JP2012121914A - 放射線障害軽減剤 - Google Patents
放射線障害軽減剤 Download PDFInfo
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- JP2012121914A JP2012121914A JP2012048534A JP2012048534A JP2012121914A JP 2012121914 A JP2012121914 A JP 2012121914A JP 2012048534 A JP2012048534 A JP 2012048534A JP 2012048534 A JP2012048534 A JP 2012048534A JP 2012121914 A JP2012121914 A JP 2012121914A
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- ascorbic acid
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
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- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
【解決手段】 α−D−グルコピラノシル−(1→2)−L−アスコルビン酸を有効成分として含有する放射線障害軽減剤及びこの放射線障害軽減剤を配合した組成物を提供することにより解決する。
【選択図】なし
Description
一定線量以上のX線を照射されたマウスは、細胞の機能障害や死滅が起こり、造血抑制や免疫能の低下などが進行し、消化管からの出血をはじめとする多臓器不全や感染症により死に至ることが知られている。そこで、このマウスのX線被曝に対するアスコルビン酸2−グルコシドの効果を以下の方法にて検討した。即ち、アスコルビン酸2−グルコシド(試薬級、株式会社林原生物化学研究所販売)を生理食塩水(大塚製薬株式会社販売)に溶解し、アスコルビン酸2−グルコシドを100mg/ml含有する試験液を調製し、生理食塩水を対照液として使用した。また、実験には、何れも、1群につき10週齢のC3H系マウスの雌(体重22〜25g)10匹を使用した。試験液或いは対照液は、その0.2mlをマウスの腹腔内に投与した。X線照射には、医療用のX線照射装置を使用した。
試験液の前投与群(X線照射120分前に試験液を投与し、照射10分後に対照液を投与)、試験液の前後投与群(X線照射120分前および10分後に試験液を投与)、対照液投与群(X線照射120分前および10分後に対照液を投与)に分け7GyのX線を照射した。最初のX線照射後、30日、60日目に同様の条件でX線照射と試験液或いは対照液の投与を行い、その後30日目まで、最初のX線照射から10日目ごとの生存マウス数(匹)をカウントして、その結果を表1に示す。
X線を被曝したマウスの死因の一つとして挙げられる造血抑制に対するアスコルビン酸2−グルコシドの効果を調べる実験を、マウスの脾細胞のコロニー形成能を指標として、以下のように行った。即ち、試験液の前投与群(X線照射120分前に試験液を投与し、照射10分後に対照液を投与)、試験液の後投与群(X線照射120分前に対照液を投与し、照射10分後に試験液を投与)、試験液の前後投与群(X線照射120分前および10分後に試験液を投与)、および対照液投与群(X線照射120分前および10分後に対照液を投与)に分けX線(5Gy)を照射した。その9日後に開腹し、幹細胞に対する試験液の放射線障害軽減作用を、脾細胞を用いたコロニー法(放射線生物学実習書編集委員会編、放射線生物学実習、第116−118頁、講談社サイエンティフィック)により検討した。なお結果は、各群の脾コロニーの形成数をカウントし、脾コロニー形成率(%)を対照液投与群のマウスの脾コロニー数の平均値を100とする相対値として求め、表2に示す。
アスコルビン酸2−グルコシド(試薬級、株式会社林原生物化学研究所販売)5質量部と含水結晶α,α−トレハロース5質量部(医薬用、株式会社林原生物化学研究所販売)とを、0.05Mリン酸緩衝生理食塩水90質量部に溶解し、常法によりpHを7.2に調整後、膜により除菌し5mlずつアンプルに封入して、パイロジェンフリーの放射線障害軽減用注射剤を調製した。
アスコルビン酸2−グルコシド(試薬級、株式会社林原生物化学研究所販売)20質量、乳糖10質量部、乳酸カルシウム10質量部、ステアリン酸マグネシウム25質量部、炭酸カルシウム5質量部を混合した後、常法により、打錠機にて打錠し、直径約8mm、重量約200mgの放射線障害軽減用錠剤を製造した。
アスコルビン酸2−グルコシド(試薬級、株式会社林原生物化学研究所販売)20質量、含水結晶α,α−トレハロース5質量部(医薬用、株式会社林原生物化学研究所販売)10質量部、乳酸カルシウム10質量部、ステアリン酸マグネシウム25質量部、炭酸カルシウム5質量部を混合した後、噴霧造粒法を用いて、25〜50メッシュの放射線障害軽減用顆粒剤を製造した。
アスコルビン酸2−グルコシド(試薬級、株式会社林原生物化学研究所販売)50質量、乳酸カルシウム20質量部、ステアリン酸マグネシウム20質量部、炭酸カルシウム10質量部、グルコシルルチン(株式会社林原生物化学研究所販売、商品名「アルファグルコシルルチン」)5質量部を混合し、これを0.5gずつゼラチンカプセルに封入し、放射線障害軽減用カプセル剤を製造した。
含水結晶α,α−トレハロース(株式会社林原商事販売、商品名「トレハ」)200質量部及びマルトース300質量部を混合し、これに、ヨウ素3質量部を溶解したメタノール50質量部を加えて混合し、更に、プルランの10%(W/V)水溶液200質量部を加えて混合して軟膏を得た。本品は、適度の延びと付着性を有する、使用感に優れた、放射線障害軽減用軟膏である。
