JP2012503489A5 - - Google Patents
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- Publication number
- JP2012503489A5 JP2012503489A5 JP2011529214A JP2011529214A JP2012503489A5 JP 2012503489 A5 JP2012503489 A5 JP 2012503489A5 JP 2011529214 A JP2011529214 A JP 2011529214A JP 2011529214 A JP2011529214 A JP 2011529214A JP 2012503489 A5 JP2012503489 A5 JP 2012503489A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- harvest
- micrometers
- respiratory syncytial
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 238000003306 harvesting Methods 0.000 claims 7
- 241000725643 Respiratory syncytial virus Species 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- 238000005352 clarification Methods 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- 229930006000 Sucrose Natural products 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- 238000011084 recovery Methods 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- 238000009295 crossflow filtration Methods 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 2
- 235000011009 potassium phosphates Nutrition 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9974908P | 2008-09-24 | 2008-09-24 | |
| US61/099,749 | 2008-09-24 | ||
| US10493308P | 2008-10-13 | 2008-10-13 | |
| US61/104,933 | 2008-10-13 | ||
| US12245608P | 2008-12-15 | 2008-12-15 | |
| US61/122,456 | 2008-12-15 | ||
| US18772109P | 2009-06-17 | 2009-06-17 | |
| US61/187,721 | 2009-06-17 | ||
| US22213109P | 2009-07-01 | 2009-07-01 | |
| US61/222,131 | 2009-07-01 | ||
| PCT/US2009/058174 WO2010036774A1 (en) | 2008-09-24 | 2009-09-24 | Methods for purification of viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503489A JP2012503489A (ja) | 2012-02-09 |
| JP2012503489A5 true JP2012503489A5 (enExample) | 2012-12-06 |
| JP5548207B2 JP5548207B2 (ja) | 2014-07-16 |
Family
ID=42060079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529214A Active JP5548207B2 (ja) | 2008-09-24 | 2009-09-24 | ウイルスの精製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8785173B2 (enExample) |
| EP (1) | EP2334328A4 (enExample) |
| JP (1) | JP5548207B2 (enExample) |
| KR (1) | KR20110074563A (enExample) |
| CN (1) | CN102215865B (enExample) |
| AU (1) | AU2009296628B2 (enExample) |
| BR (1) | BRPI0919250A2 (enExample) |
| CA (1) | CA2738024A1 (enExample) |
| WO (1) | WO2010036774A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2526170T3 (es) | 2004-12-23 | 2015-01-07 | Medimmune, Llc | Línea celular MDCK no tumorigénica para propagar virus |
| AU2007347716B2 (en) | 2006-09-15 | 2013-06-20 | Medimmune, Llc | MDCK cell lines supporting viral growth to high titers and bioreactor process using the same |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
| CN102216450B (zh) | 2008-09-24 | 2014-05-14 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
| PL2575872T3 (pl) * | 2010-06-01 | 2021-02-22 | Seqirus UK Limited | Zatężanie antygenów szczepionkowych grypy bez liofilizacji |
| WO2012015908A2 (en) | 2010-07-30 | 2012-02-02 | Millipore Corporation | Chromatography media and method |
| US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| US9611458B2 (en) * | 2010-12-27 | 2017-04-04 | Kyowa Hakko Kirin Co., Ltd | Method for preparing aqueous solution containing culture medium and chelating agent |
| CN102199198A (zh) * | 2011-03-28 | 2011-09-28 | 北京交通大学 | 人呼吸道合胞病毒f蛋白的纯化方法 |
| BR112014001049A2 (pt) * | 2011-07-20 | 2017-02-21 | Abbott Biologicals Bv | método para a produção de um antígeno viral derivado de vírus envelopado, e, uso de um método para a fabricação de uma preparação de vacina contendo o antígeno viral |
| EP3068867B1 (en) | 2013-11-16 | 2018-04-18 | Terumo BCT, Inc. | Expanding cells in a bioreactor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| KR102707370B1 (ko) * | 2014-05-13 | 2024-09-13 | 암겐 인코포레이티드 | 필터 및 여과 공정과 함께 사용하기 위한 공정 제어 시스템 및 방법 |
| EP3188816B1 (en) | 2014-09-02 | 2021-06-09 | EMD Millipore Corporation | Chromatography media comprising discrete porous bundles of nanofibrils |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| US20170298091A1 (en) | 2014-12-08 | 2017-10-19 | Emd Millipore Corporation | Mixed Bed Ion Exchange Adsorber |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| EP3353193A4 (en) * | 2015-09-22 | 2019-04-03 | Sanofi Pasteur Biologics, LLC | CLEANING OF THE RESPIRATORY SYNZYTIAL VIRUS |
| CN106337045A (zh) * | 2016-05-24 | 2017-01-18 | 微基生物科技（上海）有限公司 | 一种防止pcr污染的方法及其应用 |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| WO2018183426A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Sharp & Dohme Corp. | Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| JP7261239B2 (ja) * | 2017-10-16 | 2023-04-19 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生組換えフラビウイルスなどから成る安定したワクチン組成物およびその調製方法 |
