089B1/en not_active Not-in-force
- 2009-12-19 BR BRPI0923070A patent/BRPI0923070A2/pt not_active IP Right Cessation
- 2009-12-19 CA CA2747758A patent/CA2747758C/en active Active
- 2009-12-19 CN CN2009801570086A patent/CN102458425A/zh active Pending
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