JP2010522710A5 - - Google Patents
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- Publication number
- JP2010522710A5 JP2010522710A5 JP2010500239A JP2010500239A JP2010522710A5 JP 2010522710 A5 JP2010522710 A5 JP 2010522710A5 JP 2010500239 A JP2010500239 A JP 2010500239A JP 2010500239 A JP2010500239 A JP 2010500239A JP 2010522710 A5 JP2010522710 A5 JP 2010522710A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorine
- hydrogen
- halogen
- alkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 18
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 18
- 229910052731 fluorine Inorganic materials 0.000 claims 16
- 239000011737 fluorine Substances 0.000 claims 16
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 125000005002 aryl methyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 150000001555 benzenes Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- NJQGIDVCNBZXLG-LURJTMIESA-N (2s)-3-hydroxy-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid Chemical compound OC[C@@H](C(O)=O)N(C)C(=O)OC(C)(C)C NJQGIDVCNBZXLG-LURJTMIESA-N 0.000 claims 1
- ONNLHBQOUYFFMZ-VIFPVBQESA-N (4s)-n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-2-oxo-1,3-oxazolidine-4-carboxamide Chemical compound C1OC(=O)N(C)[C@@H]1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl ONNLHBQOUYFFMZ-VIFPVBQESA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- AUZWZAYCELKNDY-UHFFFAOYSA-N n-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-4-methyl-5-oxomorpholine-3-carboxamide Chemical compound C1OCC(=O)N(C)C1C(=O)NCC1=CC=CC(C(F)(F)F)=C1Cl AUZWZAYCELKNDY-UHFFFAOYSA-N 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000273 veterinary drug Substances 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- IHXUAUQICBCLFY-NSHDSACASA-N CCN([C@@H](CO1)C(NCc(ccc(F)c2)c2Cl)=O)C1=O Chemical compound CCN([C@@H](CO1)C(NCc(ccc(F)c2)c2Cl)=O)C1=O IHXUAUQICBCLFY-NSHDSACASA-N 0.000 description 1
- 0 Cc1c(*)c(*)c(*)c(*)c1CNC(C(*)(C(*)(*)**1)N(*)C1=O)=O Chemical compound Cc1c(*)c(*)c(*)c(*)c1CNC(C(*)(C(*)(*)**1)N(*)C1=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0706206A GB0706206D0 (en) | 2007-03-29 | 2007-03-29 | Novel compounds |
| GB0805048A GB0805048D0 (en) | 2008-03-18 | 2008-03-18 | Niovel compounds |
| PCT/EP2008/053431 WO2008119685A2 (en) | 2007-03-29 | 2008-03-20 | Oxazolidine and morpholine carboxamide derivatives as p2x7 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010522710A JP2010522710A (ja) | 2010-07-08 |
| JP2010522710A5 true JP2010522710A5 (en:Method) | 2011-05-06 |
Family
ID=39808747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500239A Withdrawn JP2010522710A (ja) | 2007-03-29 | 2008-03-20 | Ｐ２ｘ７調節因子としてのオキサゾリジンおよびモルホリンカルボキサミド誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100144727A1 (en:Method) |
| EP (1) | EP2139875A2 (en:Method) |
| JP (1) | JP2010522710A (en:Method) |
| WO (1) | WO2008119685A2 (en:Method) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2385505T3 (es) * | 2006-07-06 | 2012-07-25 | Glaxo Group Limited | N-fenilmetil-5-oxo-prolina-2-amidas sustituidas como antagonistas del receptor P2X7 y métodos de uso |
| AU2009331659B2 (en) * | 2008-12-23 | 2015-09-03 | F. Hoffmann-La Roche Ag | Dihydropyridone amides as P2X7 modulators |
| CA2768396A1 (en) * | 2009-07-30 | 2011-02-03 | F. Hoffmann-La Roche Ag | Dihydropyrimidone amides as p2x7 modulators |
| JP5819846B2 (ja) | 2009-12-08 | 2015-11-24 | バンダービルト ユニバーシティ | 静脈摘出および自家移植のための改善された方法および組成物 |
| EA201290876A1 (ru) | 2010-03-05 | 2013-03-29 | Президент Энд Феллоуз Оф Гарвард Колледж | Композиции индуцированных дендритных клеток и их использование |
| CA2838640C (en) | 2011-07-22 | 2019-06-11 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| AU2013210682B2 (en) | 2012-01-20 | 2017-05-25 | Idorsia Pharmaceuticals Ltd | Heterocyclic amide derivatives as P2X7 receptor antagonists |
| CN104812749B (zh) | 2012-12-12 | 2016-12-14 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物 |
| KR102232744B1 (ko) | 2012-12-18 | 2021-03-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체 |
| KR102220847B1 (ko) | 2013-01-22 | 2021-02-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| US9388197B2 (en) | 2013-01-22 | 2016-07-12 | Actelion Pharmaceuticals Ltd. | Heterocyclic amide derivatives as P2X7 receptor antagonists |
| US10071167B2 (en) | 2013-05-08 | 2018-09-11 | Children's Medical Center Corporation | Method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the ATP/P2X7R axis) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704546D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| US20040159600A1 (en) * | 2002-06-10 | 2004-08-19 | Stankowski Ralph J | Filtration module including unitary filter cartridge-bowl construction |
| GB0324498D0 (en) * | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| ES2385505T3 (es) * | 2006-07-06 | 2012-07-25 | Glaxo Group Limited | N-fenilmetil-5-oxo-prolina-2-amidas sustituidas como antagonistas del receptor P2X7 y métodos de uso |
-
2008
- 2008-03-20 EP EP08735456A patent/EP2139875A2/en not_active Withdrawn
- 2008-03-20 JP JP2010500239A patent/JP2010522710A/ja not_active Withdrawn
- 2008-03-20 WO PCT/EP2008/053431 patent/WO2008119685A2/en not_active Ceased
- 2008-03-20 US US12/593,357 patent/US20100144727A1/en not_active Abandoned
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