PL2324126T3 - Sposób identyfikacji czynników ryzyka choroby Alzheimera - Google Patents

Sposób identyfikacji czynników ryzyka choroby Alzheimera

Info

Publication number
PL2324126T3
PL2324126T3 PL09807152T PL09807152T PL2324126T3 PL 2324126 T3 PL2324126 T3 PL 2324126T3 PL 09807152 T PL09807152 T PL 09807152T PL 09807152 T PL09807152 T PL 09807152T PL 2324126 T3 PL2324126 T3 PL 2324126T3
Authority
PL
Poland
Prior art keywords
risk factors
disease risk
identifying alzheimer
alzheimer
identifying
Prior art date
Application number
PL09807152T
Other languages
English (en)
Inventor
Allen D Roses
Original Assignee
Zinfandel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2324126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zinfandel Pharmaceuticals Inc filed Critical Zinfandel Pharmaceuticals Inc
Publication of PL2324126T3 publication Critical patent/PL2324126T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
PL09807152T 2008-08-12 2009-08-11 Sposób identyfikacji czynników ryzyka choroby Alzheimera PL2324126T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8820308P 2008-08-12 2008-08-12
US18667309P 2009-06-12 2009-06-12
US22464709P 2009-07-10 2009-07-10
PCT/US2009/053373 WO2010019550A2 (en) 2008-08-12 2009-08-11 Method of identifying disease risk factors
EP09807152.5A EP2324126B1 (en) 2008-08-12 2009-08-11 METHOD OF IDENTIFYING Alzheimer's DISEASE RISK FACTORS

Publications (1)

Publication Number Publication Date
PL2324126T3 true PL2324126T3 (pl) 2014-09-30

Family

ID=41669605

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09807152T PL2324126T3 (pl) 2008-08-12 2009-08-11 Sposób identyfikacji czynników ryzyka choroby Alzheimera

Country Status (32)

