JP2012102109A5 - - Google Patents
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- JP2012102109A5 JP2012102109A5 JP2011274098A JP2011274098A JP2012102109A5 JP 2012102109 A5 JP2012102109 A5 JP 2012102109A5 JP 2011274098 A JP2011274098 A JP 2011274098A JP 2011274098 A JP2011274098 A JP 2011274098A JP 2012102109 A5 JP2012102109 A5 JP 2012102109A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cancer
- seq
- nos
- egfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54660204P | 2004-02-20 | 2004-02-20 | |
| US60/546,602 | 2004-02-20 | ||
| US58462304P | 2004-07-01 | 2004-07-01 | |
| US60/584,623 | 2004-07-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554221A Division JP2008501308A (ja) | 2004-02-20 | 2005-02-18 | Ｅｇｆレセプターエピトープペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012102109A JP2012102109A (ja) | 2012-05-31 |
| JP2012102109A5 true JP2012102109A5 (enExample) | 2013-03-14 |
| JP6045147B2 JP6045147B2 (ja) | 2016-12-14 |
Family
ID=34915579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554221A Pending JP2008501308A (ja) | 2004-02-20 | 2005-02-18 | Ｅｇｆレセプターエピトープペプチドおよびその使用 |
| JP2011274098A Expired - Lifetime JP6045147B2 (ja) | 2004-02-20 | 2011-12-15 | Ｅｇｆレセプターエピトープペプチドおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554221A Pending JP2008501308A (ja) | 2004-02-20 | 2005-02-18 | Ｅｇｆレセプターエピトープペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7767792B2 (enExample) |
| EP (2) | EP2514763A1 (enExample) |
| JP (2) | JP2008501308A (enExample) |
| KR (2) | KR101280267B1 (enExample) |
| AU (2) | AU2005216082B8 (enExample) |
| CA (1) | CA2556632C (enExample) |
| ES (1) | ES2536974T3 (enExample) |
| WO (1) | WO2005081854A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056762A1 (en) * | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7589180B2 (en) * | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
| AU2002319402B2 (en) * | 2001-06-28 | 2008-09-11 | Domantis Limited | Dual-specific ligand and its use |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| EP1600459A3 (en) * | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| JP2006523090A (ja) * | 2002-12-27 | 2006-10-12 | ドマンティス リミテッド | リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体 |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
| CN104857500A (zh) | 2005-11-02 | 2015-08-26 | 杜克大学 | 同时的化学疗法和免疫疗法 |
| CN101454344A (zh) * | 2005-12-01 | 2009-06-10 | 杜门蒂斯有限公司 | 与白细胞介素-1受体1型结合的非竞争性域抗体形式 |
| AU2007241130A1 (en) * | 2006-03-31 | 2007-11-01 | EMD Serono Research Centre, Inc. | Treatment of tumors expressing mutant EGF receptors |
| WO2008033495A2 (en) * | 2006-09-15 | 2008-03-20 | Life Science Pharmaceuticals | Method for detecting and treating skin disorders |
| EP2126127B1 (en) | 2007-01-25 | 2016-09-28 | Dana-Farber Cancer Institute, Inc. | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| NZ579010A (en) | 2007-02-20 | 2012-03-30 | Anaptysbio Inc | Somatic hypermutation systems |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| EP2147397A4 (en) * | 2007-04-23 | 2013-08-21 | Univ Ramot | SYSTEM, METHOD AND COMPUTER READABLE MEDIUM FOR PROVIDING AN OUTPUT IMAGE |
| NZ580530A (en) | 2007-06-06 | 2012-04-27 | Domantis Ltd | Anti vegf polypeptides, antibody variable domains and antagonists |
| WO2009023266A1 (en) * | 2007-08-14 | 2009-02-19 | Ludwig Institute For Cancer Research | Generation of antibodies to cell-surface receptors and cancer-associated proteins including egfr family members |
| US9283276B2 (en) | 2007-08-14 | 2016-03-15 | Ludwig Institute For Cancer Research Ltd. | Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| EP2222709B1 (en) | 2007-11-30 | 2016-11-23 | Glaxo Group Limited | Antigen-binding constructs |
| WO2009149094A2 (en) * | 2008-06-02 | 2009-12-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cytotoxic t cell defined egfr peptide and an optimized derivative peptide |
| JP2010006705A (ja) * | 2008-06-13 | 2010-01-14 | Atlas Antibodies Ab | Ｈｅｒ２サブセット |
| US20100004306A1 (en) * | 2008-06-18 | 2010-01-07 | Abbott Laboratories | PIGF-1 Assay and kits and components thereof |
| MX2010014228A (es) * | 2008-06-18 | 2011-03-29 | Abbott Laboratories Star | Metodos y productos de diagnostico del p/gf-1 acompañante. |
| US8741287B2 (en) * | 2008-06-18 | 2014-06-03 | Abbott Laboratories | PlGF-1 assay and kits and components thereof |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| US20100189727A1 (en) * | 2008-12-08 | 2010-07-29 | Tegopharm Corporation | Masking Ligands For Reversible Inhibition Of Multivalent Compounds |
| WO2010081173A2 (en) * | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| US8399219B2 (en) | 2009-02-23 | 2013-03-19 | Cytomx Therapeutics, Inc. | Protease activatable interferon alpha proprotein |
| US8506963B2 (en) * | 2009-09-22 | 2013-08-13 | Shanghai Cancer Institute | Anti-EFGRv3 monoclonal antibody |
| CN103539840B (zh) * | 2010-01-20 | 2015-04-01 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
| CN102127147B (zh) * | 2010-01-20 | 2014-07-02 | 上海市肿瘤研究所 | 表皮生长因子受体模拟表位肽及其应用 |
| AU2011261161A1 (en) | 2010-06-01 | 2013-01-10 | Ludwig Institute For Cancer Research Limited | Antibodies directed to the unprocessed receptor tyrosine kinase c-Met |
