JP2012505247A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012505247A5 JP2012505247A5 JP2011531221A JP2011531221A JP2012505247A5 JP 2012505247 A5 JP2012505247 A5 JP 2012505247A5 JP 2011531221 A JP2011531221 A JP 2011531221A JP 2011531221 A JP2011531221 A JP 2011531221A JP 2012505247 A5 JP2012505247 A5 JP 2012505247A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- alkyl
- group
- methyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 6
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 4
- -1 CF 3 Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 125000004982 dihaloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 108091023025 thyroid hormone binding Proteins 0.000 claims 1
- 102000028501 thyroid hormone-binding Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10409108P | 2008-10-09 | 2008-10-09 | |
| US61/104,091 | 2008-10-09 | ||
| PCT/US2009/060237 WO2010042867A2 (en) | 2008-10-09 | 2009-10-09 | Activators of human pyruvate kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207672A Division JP5960770B2 (ja) | 2008-10-09 | 2014-10-09 | ヒトピルビン酸キナーゼ活性化剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505247A JP2012505247A (ja) | 2012-03-01 |
| JP2012505247A5 true JP2012505247A5 (enExample) | 2012-10-04 |
| JP5632379B2 JP5632379B2 (ja) | 2014-11-26 |
Family
ID=41462200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011531221A Active JP5632379B2 (ja) | 2008-10-09 | 2009-10-09 | ヒトピルビン酸キナーゼ活性化剤 |
| JP2014207672A Active JP5960770B2 (ja) | 2008-10-09 | 2014-10-09 | ヒトピルビン酸キナーゼ活性化剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207672A Active JP5960770B2 (ja) | 2008-10-09 | 2014-10-09 | ヒトピルビン酸キナーゼ活性化剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8841305B2 (enExample) |
| EP (2) | EP3173415B1 (enExample) |
| JP (2) | JP5632379B2 (enExample) |
| AU (2) | AU2009303335B2 (enExample) |
| CA (2) | CA3041868C (enExample) |
| ES (1) | ES2620634T3 (enExample) |
| WO (1) | WO2010042867A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007281911B2 (en) | 2006-08-04 | 2014-02-06 | Beth Israel Deaconess Medical Center | Inhibitors of pyruvate kinase and methods of treating disease |
| ES2620634T3 (es) | 2008-10-09 | 2017-06-29 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activadores de piruvato quinasa humana |
| JP5756457B2 (ja) | 2009-04-06 | 2015-07-29 | アジオス ファーマシューティカルズ， インコーポレイテッド | ピルビン酸キナーゼｍ２調節剤、治療組成物および関連する使用方法 |
| PL2427441T3 (pl) | 2009-05-04 | 2017-06-30 | Agios Pharmaceuticals, Inc. | Aktywatory PKM2 do stosowania w leczeniu raka |
| DK2448581T3 (en) | 2009-06-29 | 2017-03-13 | Agios Pharmaceuticals Inc | Therapeutic compositions and methods for their applications |
| PE20120693A1 (es) | 2009-06-29 | 2012-07-04 | Agios Pharmaceuticals Inc | Compuestos heterociclos como moduladores de la piruvato cinasa m2 (pkm2) |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| US20130109672A1 (en) * | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| WO2012056319A1 (en) * | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
| US9221792B2 (en) | 2010-12-17 | 2015-12-29 | Agios Pharmaceuticals, Inc | N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators |
| WO2012088314A1 (en) | 2010-12-21 | 2012-06-28 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
| TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
| WO2012151440A1 (en) * | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| PT3406251T (pt) | 2011-05-03 | 2024-01-24 | Agios Pharmaceuticals Inc | Ativadores da piruvato-cinase para utilização em terapia |