Country Link
US (4) US8815508B2 (pl)
EP (2) EP2789695B1 (pl)
JP (4) JP5833922B2 (pl)
KR (3) KR20180053432A (pl)
CN (3) CN102177436B (pl)
AU (3) AU2009282114B2 (pl)
BR (1) BRPI0917948A2 (pl)
CA (1) CA2735578C (pl)
CL (1) CL2011000298A1 (pl)
CO (1) CO6351823A2 (pl)
CY (1) CY1115412T1 (pl)
DK (1) DK2324126T3 (pl)
DO (1) DOP2011000052A (pl)
EA (1) EA021399B1 (pl)
ES (1) ES2463766T3 (pl)
GE (1) GEP20146107B (pl)
HK (1) HK1153511A1 (pl)
HR (1) HRP20140709T1 (pl)
IL (2) IL211140A (pl)
MA (1) MA32619B1 (pl)
ME (1) ME01898B (pl)
MX (1) MX2011001671A (pl)
NZ (3) NZ710443A (pl)
PE (3) PE20110565A1 (pl)
PL (1) PL2324126T3 (pl)
PT (1) PT2324126E (pl)
RS (1) RS53383B (pl)
SG (1) SG193793A1 (pl)
SI (1) SI2324126T1 (pl)
SM (1) SMT201400088B (pl)
WO (1) WO2010019550A2 (pl)
ZA (1) ZA201101095B (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
SI2324126T1 (sl) * 2008-08-12 2014-07-31 Zinfandel Pharmaceuticals, Inc. Postopek identifikacije dejavnikov tveganja za Alzheimerjevo bolezen
AU2011258875B2 (en) 2010-05-25 2016-05-05 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
US9646134B2 (en) * 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
KR20180050420A (ko) 2011-01-10 2018-05-14 진판델 파마슈티컬스 인코포레이티드 알츠하이머 병 치료를 위한 방법 및 약품
AU2013204020B2 (en) * 2011-01-10 2016-03-31 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
MX358594B (es) * 2011-01-10 2018-08-27 Zinfandel Pharmaceuticals Inc Factores de riesgo de enfermedad y métodos de uso.
US20120231457A1 (en) * 2011-03-10 2012-09-13 Nikolaos Tezapsidis Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load)
US8718950B2 (en) 2011-07-08 2014-05-06 The Medical College Of Wisconsin, Inc. Methods and apparatus for identification of disease associated mutations
US20130080182A1 (en) * 2011-09-26 2013-03-28 Athleticode Inc. Methods For Using DNA Testing To Screen For Genotypes Relevant To Athleticism, Health And Risk Of Injury
WO2013106084A1 (en) * 2012-01-09 2013-07-18 Takeda Pharmaceutical Company Limited Methods and drug products for treating alzheimer's disease
GB201209689D0 (en) * 2012-05-31 2012-07-18 Imp Innovations Ltd Methods
WO2014134615A1 (en) * 2013-03-01 2014-09-04 Actx, Inc. Cloud-like medical-information service
WO2015174544A1 (ja) * 2014-05-16 2015-11-19 国立研究開発法人国立精神・神経医療研究センター 精神疾患判定マーカー
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
EP3458466A4 (en) 2016-05-20 2020-03-04 Cedars-Sinai Medical Center DIAGNOSIS OF GENE-BASED INFLAMMATORY BOWEL DISEASE
CN105969885A (zh) * 2016-06-24 2016-09-28 江苏雄鸣医药科技有限公司 一种阿尔兹海默症的基因诊断试剂盒
US11352625B2 (en) 2017-01-12 2022-06-07 Duke University Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease
EP3599842A4 (en) * 2017-03-21 2020-12-30 The Jackson Laboratory GENETICALLY MODIFIED MOUSE EXPRESSING HUMAN APOE4 AND TREM.P.R47H AND ASSOCIATED PROCEDURES FOR USE
US11361953B2 (en) * 2017-07-31 2022-06-14 Quest Diagnostics Investments Incoporated Apolipoprotein E isotype detection by mass spectrometry
WO2019086555A1 (en) * 2017-10-31 2019-05-09 Ge Healthcare Limited Medical system for diagnosing cognitive disease pathology and/or outcome
CN112805785A (zh) * 2018-01-31 2021-05-14 卡尔莱特股份有限公司 提高患者生活质量、参与度和持续性的疾病因子的早期反馈
KR102303638B1 (ko) * 2018-04-13 2021-09-23 사회복지법인 삼성생명공익재단 알츠하이머성 치매가 발병될 가능성 평가방법
EP3790994A1 (en) 2018-05-07 2021-03-17 biotx.ai GmbH Method for predicting the risk of late-onset alzheimer's diseases
EP3626835A1 (en) * 2018-09-18 2020-03-25 Sistemas Genómicos, S.L. Method for genotypically identifying both alleles of at least one locus of a subject's hla gene
KR102127903B1 (ko) * 2019-01-29 2020-06-29 연세대학교 산학협력단 염증성 호흡기 질환의 진단용 바이오마커
EP3976829A4 (en) * 2019-05-30 2023-07-12 PolygenRx Pty Ltd METHOD OF TREATMENT OR PROPHYLAXIS
CN111593107A (zh) * 2020-01-15 2020-08-28 丁玎 阿尔兹海默症易感位点rs10119与rs71352238的检测方法及试剂盒
CN111187825A (zh) * 2020-01-15 2020-05-22 丁玎 阿尔兹海默症的tomm40基因及apoe基因的易感位点的检测方法及试剂盒
KR102535235B1 (ko) * 2020-11-25 2023-05-26 서울대학교산학협력단 알츠하이머병 발병 위험도 예측을 위한 단일염기다형성 마커 및 이의 용도
RU2757522C1 (ru) * 2021-06-02 2021-10-18 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) СПОСОБ ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 1 и 2 ТИПА (варианты)
KR20230150497A (ko) * 2022-04-22 2023-10-31 사회복지법인 삼성생명공익재단 유럽-동아시아인 데이터 기반 알츠하이머병 치매의 발병 위험군 또는 조기 증상 발현 위험군, 기억상실형 경도인지장애의 발병 위험군 및/또는 아밀로이드β 침착에 대한 PET 양성 위험군을 예측하기 위한 정보를 제공하는 방법

