RS53383B - Method of identifying alzheimer's disease risk factors - Google Patents

Method of identifying alzheimer's disease risk factors

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Publication number
RS53383B
RS53383B RS20140335A RSP20140335A RS53383B RS 53383 B RS53383 B RS 53383B RS 20140335 A RS20140335 A RS 20140335A RS P20140335 A RSP20140335 A RS P20140335A RS 53383 B RS53383 B RS 53383B
Authority
RS
Serbia
Prior art keywords
alzheimer
disease
risk factors
disease risk
variant
Prior art date
Application number
RS20140335A
Other languages
Serbian (sr)
Inventor
Allen D. Roses
Original Assignee
Zinfandel Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS53383(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zinfandel Pharmaceuticals, Inc. filed Critical Zinfandel Pharmaceuticals, Inc.
Publication of RS53383B publication Critical patent/RS53383B/en

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
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Abstract

Metoda za određivanje rizika od razvoja Alchajmerove bolesti kod subjekta, naznačena time što sadrži:(a) detekciju, iz biološkog uzorka koji sadrži DNK uzet od navedenog subjekta, prisustva ili odsustva genetske varijante TOMM40 gena koja je povezana sa povećanim ili smanjenim rizikom od Alchajmerove bolesti, pri čemu je navedena varijanta polimorfizam tipa delecija/insercija u intronu 6 ili intronu 9 TOMM40 gena; i(b) određivanje da navedeni subjekat poseduje povećani ili smanjeni rizik od Alchajmerove bolesti kad je navedena varijanta prisutna ili odsutna.Prijava sadrži još 19 patentnih zahteva.A method for determining the risk of developing Alzheimer's disease in a subject, comprising: (a) detecting, from a biological sample containing DNA taken from said subject, the presence or absence of a genetic variant of the TOMM40 gene associated with an increased or decreased risk of Alzheimer's disease , wherein said variant is a deletion / insertion polymorphism in intron 6 or intron 9 of the TOMM40 gene; and (b) determining that said entity has an increased or decreased risk of Alzheimer's disease when said variant is present or absent. The application contains another 19 patent claims.

RS20140335A 2008-08-12 2009-08-11 Method of identifying alzheimer's disease risk factors RS53383B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8820308P 2008-08-12 2008-08-12
US18667309P 2009-06-12 2009-06-12
US22464709P 2009-07-10 2009-07-10
PCT/US2009/053373 WO2010019550A2 (en) 2008-08-12 2009-08-11 Method of identifying disease risk factors

Publications (1)

Publication Number Publication Date
RS53383B true RS53383B (en) 2014-10-31

Family

ID=41669605

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20140335A RS53383B (en) 2008-08-12 2009-08-11 Method of identifying alzheimer's disease risk factors

Country Status (32)

