JP2012511914A5 - - Google Patents
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- JP2012511914A5 JP2012511914A5 JP2011540984A JP2011540984A JP2012511914A5 JP 2012511914 A5 JP2012511914 A5 JP 2012511914A5 JP 2011540984 A JP2011540984 A JP 2011540984A JP 2011540984 A JP2011540984 A JP 2011540984A JP 2012511914 A5 JP2012511914 A5 JP 2012511914A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- strain
- derived
- genes
- influenza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims description 84
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 84
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 84
- 101710176177 Protein A56 Proteins 0.000 claims description 84
- 239000000185 hemagglutinin Substances 0.000 claims description 84
- 108010006232 Neuraminidase Proteins 0.000 claims description 65
- 241000700605 Viruses Species 0.000 claims description 62
- 108090000623 proteins and genes Proteins 0.000 claims description 52
- 241000712461 unidentified influenza virus Species 0.000 claims description 44
- 229960005486 vaccine Drugs 0.000 claims description 38
- 102000040430 polynucleotide Human genes 0.000 claims description 33
- 108091033319 polynucleotide Proteins 0.000 claims description 33
- 239000002157 polynucleotide Substances 0.000 claims description 33
- 102000005348 Neuraminidase Human genes 0.000 claims description 25
- 230000000890 antigenic effect Effects 0.000 claims description 18
- 101150039660 HA gene Proteins 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 238000003776 cleavage reaction Methods 0.000 claims description 14
- 208000037797 influenza A Diseases 0.000 claims description 14
- 230000007017 scission Effects 0.000 claims description 14
- 206010064097 avian influenza Diseases 0.000 claims description 12
- 241000712431 Influenza A virus Species 0.000 claims description 10
- 210000004962 mammalian cell Anatomy 0.000 claims description 10
- 230000002238 attenuated effect Effects 0.000 claims description 8
- 241001500351 Influenzavirus A Species 0.000 claims description 6
- 102000018697 Membrane Proteins Human genes 0.000 claims description 6
- 108010052285 Membrane Proteins Proteins 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 230000035772 mutation Effects 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 210000002845 virion Anatomy 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 229940031551 inactivated vaccine Drugs 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 2
- 235000019365 chlortetracycline Nutrition 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000003501 vero cell Anatomy 0.000 description 2
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12296108P | 2008-12-16 | 2008-12-16 | |
| US61/122,961 | 2008-12-16 | ||
| PCT/US2009/068321 WO2010077986A2 (en) | 2008-12-16 | 2009-12-16 | Production of viral vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511914A JP2012511914A (ja) | 2012-05-31 |
| JP2012511914A5 true JP2012511914A5 (enExample) | 2013-02-07 |
| JP5686741B2 JP5686741B2 (ja) | 2015-03-18 |
Family
ID=41666658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540984A Active JP5686741B2 (ja) | 2008-12-16 | 2009-12-16 | インフルエンザワクチンの生成 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9884105B2 (enExample) |
| EP (1) | EP2376628B1 (enExample) |
| JP (1) | JP5686741B2 (enExample) |
| KR (1) | KR20110113615A (enExample) |
| CN (2) | CN107365751B (enExample) |
| AU (2) | AU2009333208A1 (enExample) |
