JP2012504601A5 - - Google Patents
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- Publication number
- JP2012504601A5 JP2012504601A5 JP2011530023A JP2011530023A JP2012504601A5 JP 2012504601 A5 JP2012504601 A5 JP 2012504601A5 JP 2011530023 A JP2011530023 A JP 2011530023A JP 2011530023 A JP2011530023 A JP 2011530023A JP 2012504601 A5 JP2012504601 A5 JP 2012504601A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally
- alkoxy
- atom
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 45
- 150000003839 salts Chemical class 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- -1 - (C 1 -C 6) alkoxy Chemical group 0.000 claims 12
- 150000001204 N-oxides Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 claims 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- BLMTYJIZYORSGX-PIFIWZBESA-N n-cyclopropyl-3-fluoro-5-[2-(3-hydroxy-2,2-dimethylpropyl)-4-[1-[(3r)-3-(hydroxymethyl)piperazin-1-yl]ethyl]-1-oxoisoquinolin-6-yl]-4-methylbenzamide Chemical compound C=1N(CC(C)(C)CO)C(=O)C2=CC=C(C=3C(=C(F)C=C(C=3)C(=O)NC3CC3)C)C=C2C=1C(C)N1CCN[C@@H](CO)C1 BLMTYJIZYORSGX-PIFIWZBESA-N 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- ZDYXSEQHOVSTPA-UHFFFAOYSA-N 6-bromo-2h-isoquinolin-1-one Chemical compound C1=CNC(=O)C=2C1=CC(Br)=CC=2 ZDYXSEQHOVSTPA-UHFFFAOYSA-N 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- VGIVLIHKENZQHQ-UHFFFAOYSA-N n,n,n',n'-tetramethylmethanediamine Chemical compound CN(C)CN(C)C VGIVLIHKENZQHQ-UHFFFAOYSA-N 0.000 description 1
- DTFAURHMZDMFJA-LJQANCHMSA-N n-cyclopropyl-3-fluoro-5-[2-(3-hydroxy-2,2-dimethylpropyl)-4-[[(2r)-2-methylpiperazin-1-yl]methyl]-1-oxoisoquinolin-6-yl]-4-methylbenzamide Chemical compound C[C@@H]1CNCCN1CC1=CN(CC(C)(C)CO)C(=O)C2=CC=C(C=3C(=C(F)C=C(C=3)C(=O)NC3CC3)C)C=C12 DTFAURHMZDMFJA-LJQANCHMSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10176408P | 2008-10-01 | 2008-10-01 | |
| US61/101,764 | 2008-10-01 | ||
| US17941709P | 2009-05-19 | 2009-05-19 | |
| US61/179,417 | 2009-05-19 | ||
| PCT/SE2009/000432 WO2010039079A1 (en) | 2008-10-01 | 2009-10-01 | Isoquinolinone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504601A JP2012504601A (ja) | 2012-02-23 |
| JP2012504601A5 true JP2012504601A5 (enExample) | 2012-11-08 |
Family
ID=42073703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530023A Ceased JP2012504601A (ja) | 2008-10-01 | 2009-10-01 | イソキノリノン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8012980B2 (enExample) |
| EP (1) | EP2344472A4 (enExample) |
| JP (1) | JP2012504601A (enExample) |
| KR (1) | KR20110067051A (enExample) |
| CN (1) | CN102245593A (enExample) |
| AR (1) | AR073711A1 (enExample) |
| AU (1) | AU2009300456B2 (enExample) |
| BR (1) | BRPI0920756A2 (enExample) |
| CA (1) | CA2737434A1 (enExample) |
| MX (1) | MX2011003489A (enExample) |
| RU (1) | RU2512318C2 (enExample) |
| TW (1) | TW201018665A (enExample) |
| UY (1) | UY32154A (enExample) |
| WO (1) | WO2010039079A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9173395B2 (en) | 2011-07-04 | 2015-11-03 | Bayer Intellectual Property Gmbh | Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants |
| US12496297B1 (en) * | 2020-10-23 | 2025-12-16 | Washington University | Compositions of autophagy modulating agents and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055153A1 (en) | 1999-03-17 | 2000-09-21 | Astrazeneca Ab | Amide derivatives |
| JP2004143134A (ja) * | 2002-02-13 | 2004-05-20 | Takeda Chem Ind Ltd | Ｊｎｋ阻害剤 |
| US7402595B2 (en) | 2002-02-13 | 2008-07-22 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
| US6867320B2 (en) | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| JP2005526068A (ja) | 2002-03-14 | 2005-09-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 抗炎症剤としての単環式アロイルピリジノン類 |
| RU2297411C2 (ru) * | 2002-10-01 | 2007-04-20 | Мицубиси Фарма Корпорейшн | Изохинолиновые соединения, промежуточные соединения, способы их получения и применение |
| CN101031539A (zh) | 2003-08-14 | 2007-09-05 | 旭化成制药株式会社 | 取代的芳基链烷酸衍生物及其用途 |
| JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| NZ545694A (en) | 2003-12-03 | 2010-04-30 | Ym Bioscience Australia Pty Lt | Azole-based kinase inhibitors |
| GB0402812D0 (en) | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
| JP2008504363A (ja) | 2004-06-29 | 2008-02-14 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Ｐ２ｘ７受容体のベンズアミド阻害剤を利用する併用療法 |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| GB0428326D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Ab | Amide derivatives |
| AU2005317868B2 (en) | 2004-12-24 | 2009-06-04 | Astrazeneca Ab | Amide derivatives |
| JP5049970B2 (ja) | 2005-07-26 | 2012-10-17 | サノフイ | Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体 |
| GB0608837D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | Inhibitors of MAP kinase |
| JP5340918B2 (ja) | 2006-05-04 | 2013-11-13 | クロマ セラピューティクス リミテッド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| CL2008000973A1 (es) * | 2007-04-05 | 2009-01-02 | Astrazeneca Ab | Compuestos derivados de 1-oxo-isoquinolina; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento de enfermedades pulmonares obstructvas crónicas (epoc) y asma. |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
-
2009
- 2009-09-29 AR ARP090103762A patent/AR073711A1/es unknown
- 2009-09-30 UY UY0001032154A patent/UY32154A/es unknown
- 2009-09-30 TW TW098133161A patent/TW201018665A/zh unknown
- 2009-10-01 CN CN2009801481701A patent/CN102245593A/zh active Pending
- 2009-10-01 JP JP2011530023A patent/JP2012504601A/ja not_active Ceased
- 2009-10-01 BR BRPI0920756A patent/BRPI0920756A2/pt not_active IP Right Cessation
- 2009-10-01 KR KR1020117009801A patent/KR20110067051A/ko not_active Withdrawn
- 2009-10-01 RU RU2011113437/04A patent/RU2512318C2/ru not_active IP Right Cessation
- 2009-10-01 EP EP09818051A patent/EP2344472A4/en not_active Withdrawn
- 2009-10-01 CA CA2737434A patent/CA2737434A1/en not_active Abandoned
- 2009-10-01 MX MX2011003489A patent/MX2011003489A/es active IP Right Grant
- 2009-10-01 US US12/571,894 patent/US8012980B2/en not_active Expired - Fee Related
- 2009-10-01 AU AU2009300456A patent/AU2009300456B2/en not_active Ceased
- 2009-10-01 WO PCT/SE2009/000432 patent/WO2010039079A1/en not_active Ceased
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