JP2008530975A5 - - Google Patents
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- Publication number
- JP2008530975A5 JP2008530975A5 JP2007531118A JP2007531118A JP2008530975A5 JP 2008530975 A5 JP2008530975 A5 JP 2008530975A5 JP 2007531118 A JP2007531118 A JP 2007531118A JP 2007531118 A JP2007531118 A JP 2007531118A JP 2008530975 A5 JP2008530975 A5 JP 2008530975A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- seq
- cytotoxic
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 claims description 82
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 5
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 3
- 229940024606 amino acid Drugs 0.000 claims 45
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 31
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 18
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 18
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 18
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 18
- 229930182817 methionine Natural products 0.000 claims 18
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 18
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 9
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 9
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 9
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 9
- 229960000310 isoleucine Drugs 0.000 claims 9
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 9
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 210000001808 exosome Anatomy 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65685705P | 2005-02-25 | 2005-02-25 | |
| PCT/JP2006/303354 WO2006090810A2 (en) | 2005-02-25 | 2006-02-17 | Peptide vaccines for lung cancers expressing ttk, urlc10 or koc1 polypeptides |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009058801A Division JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Division JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Division JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008530975A JP2008530975A (ja) | 2008-08-14 |
| JP2008530975A5 true JP2008530975A5 (https=) | 2009-05-28 |
| JP4461179B2 JP4461179B2 (ja) | 2010-05-12 |
Family
ID=36570330
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531118A Expired - Fee Related JP4461179B2 (ja) | 2005-02-25 | 2006-02-17 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058801A Pending JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Expired - Lifetime JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Expired - Lifetime JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009295766A Pending JP2010143924A (ja) | 2005-02-25 | 2009-12-25 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009058801A Pending JP2009173661A (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058802A Expired - Lifetime JP4493054B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009058798A Expired - Lifetime JP4493053B2 (ja) | 2005-02-25 | 2009-03-12 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
| JP2009295766A Pending JP2010143924A (ja) | 2005-02-25 | 2009-12-25 | Ｔｔｋ、ｕｒｌｃ１０、またはｋｏｃ１ポリペプチドを発現する肺癌に対するペプチドワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7847060B2 (https=) |
| EP (3) | EP2325305B1 (https=) |
| JP (5) | JP4461179B2 (https=) |
| DE (1) | DE602006021283D1 (https=) |
| DK (2) | DK2325305T3 (https=) |
| ES (3) | ES2459492T3 (https=) |
| PL (2) | PL2325305T3 (https=) |
| PT (2) | PT2325305E (https=) |
| WO (1) | WO2006090810A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| EP2468887A1 (en) * | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| TWI596109B (zh) * | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| AU2012261725B2 (en) * | 2007-02-21 | 2014-11-27 | Oncotherapy Science, Inc. | Peptide vaccines for cancers expressing tumor-associated antigens |
