JP2011524887A5 - - Google Patents
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- Publication number
- JP2011524887A5 JP2011524887A5 JP2011514119A JP2011514119A JP2011524887A5 JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5 JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5
- Authority
- JP
- Japan
- Prior art keywords
- retroviral vector
- formulation
- ultrafiltration
- filter
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7368508P | 2008-06-18 | 2008-06-18 | |
| US61/073,685 | 2008-06-18 | ||
| PCT/GB2009/001527 WO2009153563A1 (en) | 2008-06-18 | 2009-06-18 | Virus purification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Division JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524887A JP2011524887A (ja) | 2011-09-08 |
| JP2011524887A5 true JP2011524887A5 (enExample) | 2012-07-19 |
| JP5615271B2 JP5615271B2 (ja) | 2014-10-29 |
Family
ID=40940324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514119A Active JP5615271B2 (ja) | 2008-06-18 | 2009-06-18 | ウイルス精製法 |
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9169491B2 (enExample) |
| EP (2) | EP3192874B1 (enExample) |
| JP (2) | JP5615271B2 (enExample) |
| CN (2) | CN102124115B (enExample) |
| DK (2) | DK2307551T3 (enExample) |
| ES (2) | ES2762864T3 (enExample) |
| PL (2) | PL3192874T3 (enExample) |
| WO (1) | WO2009153563A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2529020B1 (en) | 2010-01-28 | 2018-04-25 | The Children's Hospital of Philadelphia | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
| CN102946907A (zh) | 2010-05-28 | 2013-02-27 | 牛津生物医学（英国）有限公司 | 慢病毒载体向脑的递送 |
| GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| WO2013076309A1 (en) | 2011-11-24 | 2013-05-30 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
| PT2790737T (pt) | 2011-12-12 | 2019-02-28 | Childrens Hospital Philadelphia | Sistema de produção de vetores lentivirais a grande escala comercial e vetores produzidos pelo mesmo |
| US9365832B2 (en) | 2012-01-09 | 2016-06-14 | Sanofi Pasteur Biologics, Llc | Purification of herpes virus |
| WO2013177172A2 (en) | 2012-05-21 | 2013-11-28 | Sanofi Pasteur Limited | Herpesvirus compositions and related methods |
| RS61387B2 (sr) | 2013-02-15 | 2024-06-28 | Bioverativ Therapeutics Inc | Gen optimizovanog faktora viii |
| PT2970920T (pt) * | 2013-03-15 | 2018-07-30 | Childrens Hospital Philadelphia | Processo de fabrico escalável para produzir vetores lentivirais recombinantes em sistema de cultura de células de suspensão livres de soro |
| FR3010720B1 (fr) | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
| FR3014901B1 (fr) * | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
| GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
| US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
| CN104371982A (zh) * | 2014-10-21 | 2015-02-25 | 武汉维诺赛生物技术有限公司 | 一种慢病毒的纯化方法 |
| WO2016071758A1 (en) | 2014-11-03 | 2016-05-12 | Leiden University Medical Center | T cell receptors directed against bob1 and uses thereof |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| AU2016230828B2 (en) | 2015-03-10 | 2020-10-22 | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| ES2987957T3 (es) | 2015-11-23 | 2024-11-18 | Novartis Ag | Vectores de transferencia lentivirales optimizados y usos de los mismos |
| KR20180118659A (ko) | 2016-02-01 | 2018-10-31 | 바이오버라티브 테라퓨틱스 인크. | 최적화된 viii 인자 유전자 |
| CN107043784A (zh) * | 2016-02-05 | 2017-08-15 | 上海吉凯基因化学技术有限公司 | 一种慢病毒载体的制备方法 |
| JP2019519250A (ja) | 2016-05-10 | 2019-07-11 | ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズＵｎｉｔｅｄ Ｓｔａｔｅｓ Ｇｏｖｅｒｎｍｅｎｔ Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｖｅｔｅｒａｎｓ Ａｆｆａｉｒｓ | Ｈｉｖ−１感染と複製に必須な遺伝子を切断するｃｒｉｓｐｒ／ｃａｓの構築物のレンチウィルスによる送達 |
