CN102348723A - 肽治疗剂轭合物及其应用 - Google Patents
肽治疗剂轭合物及其应用 Download PDFInfo
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- CN102348723A CN102348723A CN200980156247XA CN200980156247A CN102348723A CN 102348723 A CN102348723 A CN 102348723A CN 200980156247X A CN200980156247X A CN 200980156247XA CN 200980156247 A CN200980156247 A CN 200980156247A CN 102348723 A CN102348723 A CN 102348723A
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- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20094708P | 2008-12-05 | 2008-12-05 | |
| US61/200,947 | 2008-12-05 | ||
| PCT/CA2009/001781 WO2010063124A1 (en) | 2008-12-05 | 2009-12-07 | Peptide therapeutic conjugates and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310616186.9A Division CN103665170A (zh) | 2008-12-05 | 2009-12-07 | 肽治疗剂轭合物及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102348723A true CN102348723A (zh) | 2012-02-08 |
Family
ID=42232848
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980156247XA Pending CN102348723A (zh) | 2008-12-05 | 2009-12-07 | 肽治疗剂轭合物及其应用 |
| CN201310616186.9A Pending CN103665170A (zh) | 2008-12-05 | 2009-12-07 | 肽治疗剂轭合物及其应用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310616186.9A Pending CN103665170A (zh) | 2008-12-05 | 2009-12-07 | 肽治疗剂轭合物及其应用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20110288011A1 (https=) |
| EP (1) | EP2794663A1 (https=) |
| JP (1) | JP2012510798A (https=) |
| CN (2) | CN102348723A (https=) |
| AU (1) | AU2009322045A1 (https=) |
| BR (1) | BRPI0923283A2 (https=) |
| CA (1) | CA2745499A1 (https=) |
| MX (1) | MX2011005964A (https=) |
| RU (1) | RU2011125366A (https=) |
| WO (1) | WO2010063124A1 (https=) |
| ZA (1) | ZA201104497B (https=) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105801709A (zh) * | 2016-04-29 | 2016-07-27 | 四川新生命干细胞科技股份有限公司 | CBLB502-Fc融合蛋白及其制备方法 |
| CN110437308A (zh) * | 2019-08-20 | 2019-11-12 | 倪京满 | 一类对铜绿假单胞菌具有特异活性的含β氨基酸的抗菌肽类似物及其应用 |
| CN110563802A (zh) * | 2019-09-04 | 2019-12-13 | 倪京满 | 一组含n-甲基化氨基酸及n端脂肪酸修饰的抗菌肽类似物及其合成方法和应用 |
| CN111808168A (zh) * | 2020-07-21 | 2020-10-23 | 南京农业大学 | 一类褐飞虱硫激肽类似物的合成及应用 |
| CN112279921A (zh) * | 2019-07-11 | 2021-01-29 | 厦门大学 | 用于胞内递送分子的复合物 |
| CN112656953A (zh) * | 2020-12-30 | 2021-04-16 | 重庆医科大学 | 凝血酶响应型双靶向脂质体及其制备方法和应用 |
| CN112851789A (zh) * | 2021-02-04 | 2021-05-28 | 大理大学 | 一种脑靶向hiv进入抑制剂多肽及其应用 |
| CN115286694A (zh) * | 2022-06-02 | 2022-11-04 | 温州医科大学 | 一种南美青蛙宿主防御肽的衍生肽ps-pt-6f及其制备方法和应用 |
| CN115806740A (zh) * | 2022-11-17 | 2023-03-17 | 四川大学 | 一种集成多模态响应的导电水凝胶及其制备方法和用途 |
| CN115948069A (zh) * | 2023-02-09 | 2023-04-11 | 广州工业智能研究院 | 一种双重抗菌超疏液涂层及其制备方法 |
| CN116036234A (zh) * | 2023-01-17 | 2023-05-02 | 青岛市中心医院 | 一种用于治疗骨质疏松的药剂 |
| CN117362388A (zh) * | 2023-04-10 | 2024-01-09 | 湖南中晟全肽生化有限公司 | 一种激活grp受体的多肽化合物及其用途 |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| RU2408605C2 (ru) | 2005-02-18 | 2011-01-10 | Анджиокем Инк. | Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| JP2010506860A (ja) | 2006-10-19 | 2010-03-04 | アンジオケム,インコーポレーテッド | P−糖タンパク質機能を刺激するための化合物およびその使用 |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CA2740316A1 (en) * | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) * | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| WO2011070573A1 (en) * | 2009-12-07 | 2011-06-16 | Ben-Gurion University Of The Negev Research And Development Authority | Antimicrobial water treatment membranes and production thereof |
| AU2010327949A1 (en) * | 2009-12-11 | 2012-06-28 | Case Western Reserve University | Insulin analogues with chlorinated amino acids |
| US20120277155A1 (en) | 2011-02-25 | 2012-11-01 | Medtronic, Inc. | Therapy for kidney disease and/or heart failure |
| EP2694083A2 (en) * | 2011-04-01 | 2014-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Peptides and pharmaceutical compositions for use in the treatment by nasal administration of patients suffering from anxiety and sleep disorders |
