JP2012510431A5 - - Google Patents
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- JP2012510431A5 JP2012510431A5 JP2011537796A JP2011537796A JP2012510431A5 JP 2012510431 A5 JP2012510431 A5 JP 2012510431A5 JP 2011537796 A JP2011537796 A JP 2011537796A JP 2011537796 A JP2011537796 A JP 2011537796A JP 2012510431 A5 JP2012510431 A5 JP 2012510431A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- composition
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- 239000012634 fragment Substances 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 229960005486 vaccine Drugs 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 8
- 208000015943 Coeliac disease Diseases 0.000 claims 6
- 108010068370 Glutens Proteins 0.000 claims 6
- 235000021312 gluten Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical group OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Chemical group OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Chemical group OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 230000030741 antigen processing and presentation Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 230000006058 immune tolerance Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 229940076144 interleukin-10 Drugs 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11864308P | 2008-11-30 | 2008-11-30 | |
| US61/118,643 | 2008-11-30 | ||
| PCT/AU2009/001556 WO2010060155A1 (en) | 2008-11-30 | 2009-11-30 | Compositions and methods for treatment of celiac disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015235197A Division JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510431A JP2012510431A (ja) | 2012-05-10 |
| JP2012510431A5 true JP2012510431A5 (OSRAM) | 2013-03-28 |
| JP5851243B2 JP5851243B2 (ja) | 2016-02-03 |
Family
ID=42225141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537796A Expired - Fee Related JP5851243B2 (ja) | 2008-11-30 | 2009-11-30 | セリアック病の処置のための組成物および方法 |
| JP2015235197A Expired - Fee Related JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015235197A Expired - Fee Related JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US8835603B2 (OSRAM) |
| EP (3) | EP2977053B1 (OSRAM) |
| JP (2) | JP5851243B2 (OSRAM) |
| CN (2) | CN105079781B (OSRAM) |
| AU (1) | AU2009321481B2 (OSRAM) |
| BR (1) | BRPI0922122A2 (OSRAM) |
| CA (2) | CA2744787C (OSRAM) |
| DK (2) | DK2367561T3 (OSRAM) |
| ES (2) | ES2549481T3 (OSRAM) |
| HK (1) | HK1249446A1 (OSRAM) |
| HR (1) | HRP20150873T1 (OSRAM) |
| HU (1) | HUE027237T2 (OSRAM) |
| MX (1) | MX346450B (OSRAM) |
| NZ (1) | NZ593474A (OSRAM) |
| PT (1) | PT2367561E (OSRAM) |
| WO (1) | WO2010060155A1 (OSRAM) |
Families Citing this family (53)
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| GB0212885D0 (en) | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| EP1755639B1 (en) | 2004-04-28 | 2017-08-16 | BTG International Limited | Epitopes related to coeliac disease |
| WO2010060155A1 (en) | 2008-11-30 | 2010-06-03 | Nexpep Pty Ltd | Compositions and methods for treatment of celiac disease |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| CN108117586A (zh) | 2010-08-10 | 2018-06-05 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| RU2017137415A (ru) * | 2011-01-20 | 2019-02-11 | Иммьюносайнсиз Лаб, Инк. | Способы и устройство для обнаружения глютеновой чувствительности и ее дифференцирования с целиакией |
| ITRM20110487A1 (it) * | 2011-09-19 | 2013-03-20 | Consiglio Per La Ricerca E La Speri Mentazione In | Peptidi aventi effetto protettivo nei confronti della attività infiammatoria del peptide 31-43 della a-gliadina nella malattia celiaca. |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| EP2812344A4 (en) | 2012-02-07 | 2015-10-28 | Vibrant Holdings Llc | SUBSTRATES, PEPTIDE NETWORKS AND METHODS |
| KR20210096312A (ko) | 2012-06-21 | 2021-08-04 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
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| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
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| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