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663780A (en) * 1898-09-09 1900-12-11 Wheeler & Wilson Mfg Co Trimming attachment for sewing-machines.
US4302204A (en) 1979-07-02 1981-11-24 The Board Of Trustees Of Leland Stanford Junior University Transfer and detection of nucleic acids
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
US6060237A (en) 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5112460A (en) 1986-10-21 1992-05-12 Northeastern University High performance microcapillary gel electrophoresis
DE3856378T2 (de) 1987-09-04 2000-05-11 Beecham Group Plc Substituierte Thiazolidindionderivate
US5595883A (en) 1990-06-01 1997-01-21 E. R. Squibb & Sons, Inc. Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid
US5171750A (en) 1991-09-26 1992-12-15 The United States Of America As Represented By The Department Of Health And Human Services Substituted phenserines as specific inhibitors of acetylcholinesterase
TW263504B (pl) 1991-10-03 1995-11-21 Pfizer
US5326770A (en) 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
IL106877A (en) 1992-09-10 1998-03-10 Lilly Co Eli Rodinin derivatives for use as drugs for the treatment of Alzheimer's disease
JP3265577B2 (ja) 1992-10-13 2002-03-11 デューク・ユニバーシティ アポリポ蛋白ｅの４型イソ型の測定法
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
ES2100129B1 (es) 1995-10-11 1998-02-16 Medichem Sa Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
JPH09176162A (ja) 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
US6128587A (en) 1997-01-14 2000-10-03 The Regents Of The University Of California Method and apparatus using Bayesian subfamily identification for sequence analysis
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
DE69838789T2 (de) * 1997-03-12 2008-10-30 Suzanne Cambridge de la Monte Verfahren zur behandlung oder prävention der alzheimerischen krankheit
ATE229004T1 (de) 1997-03-31 2002-12-15 Korea Res Inst Chem Tech Chinolinische sulfid-derivate als nmda rezeptor- antagonisten und verfahren zu ihrer herstellung
ATE325607T1 (de) * 1997-11-19 2006-06-15 Takeda Pharmaceutical Aptoptoseinhibitoren
US6964868B1 (en) 1998-01-28 2005-11-15 Nuvelo, Inc. Human genes and gene expression products II
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
WO1999058675A2 (en) 1998-05-14 1999-11-18 Chiron Corporation Human genes and gene expression products v
WO1999066072A2 (en) 1998-06-16 1999-12-23 Nova Molecular, Inc. Methods for treating a neurological disease by determining bche genotype
CA2354544A1 (en) 1998-10-01 2000-04-13 Variagenics, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant gpiiia and/or variant gpiib allele
PT1129216E (pt) 1998-11-10 2005-01-31 Genset Sa Metodos software e aparatos para identificar regioes genomicas que albergam um gene associado a uma caracteristica detectavel
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
CN1078616C (zh) * 1998-12-16 2002-01-30 中国科学院上海生命科学研究中心 一种检测样品中是否存在老年痴呆病基因的方法和试剂盒
JP2000273040A (ja) * 1999-01-19 2000-10-03 Sankyo Co Ltd トログリタゾンを含有するアポトーシス抑制剤
US6401043B1 (en) 1999-04-26 2002-06-04 Variagenics, Inc. Variance scanning method for identifying gene sequence variances
WO2000066102A2 (en) 1999-04-29 2000-11-09 City Of Hope Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (age's)
US6573049B1 (en) 1999-07-26 2003-06-03 Nuvelo, Inc. Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease
DE19936719A1 (de) 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituierte 1,5-Dihydropyrrol-2-on-Derivate
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
AR030920A1 (es) 1999-11-16 2003-09-03 Smithkline Beecham Plc Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6532467B1 (en) 2000-04-10 2003-03-11 Sas Institute Inc. Method for selecting node variables in a binary decision tree structure
US6432985B2 (en) 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
US20040122091A1 (en) 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CN1479721A (zh) 2000-10-11 2004-03-03 ͨ��ҽ�ƹ�˾ 用于胆固醇治疗和相关应用的亚砜和双亚砜化合物和组合物
CN1283610C (zh) 2000-10-11 2006-11-08 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的酮化合物以及组合物
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
CA2425674A1 (en) 2000-10-11 2002-04-18 Jean-Louis H. Dasseux Sulfide and disulfide compounds and compositions for cholesterol management and related uses
KR100865142B1 (ko) 2000-11-24 2008-10-24 바스큘라 바이오제닉스 리미티드 죽상 경화증의 예방 및 치료를 위해 정의된 산화 인지질을사용하는 방법 및 이를 함유하는 조성물
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6495335B2 (en) 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