| JP6144673B2 (ja) | 2011-06-03 | 2017-06-07 | オフィディオン インコーポレイティド | 血液脳関門を通過して輸送するための組成物及び方法 |
| EP2750697A4 (en) | 2011-09-02 | 2015-03-25 | Medtronic Inc | CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| CU24076B1 (es) * | 2011-09-30 | 2015-01-29 | Ct De Ingeniería Genética Y Biotecnología | Composición para el control de patógenos |
| CN104145015A (zh) * | 2011-12-01 | 2014-11-12 | 安吉奥开米公司 | 靶向的溶酶体酶化合物 |
| BR112014013250A2 (pt) * | 2011-12-01 | 2019-09-24 | Angiochem Inc | compostos com enzima alvo e usos dos mesmos |
| US20150025002A1 (en) * | 2012-01-12 | 2015-01-22 | University Of Ulster | Peptides and peptide derivatives based on xenin |
| WO2013173337A2 (en) * | 2012-05-15 | 2013-11-21 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| AU2013273894A1 (en) * | 2012-06-15 | 2015-02-05 | Angiochem Inc. | Targeted iduronidase compounds |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| NZ630542A (en) | 2012-08-16 | 2017-06-30 | Ipierian Inc | Methods of treating a tauopathy |
| EP3722320A3 (en) | 2012-10-25 | 2020-12-30 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
| DK2914291T3 (da) | 2012-11-02 | 2022-05-16 | Bioverativ Usa Inc | Anti-komplement-c1s-antistoffer og anvendelser deraf |
| KR20140088837A (ko) * | 2013-01-03 | 2014-07-11 | 한미약품 주식회사 | N-말단 전하가 변형된 인슐린 분비 펩티드 유도체 |
| US10450343B2 (en) | 2013-03-21 | 2019-10-22 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| CA2907454C (en) | 2013-03-21 | 2021-05-04 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| BR112015030356A2 (pt) | 2013-06-10 | 2017-12-05 | Ipierian Inc | métodos de tratamento de uma taupatia |
| BR112016010454A2 (pt) | 2013-11-27 | 2017-12-05 | Ipierian Inc | métodos para tratar uma taupatia |
| EP3094642B1 (en) | 2013-12-20 | 2018-03-21 | Tikomed AB | Surface-binding peptide |
| US20170253643A1 (en) * | 2014-09-02 | 2017-09-07 | Tokyo University Of Science Foundation | Centrally-Acting Peptide Derivative, and Pharmaceutical Composition |
| ES2748117T3 (es) * | 2015-04-22 | 2020-03-13 | Euroimmun Medizinische Labordiagnostika Ag | Diagnóstico de una nueva enfermedad autoinmune |
| IL293655B2 (en) * | 2015-05-27 | 2025-04-01 | Univ Northwestern | Modified carbohydrate particles and particulate compositions for modulating immune response |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| US10858410B2 (en) * | 2015-08-12 | 2020-12-08 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Glycosylated peptides with pseudoproline residues and having enhanced half-lives and ability to cross the blood brain barrier |
| CN106466475B (zh) * | 2015-08-21 | 2021-06-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗菌肽与聚合物结合而成的复合物、其制备方法及用途 |
| KR102863433B1 (ko) | 2015-12-16 | 2025-09-23 | 다이어트4라이프 에이피에스 | 식이 펩타이드 |
| US11530243B2 (en) * | 2016-02-18 | 2022-12-20 | Veiove Animal Health Inc. | Non-cleavable substance P conjugates and methods of use thereof |
| US10973812B2 (en) | 2016-03-03 | 2021-04-13 | Regents Of The University Of Minnesota | Ataxia therapeutic compositions and methods |
| EP3452510A4 (en) | 2016-04-04 | 2020-01-15 | Bioverativ USA Inc. | ANTI-COMPLEMENT FACTOR BB ANTIBODIES AND USES THEREOF |
| WO2017181277A1 (en) | 2016-04-19 | 2017-10-26 | Griffon Pharmaceuticals Inc. | Pegylated bioactive peptides and uses thereof |
| TWI851531B (zh) | 2016-08-09 | 2024-08-11 | 美商思進公司 | 具有改善之生理化學性質之具自我穩定連接子之藥物結合物 |
| US20190352335A1 (en) * | 2016-12-19 | 2019-11-21 | Hanmi Pharm. Co., Ltd. | Brain targeting long-acting protein conjugate |
| JP7295838B2 (ja) * | 2017-07-13 | 2023-06-21 | シティ・オブ・ホープ | ホスホロチオエートコンジュゲートペプチド及びその使用方法 |
| FR3070264A1 (fr) * | 2017-08-24 | 2019-03-01 | Adocia | Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