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US (4) US8815508B2 (en)
EP (2) EP2789695B1 (en)
JP (4) JP5833922B2 (en)
KR (3) KR101729340B1 (en)
CN (3) CN102177436B (en)
AU (3) AU2009282114B2 (en)
BR (1) BRPI0917948A2 (en)
CA (1) CA2735578C (en)
CL (1) CL2011000298A1 (en)
CO (1) CO6351823A2 (en)
CY (1) CY1115412T1 (en)
DK (1) DK2324126T3 (en)
DO (1) DOP2011000052A (en)
EA (1) EA021399B1 (en)
ES (1) ES2463766T3 (en)
GE (1) GEP20146107B (en)
HK (1) HK1153511A1 (en)
HR (1) HRP20140709T1 (en)
IL (2) IL211140A (en)
MA (1) MA32619B1 (en)
ME (1) ME01898B (en)
MX (1) MX2011001671A (en)
NZ (3) NZ619895A (en)
PE (3) PE20110565A1 (en)
PL (1) PL2324126T3 (en)
PT (1) PT2324126E (en)
RS (1) RS53383B (en)
SG (1) SG193793A1 (en)
SI (1) SI2324126T1 (en)
SM (1) SMT201400088B (en)
WO (1) WO2010019550A2 (en)
ZA (1) ZA201101095B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101729340B1 (en) * 2008-08-12 2017-04-24 진판델 파마슈티컬스 인코포레이티드 Method of identifying disease risk factors
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
CN103384887B (en) 2010-05-25 2017-01-18 加利福尼亚大学董事会 BAMBAM: parallel comparative analysis of high-throughput sequencing data
US9646134B2 (en) 2010-05-25 2017-05-09 The Regents Of The University Of California Bambam: parallel comparative analysis of high-throughput sequencing data
MX358594B (en) * 2011-01-10 2018-08-27 Zinfandel Pharmaceuticals Inc Disease risk factors and methods of use.
US9102666B2 (en) 2011-01-10 2015-08-11 Zinfandel Pharmaceuticals, Inc. Methods and drug products for treating Alzheimer's disease
AU2013204020B2 (en) * 2011-01-10 2016-03-31 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
US20120231457A1 (en) * 2011-03-10 2012-09-13 Nikolaos Tezapsidis Compositions and methods for assessing a genetic risk of developing late-onset alzheimer's disease (load)
US8718950B2 (en) 2011-07-08 2014-05-06 The Medical College Of Wisconsin, Inc. Methods and apparatus for identification of disease associated mutations
US20130080182A1 (en) * 2011-09-26 2013-03-28 Athleticode Inc. Methods For Using DNA Testing To Screen For Genotypes Relevant To Athleticism, Health And Risk Of Injury
WO2013106084A1 (en) * 2012-01-09 2013-07-18 Takeda Pharmaceutical Company Limited Methods and drug products for treating alzheimer's disease
GB201209689D0 (en) * 2012-05-31 2012-07-18 Imp Innovations Ltd Methods
EP2962270A4 (en) * 2013-03-01 2016-08-24 Actx Inc Cloud-like medical-information service
JPWO2015174544A1 (en) * 2014-05-16 2017-04-20 国立研究開発法人国立精神・神経医療研究センター Psychiatric disorder marker
AU2016297631B2 (en) 2015-07-23 2022-08-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
KR20240095363A (en) 2016-05-20 2024-06-25 세다르스-신나이 메디칼 센터 Diagnosis of inflammatory bowel disease based on genes
CN105969885A (en) * 2016-06-24 2016-09-28 江苏雄鸣医药科技有限公司 Genetic diagnosis kit of Alzheimer's disease
WO2018132755A1 (en) * 2017-01-12 2018-07-19 Duke University Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease
CN110891417B (en) * 2017-03-21 2023-05-23 杰克逊实验室 Genetically modified mice expressing human APOE4 and mouse Trem2 p.r47h and methods of use thereof
EP3662290A4 (en) * 2017-07-31 2021-03-31 Quest Diagnostics Investments LLC Apolipoprotein e isotype detection by mass spectrometry
RU2020114290A (en) * 2017-10-31 2021-12-01 ДжиИ ХЕЛТКЕР ЛИМИТЕД Medical system for diagnosing pathology and / or outcome of cognitive disease
EP3747015A4 (en) * 2018-01-31 2021-11-03 Curelator Inc. Early feedback of disease factors to improve patient quality of life, engagement and persistence
KR102303638B1 (en) * 2018-04-13 2021-09-23 사회복지법인 삼성생명공익재단 Method for evaluation of alzheimer disease risk
EP3790994A1 (en) 2018-05-07 2021-03-17 biotx.ai GmbH Method for predicting the risk of late-onset alzheimer's diseases
US20220226278A1 (en) * 2018-05-18 2022-07-21 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
EP3626835A1 (en) * 2018-09-18 2020-03-25 Sistemas Genómicos, S.L. Method for genotypically identifying both alleles of at least one locus of a subject's hla gene
KR102127903B1 (en) * 2019-01-29 2020-06-29 연세대학교 산학협력단 Biomarker for diagnosing inflammatory respiratory disease
AU2020285475A1 (en) * 2019-05-30 2021-12-23 PolygenRx Pty Ltd A method of treatment or prophylaxis
CN111593107A (en) * 2020-01-15 2020-08-28 丁玎 Detection method and kit for susceptibility sites rs10119 and rs71352238 of Alzheimer's disease
CN111187825A (en) * 2020-01-15 2020-05-22 丁玎 Method and kit for detecting susceptibility sites of TOMM40 gene and APOE gene of Alzheimer's disease
KR102535235B1 (en) * 2020-11-25 2023-05-26 서울대학교산학협력단 SNP marker for predicting a risk of developing Alzheimer's disease and use thereof
RU2757522C1 (en) * 2021-06-02 2021-10-18 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) Predicting method for development of chronic kidney disease in patients with type 1 and type 2 diabetes mellitus (options)
KR20230150497A (en) * 2022-04-22 2023-10-31 사회복지법인 삼성생명공익재단 A method of providing information for predicting a group at risk for Alzheimer's disease dementia or early onset of symptoms, a risk group for amnesia-type mild cognitive impairment, and/or a PET-positive risk group for amyloid β deposition based on European-East Asian data

