JP2012510794A5 - - Google Patents
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- JP2012510794A5 JP2012510794A5 JP2011524084A JP2011524084A JP2012510794A5 JP 2012510794 A5 JP2012510794 A5 JP 2012510794A5 JP 2011524084 A JP2011524084 A JP 2011524084A JP 2011524084 A JP2011524084 A JP 2011524084A JP 2012510794 A5 JP2012510794 A5 JP 2012510794A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
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- ctl
- apc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 57
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 12
- 108091007433 antigens Proteins 0.000 claims description 12
- 102000036639 antigens Human genes 0.000 claims description 12
- 102000040430 polynucleotide Human genes 0.000 claims description 12
- 108091033319 polynucleotide Proteins 0.000 claims description 12
- 239000002157 polynucleotide Substances 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 8
- 230000001939 inductive effect Effects 0.000 claims description 8
- 239000008177 pharmaceutical agent Substances 0.000 claims description 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 6
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 6
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 229940024606 amino acid Drugs 0.000 claims description 6
- 210000001808 exosome Anatomy 0.000 claims description 6
- 229930182817 methionine Natural products 0.000 claims description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 4
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 4
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- 108091008874 T cell receptors Proteins 0.000 claims description 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20096208P | 2008-12-05 | 2008-12-05 | |
| US61/200,962 | 2008-12-05 | ||
| US20970409P | 2009-03-09 | 2009-03-09 | |
| US61/209,704 | 2009-03-09 | ||
| PCT/JP2009/006573 WO2010064430A1 (en) | 2008-12-05 | 2009-12-03 | Wdrpuh epitope peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510794A JP2012510794A (ja) | 2012-05-17 |
| JP2012510794A5 true JP2012510794A5 (https=) | 2013-01-24 |
| JP5764823B2 JP5764823B2 (ja) | 2015-08-19 |
Family
ID=42233088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524084A Active JP5764823B2 (ja) | 2008-12-05 | 2009-12-03 | Ｗｄｒｐｕｈエピトープペプチドおよびそれを含むワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8541546B2 (https=) |
| EP (3) | EP4047009A3 (https=) |
| JP (1) | JP5764823B2 (https=) |
| KR (1) | KR101705102B1 (https=) |
| CN (2) | CN102307891B (https=) |
| AU (1) | AU2009323523B2 (https=) |
| BR (1) | BRPI0922844A2 (https=) |
| CA (2) | CA3031126C (https=) |
| DK (1) | DK3219720T3 (https=) |
| ES (1) | ES2913148T3 (https=) |
| IL (2) | IL212945B (https=) |
| MX (1) | MX2011005944A (https=) |
| NZ (2) | NZ605799A (https=) |
| RU (1) | RU2514386C2 (https=) |
| SG (1) | SG171977A1 (https=) |
| TW (2) | TWI539160B (https=) |
| WO (1) | WO2010064430A1 (https=) |
| ZA (1) | ZA201104890B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150359864A1 (en) | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| CA2873155C (en) | 2012-09-11 | 2022-07-26 | Oncotherapy Science, Inc. | Ube2t peptides and vaccines containing the same |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| WO1997005900A1 (en) | 1995-08-03 | 1997-02-20 | Rijksuniversiteit Te Leiden | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| JP2000516090A (ja) | 1996-07-26 | 2000-12-05 | スローン―ケッタリング インスティチュート フォー キャンサー リサーチ | 遺伝子的免疫化のための方法と試薬 |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| JP4413429B2 (ja) | 1998-06-25 | 2010-02-10 | 株式会社グリーンペプタイド | サイクロフィリンｂ由来の腫瘍抗原ペプチド |
| ES2361541T3 (es) * | 2002-06-06 | 2011-06-17 | Oncotherapy Science, Inc. | Genes y polipéptidos relacionados con cánceres de colon humanos. |
| EP1513934B1 (en) | 2002-06-06 | 2011-03-02 | Oncotherapy Science, Inc. | Genes and polypeptides relating to human colon cancers |
| DE60327786D1 (de) | 2002-09-12 | 2009-07-09 | Oncotherapy Science Inc | Kdr-peptide und diese enthaltende impfstoffe |
| WO2006031221A1 (en) | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Compositions comprising t cell receptors and methods of use thereof |
| ES2364670T3 (es) * | 2005-02-25 | 2011-09-12 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres de pulmón que expresan polipéptidos ttk. |
| JP5276846B2 (ja) | 2005-09-13 | 2013-08-28 | 国立大学法人三重大学 | Ｔ細胞レセプターをコードする核酸が挿入されてなるベクター及び該レセプターを発現する細胞 |
| TWI596109B (zh) | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| TW201425333A (zh) * | 2007-04-11 | 2014-07-01 | Oncotherapy Science Inc | 腫瘤血管內皮標誌８胜肽及包含此胜肽之疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2009
- 2009-12-02 TW TW103140741A patent/TWI539160B/zh not_active IP Right Cessation
- 2009-12-02 TW TW098141123A patent/TWI500932B/zh not_active IP Right Cessation
- 2009-12-03 DK DK17167553.1T patent/DK3219720T3/da active
- 2009-12-03 US US13/132,891 patent/US8541546B2/en active Active
- 2009-12-03 NZ NZ605799A patent/NZ605799A/en not_active IP Right Cessation
- 2009-12-03 EP EP22158260.4A patent/EP4047009A3/en active Pending
- 2009-12-03 NZ NZ593086A patent/NZ593086A/xx not_active IP Right Cessation
- 2009-12-03 SG SG2011041043A patent/SG171977A1/en unknown
- 2009-12-03 EP EP09830200.3A patent/EP2370454A4/en not_active Withdrawn
- 2009-12-03 KR KR1020117014316A patent/KR101705102B1/ko not_active Expired - Fee Related
- 2009-12-03 ES ES17167553T patent/ES2913148T3/es active Active
- 2009-12-03 AU AU2009323523A patent/AU2009323523B2/en not_active Ceased
- 2009-12-03 RU RU2011127429/04A patent/RU2514386C2/ru active
- 2009-12-03 MX MX2011005944A patent/MX2011005944A/es active IP Right Grant
- 2009-12-03 JP JP2011524084A patent/JP5764823B2/ja active Active
- 2009-12-03 CN CN200980156195.6A patent/CN102307891B/zh active Active
- 2009-12-03 WO PCT/JP2009/006573 patent/WO2010064430A1/en not_active Ceased
- 2009-12-03 BR BRPI0922844A patent/BRPI0922844A2/pt not_active IP Right Cessation
- 2009-12-03 EP EP17167553.1A patent/EP3219720B1/en active Active
- 2009-12-03 CA CA3031126A patent/CA3031126C/en active Active
- 2009-12-03 CN CN201410851691.6A patent/CN104650183B/zh active Active
- 2009-12-03 CA CA2745408A patent/CA2745408C/en active Active
-
2011
- 2011-05-17 IL IL212945A patent/IL212945B/en active IP Right Grant
- 2011-07-04 ZA ZA2011/04890A patent/ZA201104890B/en unknown
-
2013
- 2013-05-23 US US13/900,720 patent/US9115207B2/en active Active
- 2013-09-03 IL IL228266A patent/IL228266A/en active IP Right Grant
-
2015
- 2015-07-21 US US14/805,424 patent/US9745343B2/en active Active
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