JP2011524737A5 - - Google Patents
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- JP2011524737A5 JP2011524737A5 JP2010549745A JP2010549745A JP2011524737A5 JP 2011524737 A5 JP2011524737 A5 JP 2011524737A5 JP 2010549745 A JP2010549745 A JP 2010549745A JP 2010549745 A JP2010549745 A JP 2010549745A JP 2011524737 A5 JP2011524737 A5 JP 2011524737A5
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- JP
- Japan
- Prior art keywords
- antigen
- peptide
- peptide according
- ctl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 47
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 22
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 20
- 102000040430 polynucleotide Human genes 0.000 claims description 20
- 108091033319 polynucleotide Proteins 0.000 claims description 20
- 239000002157 polynucleotide Substances 0.000 claims description 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 18
- 150000001413 amino acids Chemical group 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 230000001939 inductive effect Effects 0.000 claims description 13
- 210000001808 exosome Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 108091008874 T cell receptors Proteins 0.000 claims description 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 229940024606 amino acid Drugs 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229930182817 methionine Natural products 0.000 claims description 4
- 239000008177 pharmaceutical agent Substances 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 4
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- 230000005809 anti-tumor immunity Effects 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 230000036039 immunity Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7406208P | 2008-06-19 | 2008-06-19 | |
| US61/074,062 | 2008-06-19 | ||
| US19759908P | 2008-10-28 | 2008-10-28 | |
| US61/197,599 | 2008-10-28 | ||
| PCT/JP2009/002771 WO2009153992A1 (en) | 2008-06-19 | 2009-06-18 | Cdca1 epitope peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524737A JP2011524737A (ja) | 2011-09-08 |
| JP2011524737A5 true JP2011524737A5 (OSRAM) | 2012-08-02 |
| JP5640262B2 JP5640262B2 (ja) | 2014-12-17 |
Family
ID=41433910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549745A Active JP5640262B2 (ja) | 2008-06-19 | 2009-06-18 | Ｃｄｃａ１エピトープペプチドおよびそれを含むワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9387238B2 (OSRAM) |
| EP (1) | EP2303912B1 (OSRAM) |
| JP (1) | JP5640262B2 (OSRAM) |
| KR (2) | KR101705011B1 (OSRAM) |
| CN (1) | CN102119171B (OSRAM) |
| AU (1) | AU2009261382B2 (OSRAM) |
| BR (1) | BRPI0914782B1 (OSRAM) |
| CA (1) | CA2728268C (OSRAM) |
| DK (1) | DK2303912T3 (OSRAM) |
| ES (1) | ES2658842T3 (OSRAM) |
| IL (1) | IL209967A (OSRAM) |
| MX (1) | MX2010014044A (OSRAM) |
| RU (1) | RU2502740C2 (OSRAM) |
| SG (1) | SG191680A1 (OSRAM) |
| TW (1) | TWI526219B (OSRAM) |
| WO (1) | WO2009153992A1 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5150909B2 (ja) | 2005-07-27 | 2013-02-27 | オンコセラピー・サイエンス株式会社 | 食道癌を診断する方法 |
| AU2008290061B2 (en) | 2007-08-20 | 2014-01-30 | Oncotherapy Science, Inc. | CDCA1 peptide and pharmaceutical agent comprising the same |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201004575D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| JP6368243B2 (ja) * | 2011-11-11 | 2018-08-08 | フレッド ハッチンソン キャンサー リサーチ センター | がんのためのサイクリンａ１に標的化されたｔ細胞免疫療法 |
| US20150359864A1 (en) | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| JP6255593B2 (ja) * | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＣＤＣＡ１エピトープペプチドおよびこれを含有するワクチン |
| HRP20192262T1 (hr) | 2013-08-05 | 2020-03-06 | Immatics Biotechnologies Gmbh | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) |
| TWI775117B (zh) | 2013-08-05 | 2022-08-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二） |
| CN107074908B (zh) * | 2014-08-04 | 2021-10-15 | 肿瘤疗法科学股份有限公司 | Cdca1衍生的肽和含有它们的疫苗 |
| WO2016080367A1 (ja) * | 2014-11-18 | 2016-05-26 | 塩野義製薬株式会社 | 安定化されたペプチド組成物 |
| CN111918661A (zh) | 2018-02-21 | 2020-11-10 | 得克萨斯大学体系董事会 | 用于活化和扩增自然杀伤细胞的方法及其用途 |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030198642A1 (en) | 1995-08-03 | 2003-10-23 | Johannes J. Geuze | Cell derived antigen presenting vesicles |
| CA2290783A1 (en) | 1997-05-23 | 1998-11-26 | Biogen, Inc. | Modulators of tissue regeneration |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| CN1318447C (zh) | 1998-06-25 | 2007-05-30 | 伊东恭悟 | 得自亲环蛋白b的肿瘤抗原肽 |
