JP2011524887A5 - - Google Patents
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- Publication number
- JP2011524887A5 JP2011524887A5 JP2011514119A JP2011514119A JP2011524887A5 JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5 JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5
- Authority
- JP
- Japan
- Prior art keywords
- retroviral vector
- formulation
- ultrafiltration
- filter
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7368508P | 2008-06-18 | 2008-06-18 | |
| US61/073,685 | 2008-06-18 | ||
| PCT/GB2009/001527 WO2009153563A1 (en) | 2008-06-18 | 2009-06-18 | Virus purification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Division JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524887A JP2011524887A (ja) | 2011-09-08 |
| JP2011524887A5 true JP2011524887A5 (enExample) | 2012-07-19 |
| JP5615271B2 JP5615271B2 (ja) | 2014-10-29 |
Family
ID=40940324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514119A Active JP5615271B2 (ja) | 2008-06-18 | 2009-06-18 | ウイルス精製法 |
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9169491B2 (enExample) |
| EP (2) | EP3192874B1 (enExample) |
| JP (2) | JP5615271B2 (enExample) |
| CN (2) | CN102124115B (enExample) |
| DK (2) | DK2307551T3 (enExample) |
| ES (2) | ES2762864T3 (enExample) |
| PL (2) | PL2307551T3 (enExample) |
| WO (1) | WO2009153563A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX340102B (es) * | 2010-01-28 | 2016-06-24 | The Children's Hospital Of Philadelphia * | Una plataforma de fabricacion ajustable en escala, para la purificacion de vector viral y vectores virales asi purificados para el uso en terapia de genes. |
| WO2011148194A1 (en) | 2010-05-28 | 2011-12-01 | Oxford Biomedica (Uk) Ltd | Delivery of lentiviral vectors to the brain |
| GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| EP3327119A1 (en) | 2011-11-24 | 2018-05-30 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
| DK2790737T3 (en) | 2011-12-12 | 2019-03-18 | Childrens Hospital Philadelphia | COMMERCIAL LARGE SCALE LENTIVIRUS VECTOR-MANUFACTURING SYSTEM AND VECTORS MADE THEREOF |
| EP2802649B1 (en) | 2012-01-09 | 2017-08-09 | Sanofi Pasteur Biologics, LLC | Purification of herpes virus |
| CA2873775C (en) | 2012-05-21 | 2021-04-20 | Sanofi Pasteur Limited | Herpesvirus compositions and related methods |
| ES2959747T3 (es) | 2013-02-15 | 2024-02-28 | Bioverativ Therapeutics Inc | Gen del factor VIII optimizado |
| WO2014145578A1 (en) * | 2013-03-15 | 2014-09-18 | The Children's Hospital Of Philadelphia | Scalable manufacturing process to produce recombinant lentiviral vectors in serum-free suspension cell culture system |
| FR3010720B1 (fr) | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
| FR3014901B1 (fr) | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
| GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| CN104371982A (zh) * | 2014-10-21 | 2015-02-25 | 武汉维诺赛生物技术有限公司 | 一种慢病毒的纯化方法 |
| EP3215522B1 (en) | 2014-11-03 | 2021-12-01 | Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | T cell receptors directed against bob1 and uses thereof |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| CA3214521A1 (en) | 2015-03-10 | 2016-09-15 | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| PL3380620T3 (pl) | 2015-11-23 | 2024-11-12 | Novartis Ag | Zoptymalizowane lentiwirusowe wektory transferowe i ich zastosowanie |
| EP3411478B1 (en) | 2016-02-01 | 2022-06-08 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| CN107043784A (zh) * | 2016-02-05 | 2017-08-15 | 上海吉凯基因化学技术有限公司 | 一种慢病毒载体的制备方法 |
| US20190225956A1 (en) | 2016-05-10 | 2019-07-25 | United States Government As Represented By The Department Of Veterans Affairs | Lentiviral delivery of crispr/cas constructs that cleave genes essential for hiv-1 infection and replication |