| GB201614050D0 (en) * | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| EP3714055A1 (en) | 2017-11-21 | 2020-09-30 | CRISPR Therapeutics AG | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| CA3084633A1 (en) | 2017-12-21 | 2019-06-27 | Crispr Therapeutics Ag | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| FI3633040T3 (fi) | 2017-12-22 | 2023-08-03 | Oxford Biomedica Ltd | Retrovirusvektori |
| BR112020020204A2 (pt) * | 2018-04-05 | 2021-01-19 | Oxford University Innovation Limited | Composições e métodos para tratamento da distrofia macular |
| SG11202012366WA (en) | 2018-06-12 | 2021-01-28 | Kentucky Bioprocessing Inc | Virus and antigen purification and conjugation |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| JP2021533831A (ja) * | 2018-08-16 | 2021-12-09 | スペースクラフト セブン リミテッド ライアビリティ カンパニー | ウイルスベクターのための生成方法 |
| CN115835887A (zh) | 2019-03-10 | 2023-03-21 | 牛津生物医学（英国）有限公司 | 用于治疗帕金森病的基因治疗组合物和方法 |
| US20220243224A1 (en) * | 2019-04-15 | 2022-08-04 | Children's Hospital Medical Center | Viral vector manufacturing methods |
| KR20220047635A (ko) | 2019-08-23 | 2022-04-18 | 론자 워커스빌 아이엔씨. | 렌티바이러스 벡터의 생산을 위한 방법 및 작제물 |
| JP7803014B2 (ja) | 2019-09-30 | 2026-01-21 | バイオベラティブ セラピューティクス インコーポレイテッド | レンチウイルスベクター製剤 |
| WO2021094752A1 (en) | 2019-11-12 | 2021-05-20 | Oxford Biomedica (Uk) Limited | Production system |
| US20240052366A1 (en) | 2020-02-13 | 2024-02-15 | Oxford Biomedica (Uk) Limited | Production of Lentiviral Vectors |
| WO2021181108A1 (en) | 2020-03-13 | 2021-09-16 | Oxford Biomedica (Uk) Limited | Lentiviral vectors |
| EP4143326A1 (en) | 2020-04-27 | 2023-03-08 | University of Iowa Research Foundation | Compositions and methods for the treatment of cystic fibrosis |
| GB202007199D0 (en) | 2020-05-15 | 2020-07-01 | Oxford Biomedica Ltd | Viral vector production |
| JP2023537565A (ja) | 2020-06-24 | 2023-09-04 | バイオベラティブ セラピューティクス インコーポレイテッド | タンパク質を発現するように改変されたレンチウイルスベクターの調製物から遊離第ｖｉｉｉ因子を除去する方法 |
| CA3188923A1 (en) * | 2020-08-13 | 2022-02-17 | Michael Sean BURNHAM | Methods for producing clinical-grade lentiviral vector |
| CN112226418B (zh) * | 2020-09-25 | 2022-07-08 | 阜外华中心血管病医院 | 重组腺相关病毒纯化方法 |
| CN116529382A (zh) * | 2020-10-02 | 2023-08-01 | 吉恩勒克斯公司 | 由贴壁细胞在生物反应器中产生病毒 |
| GB202017725D0 (en) | 2020-11-10 | 2020-12-23 | Oxford Biomedica Ltd | Method |
| CN112899242A (zh) * | 2021-02-03 | 2021-06-04 | 苏州博腾生物制药有限公司 | 慢病毒纯化工艺 |
| GB202114532D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
| GB202114534D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Novel viral regulatory elements |
| GB202114528D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| GB202114530D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Retroviral vectors |
| GB202114529D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| KR20240093931A (ko) | 2021-10-29 | 2024-06-24 | 에이지씨 가부시키가이샤 | 세포 첨가용 조성물 |
| WO2023085382A1 (ja) | 2021-11-12 | 2023-05-19 | Ａｇｃ株式会社 | ウイルスの精製方法 |
| GB202117844D0 (en) | 2021-12-09 | 2022-01-26 | Oxford Biomedica Ltd | Purification method |
| GB202211935D0 (en) | 2022-08-16 | 2022-09-28 | Oxford Biomedica Ltd | envelope proteins |
| CN116240241A (zh) * | 2022-12-30 | 2023-06-09 | 上海本导基因技术有限公司 | 重组慢病毒载体的纯化制备方法 |
| KR20250141180A (ko) * | 2023-02-01 | 2025-09-26 | 인테리우스 바이오테라퓨틱스, 인코포레이티드 | 바이러스 입자의 여과 또는 정제를 위한 방법 |
| WO2024259299A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Compositions and methods for identification of vhh antibodies that bind a target antigen |
| WO2025235738A1 (en) * | 2024-05-08 | 2025-11-13 | Interius Biotherapeutics, Inc. | Methods of detecting residual dna in viral preparations |
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|---|---|---|---|---|
