TWI526219B - Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 - Google Patents
Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 Download PDFInfo
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| DK2186889T3 (en) | 2007-08-20 | 2015-06-08 | Oncotherapy Science Inc | CDCA1 PEPTID AND PHARMACEUTICAL COMPOSITION, INCLUDING THIS |
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| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| ES2687954T3 (es) * | 2011-11-11 | 2018-10-30 | Fred Hutchinson Cancer Research Center | Inmunoterapia de linfocitos T dirigidos a ciclina A1 contra el cáncer |
| KR20140138900A (ko) | 2012-03-09 | 2014-12-04 | 온코세라피 사이언스 가부시키가이샤 | 펩티드를 포함한 의약 조성물 |
| EP2872532A4 (en) * | 2012-07-10 | 2016-04-13 | Oncotherapy Science Inc | CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH |
| SI3456339T1 (sl) | 2013-08-05 | 2022-01-31 | Immatics Biotechnologies Gmbh | Nova imunoterapija proti več tumorjem, kot je pljučni rak, vključno z nedrobnoceličnim pljučnim rakom |
| TWI636065B (zh) * | 2013-08-05 | 2018-09-21 | 伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
| CN107074908B (zh) * | 2014-08-04 | 2021-10-15 | 肿瘤疗法科学股份有限公司 | Cdca1衍生的肽和含有它们的疫苗 |
| JP6781508B2 (ja) | 2014-11-18 | 2020-11-04 | 塩野義製薬株式会社 | 安定化されたペプチド組成物 |
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| JP2002516572A (ja) | 1997-05-23 | 2002-06-04 | バイオジェン，インコーポレイテッド | 組織の再生の調節 |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| ATE375362T1 (de) | 1998-06-25 | 2007-10-15 | Kyogo Itoh | Von cyclophilin b abstammende tumorantigen- peptide |
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| US20060088825A1 (en) | 2001-09-17 | 2006-04-27 | Ian Hayes | Human delta-n p73 molecules and uses thereof |
| US7892559B2 (en) * | 2002-01-30 | 2011-02-22 | Survac Aps | Survivin-derived peptides and use thereof |
| EP1519736A2 (en) | 2002-06-12 | 2005-04-06 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
| EP1548032B9 (en) | 2002-09-12 | 2009-10-28 | Oncotherapy Science, Inc. | Kdr peptides and vaccines comprising the same |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| AU2003260965A1 (en) | 2002-09-30 | 2004-04-23 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosing testicular seminomas |
| AU2003303305A1 (en) | 2002-10-02 | 2004-09-30 | Nuvelo,Inc. | Novel nucleic acids and polypeptides |
| US20040224408A1 (en) | 2002-12-10 | 2004-11-11 | Jean-Philippe Girard | THAP proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation |
| WO2005029067A2 (en) | 2003-09-24 | 2005-03-31 | Oncotherapy Science, Inc. | Method of diagnosing breast cancer |
| TW200533376A (en) | 2004-03-24 | 2005-10-16 | Oncotherapy Science Inc | Compositions and methods for treating lung cancer |
| EP2011885B1 (en) | 2005-02-10 | 2015-04-22 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| WO2007013665A2 (en) | 2005-07-27 | 2007-02-01 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| CN101273144B (zh) | 2005-07-27 | 2011-12-28 | 肿瘤疗法科学股份有限公司 | 诊断食道癌的方法 |
| WO2007013480A2 (en) | 2005-07-29 | 2007-02-01 | Oncotherapy Science, Inc. | Screening and therapeutic method for nsclc targeting cdca1-kntc2 complex |
| US7776341B2 (en) | 2006-08-10 | 2010-08-17 | Colorado State University Research Foundation | Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens |
| CA2696591C (en) | 2007-08-20 | 2016-10-11 | Oncotherapy Science, Inc. | Cdh3 peptide and medicinal agent comprising the same |
| DK2186889T3 (en) * | 2007-08-20 | 2015-06-08 | Oncotherapy Science Inc | CDCA1 PEPTID AND PHARMACEUTICAL COMPOSITION, INCLUDING THIS |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗 |
| US20120171213A1 (en) | 2009-09-10 | 2012-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
| EP2872532A4 (en) * | 2012-07-10 | 2016-04-13 | Oncotherapy Science Inc | CDCA1-EPITOPPEPTIDES FOR TH1 CELLS AND VACCINES THEREWITH |
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| SG191680A1 (en) | 2013-07-31 |
| RU2502740C2 (ru) | 2013-12-27 |
| RU2011101709A (ru) | 2012-07-27 |
| EP2303912B1 (en) | 2018-01-03 |
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| EP2303912A4 (en) | 2012-08-29 |
| US10711047B2 (en) | 2020-07-14 |
| MX2010014044A (es) | 2011-03-03 |
| CA2728268A1 (en) | 2009-12-23 |
| EP2303912A1 (en) | 2011-04-06 |
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| US9387238B2 (en) | 2016-07-12 |
| CN102119171B (zh) | 2014-08-06 |
| DK2303912T3 (en) | 2018-03-12 |
| BRPI0914782B1 (pt) | 2021-08-31 |
| KR101705011B1 (ko) | 2017-02-23 |
| US20110189214A1 (en) | 2011-08-04 |
| US20160272692A1 (en) | 2016-09-22 |
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| AU2009261382A1 (en) | 2009-12-23 |
| CN102119171A (zh) | 2011-07-06 |
| JP5640262B2 (ja) | 2014-12-17 |
| JP2011524737A (ja) | 2011-09-08 |
| KR20160119264A (ko) | 2016-10-12 |
| CA2728268C (en) | 2017-11-07 |
| IL209967A0 (en) | 2011-02-28 |
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