JP2012012303A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2012012303A JP2012012303A JP2010147181A JP2010147181A JP2012012303A JP 2012012303 A JP2012012303 A JP 2012012303A JP 2010147181 A JP2010147181 A JP 2010147181A JP 2010147181 A JP2010147181 A JP 2010147181A JP 2012012303 A JP2012012303 A JP 2012012303A
- Authority
- JP
- Japan
- Prior art keywords
- sucralose
- cetylpyridinium chloride
- mass
- acid
- oral composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 30
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 30
- 239000004376 Sucralose Substances 0.000 claims abstract description 26
- 235000019408 sucralose Nutrition 0.000 claims abstract description 26
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 26
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000010449 maltitol Nutrition 0.000 claims abstract description 8
- 239000000845 maltitol Substances 0.000 claims abstract description 8
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 8
- 229940035436 maltitol Drugs 0.000 claims abstract description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000811 xylitol Substances 0.000 claims abstract description 8
- 235000010447 xylitol Nutrition 0.000 claims abstract description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 8
- 229960002675 xylitol Drugs 0.000 claims abstract description 8
- 210000000214 mouth Anatomy 0.000 claims description 16
- 238000013329 compounding Methods 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 abstract description 15
- 235000019658 bitter taste Nutrition 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 8
- 238000002156 mixing Methods 0.000 abstract description 8
- 230000000638 stimulation Effects 0.000 abstract 1
- -1 fatty acid esters Chemical class 0.000 description 32
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
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- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
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- 125000002091 cationic group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
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- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
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- 244000228451 Stevia rebaudiana Species 0.000 description 2
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- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
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- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
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Abstract
【解決手段】塩化セチルピリジニウムにスクラロースを0.005〜0.05質量%配合した場合、塩化セチルピリジニウムが有する苦味、刺激といった不快な味を解消した口腔用組成物を得ることが出来る。さらに、マルチトールやキシリトールをスクラロースに対して特定量配合することにより更に優れた効果を得ることが出来る。
【選択図】なし
Description
項1.
スクラロース0.005〜0.05質量%と塩化セチルピリジニウムを配合することを特徴とする口腔用組成物。
項2.
塩化セチルピリジニウムに対してスクラロースを0.02〜5質量部配合することを特徴とする項1に記載の口腔用組成物。
項3.
さらに、キシリトールおよびマルチトールから選ばれる1種以上を、スクラロースの配合量に対して200〜1000質量部配合することを特徴とする項1または項2の何れか1項に記載の口腔用組成物。
表1に示す処方に従って洗口液(実施例及び比較例)を調製し、味覚テストを行った。味覚テストは、13名の専門パネラーを用い、被検体約10mLを口に含んで約20秒間口腔内を十分にいきわたらせた後に吐き出し、直後の苦味について下記の7段階の絶対評価で行なった。各々の評価結果に下記係数を乗じることにより13名の評価結果の合計値を算出した。結果を表1に示す。
評価段階と係数
非常に強く感じる −8
強く感じる −4
やや強く感じる −1
どちらともいえない 0
やや弱く感じる 1
弱く感じる 4
非常に弱く感じる 8
表2に示す処方に従って洗口液(実施例及び比較例)を調製し、味覚テストを行った。味覚テストは、5名の専門パネラーを用い、被検体約10mLを口に含んで約20秒間口腔内を十分にいきわたらせた後に吐き出し、直後の「苦味」および「えぐ味」について下記の5段階の絶対評価で行なった。各々の評価結果に下記係数を乗じることにより得られる5名の評価結果の合計値を算出したのち、2つの評価の合計値(評価合計点)を算出した。結果を表2に示す。
評価段階と係数
強く感じる −4
やや強く感じる −1
どちらともいえない 0
やや弱く感じる 1
弱く感じる 4
常法に従って、液体歯磨剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.3
スクラロース 0.015
キシリトール 7.0
グリセリン 10.0
エタノール 10.0
ポリオキシエチレン
(60EO)硬化ヒマシ油 0.4
トラネキサム酸 0.05
クエン酸 0.01
クエン酸3ナトリウム 0.1
パラオキシ安息香酸メチル 0.1
香料 0.2
精製水 残 部
合 計 100.0
常法に従って、ペースト状の歯磨剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.05
スクラロース 0.05
グリセリン 20.0
リン酸水素カルシウム 30.0
ヒドロキシエチルセルロース 2.0
フッ化ナトリウム 0.2
ポリオキシエチレン
(40EO)硬化ヒマシ油 0.5
酸化チタン 0.5
メチルパラベン 0.5
酢酸トコフェロール 0.02
クエン酸 0.01