モノステアリン酸デカグリセリル1.2質量部、モノミリスチン酸デカグリセリル1.8質量部、ステアリルアルコール0.5質量部、ベヘニルアルコール3質量部、バチルアルコール1質量部、パルミチン酸セチル1質量部、ステアリン酸グリセリル1.8質量部、脂肪酸(C10−30)(コレステリル/ラノステリル)2質量部、パルミチン酸イソプロピル4質量部、スクワラン5質量部、ミリスチン酸オクチルドデシル5質量部、マカデミアンナッツ油0.5質量部、トリオクタノイン1.8質量部、ジメチコン0.3質量部を混合し、これに、ブチレングリコール6質量部、ペンチレングリコール2.5質量部、濃グリセリン12質量部、ポリクオタニウム−51 0.25質量部、クエン酸(1%水溶液)1質量部、国際公開WO 02/10361号明細書に記載の環状四糖5含水結晶1質量部、アスコルビン酸2−グルコシド(株式会社林原生物化学研究所販売、商品名「AA2G」)5質量部、精製水43.5質量部を混合したものと、グルコシルルチン(株式会社林原生物化学研究所販売、商品名「アルファグルコシルルチン」)1質量部を精製水5質量部に溶解したものとを混合して、常法により、化粧クリームを調製した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付した放射線障害軽減用化粧クリームとして使用することができる。
カルボキシメチルセルロース4質量部、ポリアクリル酸ナトリウム5質量部、グリセリン22質量部、カオリン10質量部、ニカゾールTS−620(日本カーバイト社販売)6質量部、ハッカ油0.3質量部、セフソール(日光ケミカルズ社製)0.3質量部、アスコルビン酸2−グルコシド(株式会社林原生物化学研究所販売、商品名「AA2G」)3質量部、精製水49.4質量部を混合して、常法により、ハップ剤を調製した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付した放射線障害軽減用ハップ剤として使用することができる。
フランスパン用小麦粉100質量部、冷凍用イースト5質量部、α,α−トレハロースの糖質誘導体含有シラップ(株式会社林原商事販売、商品名「ハローデックス」)3質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)1質量部、食塩2質量部、モルトエキス0.3質量部、イーストフード0.1質量部、少量の乳化剤、水65質量部を混捏し、小分けしてロール状に成形した。これを、28℃、湿度75%で80分間発酵させた後、20分間焼成してフランスパンを製造した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しいパンである。
小麦粉45質量部、植物性タンパク質8質量部、マーガリン6質量部、コーンスターチ6質量部、膨張剤0.7質量部、乳化剤0.3質量部、水25質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)3質量部、砂糖5質量部、適量のビタミン及びミネラルを加えて全量を100質量部とし、常法によりクッキーを調製した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しいクッキーである。
カカオマス15質量部、カカオ脂21質量部、含水結晶α,α−トレハロース(株式会社林原は商事販売、商品名「トレハ」)44質量部、レシチン1質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)1質量部、全脂粉乳19質量部を使用して、常法に従い、まずカカオマス、カカオ脂、α,α−トレハロース、レシチン、全脂粉乳、アスコルビン酸2−グルコシドをミキサーで混合し、リファイニングおよびコンチング終了後、テンパリング工程において均質化した。その後、型流し・冷却工程を経て板チョコレートを作製した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しいチョコレートである。
ガムベース20質量部、砂糖55質量部、ブドウ糖12質量部、含水結晶α,α−トレハロース(株式会社林原商事販売、商品名「トレハ」)5質量部、水飴5質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)2質量部、軟化剤1質量部、色素微量、香料2部を使用して、常法により、ガムベースをニーダーに入れ、約120℃にて溶解攪拌し、50℃まで温度を下げた後に混合機に投入した。混合機に移されたガムベースに上記成分を砂糖、ブドウ糖、α,α−トレハロース、水飴、アスコルビン酸2−グルコシド、軟化剤、色素、香料の順で投入し、同温度で45分間攪拌した。よく混合した後、射出成型器に入れブロック状に押し出し、更にロールにかけて徐々に圧延し、裁断機により細断した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しいガムである。
水飴17質量部、水60質量部、砂糖20部、練乳1質量部、バター2質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)2質量部、バニラエッセンス適量、砂糖、水飴および水を鍋に加えて煮沸し、煮沸温度が125℃に到達した後に攪拌しながら練乳とアスコルビン酸2−グルコシドを加えた。その後、攪拌しながら更に煮沸し、煮沸温度が130℃に達した後にバターを加えた。引き続き煮沸を行い、温度が130℃に到達した後、火から下ろしバニラエッセンスを添加した。その後攪拌を行い冷却盤に流し込んだ。温度を約80℃まで下げた後、棒状にして適当な長さに切断した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しい飴である。
