JP2012510798A - ペプチド治療剤コンジュゲートおよびその使用 - Google Patents

ペプチド治療剤コンジュゲートおよびその使用 Download PDF

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JP2012510798A
JP2012510798A JP2011538811A JP2011538811A JP2012510798A JP 2012510798 A JP2012510798 A JP 2012510798A JP 2011538811 A JP2011538811 A JP 2011538811A JP 2011538811 A JP2011538811 A JP 2011538811A JP 2012510798 A JP2012510798 A JP 2012510798A
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peptide
phe
ala
gly
glp
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JP2012510798A5 (https=
Inventor
カステーニュ，ジャン−ポール
ドゥムール，ミシェル
ガニョン，カトリーヌ
ローレンス，ベティ
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アンジオケム インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
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    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
JP2011538811A 2008-12-05 2009-12-07 ペプチド治療剤コンジュゲートおよびその使用 Pending JP2012510798A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20094708P 2008-12-05 2008-12-05
US61/200,947 2008-12-05
PCT/CA2009/001781 WO2010063124A1 (en) 2008-12-05 2009-12-07 Peptide therapeutic conjugates and uses thereof

Publications (2)

Publication Number Publication Date
JP2012510798A true JP2012510798A (ja) 2012-05-17
JP2012510798A5 JP2012510798A5 (https=) 2013-01-31

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JP2011538811A Pending JP2012510798A (ja) 2008-12-05 2009-12-07 ペプチド治療剤コンジュゲートおよびその使用

Country Status (11)

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US (2) US20110288011A1 (https=)
EP (1) EP2794663A1 (https=)
JP (1) JP2012510798A (https=)
CN (2) CN102348723A (https=)
AU (1) AU2009322045A1 (https=)
BR (1) BRPI0923283A2 (https=)
CA (1) CA2745499A1 (https=)
MX (1) MX2011005964A (https=)
RU (1) RU2011125366A (https=)
WO (1) WO2010063124A1 (https=)
ZA (1) ZA201104497B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504379A (ja) * 2013-01-03 2016-02-12 ハンミ ファーム．カンパニー リミテッドＨａｎｍｉ Ｐｈａｒｍ．Ｃｏ．，Ｌｔｄ． Ｎ−末端の電荷が改変されたインスリン分泌ペプチド誘導体
JP2020501611A (ja) * 2016-12-19 2020-01-23 ハンミ ファーマシューティカル カンパニー リミテッド 脳標的持続性タンパク質結合体
KR20230076561A (ko) * 2021-11-24 2023-05-31 주식회사 윙스타바이오 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도
JP2024507523A (ja) * 2021-02-22 2024-02-20 イエール ユニバーシティ 標的指向化された二官能性分解剤およびその使用方法