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US663780A (en) * 1898-09-09 1900-12-11 Wheeler & Wilson Mfg Co Trimming attachment for sewing-machines.
US4302204A (en) 1979-07-02 1981-11-24 The Board Of Trustees Of Leland Stanford Junior University Transfer and detection of nucleic acids
US4358535A (en) 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
FI63596C (en) 1981-10-16 1983-07-11 Orion Yhtymae Oy MICROBIA DIAGNOSIS FOERFARANDE SOM GRUNDAR SIG PAO SKIKTSHYBRIDISERING AV NUCLEINSYROR OCH VID FOERFARANDET ANVAENDA KOMBINATIONER AV REAGENSER
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
AR240698A1 (en) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts
US6060237A (en) 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5112460A (en) 1986-10-21 1992-05-12 Northeastern University High performance microcapillary gel electrophoresis
EP0306228B1 (en) 1987-09-04 1999-11-17 Beecham Group Plc Substituted thiazolidinedione derivatives
US5595883A (en) 1990-06-01 1997-01-21 E. R. Squibb & Sons, Inc. Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid
US5171750A (en) 1991-09-26 1992-12-15 The United States Of America As Represented By The Department Of Health And Human Services Substituted phenserines as specific inhibitors of acetylcholinesterase
TW263504B (en) 1991-10-03 1995-11-21 Pfizer
US5326770A (en) 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
NZ248573A (en) 1992-09-10 1996-02-27 Lilly Co Eli 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions
EP0625212B1 (en) 1992-10-13 2004-03-24 Duke University Methods of detecting alzheimer's disease
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
ES2100129B1 (en) 1995-10-11 1998-02-16 Medichem Sa NEW POLYCLIC AMINOPYRIDINE COMPOUNDS ACETYLCHOLINESTERASE INHIBITORS, PROCEDURE FOR THE PREPARATION AND USE.
JPH09176162A (en) 1995-12-22 1997-07-08 Toubishi Yakuhin Kogyo Kk Thiazolidinedione derivative, its production and medicinal composition containing the same
US6128587A (en) 1997-01-14 2000-10-03 The Regents Of The University Of California Method and apparatus using Bayesian subfamily identification for sequence analysis
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
EP1006794B1 (en) 1997-03-12 2007-11-28 Robert W. Esmond A method for treating or preventing alzheimer's disease
DE69809827D1 (en) 1997-03-31 2003-01-16 Korea Res Inst Chem Tech Quinolinic sulfide derivatives as NMDA receptor antagonists and process for their preparation
DE69834508T2 (en) * 1997-11-19 2006-11-23 Takeda Pharmaceutical Co. Ltd. APOPTOSIS INHIBITORS
US6964868B1 (en) 1998-01-28 2005-11-15 Nuvelo, Inc. Human genes and gene expression products II
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
WO1999058675A2 (en) 1998-05-14 1999-11-18 Chiron Corporation Human genes and gene expression products v
ATE317452T1 (en) 1998-06-16 2006-02-15 Nova Molecular Inc METHOD FOR TREATING NEUROLOGICAL DISEASES USING DETERMINATION OF THE BCHE GENOTYPE
WO2000020634A1 (en) 1998-10-01 2000-04-13 Nova Molecular, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant gpiiia and/or variant gpiib allele
US6291182B1 (en) 1998-11-10 2001-09-18 Genset Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
CN1078616C (en) * 1998-12-16 2002-01-30 中国科学院上海生命科学研究中心 Method for testing or predicting senile dementia and kit
JP2000273040A (en) * 1999-01-19 2000-10-03 Sankyo Co Ltd Apoptosis inhibitor containing troglitazone
US6401043B1 (en) 1999-04-26 2002-06-04 Variagenics, Inc. Variance scanning method for identifying gene sequence variances