| US7157091B1 (en) | 1999-06-18 | 2007-01-02 | Ludwig Institute For Cancer Research | MAGE-A1 peptides presented by HLA class II molecules |
| US6858204B2 (en) | 1999-06-30 | 2005-02-22 | Corxia Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030211510A1 (en) | 1999-06-30 | 2003-11-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030170255A1 (en) * | 1999-06-30 | 2003-09-11 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20020172952A1 (en) | 1999-06-30 | 2002-11-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| BR0012069A (pt) | 1999-06-30 | 2002-08-27 | Corixa Corp | Composições e métodos para a terapia e diagnóstico de câncer pulmonar |
| WO2001022920A2 (en) | 1999-09-29 | 2001-04-05 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
| US6432966B2 (en) | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| CA2415544A1 (en) | 2000-07-11 | 2002-01-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US7214786B2 (en) | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| WO2003025010A2 (en) | 2001-09-17 | 2003-03-27 | Eirx Therapeutics Limited | Human delta-n p73 molecules and uses thereof |
| US7892559B2 (en) * | 2002-01-30 | 2011-02-22 | Survac Aps | Survivin-derived peptides and use thereof |
| AU2003250831A1 (en) | 2002-06-12 | 2003-12-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
| US7514084B2 (en) | 2002-09-12 | 2009-04-07 | Oncotherapy Science, Inc. | KDR peptides and vaccines comprising the same |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| WO2004031410A2 (en) | 2002-09-30 | 2004-04-15 | Oncotherapy Science, Inc. | Method for diagnosing testicular seminomas |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| JP2006517094A (ja) * | 2002-10-22 | 2006-07-20 | ヌベロ， インコーポレイテッド | 新規核酸およびポリペプチド |
| AU2003300680A1 (en) | 2002-12-10 | 2004-07-09 | Centre National De La Recherche Scientifique Cnrs | Thap proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation |
| EP1668354A2 (en) | 2003-09-24 | 2006-06-14 | Oncotherapy Science, Inc. | Method of diagnosing breast cancer |
| EP2336778A1 (en) | 2004-03-24 | 2011-06-22 | Oncotherapy Science, Inc. | Compositions and methods for treating lung cancer |
| EP2011885B1 (en) | 2005-02-10 | 2015-04-22 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| EP2295570A1 (en) | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| JP5150909B2 (ja) | 2005-07-27 | 2013-02-27 | オンコセラピー・サイエンス株式会社 | 食道癌を診断する方法 |
| EP1915622A2 (en) | 2005-07-29 | 2008-04-30 | Oncotherapy Science, Inc. | Screening and therapeutic method for nsclc targeting cdca1-kntc2 complex |
| US7776341B2 (en) | 2006-08-10 | 2010-08-17 | Colorado State University Research Foundation | Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens |
| AU2008290061B2 (en) | 2007-08-20 | 2014-01-30 | Oncotherapy Science, Inc. | CDCA1 peptide and pharmaceutical agent comprising the same |
| UA100127C2 (ru) | 2007-08-20 | 2012-11-26 | Онкотерапи Саенс, Инк. | Пептид cdh3 и лекарственное средство, содержащее его |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| US20120171213A1 (en) | 2009-09-10 | 2012-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| JP6255593B2 (ja) * | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Ｔｈ１細胞のＣＤＣＡ１エピトープペプチドおよびこれを含有するワクチン |
-
2009
- 2009-06-17 TW TW098120220A patent/TWI526219B/zh active
- 2009-06-18 BR BRPI0914782-9A patent/BRPI0914782B1/pt active IP Right Grant
- 2009-06-18 CA CA2728268A patent/CA2728268C/en active Active
- 2009-06-18 SG SG2013046503A patent/SG191680A1/en unknown
- 2009-06-18 US US12/999,051 patent/US9387238B2/en active Active
- 2009-06-18 AU AU2009261382A patent/AU2009261382B2/en active Active
- 2009-06-18 KR KR1020117000740A patent/KR101705011B1/ko active Active
- 2009-06-18 CN CN200980131202.7A patent/CN102119171B/zh active Active
- 2009-06-18 DK DK09766440.3T patent/DK2303912T3/en active
- 2009-06-18 RU RU2011101709/10A patent/RU2502740C2/ru active
- 2009-06-18 MX MX2010014044A patent/MX2010014044A/es active IP Right Grant
- 2009-06-18 WO PCT/JP2009/002771 patent/WO2009153992A1/en not_active Ceased
- 2009-06-18 EP EP09766440.3A patent/EP2303912B1/en active Active
- 2009-06-18 ES ES09766440.3T patent/ES2658842T3/es active Active
- 2009-06-18 KR KR1020167027024A patent/KR20160119264A/ko not_active Ceased
- 2009-06-18 JP JP2010549745A patent/JP5640262B2/ja active Active
-
2010
- 2010-12-13 IL IL209967A patent/IL209967A/en active IP Right Grant
-
2016
- 2016-06-08 US US15/176,444 patent/US10711047B2/en active Active
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