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060403A2 (en) 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
RU2408605C2 (ru) 2005-02-18 2011-01-10 Анджиокем Инк. Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат
ES2744225T3 (es) 2005-07-15 2020-02-24 Angiochem Inc Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
JP2010506860A (ja) 2006-10-19 2010-03-04 アンジオケム，インコーポレーテッド Ｐ−糖タンパク質機能を刺激するための化合物およびその使用
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CA2740316A1 (en) * 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CA2745524C (en) 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
US8853353B2 (en) 2008-12-17 2014-10-07 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
MX2011011023A (es) 2009-04-20 2012-01-20 Angiochem Inc Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
RU2012103240A (ru) * 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
WO2011070573A1 (en) * 2009-12-07 2011-06-16 Ben-Gurion University Of The Negev Research And Development Authority Antimicrobial water treatment membranes and production thereof
AU2010327949A1 (en) * 2009-12-11 2012-06-28 Case Western Reserve University Insulin analogues with chlorinated amino acids
US20120277155A1 (en) 2011-02-25 2012-11-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
EP2694083A2 (en) * 2011-04-01 2014-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Peptides and pharmaceutical compositions for use in the treatment by nasal administration of patients suffering from anxiety and sleep disorders
JP6144673B2 (ja) 2011-06-03 2017-06-07 オフィディオン インコーポレイティド 血液脳関門を通過して輸送するための組成物及び方法
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
CU24076B1 (es) * 2011-09-30 2015-01-29 Ct De Ingeniería Genética Y Biotecnología Composición para el control de patógenos
CN104145015A (zh) * 2011-12-01 2014-11-12 安吉奥开米公司 靶向的溶酶体酶化合物
BR112014013250A2 (pt) * 2011-12-01 2019-09-24 Angiochem Inc compostos com enzima alvo e usos dos mesmos
US20150025002A1 (en) * 2012-01-12 2015-01-22 University Of Ulster Peptides and peptide derivatives based on xenin
WO2013173337A2 (en) * 2012-05-15 2013-11-21 Seattle Genetics, Inc. Self-stabilizing linker conjugates
AU2013273894A1 (en) * 2012-06-15 2015-02-05 Angiochem Inc. Targeted iduronidase compounds
JP2015526434A (ja) 2012-08-14 2015-09-10 アンジオケム インコーポレーテッド ペプチド−デンドリマーコンジュゲート及びその使用
NZ630542A (en) 2012-08-16 2017-06-30 Ipierian Inc Methods of treating a tauopathy
EP3722320A3 (en) 2012-10-25 2020-12-30 Bioverativ USA Inc. Anti-complement c1s antibodies and uses thereof
DK2914291T3 (da) 2012-11-02 2022-05-16 Bioverativ Usa Inc Anti-komplement-c1s-antistoffer og anvendelser deraf
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
BR112015030356A2 (pt) 2013-06-10 2017-12-05 Ipierian Inc métodos de tratamento de uma taupatia
BR112016010454A2 (pt) 2013-11-27 2017-12-05 Ipierian Inc métodos para tratar uma taupatia
EP3094642B1 (en) 2013-12-20 2018-03-21 Tikomed AB Surface-binding peptide
US20170253643A1 (en) * 2014-09-02 2017-09-07 Tokyo University Of Science Foundation Centrally-Acting Peptide Derivative, and Pharmaceutical Composition
