|
US663780A
(en)
*
|
1898-09-09 |
1900-12-11 |
Wheeler & Wilson Mfg Co |
Trimming attachment for sewing-machines.
|
|
US4302204A
(en)
|
1979-07-02 |
1981-11-24 |
The Board Of Trustees Of Leland Stanford Junior University |
Transfer and detection of nucleic acids
|
|
US4358535A
(en)
|
1980-12-08 |
1982-11-09 |
Board Of Regents Of The University Of Washington |
Specific DNA probes in diagnostic microbiology
|
|
FI63596C
(fi)
|
1981-10-16 |
1983-07-11 |
Orion Yhtymae Oy |
Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
|
|
US4994373A
(en)
|
1983-01-27 |
1991-02-19 |
Enzo Biochem, Inc. |
Method and structures employing chemically-labelled polynucleotide probes
|
|
AR240698A1
(es)
*
|
1985-01-19 |
1990-09-28 |
Takeda Chemical Industries Ltd |
Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
|
|
US6060237A
(en)
|
1985-02-26 |
2000-05-09 |
Biostar, Inc. |
Devices and methods for optical detection of nucleic acid hybridization
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US5112460A
(en)
*
|
1986-10-21 |
1992-05-12 |
Northeastern University |
High performance microcapillary gel electrophoresis
|
|
ATE186724T1
(de)
|
1987-09-04 |
1999-12-15 |
Beecham Group Plc |
Substituierte thiazolidindionderivate
|
|
US5595883A
(en)
*
|
1990-06-01 |
1997-01-21 |
E. R. Squibb & Sons, Inc. |
Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid
|
|
US5171750A
(en)
|
1991-09-26 |
1992-12-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
Substituted phenserines as specific inhibitors of acetylcholinesterase
|
|
TW263504B
(enExample)
|
1991-10-03 |
1995-11-21 |
Pfizer |
|
|
US5326770A
(en)
*
|
1992-07-17 |
1994-07-05 |
The Du Pont Merck Pharmaceutical Company |
Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
|
|
CZ181493A3
(en)
*
|
1992-09-10 |
1994-03-16 |
Lilly Co Eli |
The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
|
|
CA2142300C
(en)
|
1992-10-13 |
2005-08-23 |
Allen D. Roses |
Methods for detecting alzheimer's disease
|
|
TW438587B
(en)
*
|
1995-06-20 |
2001-06-07 |
Takeda Chemical Industries Ltd |
A pharmaceutical composition for prophylaxis and treatment of diabetes
|
|
ES2100129B1
(es)
|
1995-10-11 |
1998-02-16 |
Medichem Sa |
Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
|
|
JPH09176162A
(ja)
|
1995-12-22 |
1997-07-08 |
Toubishi Yakuhin Kogyo Kk |
チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
|
|
US6128587A
(en)
|
1997-01-14 |
2000-10-03 |
The Regents Of The University Of California |
Method and apparatus using Bayesian subfamily identification for sequence analysis
|
|
US5904824A
(en)
*
|
1997-03-07 |
1999-05-18 |
Beckman Instruments, Inc. |
Microfluidic electrophoresis device
|
|
JP2001514663A
(ja)
*
|
1997-03-12 |
2001-09-11 |
エスモンド，ロバート ダブリュー． |
アルツハイマー病を処置または予防するための方法
|
|
ATE229004T1
(de)
|
1997-03-31 |
2002-12-15 |
Korea Res Inst Chem Tech |
Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung
|
|
ES2259459T3
(es)
*
|
1997-11-19 |
2006-10-01 |
Takeda Pharmaceutical Company Limited |
Nuevos inhibidores de apoptosis.