| EP2704719B1 (en) | 2011-05-03 | 2018-02-21 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
| WO2013005157A1 (en) * | 2011-07-05 | 2013-01-10 | Lupin Limited | Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer |
| WO2013027168A1 (en) * | 2011-08-22 | 2013-02-28 | Pfizer Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| DE102012207707A1 (de) * | 2012-05-09 | 2013-11-28 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Minimalinvasives Instrument für die robotische Chirurgie |
| EP2909181B1 (en) * | 2012-10-16 | 2017-08-09 | Tolero Pharmaceuticals, Inc. | Pkm2 modulators and methods for their use |
| NZ707778A (en) * | 2012-11-08 | 2019-03-29 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions and their use as pkm2 modulators |
| WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| CN104370936A (zh) * | 2014-09-28 | 2015-02-25 | 苏州维泰生物技术有限公司 | 一种新型丙酮酸激酶m2激活剂及其合成方法 |
| MX384883B (es) | 2015-06-11 | 2025-03-14 | Agios Pharmaceuticals Inc | Métodos para usar activadores de piruvato cinasa. |
| KR101713678B1 (ko) * | 2015-08-24 | 2017-03-09 | 대우제약 주식회사 | 신규 화합물 4-Ethyl-7-(2-fluoro-benzylsulfanyl)-2-methyl-1-thia-3b, 5, 6-triaza-cyclopenta[a]indene 및 이를 포함하는 항암제용 약제학적 조성물 |
| US11033998B2 (en) | 2016-01-25 | 2021-06-15 | The Regents Of The University Of California | Binder compositions of tungsten tetraboride and abrasive methods thereof |
| AR111295A1 (es) * | 2017-03-20 | 2019-06-26 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr) |
| EP3668513B1 (en) | 2017-08-15 | 2021-11-10 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use in treating blood disorders |
| US20200237766A1 (en) | 2017-10-13 | 2020-07-30 | Tolero Pharmaceuticals, Inc. | Pkm2 activators in combination with reactive oxygen species for treatment of cancer |
| US12233063B2 (en) | 2017-10-20 | 2025-02-25 | The Regents Of The University Of Michigan | Compositions and methods for treating eye disorders |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20220127267A1 (en) * | 2019-02-13 | 2022-04-28 | Agios Pharmaceuticals, Inc. | Thieno[3,2-b] pyrrole[3,2-d]pyridazinone derivatives and their use as pkm2 derivatives for the treatment of cancer, obesity and diabetes related disorders |
| AU2020245437A1 (en) | 2019-03-22 | 2021-09-30 | Sumitomo Pharma Oncology, Inc. | Compositions comprising PKM2 modulators and methods of treatment using the same |
| CN110483504B (zh) * | 2019-08-02 | 2022-04-26 | 桂林理工大学 | 以DMF为甲酰化试剂构建2-(2-萘基)咪唑[1,2-a]吡啶-3-醛的新方法 |
| MX2022003025A (es) | 2019-09-19 | 2022-04-07 | Forma Therapeutics Inc | Activacion de la piruvato cinasa r. |
| DE102019129527A1 (de) | 2019-10-31 | 2021-05-06 | Forschungszentrum Jülich GmbH | Inhibitoren für Bromodomänen |
| WO2021105115A1 (en) | 2019-11-28 | 2021-06-03 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| US12478621B2 (en) | 2019-11-28 | 2025-11-25 | Deutsches Krebsforschungszentrum | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| US12337005B2 (en) | 2020-05-26 | 2025-06-24 | University Of Iowa Research Foundation | Methods of treating thrombosis |
| EP4161886A4 (en) | 2020-06-04 | 2023-12-27 | Supermetalix, Inc. | Metal boride ceramic composites and uses thereof |
| CA3183980A1 (en) * | 2020-07-21 | 2022-01-27 | The Regents Of The University Of Michigan | Compositions and methods for activating pyruvate kinase |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2023052783A1 (en) * | 2021-09-30 | 2023-04-06 | Sitryx Therapeutics Limited | Novel compounds |
| CN118434720A (zh) | 2021-12-22 | 2024-08-02 | 西特瑞治疗有限公司 | 作为丙酮酸激酶调节剂的酞嗪衍生物 |
