JP2012502048A5 - - Google Patents

Info

Publication number

JP2012502048A5

JP2012502048A5 JP2011526202A JP2011526202A JP2012502048A5 JP 2012502048 A5 JP2012502048 A5 JP 2012502048A5 JP 2011526202 A JP2011526202 A JP 2011526202A JP 2011526202 A JP2011526202 A JP 2011526202A JP 2012502048 A5 JP2012502048 A5 JP 2012502048A5

Authority

JP

Japan

Prior art keywords

group

substituted

alkyl group

unsubstituted

halo

Prior art date

2009-09-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 15
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 10
• 125000005843 halogen group Chemical group 0.000 claims 9
• 125000001931 aliphatic group Chemical group 0.000 claims 8
• 125000003342 alkenyl group Chemical group 0.000 claims 8
• 125000000217 alkyl group Chemical group 0.000 claims 8
• 125000000304 alkynyl group Chemical group 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 8
• 125000000547 substituted alkyl group Chemical group 0.000 claims 8
• 125000004122 cyclic group Chemical group 0.000 claims 7
• 125000003368 amide group Chemical group 0.000 claims 5
• 150000002148 esters Chemical class 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 claims 5
• 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 4
• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 150000001412 amines Chemical class 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 230000002255 enzymatic effect Effects 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 230000000302 ischemic effect Effects 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 231100000331 toxic Toxicity 0.000 claims 2
• 230000002588 toxic effect Effects 0.000 claims 2
• MPDDTAJMJCESGV-CTUHWIOQSA-M (3r,5r)-7-[2-(4-fluorophenyl)-5-[methyl-[(1r)-1-phenylethyl]carbamoyl]-4-propan-2-ylpyrazol-3-yl]-3,5-dihydroxyheptanoate Chemical compound C1([C@@H](C)N(C)C(=O)C2=NN(C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C2C(C)C)C=2C=CC(F)=CC=2)=CC=CC=C1 MPDDTAJMJCESGV-CTUHWIOQSA-M 0.000 claims 1
• FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 1
• 108700028369 Alleles Proteins 0.000 claims 1
• 102000009645 Mitochondrial Aldehyde Dehydrogenase Human genes 0.000 claims 1
• 108010009513 Mitochondrial Aldehyde Dehydrogenase Proteins 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000000035 biogenic effect Effects 0.000 claims 1
• 125000001246 bromo group Chemical group Br* 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 125000002346 iodo group Chemical group I* 0.000 claims 1
• 208000031225 myocardial ischemia Diseases 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 150000003254 radicals Chemical class 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 231100000027 toxicology Toxicity 0.000 claims 1