JP2016511221A5 - - Google Patents
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- Publication number
- JP2016511221A5 JP2016511221A5 JP2015545547A JP2015545547A JP2016511221A5 JP 2016511221 A5 JP2016511221 A5 JP 2016511221A5 JP 2015545547 A JP2015545547 A JP 2015545547A JP 2015545547 A JP2015545547 A JP 2015545547A JP 2016511221 A5 JP2016511221 A5 JP 2016511221A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- peptide according
- apc
- ctl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 11
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 210000001808 exosome Anatomy 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361777334P | 2013-03-12 | 2013-03-12 | |
| US61/777,334 | 2013-03-12 | ||
| PCT/JP2014/001350 WO2014141683A1 (en) | 2013-03-12 | 2014-03-11 | Kntc2 peptides and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511221A JP2016511221A (ja) | 2016-04-14 |
| JP2016511221A5 true JP2016511221A5 (OSRAM) | 2017-04-13 |
| JP6295491B2 JP6295491B2 (ja) | 2018-03-20 |
Family
ID=51536362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545547A Active JP6295491B2 (ja) | 2013-03-12 | 2014-03-11 | Ｋｎｔｃ２ペプチドおよびそれを含むワクチン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9597382B2 (OSRAM) |
| EP (1) | EP2970944B1 (OSRAM) |
| JP (1) | JP6295491B2 (OSRAM) |
| KR (1) | KR102213574B1 (OSRAM) |
| CN (1) | CN105164256B (OSRAM) |
| AR (1) | AR095386A1 (OSRAM) |
| AU (1) | AU2014232630B2 (OSRAM) |
| BR (1) | BR112015021828A2 (OSRAM) |
| CA (1) | CA2903139C (OSRAM) |
| DK (1) | DK2970944T3 (OSRAM) |
| ES (1) | ES2739693T3 (OSRAM) |
| IL (1) | IL240701B (OSRAM) |
| MX (1) | MX366365B (OSRAM) |
| RU (1) | RU2671395C2 (OSRAM) |
| SG (2) | SG10201707316WA (OSRAM) |
| TW (1) | TWI658049B (OSRAM) |
| WO (1) | WO2014141683A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008117067A2 (en) | 2007-03-27 | 2008-10-02 | Carl Arne Krister Borrebaeck | Protein signature/markers for the detection of adenocarcinoma |
| AU2016218902A1 (en) * | 2015-02-09 | 2017-08-10 | Rsem, Limited Partnership | Novel minor histocompatibility antigens and uses thereof |
| US10881611B2 (en) | 2015-06-16 | 2021-01-05 | Fondazione Città Della Speranza—Onlus | Extracellular vesicles derived from osteoblastic lineage cells for therapeutic and diagnostic use |
| GB201516801D0 (en) * | 2015-09-22 | 2015-11-04 | Immunovia Ab | Method, array and use thereof |
| HRP20220605T1 (hr) | 2017-01-25 | 2022-07-08 | Ose Immunotherapeutics | Postupak za proizvodnju stabilne emulzije za isporuku peptida |
| WO2019160099A1 (ja) * | 2018-02-15 | 2019-08-22 | 大塚製薬株式会社 | がん抗原ペプチド |
| GB202010970D0 (en) | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
| AU2021356681A1 (en) * | 2020-10-09 | 2023-05-18 | Eureka Therapeutics Inc. | Compositions targeting ndc80/mhc complexes and uses thereof |
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| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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| JP2938569B2 (ja) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
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| US20030198642A1 (en) | 1995-08-03 | 2003-10-23 | Johannes J. Geuze | Cell derived antigen presenting vesicles |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| CA2262006A1 (en) | 1996-07-26 | 1998-02-05 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
| AU6795898A (en) | 1997-04-04 | 1998-10-30 | Board Of Regents, The University Of Texas System | Proteins and compositions for modulating mitosis |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| EP1022286A4 (en) | 1997-10-07 | 2003-04-09 | Ono Pharmaceutical Co | POLYPEPTIDES, FOR ENDING CODNA AND THEIR USE |
| CN1318447C (zh) | 1998-06-25 | 2007-05-30 | 伊东恭悟 | 得自亲环蛋白b的肿瘤抗原肽 |
