JP2012126736A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012126736A5 JP2012126736A5 JP2012062968A JP2012062968A JP2012126736A5 JP 2012126736 A5 JP2012126736 A5 JP 2012126736A5 JP 2012062968 A JP2012062968 A JP 2012062968A JP 2012062968 A JP2012062968 A JP 2012062968A JP 2012126736 A5 JP2012126736 A5 JP 2012126736A5
- Authority
- JP
- Japan
- Prior art keywords
- mycobacterial
- product
- extract
- acid compound
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- -1 5-aminosalicylic acid compound Chemical class 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 10
- ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 claims 9
- 229960004909 aminosalicylic acid Drugs 0.000 claims 9
- 229960002626 clarithromycin Drugs 0.000 claims 9
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 9
- 229960004963 mesalazine Drugs 0.000 claims 9
- 229960000885 rifabutin Drugs 0.000 claims 9
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 6
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 claims 6
- 229960004287 clofazimine Drugs 0.000 claims 6
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims 6
- 230000003053 immunization Effects 0.000 claims 4
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 3
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 3
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 3
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims 3
- 229960004821 amikacin Drugs 0.000 claims 3
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 3
- 229960004099 azithromycin Drugs 0.000 claims 3
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 3
- 229960003405 ciprofloxacin Drugs 0.000 claims 3
- 229960000285 ethambutol Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 3
- 229960001699 ofloxacin Drugs 0.000 claims 3
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 3
- 229960001225 rifampicin Drugs 0.000 claims 3
- 229960005224 roxithromycin Drugs 0.000 claims 3
- 244000052616 bacterial pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 241000187481 Mycobacterium phlei Species 0.000 claims 1
- 241000187644 Mycobacterium vaccae Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO5940 | 1997-04-01 | ||
| AUPO5940A AUPO594097A0 (en) | 1997-04-01 | 1997-04-01 | Novel methods of treating inflammatory bowel disease |
| AUPO9785A AUPO978597A0 (en) | 1997-10-14 | 1997-10-14 | Methods of treating inflammatory bowel disease |
| AUPO9785 | 1997-10-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007232402A Division JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012126736A JP2012126736A (ja) | 2012-07-05 |
| JP2012126736A5 true JP2012126736A5 (https=) | 2013-05-09 |
Family
ID=25645389
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54099898A Withdrawn JP2001524951A (ja) | 1997-04-01 | 1998-04-01 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2007232402A Withdrawn JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2012062968A Pending JP2012126736A (ja) | 1997-04-01 | 2012-03-21 | 炎症性腸疾患を治療するための方法および組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54099898A Withdrawn JP2001524951A (ja) | 1997-04-01 | 1998-04-01 | 炎症性腸疾患を治療するための方法および組成物 |
| JP2007232402A Withdrawn JP2008024713A (ja) | 1997-04-01 | 2007-09-07 | 炎症性腸疾患を治療するための方法および組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6277836B1 (https=) |
| EP (1) | EP0971735B1 (https=) |
| JP (3) | JP2001524951A (https=) |
| AR (1) | AR012304A1 (https=) |
| AT (1) | ATE389417T1 (https=) |
| CA (1) | CA2285923C (https=) |
| CY (1) | CY1109783T1 (https=) |
| DE (1) | DE69839261T2 (https=) |
| DK (1) | DK0971735T3 (https=) |
| ES (1) | ES2303351T3 (https=) |
| IL (1) | IL132145A (https=) |
| NO (1) | NO325947B1 (https=) |
| NZ (1) | NZ500696A (https=) |
| PT (1) | PT971735E (https=) |
| SI (1) | SI0971735T1 (https=) |
