JP2012500814A5 - - Google Patents
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- JP2012500814A5 JP2012500814A5 JP2011524186A JP2011524186A JP2012500814A5 JP 2012500814 A5 JP2012500814 A5 JP 2012500814A5 JP 2011524186 A JP2011524186 A JP 2011524186A JP 2011524186 A JP2011524186 A JP 2011524186A JP 2012500814 A5 JP2012500814 A5 JP 2012500814A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- composition according
- cancer
- motomeko
- egfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200801202 | 2008-08-29 | ||
| DKPA200801202 | 2008-08-29 | ||
| US13639108P | 2008-09-02 | 2008-09-02 | |
| US61/136,391 | 2008-09-02 | ||
| PCT/DK2009/050217 WO2010022736A2 (en) | 2008-08-29 | 2009-08-27 | Recombinant anti-epidermal growth factor receptor antibody compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012500814A JP2012500814A (ja) | 2012-01-12 |
| JP2012500814A5 true JP2012500814A5 (enExample) | 2012-10-11 |
| JP5719298B2 JP5719298B2 (ja) | 2015-05-13 |
Family
ID=41426867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524186A Active JP5719298B2 (ja) | 2008-08-29 | 2009-08-27 | 組換え抗上皮増殖因子受容体抗体組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8663640B2 (enExample) |
| EP (1) | EP2331577B1 (enExample) |
| JP (1) | JP5719298B2 (enExample) |
| KR (1) | KR101706255B1 (enExample) |
| CN (1) | CN102137874B (enExample) |
| AU (1) | AU2009287163B2 (enExample) |
| BR (1) | BRPI0918768B1 (enExample) |
| CA (1) | CA2732856C (enExample) |
| ES (1) | ES2638579T3 (enExample) |
| IL (1) | IL210348A (enExample) |
| MX (1) | MX2011001927A (enExample) |
| RU (1) | RU2540146C2 (enExample) |
| TW (1) | TWI481412B (enExample) |
| WO (1) | WO2010022736A2 (enExample) |
| ZA (1) | ZA201100301B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| BRPI0808551B1 (pt) * | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| MX2011001927A (es) | 2008-08-29 | 2011-04-21 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| EP2337800B1 (en) | 2008-09-15 | 2013-10-02 | Yeda Research and Development Co. Ltd. | Antibody combinations and use of same for treating cancer |
| US8609095B2 (en) | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
| TW201141519A (en) * | 2010-03-04 | 2011-12-01 | Symphogen As | Anti-HER2 antibodies and compositions |
| WO2011140254A1 (en) * | 2010-05-04 | 2011-11-10 | Adimab, Llc | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| CA2815277A1 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Novel egfr-binding molecules and immunoconjugates thereof |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| WO2012059857A2 (en) | 2010-11-01 | 2012-05-10 | Symphogen A/S | Pan-her antibody composition |
| US9155802B2 (en) * | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| SG194567A1 (en) | 2011-04-21 | 2013-12-30 | Seattle Genetics Inc | Novel binder-drug conjugates (adcs) and their use |
| WO2012154983A2 (en) | 2011-05-10 | 2012-11-15 | Biocare Medical, Llc | Systems and methods for anti-pax8 antibodies |
| US9040047B2 (en) | 2011-05-16 | 2015-05-26 | Yeda Research And Development Co. Ltd. | Combinations of anti ErbB antibodies for the treatment of cancer |
| JP2014533954A (ja) | 2011-11-21 | 2014-12-18 | イミュノジェン， インコーポレイテッド | Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 |
| CN102397544A (zh) * | 2011-11-25 | 2012-04-04 | 百泰生物药业有限公司 | 一种单克隆抗体用于治疗非小细胞肺癌的用途 |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| MX371119B (es) | 2012-04-03 | 2020-01-17 | Novartis Ag | Productos de combinacion con los inhibidores de cinasa de tirosina y su uso. |
| HK1202431A1 (en) * | 2012-05-02 | 2015-10-02 | Symphogen A/S | Humanized pan-her antibody compositions |
| ES2682345T3 (es) | 2012-09-27 | 2018-09-20 | Biocare Medical, Llc | Sistemas y procedimientos de anticuerpos antiuroplaquina II |
| WO2014064682A1 (en) * | 2012-10-24 | 2014-05-01 | Yeda Research And Development Co. Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