| US11339377B2 (en) * | 2017-11-08 | 2022-05-24 | Bluesky Immunotherapies Gmbh | SO3 chromatography for use in a method for virus purification |
| IL316312A (en) | 2017-12-07 | 2024-12-01 | Merck Sharp ַ& Dohme Llc | Dengue virus vaccine compound formulations |
| US10988726B2 (en) | 2018-08-19 | 2021-04-27 | Cytera Cellworks Limited | Systems and methods for automated cell culturing |
| DE102018215551A1 (de) | 2018-09-12 | 2020-03-12 | Virolutions Biotech Gmbh | Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten |
| JP7625519B2 (ja) * | 2018-11-21 | 2025-02-03 | カリヴィル イムノセラピューティクス， インコーポレイテッド | ウイルスの製造 |
| CN111763661B (zh) * | 2019-04-02 | 2022-07-29 | 普莱柯生物工程股份有限公司 | 一种病毒纯化的方法、制备的疫苗组合物及其应用 |
| JP7712284B2 (ja) * | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| CA3194520A1 (en) * | 2020-06-11 | 2021-12-16 | 2Seventy Bio, Inc. | Methods for manufacturing viral vectors |
| CN116490515A (zh) * | 2020-06-17 | 2023-07-25 | 梅莎疫苗有限公司 | 嵌合rsv和冠状病毒蛋白、免疫原性组合物和使用方法 |
| CA3187161A1 (en) * | 2020-06-17 | 2021-12-23 | Meissa Vaccines, Inc. | Chimeric rsv and coronavirus proteins, immunogenic compositions, and methods of use |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| JP7716233B2 (ja) * | 2021-05-28 | 2025-07-31 | ダイセン・メンブレン・システムズ株式会社 | 微小有用物質の分離精製方法と分離精製装置 |
| CN113930353B (zh) * | 2021-08-31 | 2023-07-07 | 广西大学 | 一种耐亚硒酸盐的粘质沙雷氏菌及其还原特性鉴定方法 |
| JP7764758B2 (ja) | 2021-12-27 | 2025-11-06 | 株式会社島津製作所 | 濃縮装置、それを備えた分析システムおよび濃縮方法 |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN115505571B (zh) * | 2022-11-24 | 2023-03-10 | 上海倍谙基生物科技有限公司 | 适用于悬浮培养lmh细胞生产禽腺病毒的无血清添加剂 |
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| NO162160C (no) | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| US5118513A (en) | 1987-07-02 | 1992-06-02 | The Procter & Gamble Company | Method for enhancing bioavailability of iron-calcium mineral supplements |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US20060019350A1 (en) | 1989-08-28 | 2006-01-26 | Peter Palese | Recombinant negative strand RNA virus expression system and vacccines |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
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| EP1603940A2 (en) * | 2003-03-18 | 2005-12-14 | Wyeth Holdings Corporation | Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv |
| CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| AU2004274860A1 (en) | 2003-05-28 | 2005-03-31 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with a polII promoter and ribozymes |
| EP1697521B1 (en) | 2003-12-23 | 2010-06-02 | MedImmune, LLC | Multi plasmid system for the production of influenza virus |
| CN1922308A (zh) | 2004-02-23 | 2007-02-28 | 克鲁塞尔荷兰公司 | 病毒纯化方法 |
| AU2005245943A1 (en) | 2004-05-20 | 2005-12-01 | Id Biomedical Corporation | Process for the production of an influenza vaccine |
| EP1796719B1 (en) | 2004-10-06 | 2014-12-03 | MedImmune, LLC | Refrigerator-temperature stable influenza vaccine compositions |
| ES2526170T3 (es) * | 2004-12-23 | 2015-01-07 | Medimmune, Llc | Línea celular MDCK no tumorigénica para propagar virus |
| EP1917352A4 (en) | 2005-06-21 | 2009-03-25 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING HETEROLOGOUS PROTEASE |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| CN101528941B (zh) | 2006-04-19 | 2014-03-12 | 米迪缪尼有限公司 | 在犬细胞中表达负义病毒rna的方法和组合物 |
| PL2007883T3 (pl) * | 2006-04-20 | 2012-07-31 | Wyeth Llc | Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej |
| AU2007347716B2 (en) | 2006-09-15 | 2013-06-20 | Medimmune, Llc | MDCK cell lines supporting viral growth to high titers and bioreactor process using the same |
| CN102216450B (zh) | 2008-09-24 | 2014-05-14 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
-
2009
- 2009-09-24 KR KR1020117009305A patent/KR20110074563A/ko not_active Abandoned
- 2009-09-24 WO PCT/US2009/058174 patent/WO2010036774A1/en not_active Ceased
- 2009-09-24 AU AU2009296628A patent/AU2009296628B2/en not_active Ceased
- 2009-09-24 CN CN2009801468459A patent/CN102215865B/zh not_active Expired - Fee Related
- 2009-09-24 JP JP2011529214A patent/JP5548207B2/ja active Active
- 2009-09-24 CA CA2738024A patent/CA2738024A1/en not_active Abandoned
- 2009-09-24 BR BRPI0919250A patent/BRPI0919250A2/pt not_active IP Right Cessation
- 2009-09-24 US US13/120,638 patent/US8785173B2/en active Active
- 2009-09-24 EP EP09816835A patent/EP2334328A4/en not_active Withdrawn
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