| EP2185732A1 (en) * | 2007-07-30 | 2010-05-19 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| ES2632123T3 (es) | 2007-08-20 | 2017-09-11 | Oncotherapy Science, Inc. | Péptido CDH3 y agente medicinal que comprende el mismo |
| TW201008574A (en) * | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| TWI580431B (zh) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | Ｈｉｇ２與ｕｒｌｃ１０抗原決定位胜肽以及含此胜肽之疫苗 |
| SG195571A1 (en) | 2008-10-22 | 2013-12-30 | Oncotherapy Science Inc | Rab6kifl/kif20a epitope peptide and vaccines containing the same |
| TWI539160B (zh) * | 2008-12-05 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗 |
| WO2010073551A1 (en) | 2008-12-24 | 2010-07-01 | Oncotherapy Science, Inc. | C1orf59 peptides and vaccines including the same |
| CN102439147A (zh) * | 2009-03-04 | 2012-05-02 | 肿瘤疗法科学股份有限公司 | Vangl1肽及包含它们的疫苗 |
| TW201100090A (en) * | 2009-04-01 | 2011-01-01 | Oncotherapy Science Inc | C6orf167 peptides and vaccines containing the same |
| TW201102081A (en) * | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| CN102481333B (zh) * | 2009-09-03 | 2017-07-14 | 东丽株式会社 | 免疫诱导剂 |
| TW201124530A (en) * | 2009-12-01 | 2011-07-16 | Oncotherapy Science Inc | IMP-3 oligopeptides and vaccines including the same |
| TW201200525A (en) * | 2009-12-04 | 2012-01-01 | Oncotherapy Science Inc | MYBL2 peptides and vaccines containing the same |
| TW201211250A (en) * | 2010-09-07 | 2012-03-16 | Oncotherapy Science Inc | VANGL1 peptides and vaccines including the same |
| SG11201405578TA (en) * | 2012-03-09 | 2014-11-27 | Oncotherapy Science Inc | Pharmaceutical composition containing peptide |
| WO2014010232A1 (en) * | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Ly6k epitope peptides for th1 cells and vaccines containing the same |
| TWI643867B (zh) | 2013-05-24 | 2018-12-11 | 日商腫瘤療法 科學股份有限公司 | 對於ｔｈ１細胞之ｉｍｐ－３抗原決定位胜肽及含此之疫苗 |
| ES2856834T3 (es) * | 2014-08-04 | 2021-09-28 | Oncotherapy Science Inc | Péptido derivado de URLC10 y vacuna que contiene el mismo |
| AU2015300256B2 (en) * | 2014-08-04 | 2020-01-30 | Oncotherapy Science, Inc. | KOC1-Derived peptide and vaccine including same |
| JP6781508B2 (ja) * | 2014-11-18 | 2020-11-04 | 塩野義製薬株式会社 | 安定化されたペプチド組成物 |
| WO2021060343A1 (ja) * | 2019-09-24 | 2021-04-01 | オンコセラピー・サイエンス株式会社 | Ｕｒｌｃ１０由来ペプチドまたはｄｅｐｄｃ１由来ペプチドを認識するヒトｔ細胞が発現するｔ細胞受容体 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5922687A (en) | 1995-05-04 | 1999-07-13 | Board Of Trustees Of The Leland Stanford Junior University | Intracellular delivery of nucleic acids using pressure |
| US20030198642A1 (en) | 1995-08-03 | 2003-10-23 | Johannes J. Geuze | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| EP0960204A4 (en) | 1996-07-26 | 2002-01-23 | Sloan Kettering Inst Cancer | METHODS AND REAGENTS FOR GENETIC IMMUNIZATION |
| AU723543B2 (en) | 1997-04-07 | 2000-08-31 | Roche Diagnostics Gmbh | Fanconi-gene II |
| EP1007671B1 (de) | 1997-04-07 | 2002-02-13 | Roche Diagnostics GmbH | Fanconi-gen ii |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US6255055B1 (en) | 1998-03-09 | 2001-07-03 | Wisconsin Alumni Research Foundation | c-myc coding region determinant-binding protein (CRD-BP) and its nucleic acid sequence |
| US20030236209A1 (en) * | 1998-03-18 | 2003-12-25 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030045491A1 (en) * | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| AU2001251084A1 (en) | 2000-03-29 | 2001-10-08 | Diadexus, Inc. | Polynucleotides and polypeptides as well as methods for diagnosing and treating lung cancer |