| WO2019043382A1 (en) * | 2017-08-31 | 2019-03-07 | University Of Dundee | DERIVED LEPTIN PEPTIDES AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| CN107964047B (zh) * | 2017-12-18 | 2018-11-02 | 哈尔滨工业大学 | 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用 |
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| CA3142871A1 (en) * | 2019-06-06 | 2020-12-10 | Aroa Biosurgery Limited | Bioactive agents and methods related thereto |
| KR20220042129A (ko) | 2019-06-26 | 2022-04-04 | 마이클 이. 셀스테드 | 신규한 세타 디펜신 유사체(novel theta defensin analogs) |
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| AU2022222778A1 (en) * | 2021-02-22 | 2023-08-31 | Yale University | Targeted bifunctional degraders and methods using same |
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| CN114250204B (zh) * | 2021-12-29 | 2024-02-09 | 深圳瑞德林生物技术有限公司 | 一种羧酸还原酶突变体及酶法合成脱羧肌肽的方法 |
| WO2023143463A1 (en) * | 2022-01-30 | 2023-08-03 | Nanjing Reju Therapeutics , Inc. | Fusion protein and application thereof |
| CN119654336A (zh) * | 2022-05-16 | 2025-03-18 | 儿童医疗中心有限公司 | 治疗心脏病的组合物和方法 |
| CN116298281A (zh) * | 2023-03-27 | 2023-06-23 | 山西农业大学 | 一种基于距离信号读出的胰蛋白酶含量检测方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101160403A (zh) * | 2005-02-18 | 2008-04-09 | 安吉奥开米公司 | 转运化合物穿过血脑屏障的分子 |
| WO2008144919A1 (en) * | 2007-05-29 | 2008-12-04 | Angiochem, Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040052814A1 (en) * | 1998-09-28 | 2004-03-18 | Wenyuan Shi | Fusion proteins for targeted delivery of antimicrobial peptides |
| US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
| CN101511868B (zh) * | 2006-07-24 | 2013-03-06 | 比奥雷克西斯制药公司 | 毒蜥外泌肽融合蛋白 |
-
2009
- 2009-12-07 CN CN200980156247XA patent/CN102348723A/zh active Pending
- 2009-12-07 CN CN201310616186.9A patent/CN103665170A/zh active Pending
- 2009-12-07 RU RU2011125366/10A patent/RU2011125366A/ru not_active Application Discontinuation
- 2009-12-07 EP EP09829936.5A patent/EP2794663A1/en not_active Withdrawn
- 2009-12-07 BR BRPI0923283A patent/BRPI0923283A2/pt not_active IP Right Cessation
- 2009-12-07 MX MX2011005964A patent/MX2011005964A/es unknown
- 2009-12-07 US US13/133,002 patent/US20110288011A1/en not_active Abandoned
- 2009-12-07 WO PCT/CA2009/001781 patent/WO2010063124A1/en not_active Ceased
- 2009-12-07 AU AU2009322045A patent/AU2009322045A1/en not_active Abandoned
- 2009-12-07 CA CA2745499A patent/CA2745499A1/en not_active Abandoned
- 2009-12-07 JP JP2011538811A patent/JP2012510798A/ja active Pending
-
2011
- 2011-06-17 ZA ZA2011/04497A patent/ZA201104497B/en unknown
-
2015
- 2015-04-24 US US14/696,193 patent/US20160263235A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101160403A (zh) * | 2005-02-18 | 2008-04-09 | 安吉奥开米公司 | 转运化合物穿过血脑屏障的分子 |
| WO2008144919A1 (en) * | 2007-05-29 | 2008-12-04 | Angiochem, Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
Non-Patent Citations (1)
| Title |
|---|
| SUSAN L SAMSON ET AL: "Gene Therapy for Diabetes: Metabolic Effects of Helper-dependent Adenoviral Exendin 4 Expression in a Diet-induced Obesity Mouse Model", 《MOLECULAR THERAPY》 * |
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| CN105801709A (zh) * | 2016-04-29 | 2016-07-27 | 四川新生命干细胞科技股份有限公司 | CBLB502-Fc融合蛋白及其制备方法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA201104497B (en) | 2012-09-26 |
| EP2794663A4 (en) | 2014-10-29 |
| CN103665170A (zh) | 2014-03-26 |
| US20160263235A1 (en) | 2016-09-15 |
| RU2011125366A (ru) | 2013-01-10 |
| AU2009322045A1 (en) | 2011-07-07 |
| WO2010063124A1 (en) | 2010-06-10 |
| US20110288011A1 (en) | 2011-11-24 |
| JP2012510798A (ja) | 2012-05-17 |
| EP2794663A1 (en) | 2014-10-29 |
| BRPI0923283A2 (pt) | 2017-06-06 |
| MX2011005964A (es) | 2011-09-01 |
| CA2745499A1 (en) | 2010-06-10 |
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