JP2013517764A5 - - Google Patents
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- Publication number
- JP2013517764A5 JP2013517764A5 JP2012549592A JP2012549592A JP2013517764A5 JP 2013517764 A5 JP2013517764 A5 JP 2013517764A5 JP 2012549592 A JP2012549592 A JP 2012549592A JP 2012549592 A JP2012549592 A JP 2012549592A JP 2013517764 A5 JP2013517764 A5 JP 2013517764A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- peptide
- seq
- ctl
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
- 229940024606 amino acid Drugs 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 201000009273 Endometriosis Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29799610P | 2010-01-25 | 2010-01-25 | |
| US61/297,996 | 2010-01-25 | ||
| PCT/JP2011/000352 WO2011089921A1 (en) | 2010-01-25 | 2011-01-24 | Modified melk peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517764A JP2013517764A (ja) | 2013-05-20 |
| JP2013517764A5 true JP2013517764A5 (OSRAM) | 2014-03-13 |
| JP5884104B2 JP5884104B2 (ja) | 2016-03-15 |
Family
ID=44306725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549592A Active JP5884104B2 (ja) | 2010-01-25 | 2011-01-24 | 改変ｍｅｌｋペプチドおよびそれを含むワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8871719B2 (OSRAM) |
| EP (1) | EP2528937B1 (OSRAM) |
| JP (1) | JP5884104B2 (OSRAM) |
| KR (1) | KR101841475B1 (OSRAM) |
| CN (1) | CN102822193B (OSRAM) |
| AU (1) | AU2011208271B2 (OSRAM) |
| BR (1) | BR112012018457A2 (OSRAM) |
| CA (1) | CA2787369A1 (OSRAM) |
| MX (1) | MX2012008657A (OSRAM) |
| RU (1) | RU2580035C2 (OSRAM) |
| SG (1) | SG182580A1 (OSRAM) |
| TW (1) | TWI485245B (OSRAM) |
| WO (1) | WO2011089921A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014005362A2 (pt) * | 2011-09-07 | 2017-06-13 | Immunotope Inc | vacinas de tumor com nanopartículas |
| WO2013034726A1 (en) * | 2011-09-07 | 2013-03-14 | Midatech Limited | Nanoparticle-peptide compositions |
| US20150359864A1 (en) | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| TWI775117B (zh) | 2013-08-05 | 2022-08-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二） |
| HRP20192262T1 (hr) | 2013-08-05 | 2020-03-06 | Immatics Biotechnologies Gmbh | Nova imunoterapija protiv nekoliko tumora, kao što su rak pluća, uključujući mikrocelularni karcinom pluća (nsclc) |
| RU2756982C2 (ru) * | 2016-08-31 | 2021-10-07 | Онкотерапи Сайенс, Инк. | Моноклональное антитело против melk и его использование |
| WO2020106995A1 (en) * | 2018-11-21 | 2020-05-28 | Endomet Biosciences, Inc. | Compositions and methods for treating endometriosis |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| JP2938569B2 (ja) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| KR100209784B1 (ko) | 1996-10-08 | 1999-07-15 | 박원훈 | 인간 단백질 변이인산화효소 유전자(hpk 38), 그의 염기 서열, 효소 단백질 및 그의 아미노산 서열 |
| US6229001B1 (en) | 1997-01-03 | 2001-05-08 | Southern Research Institute | Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase |
| US6605709B1 (en) | 1999-04-09 | 2003-08-12 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics |
| EP1292289B1 (en) | 2000-05-31 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers |
| US6833447B1 (en) | 2000-07-10 | 2004-12-21 | Monsanto Technology, Llc | Myxococcus xanthus genome sequences and uses thereof |
| US20020156263A1 (en) | 2000-10-05 | 2002-10-24 | Huei-Mei Chen | Genes expressed in breast cancer |
| GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| US20030157082A1 (en) | 2002-01-31 | 2003-08-21 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480,20893, 33230,1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules |
| CN101967490B (zh) | 2002-06-14 | 2014-07-16 | 先正达公司 | 木聚糖酶、编码木聚糖酶的核酸以及制备和应用它们的方法 |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| DK3170906T3 (en) | 2003-06-24 | 2018-11-05 | Genomic Health Inc | PREDICTION OF THE LIKELI REVENUE OF CANCER |
| AU2004264936A1 (en) | 2003-08-14 | 2005-02-24 | Exelixis, Inc. | MELKs as modifiers of the RAC pathway and methods of use |
| WO2005073374A1 (ja) * | 2004-01-29 | 2005-08-11 | Dainippon Sumitomo Pharma Co., Ltd. | 新規腫瘍抗原蛋白質及びその利用 |
| EP1786925B1 (en) | 2004-08-10 | 2010-12-08 | Oncotherapy Science, Inc. | Genes and polypeptides relating to breast cancers |
| EP2011885B1 (en) | 2005-02-10 | 2015-04-22 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| EP1859266A4 (en) | 2005-02-24 | 2010-07-28 | Cemines Inc | COMPOSITIONS AND METHODS FOR CLASSIFYING BIOLOGICAL SAMPLES |
| US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| EP2295570A1 (en) | 2005-07-27 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| RU2449020C2 (ru) * | 2005-07-27 | 2012-04-27 | Онкотерапи Сайенс, Инк. | Связанный с раком толстого кишечника ген том34 |
| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| WO2008023841A1 (en) | 2006-08-25 | 2008-02-28 | Oncotherapy Science, Inc. | Breast cancer-associated gene, melk, and its interactions with bcl-g |
| TWI466680B (zh) | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Ｍｅｌｋ抗原決定位胜肽及含此胜肽的疫苗 |
-
2011
- 2011-01-21 TW TW100102242A patent/TWI485245B/zh not_active IP Right Cessation
- 2011-01-24 CA CA2787369A patent/CA2787369A1/en not_active Abandoned
- 2011-01-24 KR KR1020127021961A patent/KR101841475B1/ko not_active Expired - Fee Related
- 2011-01-24 MX MX2012008657A patent/MX2012008657A/es active IP Right Grant
- 2011-01-24 US US13/574,774 patent/US8871719B2/en active Active
- 2011-01-24 JP JP2012549592A patent/JP5884104B2/ja active Active
- 2011-01-24 AU AU2011208271A patent/AU2011208271B2/en not_active Ceased
- 2011-01-24 RU RU2012136464/10A patent/RU2580035C2/ru not_active IP Right Cessation
- 2011-01-24 SG SG2012052999A patent/SG182580A1/en unknown
- 2011-01-24 BR BR112012018457A patent/BR112012018457A2/pt active Search and Examination
- 2011-01-24 CN CN201180015963.3A patent/CN102822193B/zh active Active
- 2011-01-24 WO PCT/JP2011/000352 patent/WO2011089921A1/en not_active Ceased
- 2011-01-24 EP EP11734528.0A patent/EP2528937B1/en active Active
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