| WO (1) | WO1998043667A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551632B2 (en) * | 1997-04-01 | 2003-04-22 | Thomas Julius Borody | Methods and compositions for treating inflammatory bowel disease |
| AUPP325398A0 (en) * | 1998-04-30 | 1998-05-21 | Borody, Thomas J. | Improved method for eradicating h. pylori |
| ATE446767T1 (de) * | 1999-02-12 | 2009-11-15 | Univ Washington | Gm-csf zur behandlung von morbus crohn |
| HU230030B1 (hu) | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| JP3369535B2 (ja) | 1999-11-09 | 2003-01-20 | 松下電器産業株式会社 | プラズマディスプレイ装置 |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| AU2001263812B2 (en) * | 2000-03-28 | 2004-09-23 | Sandoz Ag | Granulated particles with masked taste |
| DK1313697T3 (da) | 2000-08-29 | 2006-04-10 | Nobex Corp | Immunregulatoriske forbindelser, derivater deraf samt anvendelse deraf |
| EP1560584B1 (en) * | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| US8048924B2 (en) | 2001-08-29 | 2011-11-01 | Biocon Limited | Methods and compositions employing 4-aminophenylacetic acid compounds |
| US20030118329A1 (en) * | 2001-12-21 | 2003-06-26 | Pere Obrador | Video indexing using high resolution still images |
| AUPS088702A0 (en) | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| EP1575951B1 (en) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| WO2005046567A2 (en) * | 2003-09-10 | 2005-05-26 | Meena Shelgaonkar | Synergistic formulation of antioxidants and antimycobacterial agents: a method of making the same |
| AU2004314731B2 (en) | 2004-01-20 | 2011-07-07 | The Board Of Regents Of The University Of Oklahoma | Compositions and methods of treatment for inflammatory diseases |
| JP2007520495A (ja) | 2004-02-06 | 2007-07-26 | ボロディー トーマス ユリウス | 下痢型過敏性腸症候群におけるアミノサリチル酸の使用法 |
| US20080306029A1 (en) * | 2004-05-28 | 2008-12-11 | Salix Pharmaceuticals, Inc. | Prevention, Treatment, and Amelioration of Radiation Induced Enteritis |
| DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| DK1773767T3 (en) | 2004-07-07 | 2016-03-21 | Biocon Ltd | Synthesis of azo bound in immune regulatory relations |
| EP2529729A1 (en) * | 2005-08-24 | 2012-12-05 | Salix Pharmaceuticals, Inc. | Balsalazide formulations and manufacture thereof |
| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| US7452872B2 (en) * | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| CA2531261A1 (en) * | 2005-12-21 | 2007-06-21 | Institut Pasteur | Control of intestinal inflammatory syndromes with a preparation of killed or non infectious bacteria |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| US8436051B2 (en) | 2007-06-08 | 2013-05-07 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| US7541384B2 (en) | 2007-06-08 | 2009-06-02 | Axcan Pharma Inc. | Mesalamine suppository |
| US8217083B2 (en) * | 2007-06-08 | 2012-07-10 | Aptalis Pharma Canada Inc. | Mesalamine suppository |
| JP2011500552A (ja) * | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | 胃腸障害を処置するための医薬用組み合わせおよび組成物 |
| US20090098088A1 (en) * | 2007-10-10 | 2009-04-16 | The Procter & Gamble Company | Methods And Kits For The Treatment Of Diverticular Conditions |
| US20090131343A1 (en) * | 2007-11-15 | 2009-05-21 | Ly Tam Phan | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
| PT2247291T (pt) | 2008-02-08 | 2019-02-01 | Red Hill Biopharma Ltd | Métodos e composições para tratamento de doença inflamatória do intestino |
| MX2010011995A (es) * | 2008-05-01 | 2010-12-02 | Procter & Gamble | Metodos y estuches para el tratamiento de condiciones y trastornos inflamatorios del intestino. |
| WO2011044140A1 (en) * | 2009-10-05 | 2011-04-14 | Catabasis Pharmaceuticals, Inc. | Substituted thioacetic acid salicylate derivatives and their uses |
| US8772242B2 (en) * | 2009-10-26 | 2014-07-08 | Thomas Julius Borody | Therapy for enteric infections |