| US6703491B1 (en) * | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
| AU2001277172A1 (en) | 2000-07-26 | 2002-02-05 | Applied Genomics, Inc. | Bstp-trans protein and related reagents and methods of use thereof |
| US20090062512A1 (en) | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| WO2002072631A2 (en) | 2001-03-14 | 2002-09-19 | Dakocytomation Denmark A/S | Mhc molecule constructs and their usesfor diagnosis and therapy |
| WO2002078524A2 (en) | 2001-03-28 | 2002-10-10 | Zycos Inc. | Translational profiling |
| GB2392158B (en) | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| US20070224201A1 (en) | 2002-10-02 | 2007-09-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
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| WO2004058153A2 (en) | 2002-12-20 | 2004-07-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476. |
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| EP1915622A2 (en) | 2005-07-29 | 2008-04-30 | Oncotherapy Science, Inc. | Screening and therapeutic method for nsclc targeting cdca1-kntc2 complex |
| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| US7507536B2 (en) * | 2005-10-07 | 2009-03-24 | The Johns Hopkins University | Methylation markers for diagnosis and treatment of ovarian cancer |
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| TWI596109B (zh) * | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| UA100127C2 (ru) | 2007-08-20 | 2012-11-26 | Онкотерапи Саенс, Инк. | Пептид cdh3 и лекарственное средство, содержащее его |
| US9273100B2 (en) * | 2007-11-09 | 2016-03-01 | Board Of Trustees Of Michigan State University | Use of Galerina marginata genes and proteins for peptide production |
| WO2009099580A2 (en) * | 2008-02-05 | 2009-08-13 | Monsanto Technology, Llc | Isolated novel nucleic acid and protein molecules from soy and methods of using those molecules to generate transgenic plants with enhanced agronomic traits |
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| WO2011039289A1 (de) | 2009-09-29 | 2011-04-07 | Protagen Ag | Markersequenzen für pankreaskrebserkrankungen, pankreaskarzinom und deren verwendung |
| MX2015013163A (es) * | 2013-03-15 | 2016-04-04 | Zyngenia Inc | Complejos multiespecificos multivalente y monovalentes y sus usos. |
| EP3008204B1 (en) * | 2013-06-10 | 2024-03-13 | Iogenetics, LLC. | Mathematical processes for determination of peptidase cleavage |
-
2014
- 2014-03-06 TW TW103107588A patent/TWI658049B/zh not_active IP Right Cessation
- 2014-03-11 SG SG10201707316WA patent/SG10201707316WA/en unknown
- 2014-03-11 AU AU2014232630A patent/AU2014232630B2/en not_active Ceased
- 2014-03-11 MX MX2015012012A patent/MX366365B/es active IP Right Grant
- 2014-03-11 EP EP14763683.1A patent/EP2970944B1/en active Active
- 2014-03-11 KR KR1020157027357A patent/KR102213574B1/ko not_active Expired - Fee Related
- 2014-03-11 CN CN201480022294.6A patent/CN105164256B/zh not_active Expired - Fee Related
- 2014-03-11 DK DK14763683.1T patent/DK2970944T3/da active
- 2014-03-11 WO PCT/JP2014/001350 patent/WO2014141683A1/en not_active Ceased
- 2014-03-11 RU RU2015143164A patent/RU2671395C2/ru active
- 2014-03-11 SG SG11201507236XA patent/SG11201507236XA/en unknown
- 2014-03-11 ES ES14763683T patent/ES2739693T3/es active Active
- 2014-03-11 US US14/772,003 patent/US9597382B2/en active Active
- 2014-03-11 CA CA2903139A patent/CA2903139C/en active Active
- 2014-03-11 JP JP2015545547A patent/JP6295491B2/ja active Active
- 2014-03-11 BR BR112015021828A patent/BR112015021828A2/pt not_active Application Discontinuation
- 2014-03-13 AR ARP140100928A patent/AR095386A1/es unknown
-
2015
- 2015-08-20 IL IL240701A patent/IL240701B/en unknown
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