| CN115010721B (zh) * | 2022-03-14 | 2023-06-13 | 五邑大学 | 一种荧光探针及其制备方法和应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998828A (en) * | 1975-01-31 | 1976-12-21 | Pfizer Inc. | 4-[2-(1,3-Dialkyl-1,2,3,4-tetra-hydropyrimidine-2,4-dione-5-carboxamido)ethyl]-1-piperidine sulfonamide |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| DE2948434A1 (de) * | 1979-12-01 | 1981-06-11 | Hoechst Ag, 6000 Frankfurt | 1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4593102A (en) * | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
| US5019369A (en) * | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| JPH0667926B2 (ja) * | 1985-11-12 | 1994-08-31 | 旭化成工業株式会社 | 環状のイソキノリンスルホンアミド誘導体 |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| IT1252567B (it) * | 1991-12-20 | 1995-06-19 | Italfarmaco Spa | Derivati di 5-isochinolinsolfonammidi inibitori delle protein-chinasi |
| DE69637380T2 (de) | 1995-01-20 | 2009-09-17 | G.D. Searle Llc, Chicago | Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| PL351767A1 (en) * | 1999-02-09 | 2003-06-16 | Dimensional Pharmaceuticals 3 | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
| US6211182B1 (en) | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
| IT1313592B1 (it) * | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Derivati di 1h-pirido 3,4-b indol-1-one. |
| AR032885A1 (es) * | 2000-08-16 | 2003-12-03 | Actelion Pharmaceuticals Ltd | Bis-sulfonamidas, composiciones farmaceuticas, procedimiento para prepararlas y el uso de las mismas para la produccion de las composiciones farmaceuticas |
| DE60228233D1 (de) * | 2001-05-23 | 2008-09-25 | Max Planck Gesellschaft | Pyruvat-kinase als einem neuen zielmolekül |
| EP1492794B1 (en) * | 2002-03-28 | 2007-12-12 | Eli Lilly And Company | Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders |
| AU2003237532B2 (en) * | 2002-06-12 | 2009-07-30 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| WO2004016646A2 (en) * | 2002-08-12 | 2004-02-26 | Amynon Bio Tech Gmbh | Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) |
| US7754884B2 (en) * | 2005-01-03 | 2010-07-13 | Vanderbilt University | Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging |
| WO2004076640A2 (en) * | 2003-02-25 | 2004-09-10 | Ambion, Inc. | Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same |
| WO2005074946A1 (en) * | 2004-02-10 | 2005-08-18 | Adenobio N.V. | Stable and active complexes of adenosine and adenosine phosphates with aminoalcohols for the treatment of pulmonary artery hypertension, cardiac failure and other diseases |
| WO2005080394A1 (en) * | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
| US8058313B2 (en) * | 2004-06-24 | 2011-11-15 | Temple University—Of the Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| TW200606152A (en) | 2004-07-02 | 2006-02-16 | Tanabe Seiyaku Co | Piperidine compound and process for preparing the same |
| FR2872704B1 (fr) | 2004-07-12 | 2007-11-02 | Laurent Schwartz | Pluritherapie contre le cancer |
| WO2006055880A2 (en) * | 2004-11-16 | 2006-05-26 | Genzyme Corporation | Diagnostic pkm2 methods and compositions |
| ES2430569T3 (es) * | 2005-02-18 | 2013-11-21 | Astrazeneca Ab | Compuestos antibacterianos derivados de piperidina |
| EP1965799A2 (en) * | 2005-12-22 | 2008-09-10 | Merck & Co., Inc. | Substituted piperidines as calcium channel blockers |
| EP1962851A2 (en) * | 2005-12-22 | 2008-09-03 | SmithKline Beecham Corporation | Compounds |
| CN101404987A (zh) * | 2006-01-20 | 2009-04-08 | 史密丝克莱恩比彻姆公司 | 磺酰胺衍生物在治疗代射和神经系统疾病中的用途 |