US6680299B2 (en) 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
US20050020694A1 (en) 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US6828462B2 (en) 2001-11-07 2004-12-07 Merz Pharma Gmbh & Co. Kgaa Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
US7132244B2 (en) 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7135297B2 (en) 2001-11-23 2006-11-14 Nanogen Inc. Protein biopolymer markers indicative of insulin resistance
US7052849B2 (en) 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US20030220374A1 (en) 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
WO2004005510A1 (ja) 2002-07-05 2004-01-15 Shionogi & Co., Ltd. 新規Nogo受容体様ポリペプチドおよびそのＤＮＡ
US20040265849A1 (en) * 2002-11-22 2004-12-30 Applera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
CN1753662A (zh) * 2002-12-24 2006-03-29 神经化学（国际）有限公司 用于治疗β－淀粉状蛋白相关疾病的治疗制剂
AU2004214480A1 (en) * 2003-02-14 2004-09-02 Intergenetics Incorporated Statistically identifying an increased risk for disease
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US20050004179A1 (en) 2003-05-22 2005-01-06 Pedersen Ward A. Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease
US20070203083A1 (en) 2003-06-13 2007-08-30 Mootha Vamsi K Methods Of Regulating Metabolism And Mitochondrial Function
JP4931419B2 (ja) 2003-09-19 2012-05-16 中外製薬株式会社 新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのｍｅｋ阻害剤としての使用
WO2005072151A2 (en) 2004-01-22 2005-08-11 Genaissance Pharmaceuticals, Inc. Apoe genetic markers associated with age of onset of alzheimer's disease
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2006054297A2 (en) 2004-11-17 2006-05-26 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CA2596523A1 (en) * 2005-01-31 2006-08-10 Perlegen Sciences, Inc. Genetic basis of alzheimer's disease and diagnosis and treatment thereof
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009508959A (ja) 2005-09-22 2009-03-05 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド 認識機能の改善のためのロシグリタゾンおよびドネペジルの組合せ
WO2007044522A1 (en) 2005-10-05 2007-04-19 Auburn University P62 as a risk determinant for metabolic syndrome
PL2902026T3 (pl) 2006-03-16 2018-03-30 Metabolic Solutions Development Company Llc Analogi tiazolidynodionu do leczenia choroby metabolicznej pośredniczonej przez zapalenie
US20080045582A1 (en) 2006-05-15 2008-02-21 Issam Zineh ENA-78 Gene Polymorphisms and Protein Concentrations as Diagnostic and Prognostic Tools
DK2687223T3 (en) 2006-05-30 2017-10-23 Mayo Foundation Detection and treatment of dementia
US7651840B2 (en) 2006-07-14 2010-01-26 Celera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
WO2008036678A2 (en) 2006-09-19 2008-03-27 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
US20090042849A1 (en) 2006-12-06 2009-02-12 Yochai Birnbaum Phosphorylation of 5-lipoxygenase at ser523 and uses thereof
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0702537D0 (en) 2007-02-12 2007-03-21 Leuven K U Res & Dev Treatment for excessive adiposity
US20080286876A1 (en) 2007-05-14 2008-11-20 Chissoe Stephanie GENES ASSOCIATED WITH ALZHEIMER'S DISEASE - Hltdip
US8652508B2 (en) 2007-05-25 2014-02-18 Children's Medical Center Corporation Dietary formulations and methods for treatment of inflammation and other disorders
TW200914006A (en) 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
US8846315B2 (en) * 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
SI2324126T1 (sl) * 2008-08-12 2014-07-31 Zinfandel Pharmaceuticals, Inc. Postopek identifikacije dejavnikov tveganja za Alzheimerjevo bolezen
US20100136584A1 (en) 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
US20100092470A1 (en) 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
CA2742324A1 (en) 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods for assessing rna patterns
CA2743211A1 (en) 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
JP5485292B2 (ja) 2008-12-12 2014-05-07 ポクセル・エスアーエス Ａｍｐｋ活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物
WO2010100653A2 (en) 2009-02-02 2010-09-10 Laila Nutraceuticals Composition from sphaeranthus indicus and garcinia mangostana for the control of metabolic syndrome
CN102388308B (zh) 2009-04-23 2015-08-19 西门子医疗保健诊断公司 单体和二聚形式的脂连蛋白受体片段和使用方法
CA2709621A1 (en) 2009-09-11 2011-03-11 Electrophoretics Limited Markers and methods relating to the assessment of alzheimer's disease
US8318641B2 (en) 2010-02-10 2012-11-27 Selinfreund Richard H Systems and methods for the detection of biomarkers
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
KR20180050420A (ko) * 2011-01-10 2018-05-14 진판델 파마슈티컬스 인코포레이티드 알츠하이머 병 치료를 위한 방법 및 약품