| US9464136B2 (en) | 2010-08-20 | 2016-10-11 | Massachusetts Institute Of Technology | Antibody-based constructs directed against tyrosine kinase receptors |
| EP3501546A3 (de) | 2011-04-21 | 2019-09-18 | Seattle Genetics, Inc. | Cystein-wirkstoff konjugate und ihre verwendung |
| WO2013147509A1 (ko) * | 2012-03-27 | 2013-10-03 | 주식회사 녹십자 | 표피 성장 인자 수용체 표면 항원상의 에피토프 및 이의 용도 |
| JP6103832B2 (ja) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | Ｅｇｆｒ結合性ペプチド |
| CA2934617A1 (en) | 2013-12-23 | 2015-07-02 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with kinesin spindle protein (ksp) |
| MY178160A (en) | 2014-03-11 | 2020-10-06 | Regeneron Pharma | Anti-egfrviii antibodies and uses thereof |
| TW202214691A (zh) | 2014-03-21 | 2022-04-16 | 美商艾伯維有限公司 | 抗-egfr抗體及抗體藥物結合物 |
| WO2016164833A1 (en) * | 2015-04-08 | 2016-10-13 | Nantomics, Llc | Cancer neoepitopes |
| RU2719033C2 (ru) | 2015-04-23 | 2020-04-16 | Нантомикс, Ллс | Способ получения фармацевтического агента для иммунотерапии рака |
| AU2016282723B2 (en) | 2015-06-22 | 2021-09-23 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (ADCs) and antibody prodrug conjugates (APDCs) with enzymatically cleavable groups |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| CA3003251A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
| JP7251981B2 (ja) | 2016-03-24 | 2023-04-04 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂基を有する細胞毒性活性剤のプロドラッグ |
| WO2017216028A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| KR102556826B1 (ko) | 2016-12-21 | 2023-07-18 | 바이엘 파마 악티엔게젤샤프트 | 효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc) |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| SG11202108311RA (en) | 2019-02-26 | 2021-09-29 | Janssen Biotech Inc | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
| JP7727549B2 (ja) * | 2019-03-22 | 2025-08-21 | セルティス・セラピューティクス・ピーティーワイ・リミテッド | 抗ｈｅｒ２結合分子 |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| PH12021552798A1 (en) | 2019-05-14 | 2022-09-19 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| JP7783182B2 (ja) | 2020-02-12 | 2025-12-09 | ヤンセン バイオテツク，インコーポレーテツド | ｃ－ＭＥＴエクソン１４スキッピング変異を有する患者の治療 |
| CN111647074B (zh) * | 2020-06-01 | 2023-12-19 | 皖南医学院 | 一种her3二聚化界面抗原肽、重组抗原肽、编码基因及其应用 |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| IL309048A (en) | 2021-06-22 | 2024-02-01 | Regeneron Pharma | Anti-EGFRVIII drug antibody conjugates and uses thereof |
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| US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| USRE31006E (en) | 1968-09-24 | 1982-08-03 | Akzona Incorporated | Process for the demonstration and determination of reaction components having specific binding affinity for each other |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| DE3167442D1 (en) | 1980-07-07 | 1985-01-10 | Nat Res Dev | Improvements in or relating to cell lines |
| US4341761A (en) | 1980-07-25 | 1982-07-27 | E. I. Du Pont De Nemours And Company | Antibodies to immunogenic peptides and their use to purify human fibroblast interferon |
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| WO2002100348A2 (en) * | 2001-06-13 | 2002-12-19 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (egfr) |
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| JP4225487B2 (ja) * | 2002-04-11 | 2009-02-18 | 清 黒川 | メグシン中和モノクローナル抗体 |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| EP3042964A1 (en) * | 2004-06-04 | 2016-07-13 | Genentech, Inc. | Egfr mutations |
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| WO2008033495A2 (en) | 2006-09-15 | 2008-03-20 | Life Science Pharmaceuticals | Method for detecting and treating skin disorders |
| EP2126127B1 (en) * | 2007-01-25 | 2016-09-28 | Dana-Farber Cancer Institute, Inc. | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| CA2680854C (en) * | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US9283276B2 (en) * | 2007-08-14 | 2016-03-15 | Ludwig Institute For Cancer Research Ltd. | Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof |
| US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2005
- 2005-02-17 US US11/060,646 patent/US7767792B2/en active Active
- 2005-02-18 CA CA2556632A patent/CA2556632C/en not_active Expired - Lifetime
- 2005-02-18 KR KR1020067019405A patent/KR101280267B1/ko not_active Expired - Lifetime
- 2005-02-18 EP EP12164335A patent/EP2514763A1/en not_active Withdrawn
- 2005-02-18 WO PCT/US2005/005155 patent/WO2005081854A2/en not_active Ceased
- 2005-02-18 AU AU2005216082A patent/AU2005216082B8/en not_active Expired
- 2005-02-18 KR KR1020127010335A patent/KR101270443B1/ko not_active Expired - Lifetime
- 2005-02-18 JP JP2006554221A patent/JP2008501308A/ja active Pending
- 2005-02-18 EP EP05723258.9A patent/EP1722808B1/en not_active Expired - Lifetime
- 2005-02-18 ES ES05723258.9T patent/ES2536974T3/es not_active Expired - Lifetime
-
2010
- 2010-01-29 US US12/657,919 patent/US8652473B2/en not_active Expired - Fee Related
- 2010-09-20 AU AU2010224335A patent/AU2010224335B2/en not_active Expired
-
2011
- 2011-12-15 JP JP2011274098A patent/JP6045147B2/ja not_active Expired - Lifetime
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