| AU2002215345A1 (en) | 2000-10-13 | 2002-04-22 | Eos Biotechnology, Inc. | Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer |
| CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| CA2438092C (en) | 2001-02-21 | 2011-08-09 | Chiron Corporation | Ttk in diagnosis and as a therapeutic target in cancer |
| CA2444691A1 (en) | 2001-04-18 | 2002-10-31 | Protein Design Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| US7189507B2 (en) * | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| IL160905A0 (en) | 2001-10-31 | 2004-08-31 | Pfizer Prod Inc | Therapeutics and diagnostics for disorders of erythropoiesis |
| US20030232350A1 (en) * | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| WO2003042661A2 (en) | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| JP2005525789A (ja) | 2001-11-13 | 2005-09-02 | プロテイン デザイン ラブス インコーポレイティド | ガンの診断方法、ガンのモジュレータのスクリーニング組成物及び方法 |
| JP2005523688A (ja) | 2002-01-18 | 2005-08-11 | ブリストル−マイヤーズ スクイブ カンパニー | タンパク質チロシンキナーゼおよび／またはタンパク質チロシンキナーゼ経路と相互作用する化合物の活性を予測するためのポリヌクレオチドおよびポリペプチドの同定 |
| CN101613406A (zh) * | 2002-06-06 | 2009-12-30 | 肿瘤疗法科学股份有限公司 | 与人结肠癌相关的基因和多肽 |
| DK2261249T3 (en) | 2002-09-12 | 2015-02-16 | Oncotherapy Science Inc | KDR peptides and vaccines comprising the same |
| US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20100150968A1 (en) | 2003-06-09 | 2010-06-17 | Corixa Corporation | Dna vectors |
| JP4721903B2 (ja) | 2004-01-29 | 2011-07-13 | 大日本住友製薬株式会社 | 新規腫瘍抗原蛋白質及びその利用 |
| EP1584684A1 (en) | 2004-02-20 | 2005-10-12 | Samsung Electronics Co., Ltd. | Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene |
| ATE496142T1 (de) | 2004-03-23 | 2011-02-15 | Oncotherapy Science Inc | Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs |
| EP1854473A1 (en) | 2005-03-03 | 2007-11-14 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| EP2468887A1 (en) | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| EP2185732A1 (en) | 2007-07-30 | 2010-05-19 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2006
- 2006-02-17 ES ES10010438.9T patent/ES2459492T3/es not_active Expired - Lifetime
- 2006-02-17 EP EP10010438.9A patent/EP2325305B1/en not_active Expired - Lifetime
- 2006-02-17 JP JP2007531118A patent/JP4461179B2/ja not_active Expired - Fee Related
- 2006-02-17 EP EP10010439.7A patent/EP2325306B1/en not_active Expired - Lifetime
- 2006-02-17 ES ES06714493T patent/ES2364670T3/es not_active Expired - Lifetime
- 2006-02-17 PT PT100104389T patent/PT2325305E/pt unknown
- 2006-02-17 PL PL10010438T patent/PL2325305T3/pl unknown
- 2006-02-17 DE DE602006021283T patent/DE602006021283D1/de not_active Expired - Lifetime
- 2006-02-17 DK DK10010438.9T patent/DK2325305T3/en active
- 2006-02-17 DK DK10010439.7T patent/DK2325306T3/en active
- 2006-02-17 EP EP06714493A patent/EP1853703B1/en not_active Expired - Lifetime
- 2006-02-17 PL PL10010439T patent/PL2325306T3/pl unknown
- 2006-02-17 PT PT100104397T patent/PT2325306E/pt unknown
- 2006-02-17 US US11/816,616 patent/US7847060B2/en not_active Expired - Lifetime
- 2006-02-17 ES ES10010439.7T patent/ES2459466T3/es not_active Expired - Lifetime
- 2006-02-17 WO PCT/JP2006/303354 patent/WO2006090810A2/en not_active Ceased
-
2009
- 2009-03-12 JP JP2009058801A patent/JP2009173661A/ja active Pending
- 2009-03-12 JP JP2009058802A patent/JP4493054B2/ja not_active Expired - Lifetime
- 2009-03-12 JP JP2009058798A patent/JP4493053B2/ja not_active Expired - Lifetime
- 2009-12-25 JP JP2009295766A patent/JP2010143924A/ja active Pending
-
2010
- 2010-10-13 US US12/903,961 patent/US8614176B2/en active Active
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