| WO2014100220A2 (en) | 2012-12-18 | 2014-06-26 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| DK2962113T3 (da) | 2013-02-28 | 2019-07-01 | Biocare Medical Llc | Systemer og fremgangsmåder med anti-p40-antistoffer |
| US9840560B2 (en) * | 2013-03-15 | 2017-12-12 | Alper Biotech Llc | Monoclonal antibodies to EGFR, and uses therefor |
| TWI714869B (zh) * | 2013-08-05 | 2021-01-01 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
| US9816997B2 (en) | 2013-10-03 | 2017-11-14 | Biocare Medical, Llc | Anti-SOX10 antibody systems and methods |
| AU2014372833B2 (en) | 2013-12-23 | 2019-08-22 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) with kinesin spindel protein (KSP) |
| CA2941030C (en) | 2014-02-28 | 2025-05-13 | Merus N.V. | ANTIBODIES THAT BIND TO EGFR AND ERBB3 |
| CN104530237B (zh) * | 2014-12-31 | 2017-09-05 | 百泰生物药业有限公司 | 抗Her1的治疗性抗体 |
| SG11201710639YA (en) | 2015-06-22 | 2018-01-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| JP7296728B2 (ja) | 2015-10-23 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 癌の成長を抑制する結合分子 |
| SG10202008909VA (en) | 2016-03-24 | 2020-10-29 | Bayer Pharma AG | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| AU2017380871C1 (en) | 2016-12-21 | 2025-05-15 | Bayer Aktiengesellschaft | Antibody drug conjugates (ADCs) having enzymatically cleavable groups |
| US11433140B2 (en) | 2016-12-21 | 2022-09-06 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (ADCs) having KSP inhibitors |
| US12059472B2 (en) | 2016-12-21 | 2024-08-13 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| JP7737220B2 (ja) | 2017-03-31 | 2025-09-10 | メルス ナムローゼ フェンノートシャップ | ＮＲＧ１融合遺伝子を有する細胞の処置における使用のためのＥｒｂＢ－２及びＥｒｂＢ３結合二重特異性抗体 |
| EP3625264B9 (en) | 2017-05-17 | 2023-10-25 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| RS66708B9 (sr) | 2017-08-09 | 2025-08-29 | Merus Nv | Antitela koja se vezuju za egfr i cmet |
| WO2019043059A1 (en) | 2017-08-30 | 2019-03-07 | Symphogen A/S | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER BY ANTI-EGFR ANTIBODIES |
| TR201906951A2 (tr) * | 2019-05-09 | 2019-05-21 | Ankara Ueniversitesi Rektoerluegue | Enzimatik İşlemlerle Nar Suyu Kusurlarının Giderilmesi İçin Yöntem |
| WO2022104127A1 (en) * | 2020-11-13 | 2022-05-19 | SAB Biotherapeutics, Inc. | Ungulate-derived polyclonal immunoglobulin specific for egfr and uses thereof |
| CN116333120B (zh) * | 2021-12-16 | 2024-03-05 | 徕特康(苏州)生物制药有限公司 | 抗表皮生长因子受体抗体及其制备方法和用途 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| US5459061A (en) | 1990-01-26 | 1995-10-17 | W. Alton Jones Cell Science Center, Inc. | Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor |
| AU658396B2 (en) | 1991-03-06 | 1995-04-13 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Humanized and chimeric monoclonal antibodies |
| JPH08504172A (ja) | 1992-06-30 | 1996-05-07 | オンコロジクス，インコーポレイティド | 抗−ｅｒｂＢ−２モノクロナール抗体の組み合わせ物及び使用方法 |
| WO1994028929A1 (en) * | 1993-06-07 | 1994-12-22 | Genentech, Inc. | Hiv envelope polypeptides |
| GB9401182D0 (en) | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
| CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| US7060808B1 (en) | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| CN1314404A (zh) | 2000-03-22 | 2001-09-26 | 上海博德基因开发有限公司 | 一种新的多肽——人调控转录因子15和编码这种多肽的多核苷酸 |
| WO2001070985A2 (en) | 2000-03-23 | 2001-09-27 | Greenville Hospital System | Bi-functional cancer treatment agents |
| US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| WO2002066058A1 (en) * | 2001-02-19 | 2002-08-29 | Merck Patent Gmbh | Modified anti-egfr antibodies with reduced immunogenicity |
| DK1392359T4 (da) | 2001-05-11 | 2013-06-10 | Ludwig Inst For Cancer Res Ltd | Specifikke bindingsproteiner og deres anvendelser. |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR100945108B1 (ko) | 2001-06-13 | 2010-03-02 | 젠맵 에이/에스 | 표피 성장 인자 수용체 (ｅｇｆｒ)에 대한 인간모노클로날 항체 |
| AU2002326531A1 (en) | 2001-08-03 | 2003-02-17 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbb family members and methods of use thereof |
| EP1482043A4 (en) | 2002-03-01 | 2005-08-10 | Japan Enviro Chemicals Ltd | FOR BINDING TO ENVIRONMENTAL MORNES, PROTEINS AND METHOD FOR THE PRODUCTION THEREOF |
