KR20110113615A - 인플루엔자 백신의 생산 - Google Patents

인플루엔자 백신의 생산 Download PDF

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KR20110113615A
KR20110113615A KR1020117016500A KR20117016500A KR20110113615A KR 20110113615 A KR20110113615 A KR 20110113615A KR 1020117016500 A KR1020117016500 A KR 1020117016500A KR 20117016500 A KR20117016500 A KR 20117016500A KR 20110113615 A KR20110113615 A KR 20110113615A
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virus
vietnam
influenza
genes
strain
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Korean (ko)
Inventor
오트프리트 키스트너
팔코-귄터 팔크너
하르트무트 에를리히
노엘 배릿
Original Assignee
백스터 인터내셔널 인코포레이티드
박스터 헬쓰케어 에스.에이.
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Publication of KR20110113615A publication Critical patent/KR20110113615A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020117016500A 2008-12-16 2009-12-16 인플루엔자 백신의 생산 Ceased KR20110113615A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12296108P 2008-12-16 2008-12-16
US61/122,961 2008-12-16

Publications (1)

Publication Number Publication Date
KR20110113615A true KR20110113615A (ko) 2011-10-17

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KR1020117016500A Ceased KR20110113615A (ko) 2008-12-16 2009-12-16 인플루엔자 백신의 생산

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US (1) US9884105B2 (enExample)
EP (1) EP2376628B1 (enExample)
JP (1) JP5686741B2 (enExample)
KR (1) KR20110113615A (enExample)
CN (2) CN107365751B (enExample)
AU (2) AU2009333208A1 (enExample)
BR (1) BRPI0923448A2 (enExample)
ES (1) ES2675771T3 (enExample)
SG (1) SG172220A1 (enExample)
WO (1) WO2010077986A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101250005B1 (ko) * 2010-12-31 2013-04-03 연세대학교 산학협력단 바이러스 유전자 조작을 통한 생백신 제조방법
KR20180083687A (ko) * 2017-01-13 2018-07-23 전북대학교산학협력단 시가 독소 Stx2e를 제조하는 방법 및 이를 포함하는 부종병을 예방하기 위한 백신 조성물
KR20200001418A (ko) * 2018-06-27 2020-01-06 대한민국(농림축산식품부 농림축산검역본부장) 재조합 인플루엔자 a 바이러스 h5n1주 및 이를 포함하는 고병원성 인플루엔자 a 바이러스 백신 조성물

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EP2563389B1 (en) * 2010-04-30 2015-07-08 Temasek Life Sciences Laboratory Limited Universal vaccine against h5n1 lineages
ES2628301T3 (es) * 2012-03-02 2017-08-02 Seqirus UK Limited Recombinación de virus de gripe
EP2925356A2 (en) 2012-12-03 2015-10-07 Novartis AG Reassortant influenza a viren
US10232031B2 (en) * 2013-03-13 2019-03-19 Seqirus UK Limited Influenza virus reassortment
CN104073513B (zh) * 2013-03-25 2018-04-20 中国科学院上海巴斯德研究所 甲型流感病毒疫苗哺乳动物细胞适应株的获得方法和适应位点
WO2014180999A1 (en) * 2013-05-10 2014-11-13 Novartis Ag Avoiding narcolepsy risk in influenza vaccines
CN105483149A (zh) * 2015-12-25 2016-04-13 吉林农业大学 广谱型抗禽流感重组乳酸菌及其制备方法
CN105950789A (zh) * 2016-07-14 2016-09-21 广西壮族自治区兽医研究所 一种鉴定h5亚型aiv、n6亚型aiv和aiv的引物组合及其应用
US20210130793A1 (en) 2017-08-28 2021-05-06 The Research Foundation For Microbial Diseases Of Osaka University Method for gradual construction of reassortant influenza virus
CN109134624A (zh) * 2018-09-19 2019-01-04 天康生物股份有限公司 禽流感病毒血凝素抗原及其制备方法、应用和禽流感疫苗
CN109096377B (zh) * 2018-09-19 2021-03-23 天康生物股份有限公司 禽流感病毒血凝素抗原及表达其的bhk-21细胞株、制备方法和疫苗
KR102182997B1 (ko) * 2019-01-04 2020-11-26 대한민국 H5N6형 재조합 인플루엔자 A 바이러스 및 이를 포함하는 clade 2.3.4.4D에 속하는 H5 혈청형 인플루엔자 A 바이러스에 대한 백신 조성물
KR102182999B1 (ko) * 2019-01-04 2020-11-25 대한민국 재조합 인플루엔자 A 바이러스 및 이를 포함하는 clade 2.3.4.4B에 속하는 H5 혈청형 인플루엔자 A 바이러스에 대한 백신 조성물
CN111647610B (zh) * 2020-06-02 2021-09-03 扬州大学 一种互换ha和ns1缺失基因包装信号的h9n2亚型禽流感病毒及其构建方法和应用
WO2021257469A1 (en) * 2020-06-15 2021-12-23 Icahn School Of Medicine At Mount Sinai Immunoassay for the detection of anti-sars-cov-2 spike protein antibody in milk samples
CN114524862B (zh) * 2021-12-16 2022-12-27 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 禽流感(h5+h7)三价dna疫苗的构建及其应用

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101250005B1 (ko) * 2010-12-31 2013-04-03 연세대학교 산학협력단 바이러스 유전자 조작을 통한 생백신 제조방법
US8834892B2 (en) 2010-12-31 2014-09-16 Industry-Academic Cooperation Foundation, Yonsei University Method of preparing live viral vaccines by genetic engineering of viral genome
KR20180083687A (ko) * 2017-01-13 2018-07-23 전북대학교산학협력단 시가 독소 Stx2e를 제조하는 방법 및 이를 포함하는 부종병을 예방하기 위한 백신 조성물
KR20200001418A (ko) * 2018-06-27 2020-01-06 대한민국(농림축산식품부 농림축산검역본부장) 재조합 인플루엔자 a 바이러스 h5n1주 및 이를 포함하는 고병원성 인플루엔자 a 바이러스 백신 조성물

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SG172220A1 (en) 2011-07-28
CN102257135A (zh) 2011-11-23
EP2376628A2 (en) 2011-10-19
WO2010077986A2 (en) 2010-07-08
US9884105B2 (en) 2018-02-06
CN102257135B (zh) 2017-06-09
WO2010077986A3 (en) 2010-10-07
JP5686741B2 (ja) 2015-03-18
JP2012511914A (ja) 2012-05-31
US20100189745A1 (en) 2010-07-29
ES2675771T3 (es) 2018-07-12
EP2376628B1 (en) 2018-05-16
BRPI0923448A2 (pt) 2018-10-09
AU2016201038A1 (en) 2016-03-10
CN107365751A (zh) 2017-11-21
CN107365751B (zh) 2021-07-09
AU2009333208A1 (en) 2010-07-08

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