| IL78703A (en) | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| US5512421A (en) | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| ATE188740T1 (de) | 1991-02-19 | 2000-01-15 | Univ California | Viruspartikel mit veraendertem wirtspektrum |
| EP0738319A4 (en) * | 1994-01-12 | 2000-03-29 | Genetic Therapy Inc | Purification of retroviral vectors |
| WO1995025789A1 (en) | 1994-03-22 | 1995-09-28 | The Immune Response Corporation | Highly efficient production and isolation of viral particles |
| US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| CZ297278B6 (cs) | 1996-08-07 | 2006-10-11 | Darwin Discovery Limited | Deriváty hydroxamové a karboxylové kyseliny a jejich pouzití |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| PT904392E (pt) | 1996-10-17 | 2001-06-29 | Oxford Biomedica Ltd | Vectores retrovirais |
| EP0968284B1 (en) * | 1996-11-20 | 2006-12-13 | Introgen Therapeutics, Inc. | An improved method for the production and purification of adenoviral vectors |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| DE69941049D1 (de) | 1998-05-22 | 2009-08-13 | Oxford Biomedica Ltd | Retrovirales verabreichungssystem |
| GB9904905D0 (en) | 1999-03-03 | 1999-04-28 | Oxford Biomedica Ltd | Cells |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| GB0024550D0 (enExample) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
| JP2005521417A (ja) * | 2002-03-29 | 2005-07-21 | メルク エンド カムパニー インコーポレーテッド | アデノウイルスの大規模産生方法及びアデノウイルス種子ストック |
| EP1506287B1 (en) | 2002-05-14 | 2007-04-25 | Merck & Co., Inc. | Methods of adenovirus purification |
| AU2003260769A1 (en) | 2002-09-03 | 2004-03-29 | Oxford Biomedica (Uk) Limited | Retroviral vector and stable packaging cell lines |
| DE602004030105D1 (de) | 2003-05-05 | 2010-12-30 | Virxsys Corp | Erhöhte transduktion mit abc-transportersubstratenhemmern |
| SE0302509D0 (sv) | 2003-09-19 | 2003-09-19 | Amersham Biosciences Ab | Matrix for separation of polyethers and method of separation |
| AU2004283053A1 (en) * | 2003-10-20 | 2005-05-06 | Nsgene A/S | In vivo gene therapy of Parkinson's Disease |
| CN1922308A (zh) * | 2004-02-23 | 2007-02-28 | 克鲁塞尔荷兰公司 | 病毒纯化方法 |
| GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| GB0526210D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
| PL2007883T3 (pl) * | 2006-04-20 | 2012-07-31 | Wyeth Llc | Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej |
| WO2008065430A2 (en) * | 2006-12-01 | 2008-06-05 | Oxford Biomedica (Uk) Limited | Promoter construct |
| MX2009009200A (es) * | 2007-03-01 | 2009-10-28 | Advanced Vision Therapies Inc | Tratamiento de enfermedades caracterizadas por la inflamacion. |
| RU2501811C2 (ru) * | 2007-11-13 | 2013-12-20 | Био-Текнолоджи Дженерал (Изрейел) Лтд. | Способ стерилизации посредством фильтрации разбавленных вязкоэластичных биополимеров (варианты) |
-
2009
- 2009-06-18 WO PCT/GB2009/001527 patent/WO2009153563A1/en not_active Ceased
- 2009-06-18 EP EP16002644.9A patent/EP3192874B1/en active Active
- 2009-06-18 PL PL16002644T patent/PL3192874T3/pl unknown
- 2009-06-18 CN CN200980132555.9A patent/CN102124115B/zh not_active Expired - Fee Related
- 2009-06-18 CN CN201410244813.5A patent/CN103993040B/zh not_active Expired - Fee Related
- 2009-06-18 PL PL09766124T patent/PL2307551T3/pl unknown
- 2009-06-18 US US12/487,215 patent/US9169491B2/en active Active
- 2009-06-18 ES ES16002644T patent/ES2762864T3/es active Active
- 2009-06-18 DK DK09766124.3T patent/DK2307551T3/en active
- 2009-06-18 DK DK16002644.9T patent/DK3192874T3/da active
- 2009-06-18 EP EP09766124.3A patent/EP2307551B1/en active Active
- 2009-06-18 JP JP2011514119A patent/JP5615271B2/ja active Active
- 2009-06-18 ES ES09766124.3T patent/ES2618851T3/es active Active
-
2014
- 2014-07-10 JP JP2014142447A patent/JP6002720B2/ja not_active Expired - Fee Related
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