ES2748117T3 (es) * 2015-04-22 2020-03-13 Euroimmun Medizinische Labordiagnostika Ag Diagnóstico de una nueva enfermedad autoinmune
IL293655B2 (en) * 2015-05-27 2025-04-01 Univ Northwestern Modified carbohydrate particles and particulate compositions for modulating immune response
EP3307326B9 (en) 2015-06-15 2021-02-24 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
US10858410B2 (en) * 2015-08-12 2020-12-08 Arizona Board Of Regents On Behalf Of The University Of Arizona Glycosylated peptides with pseudoproline residues and having enhanced half-lives and ability to cross the blood brain barrier
CN106466475B (zh) * 2015-08-21 2021-06-08 中国人民解放军军事医学科学院毒物药物研究所 抗菌肽与聚合物结合而成的复合物、其制备方法及用途
KR102863433B1 (ko) 2015-12-16 2025-09-23 다이어트4라이프 에이피에스 식이 펩타이드
US11530243B2 (en) * 2016-02-18 2022-12-20 Veiove Animal Health Inc. Non-cleavable substance P conjugates and methods of use thereof
US10973812B2 (en) 2016-03-03 2021-04-13 Regents Of The University Of Minnesota Ataxia therapeutic compositions and methods
EP3452510A4 (en) 2016-04-04 2020-01-15 Bioverativ USA Inc. ANTI-COMPLEMENT FACTOR BB ANTIBODIES AND USES THEREOF
WO2017181277A1 (en) 2016-04-19 2017-10-26 Griffon Pharmaceuticals Inc. Pegylated bioactive peptides and uses thereof
CN105801709B (zh) * 2016-04-29 2019-10-08 北京纽莱福生物科技有限公司 CBLB502-Fc融合蛋白及其制备方法
TWI851531B (zh) 2016-08-09 2024-08-11 美商思進公司 具有改善之生理化學性質之具自我穩定連接子之藥物結合物
JP7295838B2 (ja) * 2017-07-13 2023-06-21 シティ・オブ・ホープ ホスホロチオエートコンジュゲートペプチド及びその使用方法
FR3070264A1 (fr) * 2017-08-24 2019-03-01 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
WO2019043382A1 (en) * 2017-08-31 2019-03-07 University Of Dundee DERIVED LEPTIN PEPTIDES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
CN107964047B (zh) * 2017-12-18 2018-11-02 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN110337302B (zh) * 2018-01-15 2023-07-21 深圳市星银医药有限公司 一种马栗树提取物和利那洛肽组合物
NZ766762A (en) * 2018-01-31 2026-03-27 Sanofi Sa Modified lipidated relaxin b chain peptides and their therapeutic use
CN108490178B (zh) * 2018-02-13 2019-08-30 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于npc诊断及预后预测的标志物及其应用
KR102250412B1 (ko) 2018-05-04 2021-05-17 트윈피그바이오랩(주) 멜리틴-기반 세포사멸 유발 펩타이드로 m2 유사 종앙관련 대식세포의 표적화
EP3843768A4 (en) 2018-05-15 2022-11-23 Tran, Lloyd Hung Loi THERAPEUTIC COMPOSITION AND METHODS OF USE IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT, DEPRESSION AND MENTAL DISORDERS
CA3142871A1 (en) * 2019-06-06 2020-12-10 Aroa Biosurgery Limited Bioactive agents and methods related thereto
KR20220042129A (ko) 2019-06-26 2022-04-04 마이클 이. 셀스테드 신규한 세타 디펜신 유사체(novel theta defensin analogs)
CN112279921B (zh) * 2019-07-11 2025-07-29 厦门大学 用于胞内递送分子的复合物
CN110420317B (zh) * 2019-07-25 2022-11-22 中国人民解放军军事科学院军事医学研究院 Cblb502蛋白在防治创伤后应激障碍中的应用
CN110437308B (zh) * 2019-08-20 2023-05-05 倪京满 一类对铜绿假单胞菌具有特异活性的含β氨基酸的抗菌肽类似物及其应用
CN110563802B (zh) * 2019-09-04 2023-04-07 倪京满 一组含n-甲基化氨基酸及n端脂肪酸修饰的抗菌肽类似物及其合成方法和应用
CN111808168A (zh) * 2020-07-21 2020-10-23 南京农业大学 一类褐飞虱硫激肽类似物的合成及应用
CN111704651B (zh) * 2020-07-27 2021-10-08 南京安吉生物科技有限公司 具有抗衰老作用的多肽rv3和rv4及其应用