| GB201614050D0 (en) | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| EP3714055A1 (en) | 2017-11-21 | 2020-09-30 | CRISPR Therapeutics AG | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| CN111836892B (zh) | 2017-12-21 | 2025-03-11 | 克里斯珀医疗股份公司 | 用于治疗2a型乌谢尔综合征的材料和方法 |
| EP3728595A1 (en) | 2017-12-21 | 2020-10-28 | CRISPR Therapeutics AG | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| EP3502260A1 (en) | 2017-12-22 | 2019-06-26 | Oxford BioMedica (UK) Limited | Retroviral vector |
| WO2019195727A1 (en) * | 2018-04-05 | 2019-10-10 | Oxford University Innovation Limited | Compositions and methods for treating macular dystrophy |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| CN112566494B (zh) | 2018-06-12 | 2023-05-23 | Kbio控股有限公司 | 病毒和抗原纯化和偶联 |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| CA3109640A1 (en) * | 2018-08-16 | 2020-02-20 | Spacecraft Seven, Llc | Production methods for viral vectors |
| KR20220034719A (ko) | 2019-03-10 | 2022-03-18 | 시오 진 테라피스 인코포레이티드 | 파킨슨병을 치료하기 위한 유전자 요법 조성물 및 방법 |
| WO2020214676A1 (en) * | 2019-04-15 | 2020-10-22 | Children's Hospital Medical Center | Viral vector manufacturing methods |
| JP2022551219A (ja) | 2019-08-23 | 2022-12-08 | ロンザ ウォーカーズヴィル,インコーポレーテッド | レンチウイルスベクターの製造方法および構築物 |
| US12403164B2 (en) | 2019-09-30 | 2025-09-02 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| KR20220097492A (ko) | 2019-11-12 | 2022-07-07 | 옥스포드 바이오메디카(유케이) 리미티드 | 생산 시스템 |
| KR20220139911A (ko) | 2020-02-13 | 2022-10-17 | 옥스포드 바이오메디카(유케이) 리미티드 | 렌티바이러스 벡터의 생산 |
| EP4118217A1 (en) | 2020-03-13 | 2023-01-18 | Oxford BioMedica (UK) Limited | Lentiviral vectors |
| WO2021222222A1 (en) | 2020-04-27 | 2021-11-04 | Mccray Jr Paul B | Compositions and methods for the treatment of cystic fibrosis |
| GB202007199D0 (en) | 2020-05-15 | 2020-07-01 | Oxford Biomedica Ltd | Viral vector production |
| JP2023537565A (ja) | 2020-06-24 | 2023-09-04 | バイオベラティブ セラピューティクス インコーポレイテッド | タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第viii因子を除去する方法 |
| US20230304037A1 (en) * | 2020-08-13 | 2023-09-28 | Tmunity Therapeutics Inc. | Methods for producing clinical-grade lentiviral vector |
| CN112226418B (zh) * | 2020-09-25 | 2022-07-08 | 阜外华中心血管病医院 | 重组腺相关病毒纯化方法 |
| WO2022071966A1 (en) * | 2020-10-02 | 2022-04-07 | Genelux Corporation | Bioreactor production of virus from adherent cells |
| GB202017725D0 (en) | 2020-11-10 | 2020-12-23 | Oxford Biomedica Ltd | Method |
| CN112899242A (zh) * | 2021-02-03 | 2021-06-04 | 苏州博腾生物制药有限公司 | 慢病毒纯化工艺 |
| GB202114530D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Retroviral vectors |
| GB202114528D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| GB202114532D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
| GB202114534D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Novel viral regulatory elements |
| GB202114529D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| EP4424705A1 (en) | 2021-10-29 | 2024-09-04 | Agc Inc. | Composition for cell addition |
| EP4431600A1 (en) | 2021-11-12 | 2024-09-18 | Agc Inc. | Virus purification method |
| GB202117844D0 (en) | 2021-12-09 | 2022-01-26 | Oxford Biomedica Ltd | Purification method |
| GB202211935D0 (en) | 2022-08-16 | 2022-09-28 | Oxford Biomedica Ltd | envelope proteins |
| CN116240241A (zh) * | 2022-12-30 | 2023-06-09 | 上海本导基因技术有限公司 | 重组慢病毒载体的纯化制备方法 |
| EP4658797A2 (en) * | 2023-02-01 | 2025-12-10 | Interius Biotherapeutics, Inc. | Processes for the filtration or purification of viral particles |
| WO2024259299A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Compositions and methods for identification of vhh antibodies that bind a target antigen |
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|---|---|---|---|---|