|
|
US6964868B1
(en)
|
1998-01-28 |
2005-11-15 |
Nuvelo, Inc. |
Human genes and gene expression products II
|
|
US20040058873A1
(en)
*
|
1998-03-12 |
2004-03-25 |
Esmond Robert W. |
Method for treating or preventing Alzheimer's disease
|
|
JP2002534055A
(ja)
|
1998-05-14 |
2002-10-15 |
カイロン コーポレイション |
ヒト遺伝子および遺伝子発現産物ｖ
|
|
ATE317452T1
(de)
|
1998-06-16 |
2006-02-15 |
Nova Molecular Inc |
Verfahren zur behandlung von neurologischen erkrankungen mit hilfe der bestimmung des bche genotyps
|
|
US6368797B1
(en)
|
1998-10-01 |
2002-04-09 |
Variagenics, Inc. |
Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant GPIIIa and/or variant BPIIb allele
|
|
DE69920032T2
(de)
|
1998-11-10 |
2005-09-15 |
Genset |
Methoden, software und apparate zur identifizierung genomischer bereiche, die ein gen umfassen, das mit einem nachweisbaren merkmal assoziiert ist
|
|
US6191154B1
(en)
*
|
1998-11-27 |
2001-02-20 |
Case Western Reserve University |
Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
|
|
CN1078616C
(zh)
*
|
1998-12-16 |
2002-01-30 |
中国科学院上海生命科学研究中心 |
一种检测样品中是否存在老年痴呆病基因的方法和试剂盒
|
|
JP2000273040A
(ja)
*
|
1999-01-19 |
2000-10-03 |
Sankyo Co Ltd |
トログリタゾンを含有するアポトーシス抑制剤
|
|
US6401043B1
(en)
|
1999-04-26 |
2002-06-04 |
Variagenics, Inc. |
Variance scanning method for identifying gene sequence variances
|
|
EP1210087A2
(en)
|
1999-04-29 |
2002-06-05 |
City of Hope |
Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's)
|
|
US6573049B1
(en)
|
1999-07-26 |
2003-06-03 |
Nuvelo, Inc. |
Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease
|
|
DE19936719A1
(de)
*
|
1999-08-06 |
2001-02-15 |
Gruenenthal Gmbh |
Substituierte 1,5-Dihydropyrrol-2-on-Derivate
|
|
US6559188B1
(en)
|
1999-09-17 |
2003-05-06 |
Novartis Ag |
Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
|
|
MY125516A
(en)
|
1999-11-16 |
2006-08-30 |
Smithkline Beecham Plc |
Novel composition based on thiazolidinedione and metformin and use
|
|
US6680322B2
(en)
|
1999-12-02 |
2004-01-20 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A1 receptors and uses thereof
|
|
US6532467B1
(en)
*
|
2000-04-10 |
2003-03-11 |
Sas Institute Inc. |
Method for selecting node variables in a binary decision tree structure
|
|
US6432985B2
(en)
|
2000-04-25 |
2002-08-13 |
Hoffmann-La Roche Inc. |
Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
|
|
JP2004531459A
(ja)
*
|
2000-10-11 |
2004-10-14 |
エスペリオン セラピューティクス，インコーポレイテッド |
コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用
|
|
US7304093B2
(en)
*
|
2000-10-11 |
2007-12-04 |
Esperion Therapeutics, Inc. |
Ketone compounds and compositions for cholesterol management and related uses
|
|
CN1962596A
(zh)
|
2000-10-11 |
2007-05-16 |
埃斯佩里安医疗公司 |
用于控制胆固醇以及相关用途的酮化合物以及组合物
|
|
US20040122091A1
(en)
|
2000-10-11 |
2004-06-24 |
Esperion Therapeutics, Inc. |
Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
|
|
WO2002030884A2
(en)
|
2000-10-11 |
2002-04-18 |
Esperion Therapeutics, Inc. |
Sulfide and disulfide compounds and compositions for cholesterol management and related uses
|
|
IL156015A0
(en)
|
2000-11-24 |
2003-12-23 |
Vascular Biogenics Ltd |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
US6838452B2
(en)
*
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
US6680324B2
(en)
|