AU776162B2 (en) 1999-04-29 2004-08-26 City Of Hope Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (AGE's)
US6573049B1 (en) 1999-07-26 2003-06-03 Nuvelo, Inc. Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease
DE19936719A1 (en) 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituted 1,5-dihydropyrrol-2-one derivatives
US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
AR030920A1 (en) 1999-11-16 2003-09-03 Smithkline Beecham Plc PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF MELLITUS DIABETES AND CONDITIONS ASSOCIATED WITH MELLITUS DIABETES, AND PROCEDURES FOR PREPARING SUCH COMPOSITIONS
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6532467B1 (en) 2000-04-10 2003-03-11 Sas Institute Inc. Method for selecting node variables in a binary decision tree structure
US6432985B2 (en) 2000-04-25 2002-08-13 Hoffmann-La Roche Inc. Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
CN1283610C (en) 2000-10-11 2006-11-08 埃斯佩里安医疗公司 Ketone compounds and compositions for cholesterol management and related uses
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
WO2002030882A2 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
BR0114619A (en) 2000-10-11 2005-12-13 Esperion Therapeutics Inc Compound, pharmaceutical composition, methods for treating or preventing cardiovascular disease, dyslipidemia, dyslipoproteinemia, glucose metabolism disorder, thrombotic and associated with peroxisome proliferator activated receptor, alzheimer's disease, x syndrome or metabolic syndrome , septicemia, obesity, pancreatitis, hypertension, kidney disease, cancer, inflammation and impotence, in a patient and to reduce the fat content of poultry eggs and poultry meat
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
IL156015A0 (en) 2000-11-24 2003-12-23 Vascular Biogenics Ltd Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6495335B2 (en) 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
DE10132725A1 (en) 2001-07-05 2006-08-03 Grünenthal GmbH Substituted γ-lactone compounds
US6680299B2 (en) 2001-07-27 2004-01-20 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
US20040204502A1 (en) 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US6828462B2 (en) 2001-11-07 2004-12-07 Merz Pharma Gmbh & Co. Kgaa Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
US7132244B2 (en) 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7052849B2 (en) 2001-11-23 2006-05-30 Syn X Pharma, Inc. Protein biopolymer markers predictive of insulin resistance
US7135297B2 (en) 2001-11-23 2006-11-14 Nanogen Inc. Protein biopolymer markers indicative of insulin resistance
US20030220374A1 (en) 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
WO2004005510A1 (en) 2002-07-05 2004-01-15 Shionogi & Co., Ltd. NOVEL Nogo RECEPTOR-LIKE POLYPEPTIDE AND DNA THEREOF
US20040265849A1 (en) 2002-11-22 2004-12-30 Applera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
CN101103969A (en) * 2002-12-24 2008-01-16 神经化学（国际）有限公司 Therapeutic formulations for the treatment of beta-amyloid related diseases
JP2006519440A (en) * 2003-02-14 2006-08-24 インタージェネティックス インコーポレイテッド Statistical identification of increased risk of disease
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US20050004179A1 (en) 2003-05-22 2005-01-06 Pedersen Ward A. Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease
WO2005003766A2 (en) 2003-06-13 2005-01-13 Whitehead Institute For Biomedical Research Methods of regulating metabolism and mitochondrial function
JP4931419B2 (en) 2003-09-19 2012-05-16 中外製薬株式会社 Novel 4-phenylamino-benzaldoxime derivatives and their use as MEK inhibitors