| BR (1) | BRPI0923448A2 (enExample) |
| ES (1) | ES2675771T3 (enExample) |
| SG (1) | SG172220A1 (enExample) |
| WO (1) | WO2010077986A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2563389B1 (en) * | 2010-04-30 | 2015-07-08 | Temasek Life Sciences Laboratory Limited | Universal vaccine against h5n1 lineages |
| KR101250005B1 (ko) | 2010-12-31 | 2013-04-03 | 연세대학교 산학협력단 | 바이러스 유전자 조작을 통한 생백신 제조방법 |
| ES2628301T3 (es) * | 2012-03-02 | 2017-08-02 | Seqirus UK Limited | Recombinación de virus de gripe |
| EP2925356A2 (en) | 2012-12-03 | 2015-10-07 | Novartis AG | Reassortant influenza a viren |
| US10232031B2 (en) * | 2013-03-13 | 2019-03-19 | Seqirus UK Limited | Influenza virus reassortment |
| CN104073513B (zh) * | 2013-03-25 | 2018-04-20 | 中国科学院上海巴斯德研究所 | 甲型流感病毒疫苗哺乳动物细胞适应株的获得方法和适应位点 |
| WO2014180999A1 (en) * | 2013-05-10 | 2014-11-13 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
| CN105483149A (zh) * | 2015-12-25 | 2016-04-13 | 吉林农业大学 | 广谱型抗禽流感重组乳酸菌及其制备方法 |
| CN105950789A (zh) * | 2016-07-14 | 2016-09-21 | 广西壮族自治区兽医研究所 | 一种鉴定h5亚型aiv、n6亚型aiv和aiv的引物组合及其应用 |
| KR101966346B1 (ko) * | 2017-01-13 | 2019-04-05 | 전북대학교 산학협력단 | 시가 독소 Stx2e를 제조하는 방법 및 이를 포함하는 부종병을 예방하기 위한 백신 조성물 |
| US20210130793A1 (en) | 2017-08-28 | 2021-05-06 | The Research Foundation For Microbial Diseases Of Osaka University | Method for gradual construction of reassortant influenza virus |
| KR102182987B1 (ko) * | 2018-06-27 | 2020-11-27 | 대한민국 | 재조합 인플루엔자 a 바이러스 h5n1주 및 이를 포함하는 고병원성 인플루엔자 a 바이러스 백신 조성물 |
| CN109134624A (zh) * | 2018-09-19 | 2019-01-04 | 天康生物股份有限公司 | 禽流感病毒血凝素抗原及其制备方法、应用和禽流感疫苗 |
| CN109096377B (zh) * | 2018-09-19 | 2021-03-23 | 天康生物股份有限公司 | 禽流感病毒血凝素抗原及表达其的bhk-21细胞株、制备方法和疫苗 |
| KR102182997B1 (ko) * | 2019-01-04 | 2020-11-26 | 대한민국 | H5N6형 재조합 인플루엔자 A 바이러스 및 이를 포함하는 clade 2.3.4.4D에 속하는 H5 혈청형 인플루엔자 A 바이러스에 대한 백신 조성물 |
| KR102182999B1 (ko) * | 2019-01-04 | 2020-11-25 | 대한민국 | 재조합 인플루엔자 A 바이러스 및 이를 포함하는 clade 2.3.4.4B에 속하는 H5 혈청형 인플루엔자 A 바이러스에 대한 백신 조성물 |
| CN111647610B (zh) * | 2020-06-02 | 2021-09-03 | 扬州大学 | 一种互换ha和ns1缺失基因包装信号的h9n2亚型禽流感病毒及其构建方法和应用 |
| WO2021257469A1 (en) * | 2020-06-15 | 2021-12-23 | Icahn School Of Medicine At Mount Sinai | Immunoassay for the detection of anti-sars-cov-2 spike protein antibody in milk samples |
| CN114524862B (zh) * | 2021-12-16 | 2022-12-27 | 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） | 禽流感(h5+h7)三价dna疫苗的构建及其应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552758A (en) | 1983-12-20 | 1985-11-12 | St. Jude Children's Research Hospital | Human use of avian-human reassortants as vaccines for influenza A virus |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US6022726A (en) | 1992-02-03 | 2000-02-08 | Palese; Peter | Genetically engineered attenuated viruses |
| US7344722B1 (en) | 1993-06-29 | 2008-03-18 | The Regents Of The University Of Michigan | Cold-adapted influenza virus |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6146873A (en) | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US6254873B1 (en) | 1995-04-17 | 2001-07-03 | The United States Of America As Represented By The Secretary Of The Army | Inactivated dengue virus vaccine |
| US5840565A (en) | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| AU771110B2 (en) | 1998-06-12 | 2004-03-11 | Mount Sinai School Of Medicine Of The City University Of New York, The | Novel methods and interferon deficient substrates for the propagation of viruses |