2000-12-01 |
2004-01-20 |
Osi Pharmaceuticals, Inc. |
Compounds specific to adenosine A1 receptors and uses thereof
|
|
US6495335B2
(en)
|
2000-12-07 |
2002-12-17 |
Mario Chojkier |
Compositions and methods for diagnosing alzheimer's disease
|
|
DE10132725A1
(de)
|
2001-07-05 |
2006-08-03 |
Grünenthal GmbH |
Substituierte γ-Lactonverbindungen
|
|
US6680299B2
(en)
|
2001-07-27 |
2004-01-20 |
Enanta Pharmaceuticals, Inc. |
4'-substituted leucomycins
|
|
US20050020694A1
(en)
|
2001-10-11 |
2005-01-27 |
Dasseux Jean-Louis Henri |
Sulfide and disulfide compounds and compositions for cholesterol management and related uses
|
|
US20040204502A1
(en)
*
|
2001-10-11 |
2004-10-14 |
Dasseux Jean-Louis Henri |
Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
|
|
US6828462B2
(en)
|
2001-11-07 |
2004-12-07 |
Merz Pharma Gmbh & Co. Kgaa |
Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
|
|
US7132244B2
(en)
|
2001-11-21 |
2006-11-07 |
Syn X Pharma, Inc. |
Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
|
|
US7052849B2
(en)
|
2001-11-23 |
2006-05-30 |
Syn X Pharma, Inc. |
Protein biopolymer markers predictive of insulin resistance
|
|
US7135297B2
(en)
|
2001-11-23 |
2006-11-14 |
Nanogen Inc. |
Protein biopolymer markers indicative of insulin resistance
|
|
US20030220374A1
(en)
*
|
2002-01-14 |
2003-11-27 |
Pharmacia Corporation |
Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
|
|
WO2004005510A1
(ja)
|
2002-07-05 |
2004-01-15 |
Shionogi & Co., Ltd. |
新規Nogo受容体様ポリペプチドおよびそのＤＮＡ
|
|
US20040265849A1
(en)
*
|
2002-11-22 |
2004-12-30 |
Applera Corporation |
Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
|
|
CN1753662A
(zh)
*
|
2002-12-24 |
2006-03-29 |
神经化学（国际）有限公司 |
用于治疗β－淀粉状蛋白相关疾病的治疗制剂
|
|
JP2006519440A
(ja)
*
|
2003-02-14 |
2006-08-24 |
インタージェネティックス インコーポレイテッド |
疾患の増大リスクの統計学的同定法
|
|
US7141669B2
(en)
|
2003-04-23 |
2006-11-28 |
Pfizer Inc. |
Cannabiniod receptor ligands and uses thereof
|
|
US20050004179A1
(en)
*
|
2003-05-22 |
2005-01-06 |
Pedersen Ward A. |
Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease
|
|
US20070203083A1
(en)
|
2003-06-13 |
2007-08-30 |
Mootha Vamsi K |
Methods Of Regulating Metabolism And Mitochondrial Function
|
|
JP4931419B2
(ja)
|
2003-09-19 |
2012-05-16 |
中外製薬株式会社 |
新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのｍｅｋ阻害剤としての使用
|
|
US20050277129A1
(en)
|
2004-01-22 |
2005-12-15 |
Genaissance Pharmaceuticals |
APOE genetic markers associated with age of onset of Alzheimer's disease
|
|
TW200538738A
(en)
|
2004-02-20 |
2005-12-01 |
Univ California |
Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
|
|
WO2006054297A2
(en)
|
2004-11-17 |
2006-05-26 |
Compugen Ltd. |
Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
|
|
US7833513B2
(en)
|
2004-12-03 |
2010-11-16 |
Rhode Island Hospital |
Treatment of Alzheimer's Disease
|
|
US20060228728A1
(en)
|
2005-01-31 |
2006-10-12 |
Perlegen Sciences, Inc. |
Genetic basis of Alzheimer's disease and diagnosis and treatment thereof
|
|
EP2275096A3
(en)
|
2005-08-26 |
2011-07-13 |
Braincells, Inc. |
Neurogenesis via modulation of the muscarinic receptors
|
|
EA200800879A1
(ru)
*
|
2005-09-22 |
2008-10-30 |
ЭсБи ФАРМКО ПУЭРТО РИКО ИНК. |
Агонисты ppar гамма для улучшения когнитивной функции у apoe4 отрицательных пациентов