| WO2003097086A2 (en) | 2002-05-15 | 2003-11-27 | Technische Universität München | Egf receptor antagonists in the treatment of gastric cancer |
| WO2003099205A2 (en) | 2002-05-20 | 2003-12-04 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
| HUP0600340A3 (en) | 2002-07-15 | 2011-06-28 | Genentech Inc | Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| JP2006505546A (ja) | 2002-10-10 | 2006-02-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 二重特異性抗ＥｒｂＢ抗体および腫瘍治療でのその使用 |
| US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| EA013225B1 (ru) | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
| CA2450289A1 (en) | 2003-03-20 | 2005-05-19 | Imclone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| AT500651B9 (de) | 2003-05-27 | 2010-04-15 | Altropus Gmbh | Aktiv immunisierender antikörper |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| EP1712620A4 (en) | 2004-01-23 | 2008-05-28 | Greenpeptide Co Ltd | EGF (EPIDERMAL GROWTH FACTOR) RECEPTOR-ORGANIC PEPTIDE |
| US20110142822A1 (en) | 2004-06-14 | 2011-06-16 | Kussie Paul H | Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof |
| ES2332524T3 (es) | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| JP4926054B2 (ja) | 2004-07-20 | 2012-05-09 | シムフォゲン・アクティーゼルスカブ | 抗−ＲｈＤ組換えポリクローナル抗体及び製造方法 |
| EP3698807A1 (en) | 2005-01-21 | 2020-08-26 | Genentech, Inc. | Fixed dosing of her antibodies |
| US20070009972A1 (en) | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
| RS53128B (sr) | 2005-02-23 | 2014-06-30 | Genentech Inc. | Produžavanje vremena progresije bolesti ili preživljavanja kod pacijenata obolelih od kancera jajnika korišćenjem pertuzumaba |
| CA2601936C (en) | 2005-02-24 | 2014-06-17 | Amgen Inc. | Epidermal growth factor receptor mutations |
| US20060216288A1 (en) | 2005-03-22 | 2006-09-28 | Amgen Inc | Combinations for the treatment of cancer |
| WO2006110478A2 (en) | 2005-04-11 | 2006-10-19 | Novartis Ag | Mutations and polymorphisms of epidermal growth factor receptor |
| AU2006233675A1 (en) | 2005-04-14 | 2006-10-19 | Merck Patent Gmbh | Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues |
| EP1877083A2 (en) | 2005-04-27 | 2008-01-16 | Welson Pharmaceuticals, Inc. | Antibodies for the treatment of cancers |
| WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| US7498142B2 (en) | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
| US20100040606A1 (en) | 2006-03-06 | 2010-02-18 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
| BRPI0808551B1 (pt) * | 2007-03-01 | 2022-04-05 | Symphogen A/S | Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| MX2011001927A (es) | 2008-08-29 | 2011-04-21 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| WO2012059857A2 (en) * | 2010-11-01 | 2012-05-10 | Symphogen A/S | Pan-her antibody composition |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
-
2009
- 2009-08-27 MX MX2011001927A patent/MX2011001927A/es active IP Right Grant
- 2009-08-27 CA CA2732856A patent/CA2732856C/en active Active
- 2009-08-27 US US13/061,417 patent/US8663640B2/en active Active
- 2009-08-27 CN CN200980133687.3A patent/CN102137874B/zh active Active
- 2009-08-27 JP JP2011524186A patent/JP5719298B2/ja active Active
- 2009-08-27 ES ES09776272.8T patent/ES2638579T3/es active Active
- 2009-08-27 WO PCT/DK2009/050217 patent/WO2010022736A2/en not_active Ceased
- 2009-08-27 RU RU2011111746/10A patent/RU2540146C2/ru active
- 2009-08-27 AU AU2009287163A patent/AU2009287163B2/en active Active
- 2009-08-27 EP EP09776272.8A patent/EP2331577B1/en active Active
- 2009-08-27 KR KR1020117007247A patent/KR101706255B1/ko active Active
- 2009-08-27 BR BRPI0918768-5A patent/BRPI0918768B1/pt active IP Right Grant
- 2009-08-31 TW TW098129193A patent/TWI481412B/zh active
-
2010
- 2010-12-29 IL IL210348A patent/IL210348A/en active IP Right Grant
-
2011
- 2011-01-11 ZA ZA2011/00301A patent/ZA201100301B/en unknown
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