CN114057831B (zh) * 2020-08-07 2024-03-12 三凡生技研发股份有限公司 促进血管增生的短链胜肽及其促进糖尿病伤口愈合的用途
KR20220076375A (ko) * 2020-11-30 2022-06-08 세종대학교산학협력단 신규 퇴행성 신경질환 치료용 약학적 조성물
CN112656953A (zh) * 2020-12-30 2021-04-16 重庆医科大学 凝血酶响应型双靶向脂质体及其制备方法和应用
CN112851789B (zh) * 2021-02-04 2022-10-18 大理大学 一种脑靶向hiv进入抑制剂多肽及其应用
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CN114250204B (zh) * 2021-12-29 2024-02-09 深圳瑞德林生物技术有限公司 一种羧酸还原酶突变体及酶法合成脱羧肌肽的方法
WO2023143463A1 (en) * 2022-01-30 2023-08-03 Nanjing Reju Therapeutics , Inc. Fusion protein and application thereof
CN119654336A (zh) * 2022-05-16 2025-03-18 儿童医疗中心有限公司 治疗心脏病的组合物和方法
CN115286694B (zh) * 2022-06-02 2024-08-20 温州医科大学 一种南美青蛙宿主防御肽的衍生肽ps-pt-6f及其制备方法和应用
CN115806740B (zh) * 2022-11-17 2024-01-30 四川大学 一种集成多模态响应的导电水凝胶及其制备方法和用途
CN116036234B (zh) * 2023-01-17 2024-02-06 青岛市中心医院 一种用于治疗骨质疏松的药剂
CN115948069B (zh) * 2023-02-09 2024-11-29 广州工业智能研究院 一种双重抗菌超疏液涂层及其制备方法
CN116298281A (zh) * 2023-03-27 2023-06-23 山西农业大学 一种基于距离信号读出的胰蛋白酶含量检测方法
CN116333041A (zh) * 2023-04-10 2023-06-27 湖南中晟全肽生化有限公司 一种激活grp受体的多肽化合物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
WO2006086870A1 (en) * 2005-02-18 2006-08-24 Angiochem Inc. Aprotinin polypeptides for transporting a compound across the blood-brain barrier
WO2008012629A2 (en) * 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
WO2008144919A1 (en) * 2007-05-29 2008-12-04 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052814A1 (en) * 1998-09-28 2004-03-18 Wenyuan Shi Fusion proteins for targeted delivery of antimicrobial peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
WO2006086870A1 (en) * 2005-02-18 2006-08-24 Angiochem Inc. Aprotinin polypeptides for transporting a compound across the blood-brain barrier
WO2008012629A2 (en) * 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
WO2008144919A1 (en) * 2007-05-29 2008-12-04 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6014015829; Ｊ．　Ｐｈａｒｍａｃｏｌ．　Ｅｘｐ．　Ｔｈｅｒ． Ｖｏｌ．　３２４, 200803, ｐｐ．１０６４-１０７２ *
JPN6014021551; Ｂｏｕｌｅｓ　Ｍ．　ｅｔ　ａｌ．: ＰＥＰＴＩＤＥＳ Ｖｏｌ．２７, 2006, ｐｐ．２５２３-２５３３ *
JPN6014021555; Ｗｉｌｌｉａｍｓｏｎ　Ｐ．Ｔ．Ｆ．　ｅｔ　ａｌ．: Ｐｒｏｔｅｉｎ　Ｅｘｐｒｅｓｓｉｏｎ　ａｎｄ　Ｐｕｒｉｆｉｃａｔｉｏｎ Ｖｏｌ．１９, 2000, ｐｐ．２７１-２７５ *
JPN6014021559; Ｙａｎｏ　Ｋ．　ｅｔ　ａｌ．: Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｍａｃｅｕｔｉｃａｌ　Ｓｃｉｅｎｃｅｓ Ｖｏｌ．７, 1998, ｐｐ．４１-４８ *
JPN6014021564; Ｐａｒｋ　Ｊ-Ｈ．　ｅｔ　ａｌ．: Ｐｒｏｔｅｉｎ　Ｅｘｐｒｅｓｓｉｏｎ　ａｎｄ　Ｐｕｒｉｆｉｃａｔｉｏｎ Ｖｏｌ．２２, 2001, ｐ．６０-６９ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504379A (ja) * 2013-01-03 2016-02-12 ハンミ ファーム．カンパニー リミテッドＨａｎｍｉ Ｐｈａｒｍ．Ｃｏ．，Ｌｔｄ． Ｎ−末端の電荷が改変されたインスリン分泌ペプチド誘導体
JP2019081777A (ja) * 2013-01-03 2019-05-30 ハンミ ファーム．カンパニー リミテッドＨａｎｍｉ Ｐｈａｒｍ．Ｃｏ．，Ｌｔｄ． Ｎ−末端の電荷が改変されたインスリン分泌ペプチド誘導体
JP2020501611A (ja) * 2016-12-19 2020-01-23 ハンミ ファーマシューティカル カンパニー リミテッド 脳標的持続性タンパク質結合体
JP2024507523A (ja) * 2021-02-22 2024-02-20 イエール ユニバーシティ 標的指向化された二官能性分解剤およびその使用方法
KR20230076561A (ko) * 2021-11-24 2023-05-31 주식회사 윙스타바이오 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도
KR102819567B1 (ko) 2021-11-24 2025-06-13 주식회사 윙스타바이오 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도

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