|
|
US7608412B2
(en)
|
2005-10-05 |
2009-10-27 |
Auburn University |
P62 as a diagnostic tool for alzheimer's disease
|
|
EP2902026B1
(en)
|
2006-03-16 |
2017-10-04 |
Metabolic Solutions Development Company LLC |
Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
|
|
US20080045582A1
(en)
|
2006-05-15 |
2008-02-21 |
Issam Zineh |
ENA-78 Gene Polymorphisms and Protein Concentrations as Diagnostic and Prognostic Tools
|
|
JP5123936B2
(ja)
|
2006-05-30 |
2013-01-23 |
メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ |
認知症の検出および治療
|
|
US7651840B2
(en)
|
2006-07-14 |
2010-01-26 |
Celera Corporation |
Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
|
|
EP2066355A2
(en)
|
2006-09-19 |
2009-06-10 |
Braincells, Inc. |
Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
|
|
US20090042849A1
(en)
|
2006-12-06 |
2009-02-12 |
Yochai Birnbaum |
Phosphorylation of 5-lipoxygenase at ser523 and uses thereof
|
|
US7794937B2
(en)
|
2006-12-22 |
2010-09-14 |
Quest Diagnostics Investments Incorporated |
Cystic fibrosis transmembrane conductance regulator gene mutations
|
|
GB0702537D0
(en)
|
2007-02-12 |
2007-03-21 |
Leuven K U Res & Dev |
Treatment for excessive adiposity
|
|
US20080286876A1
(en)
|
2007-05-14 |
2008-11-20 |
Chissoe Stephanie |
GENES ASSOCIATED WITH ALZHEIMER'S DISEASE - Hltdip
|
|
WO2008147562A2
(en)
|
2007-05-25 |
2008-12-04 |
Childrens's Medical Center Corporation |
Dietary formulations and methods for treatment of inflammation and other disorders
|
|
TW200914006A
(en)
|
2007-07-12 |
2009-04-01 |
Takeda Pharmaceutical |
Coated preparation
|
|
KR20160127181A
(ko)
|
2008-08-12 |
2016-11-02 |
진판델 파마슈티컬스 인코포레이티드 |
질환 위험 인자의 식별 방법
|
|
US8846315B2
(en)
*
|
2008-08-12 |
2014-09-30 |
Zinfandel Pharmaceuticals, Inc. |
Disease risk factors and methods of use
|
|
WO2010033913A1
(en)
|
2008-09-22 |
2010-03-25 |
Icb International, Inc. |
Antibodies, analogs and uses thereof
|
|
US20100136584A1
(en)
|
2008-09-22 |
2010-06-03 |
Icb International, Inc. |
Methods for using antibodies and analogs thereof
|
|
JP2012507300A
(ja)
|
2008-10-30 |
2012-03-29 |
カリス ライフ サイエンシズ ルクセンブルク ホールディングス |
Ｒｎａパターンを評価する方法
|
|
EP2350320A4
(en)
|
2008-11-12 |
2012-11-14 |
Caris Life Sciences Luxembourg Holdings |
METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES
|
|
JP5485292B2
(ja)
|
2008-12-12 |
2014-05-07 |
ポクセル・エスアーエス |
Ａｍｐｋ活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物
|
|
CN102292093B
(zh)
|
2009-02-02 |
2015-01-28 |
莱拉营养食品有限公司 |
用于代谢综合症控制的选自绒毛戴星草和莽吉柿的混合物
|
|
EP3444611A1
(en)
|
2009-04-23 |
2019-02-20 |
Siemens Healthcare Diagnostics Inc. |
Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
|
|
AU2010202926B2
(en)
|
2009-09-11 |
2016-07-14 |
Electrophoretics Limited |
Markers and methods relating to the assessment of Alzheimer's disease
|
|
US20110194996A1
(en)
|
2010-02-10 |
2011-08-11 |
Selinfreund Richard H |
Transport container for stabilized liquid samples
|
|
AU2011223789A1
(en)
|
2010-03-01 |
2012-09-20 |
Caris Life Sciences Switzerland Holdings Gmbh |
Biomarkers for theranostics
|
|
KR20130043104A
(ko)
|
2010-04-06 |
2013-04-29 |
카리스 라이프 사이언스 룩셈부르크 홀딩스 |
질병용 순환 생물학적 지표들
|
|
CN107362165A
(zh)
*
|
2011-01-10 |
2017-11-21 |
金帆德尔制药股份有限公司 |
用于治疗阿尔茨海默病的方法和药物产品
|