| JP2013525440A (ja) | 2010-04-26 | 2013-06-20 | サリックス ファーマシューティカルズ リミテッド | 男性の治療のための２−ヒドロキシ−５−フェニルアゾ安息香酸誘導体の製剤および使用 |
| AU2011342368B2 (en) | 2010-12-13 | 2016-11-17 | Rite-Prep Pty Ltd | Gastric and colonic formulations and methods for making and using them |
| TWI573590B (zh) | 2011-09-20 | 2017-03-11 | 雷希爾生藥有限公司 | 治療自體免疫疾病之組成物及方法 |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| PT2877163T (pt) | 2012-07-27 | 2019-05-24 | Redhill Biopharma Ltd | Formulações e métodos de fabrico de formulações para utilização na evacuação colónica |
| EP3145510B8 (en) * | 2014-05-22 | 2021-10-27 | Kuenstner, John, Todd | Treatment of diseases using combination of ultraviolet blood irradiation and antibiotics |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
| WO2022003421A2 (en) | 2020-06-30 | 2022-01-06 | Redhill Biopharma Ltd. | Triple antibiotic fixed-dose combination products, dosing regimen, methods, and kits for treating pulmonary non-tuberculosis mycobacterial infections |
| WO2025026423A1 (en) * | 2023-08-02 | 2025-02-06 | Shenzhen Pharmacin Co., Ltd. | Compositions, their use and manufacture for treatment of gastrointestinal conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440763A (en) * | 1981-03-18 | 1984-04-03 | Block Drug Company, Inc. | Use of 4-aminosalicyclic acid as an anti-inflammatory agent |
| GB8919321D0 (en) * | 1989-08-25 | 1989-10-11 | Univ London | Treatment of chronic inflammatory conditions |
-
1998
- 1998-04-01 EP EP98912149A patent/EP0971735B1/en not_active Expired - Lifetime
- 1998-04-01 AT AT98912149T patent/ATE389417T1/de active
- 1998-04-01 DK DK98912149T patent/DK0971735T3/da active
- 1998-04-01 WO PCT/AU1998/000222 patent/WO1998043667A1/en not_active Ceased
- 1998-04-01 PT PT98912149T patent/PT971735E/pt unknown
- 1998-04-01 US US09/381,960 patent/US6277836B1/en not_active Expired - Lifetime
- 1998-04-01 IL IL13214598A patent/IL132145A/xx not_active IP Right Cessation
- 1998-04-01 ES ES98912149T patent/ES2303351T3/es not_active Expired - Lifetime
- 1998-04-01 CA CA2285923A patent/CA2285923C/en not_active Expired - Lifetime
- 1998-04-01 AR ARP980101486A patent/AR012304A1/es unknown
- 1998-04-01 JP JP54099898A patent/JP2001524951A/ja not_active Withdrawn
- 1998-04-01 DE DE69839261T patent/DE69839261T2/de not_active Expired - Lifetime
- 1998-04-01 SI SI9830905T patent/SI0971735T1/sl unknown
- 1998-04-01 NZ NZ500696A patent/NZ500696A/en not_active IP Right Cessation
-
1999
- 1999-09-30 NO NO19994778A patent/NO325947B1/no not_active IP Right Cessation
-
2007
- 2007-09-07 JP JP2007232402A patent/JP2008024713A/ja not_active Withdrawn
-
2008
- 2008-06-05 CY CY20081100591T patent/CY1109783T1/el unknown
-
2012
- 2012-03-21 JP JP2012062968A patent/JP2012126736A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012126736A5 (https=) | ||
| Coler et al. | Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment | |
| IL277110B2 (en) | Immunogenic anti-inflammatory preparations | |
| JP2014528474A5 (https=) | ||
| JP2018507914A5 (https=) | ||
| JP2016530239A5 (https=) | ||
| JP2012126736A (ja) | 炎症性腸疾患を治療するための方法および組成物 | |
| JP2015057451A5 (https=) | ||
| JP2016074740A5 (https=) | ||
| JP2015529225A5 (https=) | ||
| JP2019525944A5 (https=) | ||
| JP2015519329A5 (https=) | ||
| JP2013505205A5 (https=) | ||
| JP2014532704A5 (https=) | ||
| JP2014526503A5 (https=) | ||
| JP2013541583A5 (https=) | ||
| JP2012517427A5 (https=) | ||
| WO2012007159A3 (en) | Novel gastro-retentive dosage forms | |
| JP2013528654A (ja) | インフルエンザ、一般的な感冒および炎症の治療におけるレボセチリジンおよびモンテルカストの使用 | |
| JP2021509395A5 (https=) | ||
| JP2011511012A5 (https=) | ||
| JP2019535760A5 (ja) | ガボキサドールを用いた注意欠陥多動性障害（ａｄｈｄ）の治療方法 | |
| JP2017533220A5 (https=) | ||
| JP2022531251A5 (https=) | ||
| JP2014507475A5 (https=) |