JP2011530514A5 - - Google Patents

Info

Publication number

JP2011530514A5

JP2011530514A5 JP2011522119A JP2011522119A JP2011530514A5 JP 2011530514 A5 JP2011530514 A5 JP 2011530514A5 JP 2011522119 A JP2011522119 A JP 2011522119A JP 2011522119 A JP2011522119 A JP 2011522119A JP 2011530514 A5 JP2011530514 A5 JP 2011530514A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

nos

acid sequences

sequences shown

Prior art date

2009-07-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims description 13
• 102400001151 Hepcidin-25 Human genes 0.000 claims description 12
• 101800003310 Hepcidin-25 Proteins 0.000 claims description 12
• 229920001184 polypeptide Polymers 0.000 claims description 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
• 210000002966 serum Anatomy 0.000 claims description 4
• 102000009052 human hepcidin 25 Human genes 0.000 claims description 3
• 108700022871 human hepcidin 25 Proteins 0.000 claims description 3
• 238000003018 immunoassay Methods 0.000 claims description 3
• 102000004169 proteins and genes Human genes 0.000 claims description 3
• 108090000623 proteins and genes Proteins 0.000 claims description 3
• 150000001413 amino acids Chemical group 0.000 claims 25
• 238000000034 method Methods 0.000 claims 8
• 239000007787 solid Substances 0.000 claims 4
• 239000013060 biological fluid Substances 0.000 claims 3
• 210000001519 tissue Anatomy 0.000 claims 3
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 208000007502 anemia Diseases 0.000 claims 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
• 206010003445 Ascites Diseases 0.000 claims 1
• 238000002965 ELISA Methods 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000001554 Hemoglobins Human genes 0.000 claims 1
• 108010054147 Hemoglobins Proteins 0.000 claims 1
• 210000004381 amniotic fluid Anatomy 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000004820 blood count Methods 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 210000002726 cyst fluid Anatomy 0.000 claims 1
• 210000003743 erythrocyte Anatomy 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 238000005534 hematocrit Methods 0.000 claims 1
• 210000004251 human milk Anatomy 0.000 claims 1
• 235000020256 human milk Nutrition 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 210000002751 lymph Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 238000001556 precipitation Methods 0.000 claims 1
• 238000003127 radioimmunoassay Methods 0.000 claims 1
• 210000001995 reticulocyte Anatomy 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 238000003118 sandwich ELISA Methods 0.000 claims 1
• 210000004243 sweat Anatomy 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 102000018511 hepcidin Human genes 0.000 description 2
• 108060003558 hepcidin Proteins 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 229940066919 hepcidin Drugs 0.000 description 1
• 241000894007 species Species 0.000 description 1