| AU2007281911B2 (en) * | 2006-08-04 | 2014-02-06 | Beth Israel Deaconess Medical Center | Inhibitors of pyruvate kinase and methods of treating disease |
| CL2007003223A1 (es) * | 2006-11-10 | 2008-01-11 | Wyeth Corp | Compuestos derivados de piperidinil 4-arilsulfonamidas n-sustituidas, que actuan como moduladores de la proteina sfrp-1; proceso para preparar los compuestos; co mposicion farmaceutica que comprende a dichos copmpuestos y uso de los compuestos para preparar medicamentos para el tratamiento de enfermedades. |
| EP2132169A1 (en) * | 2007-03-05 | 2009-12-16 | Biolipox AB | New methylenebisphenyl compounds useful in the treatment of inflammation |
| WO2008130718A1 (en) * | 2007-04-23 | 2008-10-30 | Atherogenics, Inc. | Sulfonamide containing compounds for treatment of inflammatory disorders |
| WO2009025781A1 (en) | 2007-08-16 | 2009-02-26 | Beth Israel Deaconess Medical Center | Activators of pyruvate kinase m2 and methods of treating disease |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| ES2620634T3 (es) | 2008-10-09 | 2017-06-29 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activadores de piruvato quinasa humana |
| WO2011153359A1 (en) * | 2010-06-04 | 2011-12-08 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
-
2009
- 2009-10-09 ES ES09740795.1T patent/ES2620634T3/es active Active
- 2009-10-09 WO PCT/US2009/060237 patent/WO2010042867A2/en not_active Ceased
- 2009-10-09 EP EP16207004.9A patent/EP3173415B1/en not_active Not-in-force
- 2009-10-09 US US13/123,297 patent/US8841305B2/en active Active
- 2009-10-09 AU AU2009303335A patent/AU2009303335B2/en active Active
- 2009-10-09 CA CA3041868A patent/CA3041868C/en active Active
- 2009-10-09 CA CA2740148A patent/CA2740148C/en active Active
- 2009-10-09 JP JP2011531221A patent/JP5632379B2/ja active Active
- 2009-10-09 EP EP09740795.1A patent/EP2344453B1/en active Active
-
2012
- 2012-03-29 US US13/433,656 patent/US8937067B2/en active Active
-
2014
- 2014-10-09 JP JP2014207672A patent/JP5960770B2/ja active Active
- 2014-12-19 US US14/576,333 patent/US9290512B2/en active Active
-
2016
- 2016-03-21 US US15/076,258 patent/US9707230B2/en active Active
- 2016-08-19 AU AU2016216705A patent/AU2016216705B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602004024375D1 (de) | Carboxamidderivate | |
| JP2020521740A5 (enExample) | ||
| JP2013537203A5 (enExample) | ||
| JP2016503799A5 (enExample) | ||
| JP2016531126A5 (enExample) | ||
| JP2014511891A5 (enExample) | ||
| JP2015531366A5 (enExample) | ||
| HRP20180063T1 (hr) | Lipidirani derivati imidazokinolina | |
| JP2014511892A5 (enExample) | ||
| SE0300480D0 (sv) | Novel compounds | |
| JP2017519781A5 (enExample) | ||
| RU2016134751A (ru) | Соединения | |
| JP2009536660A5 (enExample) | ||
| JP2020520955A5 (enExample) | ||
| RU2009144848A (ru) | Химические соединения-759 | |
| JP2005538089A5 (enExample) | ||
| RU2019142472A (ru) | Глюкуронидные пролекарства ингибиторов янус-киназы | |
| JP2017504635A5 (enExample) | ||
| JP2003306481A5 (enExample) | ||
| ATE386725T1 (de) | Heterocyclylverbindungen | |
| RU2015135824A (ru) | Бициклические соединения пиримидона в качестве ингибиторов lp-pla2 | |
| CY1111022T1 (el) | Νεοι φαρμακευτικοι συνδυασμοι για τη θεραπεια νοσων των αναπνευστικων οδων | |
| SE0402925D0 (sv) | Novel Compounds | |
| RU2015135722A (ru) | Дейтерированный фениламинопиримидин и фармацевтическая композиция, содержащая такое соединение | |
| NO20060665L (no) | N-substituerte pyrazolyl-amidyl-benzimidazolyl C-kit inhibitorer |