クエン酸3ナトリウム 0.1
香料 1.0
精製水 残 部
合 計 100.0
常法に従って、ジェル剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.1
スクラロース 0.02
グリセリン 10.0
プロピレングリコール 10.0
ヒドロキシエチルセルロース 1.0
ポリオキシエチレン
(60EO)硬化ヒマシ油 0.4
クエン酸 0.01
クエン酸3ナトリウム 0.1
香料 0.1
メチルパラベン 0.1
精製水 残 部
合 計 100.0
常法に従って、洗口剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.01
スクラロース 0.005
グリセリン 6.0
1,3−プロパンジオール 3.0
モノラウリン酸ショ糖脂肪酸エステル
0.3
イソプロピルメチルフェノール 0.05
クエン酸 0.01
クエン酸3ナトリウム 0.1
安息香酸ナトリウム 0.2
香料 0.1
精製水 残 部
合 計 100.0
常法に従って、マウススプレイを調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.01
スクラロース 0.01
マルチトール 2.0
エタノール 10.0
グリセリン 6.0
ポリオキシエチレン
(60EO)硬化ヒマシ油 2.0
クエン酸 0.1
クエン酸3ナトリウム 0.2
l−メントール 0.3
香料 0.8
精製水 残 部
合 計 100.0
常法に従って、液状の口腔乾燥防止剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム 0.02
スクラロース 0.03
グリセリン 5.0
ヒアルロン酸 2.0
ポリオキシエチレン
(60EO)硬化ヒマシ油 0.1
クエン酸 0.02
クエン酸3ナトリウム 0.1
香料 0.8
精製水 残 部
合 計 100.0
Claims (3)
- スクラロース0.005〜0.05質量%と塩化セチルピリジニウムを配合
することを特徴とする口腔用組成物。 - 塩化セチルピリジニウムに対してスクラロースを0.02〜5質量部配合することを特徴とする請求項1に記載の口腔用組成物。
- さらに、キシリトールおよびマルチトールから選ばれる1種以上を、スクラロースの配合量に対して200〜1000質量部配合することを特徴とする請求項1または2の何れか1項に記載の口腔用組成物。
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2018002634A (ja) * | 2016-06-30 | 2018-01-11 | サンスター株式会社 | 口腔用ペースト状組成物 |
JPWO2017002891A1 (ja) * | 2015-06-30 | 2018-04-19 | 日油株式会社 | 矯味剤およびこれを含有する口腔用組成物 |
EP3942931A1 (en) * | 2014-06-10 | 2022-01-26 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
JP2022021546A (ja) * | 2020-07-22 | 2022-02-03 | 花王株式会社 | 液体口腔用組成物 |
CN114010521A (zh) * | 2021-11-17 | 2022-02-08 | 重庆登康口腔护理用品股份有限公司 | 一种口感良好的抑菌防腐组合物、口腔护理液及其制备方法 |
US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
US12121022B2 (en) | 2023-05-26 | 2024-10-22 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02501440A (ja) * | 1987-10-06 | 1990-05-24 | テイト アンド ライル パブリック リミテッド カンパニー | シユクラロース組成物 |
JPH02177869A (ja) * | 1988-10-28 | 1990-07-10 | Warner Lambert Co | クロロデオキシ糖およびマルチトールを含有する相乗甘味組成物およびその製造方法 |
JPH02177870A (ja) * | 1988-10-28 | 1990-07-10 | Warner Lambert Co | 不快な味をマスキングする組成物およびその調製方法 |
JP2005029506A (ja) * | 2003-07-14 | 2005-02-03 | Kao Corp | 口腔用組成物 |
JP2008509225A (ja) * | 2004-08-12 | 2008-03-27 | ザ プロクター アンド ギャンブル カンパニー | 口腔用組成物及びそのシステム |
JP2008303188A (ja) * | 2007-06-08 | 2008-12-18 | Univ Of Tokushima | カンジダバイオフィルム除去剤 |
JP2010042021A (ja) * | 1998-10-28 | 2010-02-25 | Sanei Gen Ffi Inc | スクラロースを含有する組成物及びその応用 |
-
2010
- 2010-06-29 JP JP2010147181A patent/JP5721973B2/ja active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02501440A (ja) * | 1987-10-06 | 1990-05-24 | テイト アンド ライル パブリック リミテッド カンパニー | シユクラロース組成物 |
JPH02177869A (ja) * | 1988-10-28 | 1990-07-10 | Warner Lambert Co | クロロデオキシ糖およびマルチトールを含有する相乗甘味組成物およびその製造方法 |
JPH02177870A (ja) * | 1988-10-28 | 1990-07-10 | Warner Lambert Co | 不快な味をマスキングする組成物およびその調製方法 |
JP2010042021A (ja) * | 1998-10-28 | 2010-02-25 | Sanei Gen Ffi Inc | スクラロースを含有する組成物及びその応用 |
JP2005029506A (ja) * | 2003-07-14 | 2005-02-03 | Kao Corp | 口腔用組成物 |
JP2008509225A (ja) * | 2004-08-12 | 2008-03-27 | ザ プロクター アンド ギャンブル カンパニー | 口腔用組成物及びそのシステム |
JP2008303188A (ja) * | 2007-06-08 | 2008-12-18 | Univ Of Tokushima | カンジダバイオフィルム除去剤 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3942931A1 (en) * | 2014-06-10 | 2022-01-26 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
US11672247B2 (en) | 2014-06-10 | 2023-06-13 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
JPWO2017002891A1 (ja) * | 2015-06-30 | 2018-04-19 | 日油株式会社 | 矯味剤およびこれを含有する口腔用組成物 |
JP2018002634A (ja) * | 2016-06-30 | 2018-01-11 | サンスター株式会社 | 口腔用ペースト状組成物 |
US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
JP2022021546A (ja) * | 2020-07-22 | 2022-02-03 | 花王株式会社 | 液体口腔用組成物 |
JP7402765B2 (ja) | 2020-07-22 | 2023-12-21 | 花王株式会社 | 液体口腔用組成物 |
CN114010521A (zh) * | 2021-11-17 | 2022-02-08 | 重庆登康口腔护理用品股份有限公司 | 一种口感良好的抑菌防腐组合物、口腔护理液及其制备方法 |
US12121022B2 (en) | 2023-05-26 | 2024-10-22 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
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