ブドウ糖果糖液糖3質量部、含水結晶α,α−トレハロース(株式会社林原商事販売、商品名「トレハ」)4質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)4質量部、グリコシルヘスペリジン(株式会社林原生物化学研究所販売、商品名「アルファグルコシルヘスペリジン」)1質量部、ミネラル・調味料適量、酸味料2質量部、香料適量、水92質量部の配合を使用し、300mlの精製水を70℃に加熱し、これに少量のミネラル、調味料および酸類を加えて攪拌・混合した。これにトレハロース、ブドウ糖果糖液糖、アスコルビン酸2−グルコシドおよび1500ml精製水を加えて攪拌・溶解した。ポアサイズ1μmのフィルターで濾過し、さらに適量の精製水を加えて最終製品約3000mlに液量調整し、少量の香料を加えて攪拌した。中間タンクでブリックスおよび酸度調整を施し、85℃に達するまで加熱し、80℃にて缶または瓶に充填した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる美味しい飲料である。
アミノ酸混合物として、イソロイシン4質量部、ロイシン6質量部、リジン8質量部、フェニルアラニン8質量部、チロシン1質量部、トリプトファン12質量部、バリン8質量部、アスパラギン酸1質量部、セリン1質量部、アミノ酢酸8質量部、アラニン8質量部、ヒスチジン2質量部、アルギニン8質量部、スレオニン2質量部、メチオニン1質量部の混合物を調製し、水に溶解して1%溶液を調製し、これにオレンジ果汁を2%、α,α−トレハロースの糖質誘導体含有シラップ(株式会社林原商事販売、商品名「ハローデックス」)2質量部、アスコルビン酸2−グルコシド(株式会社林原商事販売、商品名「アスコフレッシュ」)2質量部を添加した栄養ドリンクを調製した。本品は、放射線障害の軽減のために用いられるものである旨の表示を付して放射線障害軽減に使用することができる風味のよい栄養ドリンクである。
Claims (3)
- 1日当たりの摂取量として0.01乃至100gのα−D−グルコピラノシル−(1→2)−L−アスコルビン酸を有効成分として含有し、α−D−グルコピラノシル−(1→2)−L−アスコルビン酸による酸味を緩衝するに足る量のクエン酸ナトリウムを緩衝剤として含有する、X線又はγ線による放射線障害を軽減するための液状の経口用剤。
- 本質的に、1日当たりの摂取量として0.01乃至100gのα−D−グルコピラノシル−(1→2)−L−アスコルビン酸、クエン酸ナトリウム、非還元性糖質、高甘味度甘味料、及び水からなる、X線又はγ線による放射線障害を軽減するための液状の経口用剤。
- 1日当たりの摂取量として0.01乃至100gのα−D−グルコピラノシル−(1→2)−L−アスコルビン酸を有効成分として含有し、さらに非還元性糖質及び高甘味度甘味料を含有する、X線又はγ線による放射線障害を軽減するための顆粒状の経口用剤。
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JP2015510503A (ja) * | 2012-11-22 | 2015-04-09 | オリジナル バイオメディカルズ カンパニー,リミテット | 遊離基による損害を減少するための医薬組成物 |
JP2015140306A (ja) * | 2014-01-28 | 2015-08-03 | 花王株式会社 | 固形状組成物 |
JP2018090640A (ja) * | 2018-03-16 | 2018-06-14 | 花王株式会社 | 固形状組成物 |
JP2020507600A (ja) * | 2017-02-16 | 2020-03-12 | ファーストストリング・リサーチ・インコーポレイテッドFirststring Research,Inc. | 放射線障害を予防し、組織再生を促進するための組成物および方法 |
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JPWO2006033412A1 (ja) * | 2004-09-24 | 2008-05-15 | 株式会社林原生物化学研究所 | 放射線障害軽減剤 |
JP2007176879A (ja) * | 2005-12-28 | 2007-07-12 | Natl Inst Of Radiological Sciences | 酵母を有効成分とする放射線防護剤 |
MX2012002696A (es) | 2009-09-03 | 2012-08-15 | Hayashibara Biochem Lab | Composicion particulada que contiene ácido 2-0-alfa-d-glucosil-l-a scórbico anhidro cristalino, procedimiento para la producción de la misma, y sus usos. |
WO2012033218A1 (ja) | 2010-09-07 | 2012-03-15 | 株式会社林原生物化学研究所 | 2−O−α−D−グルコシル−L−アスコルビン酸含水結晶及び2−O−α−D−グルコシル−L−アスコルビン酸含水結晶含有粉末とそれらの製造方法並びに用途 |
MY165639A (en) | 2011-03-07 | 2018-04-18 | Hayashibara Co | A process for producing a particulate composition comprising anhydrous crystalline 2-o-alpha-d-glucosyl-l-ascorbic |
WO2014017046A1 (ja) | 2012-07-23 | 2014-01-30 | 国立大学法人東京大学 | 放射線障害の予防及び/又は治療剤 |
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