| DE69937999T2 (de) | 1998-06-12 | 2009-01-29 | Avir Green Hills Biotechnology Research Development Trade Ag | Interferon induzierende genetisch veränderte attenuierte viren |
| AT407958B (de) | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
| US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| US6803041B2 (en) | 2001-03-20 | 2004-10-12 | Boehringer Ingelheim Vetmedica, Inc. | Equine herpesvirus vaccine |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US20050158342A1 (en) | 2003-12-23 | 2005-07-21 | Medimmune, Inc. | Multi plasmid system for the production of influenza virus |
| CN103540613A (zh) | 2002-04-26 | 2014-01-29 | 米迪缪尼有限公司 | 制备流感病毒的多质粒系统 |
| EP1597400B8 (en) | 2003-02-25 | 2013-10-09 | MedImmune, LLC | Methods of producing influenza vaccine compositions |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| CA2816222A1 (en) | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| US7037707B2 (en) | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| CN1618956A (zh) * | 2003-11-20 | 2005-05-25 | 中国科学院武汉病毒研究所 | 一种禽流感预防用病毒株及其动物感染模型 |
| EP1748790B1 (en) | 2004-05-24 | 2015-07-15 | MedImmune, LLC | Multi plasmid system for the production of influenza virus |
| EP2530147B1 (en) | 2004-05-25 | 2014-09-10 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
| CN1993140A (zh) | 2004-06-01 | 2007-07-04 | 纽约大学西奈山医学院 | 遗传工程猪流感病毒及其应用 |
| KR101346989B1 (ko) | 2004-10-06 | 2014-02-06 | 메디뮨 엘엘씨 | 냉장 온도 안정성 인플루엔자 백신 조성물 |
| KR101316350B1 (ko) | 2004-12-08 | 2013-10-15 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| ES2527503T3 (es) | 2005-03-08 | 2015-01-26 | Medimmune, Llc | Virus influenza reordenantes |
| EP1945778B1 (en) | 2005-10-17 | 2012-12-26 | MedImmune, LLC | Methods of increasing influenza virus replication |
| US20080014217A1 (en) | 2006-07-17 | 2008-01-17 | Emmanuel Jules Hanon | Influenza vaccine |
| US7601356B2 (en) | 2006-07-21 | 2009-10-13 | Medimmune, Llc | Methods and compositions for increasing replication capacity of an influenza virus |
| JP2010500034A (ja) | 2006-08-09 | 2010-01-07 | メッドイミューン バクシーンズ，インコーポレイティド | インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体 |
| WO2008039494A1 (en) | 2006-09-26 | 2008-04-03 | Id Biomedical Corporation Of Quebec | Device and methods of inactivating influenza virus and adventitious agents with ultraviolet light |
| CA2671869A1 (en) | 2006-12-15 | 2008-06-26 | Schering-Plough Ltd. | Method for replicating influenza virus in culture |
| JP5666905B2 (ja) | 2007-06-18 | 2015-02-12 | メディミューン，エルエルシー | ヘマグルチニンポリペプチド中に変化を有するインフルエンザｂウイルス |
-
2009
- 2009-12-16 CN CN201710352474.6A patent/CN107365751B/zh active Active
- 2009-12-16 EP EP09774806.5A patent/EP2376628B1/en active Active
- 2009-12-16 WO PCT/US2009/068321 patent/WO2010077986A2/en not_active Ceased
- 2009-12-16 ES ES09774806.5T patent/ES2675771T3/es active Active
- 2009-12-16 KR KR1020117016500A patent/KR20110113615A/ko not_active Ceased
- 2009-12-16 SG SG2011044385A patent/SG172220A1/en unknown
- 2009-12-16 US US12/639,917 patent/US9884105B2/en active Active
- 2009-12-16 JP JP2011540984A patent/JP5686741B2/ja active Active
- 2009-12-16 BR BRPI0923448A patent/BRPI0923448A2/pt not_active IP Right Cessation
- 2009-12-16 CN CN200980150850.7A patent/CN102257135B/zh active Active
- 2009-12-16 AU AU2009333208A patent/AU2009333208A1/en not_active Abandoned
-
2016
- 2016-02-19 AU AU2016201038A patent/AU2016201038A1/en not_active Abandoned
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