JP2012511586A - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP2012511586A
JP2012511586A JP2011540882A JP2011540882A JP2012511586A JP 2012511586 A JP2012511586 A JP 2012511586A JP 2011540882 A JP2011540882 A JP 2011540882A JP 2011540882 A JP2011540882 A JP 2011540882A JP 2012511586 A JP2012511586 A JP 2012511586A
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JP
Japan
Prior art keywords
glp
pharmaceutical composition
human
polypeptide
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011540882A
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English (en)
Japanese (ja)
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JP2012511586A5 (https=
Inventor
マーク、エイ．ブッシュ
マレー、ダブリュ．スチュワート
ヨンホン、ヤン
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GlaxoSmithKline LLC
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GlaxoSmithKline LLC
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Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of JP2012511586A publication Critical patent/JP2012511586A/ja
Publication of JP2012511586A5 publication Critical patent/JP2012511586A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2011540882A 2008-12-10 2009-12-10 医薬組成物 Pending JP2012511586A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12122908P 2008-12-10 2008-12-10
US61/121,229 2008-12-10
US15090909P 2009-02-09 2009-02-09
US61/150,909 2009-02-09
US16399509P 2009-03-27 2009-03-27
US61/163,995 2009-03-27
US23872309P 2009-09-01 2009-09-01
US61/238,723 2009-09-01
PCT/US2009/067469 WO2010068735A1 (en) 2008-12-10 2009-12-10 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2012511586A true JP2012511586A (ja) 2012-05-24
JP2012511586A5 JP2012511586A5 (https=) 2013-01-31

Family

ID=42243062

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011540882A Pending JP2012511586A (ja) 2008-12-10 2009-12-10 医薬組成物

Country Status (14)

Country Link
US (3) US8748377B2 (https=)
EP (1) EP2373681B1 (https=)
JP (1) JP2012511586A (https=)
CY (1) CY1118731T1 (https=)
DK (1) DK2373681T3 (https=)
ES (1) ES2620610T3 (https=)
HR (1) HRP20170478T1 (https=)
HU (1) HUE031900T2 (https=)
LT (1) LT2373681T (https=)
PL (1) PL2373681T3 (https=)
PT (1) PT2373681T (https=)
SI (1) SI2373681T1 (https=)
SM (1) SMT201700189T1 (https=)
WO (1) WO2010068735A1 (https=)

Families Citing this family (24)

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PT2373681T (pt) 2008-12-10 2017-04-11 Glaxosmithkline Llc Composições farmacêuticas de albiglutida
US8691763B2 (en) 2010-05-04 2014-04-08 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
UY34347A (es) 2011-09-26 2013-04-30 Novartis Ag Proteínas de función dual para tratar trastornos metabólicos
EP2866825B1 (en) 2012-07-01 2020-04-08 Novo Nordisk A/S Use of long-acting glp-1 peptides
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
AU2013366692B2 (en) 2012-12-21 2017-11-23 Sanofi Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
US9849066B2 (en) 2013-04-24 2017-12-26 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
SI3004155T1 (sl) 2013-05-28 2022-02-28 Takeda Pharmaceutical Company Limited Peptidna spojina
US20140378374A1 (en) * 2013-06-21 2014-12-25 Glaxosmithkline Intellectual Property (No.2) Limited Methods of treatment
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
TW201613630A (en) * 2014-06-25 2016-04-16 Glaxosmithkline Llc Pharmaceutical compositions
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
JP6995042B2 (ja) 2016-05-24 2022-02-04 武田薬品工業株式会社 ペプチド化合物
EP3684793A1 (en) 2017-09-22 2020-07-29 Regeneron Pharmaceuticals, Inc. Glucagon-like peptide 1 receptor agonists and uses thereof
CA3078652A1 (en) 2017-10-12 2019-04-18 Novo Nordisk A/S Semaglutide in medical therapy
WO2024064842A1 (en) 2022-09-21 2024-03-28 Regeneron Pharmaceuticals, Inc. Methods of treating obesity, diabetes, and liver dysfunction

Citations (4)

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JPH05506427A (ja) * 1990-01-24 1993-09-22 バツクレイ，ダグラス　アイ． 糖尿病治療に有用なｇｌｐ―１アナログ
JP2003505347A (ja) * 1999-07-12 2003-02-12 ジーランド ファーマ エー／エス 血糖値を降下させるペプチド
WO2007056681A2 (en) * 2005-11-04 2007-05-18 Smithkline Beecham Corporation Methods for administering hypoglycemic agents
WO2008033888A2 (en) * 2006-09-13 2008-03-20 Smithkline Beecham Corporation Methods for administering long-lasting hypoglycemic agents

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US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
ATE493998T1 (de) 1996-08-08 2011-01-15 Amylin Pharmaceuticals Inc Pharmazeutische zusammensetzung mit einem exendin-4-peptid
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
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AR036711A1 (es) 2001-10-05 2004-09-29 Bayer Corp Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
KR20040054729A (ko) 2001-10-18 2004-06-25 브리스톨-마이어스 스큅 컴퍼니 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH05506427A (ja) * 1990-01-24 1993-09-22 バツクレイ，ダグラス　アイ． 糖尿病治療に有用なｇｌｐ―１アナログ
JP2003505347A (ja) * 1999-07-12 2003-02-12 ジーランド ファーマ エー／エス 血糖値を降下させるペプチド
WO2007056681A2 (en) * 2005-11-04 2007-05-18 Smithkline Beecham Corporation Methods for administering hypoglycemic agents
WO2008033888A2 (en) * 2006-09-13 2008-03-20 Smithkline Beecham Corporation Methods for administering long-lasting hypoglycemic agents

Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
US8748377B2 (en) 2014-06-10
HRP20170478T1 (hr) 2017-05-19
ES2620610T3 (es) 2017-06-29
US20140228284A1 (en) 2014-08-14
EP2373681A4 (en) 2013-11-06
PT2373681T (pt) 2017-04-11
LT2373681T (lt) 2017-04-10
US20110301080A1 (en) 2011-12-08
PL2373681T3 (pl) 2017-07-31
WO2010068735A1 (en) 2010-06-17
SMT201700189T1 (it) 2017-05-08
DK2373681T3 (en) 2017-04-24
CY1118731T1 (el) 2017-07-12
EP2373681B1 (en) 2017-01-18
HUE031900T2 (en) 2017-08-28
US20140228288A1 (en) 2014-08-14
SI2373681T1 (sl) 2017-05-31
EP2373681A1 (en) 2011-10-12

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