Also Published As

Publication number Publication date
US8815508B2 (en) 2014-08-26
IL211140A0 (en) 2011-04-28
US20110189165A1 (en) 2011-08-04
CY1115412T1 (el) 2017-01-04
PE20151924A1 (es) 2016-01-13
JP2018075005A (ja) 2018-05-17
JP2016047058A (ja) 2016-04-07
RS53383B (en) 2014-10-31
US20210095345A1 (en) 2021-04-01
NZ619895A (en) 2015-12-24
KR101729340B1 (ko) 2017-04-24
JP6815372B2 (ja) 2021-01-20
MX2011001671A (es) 2011-06-17
NZ710443A (en) 2019-03-29
JP2012500004A (ja) 2012-01-05
AU2009282114A2 (en) 2011-04-28
US20150073025A1 (en) 2015-03-12
NZ591107A (en) 2012-08-31
PE20150362A1 (es) 2015-03-20
JP2019076095A (ja) 2019-05-23
DK2324126T3 (da) 2014-06-16
EP2789695A1 (en) 2014-10-15
GEP20146107B (en) 2014-06-10
CN104805198A (zh) 2015-07-29
CN104611421B (zh) 2018-08-07
KR20110063453A (ko) 2011-06-10
US20180363060A1 (en) 2018-12-20
AU2016204678A1 (en) 2016-07-21
HK1153511A1 (en) 2012-03-30
CA2735578C (en) 2018-10-23
EP2324126A4 (en) 2012-05-30
PE20110565A1 (es) 2011-09-02
EP2324126A2 (en) 2011-05-25
JP5833922B2 (ja) 2015-12-16
EP2324126B1 (en) 2014-04-23
SG193793A1 (en) 2013-10-30
KR20160127181A (ko) 2016-11-02
MA32619B1 (fr) 2011-09-01
WO2010019550A3 (en) 2010-04-22
AU2009282114A1 (en) 2010-02-18
IL211140A (en) 2015-06-30
ES2463766T3 (es) 2014-05-29
SMT201400088B (it) 2014-09-08
AU2009282114B2 (en) 2016-04-07
ME01898B (me) 2014-12-20
US10865449B2 (en) 2020-12-15
CN104805198B (zh) 2019-04-26
ZA201101095B (en) 2012-07-25
PT2324126E (pt) 2014-06-02
CN104611421A (zh) 2015-05-13
SI2324126T1 (sl) 2014-07-31
DOP2011000052A (es) 2011-04-15
CN102177436A (zh) 2011-09-07
CO6351823A2 (es) 2011-12-20
HRP20140709T1 (hr) 2014-09-26
IL239277A0 (en) 2015-07-30
BRPI0917948A2 (pt) 2017-06-20
WO2010019550A4 (en) 2011-01-13
AU2018202373A1 (en) 2018-04-26
AU2016204678B2 (en) 2018-04-19
CL2011000298A1 (es) 2012-07-13
CA2735578A1 (en) 2010-02-18
EA021399B1 (ru) 2015-06-30
EP2789695B1 (en) 2019-10-30
KR20180053432A (ko) 2018-05-21
EA201170332A1 (ru) 2011-10-31
WO2010019550A2 (en) 2010-02-18
CN102177436B (zh) 2015-05-13

Similar Documents

Publication Publication Date Title
PT2324126E (pt) Método de identificação de factores de risco da doença de alzheimer
IL211540A0 (en) Optical method for the detection of alzheimer's disease
EP2485733A4 (en) METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EP2312945A4 (en) PURE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
ZA201007460B (en) Use of epothelone in treating tau-associated disease including alzheimer's disease
DE602006009764D1 (de) Terphenylderivate zur Alzheimerbehandlung
GB2496801B (en) A method of treating alzheimer's disease
EP2231180A4 (en) VACCINE AGAINST ALZHEIMER'S DISEASE
IL213120A0 (en) Method for treating parkinson' s disease
EP2398789A4 (en) SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EP2375895A4 (en) METHOD OF TREATING ALZHEIMER'S DISEASE AND RELATED STATES
IL217149A0 (en) Compositions and methods for treating parkinson's disease
EP2391379A4 (en) COMPOUNDS AND METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER
EP2344881A4 (en) BIOMARKER FOR MORBUS ALZHEIMER
EP2349308A4 (en) COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EP2168499A4 (en) METHOD FOR COLLECTING INFORMATION ABOUT BIOLOGICAL RHYTHM
EP2412811A4 (en) DNA VACCINE FOR MORBUS ALZHEIMER
EP2287604A4 (en) METHOD FOR THE STUDY OF MORBUS ALZHEIMER
EP2305629A4 (en) THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE
EP2099476A4 (en) METHODS OF TREATING ALZHEIMER'S DISEASE
EP2496080A4 (en) METHOD FOR THE TREATMENT OF MORBUS PARKINSON
GB0806635D0 (en) Method for detecting alzheimer's disease
GB0906398D0 (en) Method for detecting alzheimer's disease
GB0811555D0 (en) Treatment of Alzheimer's disease
IL206998A0 (en) Vaccine for alzheimer's disease