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| US10900964B2 (en) | 2014-09-10 | 2021-01-26 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| AU2015349728A1 (en) | 2014-11-21 | 2017-07-13 | Immusant, Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
| KR101736744B1 (ko) | 2014-12-03 | 2017-05-17 | 주식회사 한국유전자정보연구원 | 셀리악병 진단용 프라이머 세트와 이를 이용한 셀리악병 진단방법 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20180250359A1 (en) * | 2015-08-30 | 2018-09-06 | Diamyd Medical Ab | Combination therapy using gliadin and gamma aminobutyric acid |
| JP7194593B2 (ja) | 2015-12-23 | 2022-12-22 | クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド | 共有ポリマー抗原コンジュゲート化粒子 |
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| EP3464322B1 (en) * | 2016-06-05 | 2023-04-05 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Novel molecules for the treatment of inflammation |
| EP3474881A1 (en) | 2016-06-28 | 2019-05-01 | Immusant, Inc. | Escalating dosage schedules for treating celiac disease |
| BR112019014418A2 (pt) * | 2017-01-12 | 2020-04-14 | Probi Ab | composições probióticas e usos das mesmas |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| CA3074839A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof |
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| WO2014152233A1 (en) | 2013-03-14 | 2014-09-25 | Immusant, Inc. | Placebo-controlled gluten challenge method |
| CA2923822A1 (en) | 2013-09-10 | 2015-03-19 | Immusant, Inc. | Dosage of a gluten peptide composition |
| US20160238590A1 (en) | 2013-09-20 | 2016-08-18 | Immusant, Inc. | Compositions and methods related to oat sensitivity |
| EP3134730A4 (en) | 2014-04-24 | 2018-01-17 | Immusant Inc. | Methods for diagnosing celiac disease using circulating cytokines/chemokines |
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2009
- 2009-11-30 WO PCT/AU2009/001556 patent/WO2010060155A1/en not_active Ceased
- 2009-11-30 HR HRP20150873TT patent/HRP20150873T1/hr unknown
- 2009-11-30 DK DK09828453.2T patent/DK2367561T3/en active
- 2009-11-30 NZ NZ593474A patent/NZ593474A/xx not_active IP Right Cessation
- 2009-11-30 CN CN201510292861.6A patent/CN105079781B/zh not_active Expired - Fee Related
- 2009-11-30 DK DK15168279.6T patent/DK2977053T3/en active
- 2009-11-30 CN CN200980155615.9A patent/CN102438643B/zh not_active Expired - Fee Related
- 2009-11-30 MX MX2011005632A patent/MX346450B/es active IP Right Grant
- 2009-11-30 PT PT98284532T patent/PT2367561E/pt unknown
- 2009-11-30 CA CA2744787A patent/CA2744787C/en active Active
- 2009-11-30 BR BRPI0922122A patent/BRPI0922122A2/pt not_active IP Right Cessation
- 2009-11-30 EP EP15168279.6A patent/EP2977053B1/en not_active Not-in-force
- 2009-11-30 ES ES09828453.2T patent/ES2549481T3/es active Active
- 2009-11-30 EP EP20090828453 patent/EP2367561B1/en not_active Not-in-force
- 2009-11-30 ES ES15168279.6T patent/ES2642096T3/es active Active
- 2009-11-30 HU HUE09828453A patent/HUE027237T2/en unknown
- 2009-11-30 CA CA3042826A patent/CA3042826A1/en not_active Abandoned
- 2009-11-30 AU AU2009321481A patent/AU2009321481B2/en not_active Ceased
- 2009-11-30 US US13/131,787 patent/US8835603B2/en active Active
- 2009-11-30 JP JP2011537796A patent/JP5851243B2/ja not_active Expired - Fee Related
- 2009-11-30 EP EP17175226.4A patent/EP3269379A1/en not_active Withdrawn
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2014
- 2014-08-13 US US14/459,060 patent/US9464120B2/en not_active Expired - Fee Related
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2015
- 2015-12-01 JP JP2015235197A patent/JP6027215B2/ja not_active Expired - Fee Related
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- 2016-09-09 US US15/260,990 patent/US20170158743A1/en not_active Abandoned
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2018
- 2018-06-18 US US16/010,596 patent/US20190048047A1/en not_active Abandoned
- 2018-07-16 HK HK18109154.3A patent/HK1249446A1/en unknown
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2020
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