| IL78703A (en) | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| US5512421A (en) | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| EP0572401B2 (en) | 1991-02-19 | 2007-11-07 | The Regents of the University of California | Viral particles having altered host range |
| WO1995019427A1 (en) * | 1994-01-12 | 1995-07-20 | Genetic Therapy, Inc. | Purification of retroviral vectors |
| WO1995025789A1 (en) | 1994-03-22 | 1995-09-28 | The Immune Response Corporation | Highly efficient production and isolation of viral particles |
| US5681746A (en) * | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| EP0968182B1 (en) | 1996-08-07 | 2004-05-06 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| CZ137399A3 (cs) | 1996-10-17 | 1999-07-14 | Oxford Biomedica (Uk) Limited | Retrovirový produkční systém pro produkci replikačně defektivních vektorovýh partikulí |
| WO1998022588A2 (en) * | 1996-11-20 | 1998-05-28 | Introgen Therapeutics, Inc. | An improved method for the production and purification of adenoviral vectors |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| GB2351290A (en) | 1998-05-22 | 2000-12-27 | Oxford Biomedica Ltd | Retroviral delivery sytem |
| GB9904905D0 (en) | 1999-03-03 | 1999-04-28 | Oxford Biomedica Ltd | Cells |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| GB0024550D0 (enExample) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
| WO2003084479A2 (en) * | 2002-03-29 | 2003-10-16 | Merck & Co., Inc. | Large scale methods of producing adenovirus and adenovirus seed stocks |
| US7326555B2 (en) | 2002-05-14 | 2008-02-05 | Merck & Co., Inc. | Methods of adenovirus purification |
| WO2004022761A1 (en) | 2002-09-03 | 2004-03-18 | Oxford Biomedica (Uk) Limited | Retroviral vector and stable packaging cell lines |
| WO2004098531A2 (en) | 2003-05-05 | 2004-11-18 | Virxsys Corporation | Increased transduction using abc transporter substrates and/or inhibitors |
| SE0302509D0 (sv) | 2003-09-19 | 2003-09-19 | Amersham Biosciences Ab | Matrix for separation of polyethers and method of separation |
| KR20060095568A (ko) | 2003-10-20 | 2006-08-31 | 엔에스진 에이/에스 | 파킨슨병의 생체내 유전자 요법 |
| JP2007522814A (ja) * | 2004-02-23 | 2007-08-16 | クルセル ホランド ベー ヴェー | ウイルスの精製方法 |
| GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| GB0526210D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
| DK2007883T3 (da) * | 2006-04-20 | 2012-02-06 | Wyeth Llc | Rensningsfremgangsmåder til isolering af renset vesikulær stomatitis-virus fra cellekultur |
| WO2008065430A2 (en) * | 2006-12-01 | 2008-06-05 | Oxford Biomedica (Uk) Limited | Promoter construct |
| CA2678774A1 (en) | 2007-03-01 | 2008-09-04 | Advanced Vision Therapies, Inc. | Treatment of diseases characterized by inflammation |
| EP2209814B1 (en) * | 2007-11-13 | 2017-01-25 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
-
2009
- 2009-06-18 US US12/487,215 patent/US9169491B2/en active Active
- 2009-06-18 JP JP2011514119A patent/JP5615271B2/ja active Active
- 2009-06-18 EP EP16002644.9A patent/EP3192874B1/en active Active
- 2009-06-18 DK DK09766124.3T patent/DK2307551T3/en active
- 2009-06-18 PL PL09766124T patent/PL2307551T3/pl unknown
- 2009-06-18 DK DK16002644.9T patent/DK3192874T3/da active
- 2009-06-18 EP EP09766124.3A patent/EP2307551B1/en active Active
- 2009-06-18 CN CN200980132555.9A patent/CN102124115B/zh not_active Expired - Fee Related
- 2009-06-18 ES ES16002644T patent/ES2762864T3/es active Active
- 2009-06-18 ES ES09766124.3T patent/ES2618851T3/es active Active
- 2009-06-18 CN CN201410244813.5A patent/CN103993040B/zh not_active Expired - Fee Related
- 2009-06-18 PL PL16002644T patent/PL3192874T3/pl unknown
- 2009-06-18 WO PCT/GB2009/001527 patent/WO2009153563A1/en not_active Ceased
-
2014
- 2014-07-10 JP JP2014142447A patent/JP6002720B2/ja not_active Expired - Fee Related
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