WO2005072151A2 (en) 2004-01-22 2005-08-11 Genaissance Pharmaceuticals, Inc. Apoe genetic markers associated with age of onset of alzheimer's disease
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2006054297A2 (en) 2004-11-17 2006-05-26 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US20060228728A1 (en) * 2005-01-31 2006-10-12 Perlegen Sciences, Inc. Genetic basis of Alzheimer's disease and diagnosis and treatment thereof
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
KR20080058413A (en) 2005-09-22 2008-06-25 에스비 팜코 푸에르토 리코 인크. Ppar-gamma agonists for improvement of cognitive function in apoe4 negative patients
US7608412B2 (en) 2005-10-05 2009-10-27 Auburn University P62 as a diagnostic tool for alzheimer's disease
CN101454005B (en) 2006-03-16 2013-01-02 新陈代谢解决方案开发公司 Thiazolidinedione analogues for the treating metabolic inflammation mediated disease
US20080045582A1 (en) 2006-05-15 2008-02-21 Issam Zineh ENA-78 Gene Polymorphisms and Protein Concentrations as Diagnostic and Prognostic Tools
JP5123936B2 (en) 2006-05-30 2013-01-23 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Detection and treatment of dementia
US7651840B2 (en) * 2006-07-14 2010-01-26 Celera Corporation Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof
AU2007299920A1 (en) 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20090042849A1 (en) 2006-12-06 2009-02-12 Yochai Birnbaum Phosphorylation of 5-lipoxygenase at ser523 and uses thereof
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0702537D0 (en) 2007-02-12 2007-03-21 Leuven K U Res & Dev Treatment for excessive adiposity
US20080286876A1 (en) 2007-05-14 2008-11-20 Chissoe Stephanie GENES ASSOCIATED WITH ALZHEIMER'S DISEASE - Hltdip
WO2008147562A2 (en) 2007-05-25 2008-12-04 Childrens's Medical Center Corporation Dietary formulations and methods for treatment of inflammation and other disorders
TW200914006A (en) 2007-07-12 2009-04-01 Takeda Pharmaceutical Coated preparation
US8846315B2 (en) * 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
KR101729340B1 (en) * 2008-08-12 2017-04-24 진판델 파마슈티컬스 인코포레이티드 Method of identifying disease risk factors
WO2010033913A1 (en) 2008-09-22 2010-03-25 Icb International, Inc. Antibodies, analogs and uses thereof
US20100136584A1 (en) 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
CA2742324A1 (en) 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods for assessing rna patterns
BRPI0921043A2 (en) 2008-11-12 2018-08-07 Caris Life Sciences Luxembourg Holdings methods and systems for using exosomes to determine phenotypes
EP2367802B1 (en) 2008-12-12 2016-04-20 Poxel Tetrahydrotriazine compounds for treating diseases associated with ampk activity
EP2391374B1 (en) 2009-02-02 2018-11-14 Laila Nutraceuticals Composition from sphaeranthus indicus and garcinia mangostana for the control of metabolic syndrome
EP3444611A1 (en) 2009-04-23 2019-02-20 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
AU2010202926B2 (en) 2009-09-11 2016-07-14 Electrophoretics Limited Markers and methods relating to the assessment of Alzheimer's disease
US20110195856A1 (en) 2010-02-10 2011-08-11 Selinfreund Richard H Methods of determining stabilization compounds for predictive biomarkers
JP5808349B2 (en) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー Biomarkers for theranosis
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
US9102666B2 (en) * 2011-01-10 2015-08-11 Zinfandel Pharmaceuticals, Inc. Methods and drug products for treating Alzheimer's disease

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