PL2328931T3 - Wybiórcze przeciwciała anty-hepcydyna-25 i ich zastosowania - Google Patents

Wybiórcze przeciwciała anty-hepcydyna-25 i ich zastosowania

Info

Publication number
PL2328931T3
PL2328931T3 PL09790908T PL09790908T PL2328931T3 PL 2328931 T3 PL2328931 T3 PL 2328931T3 PL 09790908 T PL09790908 T PL 09790908T PL 09790908 T PL09790908 T PL 09790908T PL 2328931 T3 PL2328931 T3 PL 2328931T3
Authority
PL
Poland
Prior art keywords
hepcidin
selective antibodies
antibodies
selective
Prior art date
Application number
PL09790908T
Other languages
English (en)
Polish (pl)
Inventor
Donmienne Doen Mun Leung
Peng Luan
Ying Tang
Derrick Ryan Witcher
Pia Pauliina Yachi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL2328931T3 publication Critical patent/PL2328931T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL09790908T 2008-08-06 2009-07-29 Wybiórcze przeciwciała anty-hepcydyna-25 i ich zastosowania PL2328931T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8655708P 2008-08-06 2008-08-06
PCT/US2009/052044 WO2010017070A1 (en) 2008-08-06 2009-07-29 Anti-hepcidin-25 selective antibodies and uses thereof
EP09790908.9A EP2328931B1 (en) 2008-08-06 2009-07-29 Anti-hepcidin-25 selective antibodies and uses thereof

Publications (1)

Publication Number Publication Date
PL2328931T3 true PL2328931T3 (pl) 2014-01-31

Family

ID=41165490

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09790908T PL2328931T3 (pl) 2008-08-06 2009-07-29 Wybiórcze przeciwciała anty-hepcydyna-25 i ich zastosowania

Country Status (19)

Country Link
US (1) US8609817B2 (https=)
EP (1) EP2328931B1 (https=)
JP (1) JP5730200B2 (https=)
KR (1) KR101462307B1 (https=)
CN (1) CN102112489B (https=)
AU (1) AU2009279865B2 (https=)
BR (1) BRPI0916624A2 (https=)
CA (1) CA2733497C (https=)
DK (1) DK2328931T3 (https=)
EA (1) EA201170312A1 (https=)
ES (1) ES2432018T3 (https=)
IL (1) IL210643A (https=)
MX (1) MX2011001363A (https=)
NZ (1) NZ590863A (https=)
PL (1) PL2328931T3 (https=)
PT (1) PT2328931E (https=)
UA (1) UA103032C2 (https=)
WO (1) WO2010017070A1 (https=)
ZA (1) ZA201100261B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1608683B1 (en) * 2003-04-01 2011-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antibodies directed against hepatitis c virus e1e2 complex and pharmaceutical compositions
PE20091261A1 (es) * 2007-11-02 2009-08-17 Lilly Co Eli Anticuerpos anti-hepcidina
NZ606584A (en) 2010-08-16 2014-10-31 Pieris Ag Binding proteins for hepcidin
AU2012350654C1 (en) 2011-12-12 2018-05-10 Pieris Ag Methods for preventing or treating disorders by increasing bioavailability of iron and related pharmaceutical formulation
US10316103B1 (en) 2012-03-30 2019-06-11 Biocare Medical, Llc Systems and methods for anti-Uroplakin III antibodies
US20140120560A1 (en) * 2012-10-26 2014-05-01 Claresa Levetan Generation of new pancreatic beta cells
US10429390B2 (en) 2012-12-18 2019-10-01 Biocare Medical, Llc Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer
US9657098B2 (en) * 2013-03-15 2017-05-23 Intrinsic Lifesciences, Llc Anti-hepcidin antibodies and uses thereof
WO2015051320A2 (en) * 2013-10-03 2015-04-09 Biocare Medical, Llc Anti-sox10 antibody systems and methods
WO2016027469A1 (ja) * 2014-08-21 2016-02-25 国立大学法人旭川医科大学 ヘプシジンのスプライシングバリアント並びに該バリアントを指標とした癌の診断方法
AU2015321462B2 (en) * 2014-09-22 2020-04-30 Intrinsic Lifesciences Llc Humanized anti-hepcidin antibodies and uses thereof
EP3268027B1 (en) 2015-03-13 2022-11-02 Institut National de la Santé et de la Recherche Médicale (INSERM) Hepcidin antagonists for use in the treatment of inflammation
CA3038894A1 (en) * 2016-09-28 2018-04-05 Board Of Regents, The University Of Texas System Antibody and protein therapeutic formulations and uses thereof
EP3559039A1 (en) 2016-12-22 2019-10-30 Università Degli Studi Magna Graecia Catanzaro A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43
WO2018234538A1 (en) 2017-06-23 2018-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Hepcidin antagonist or agonist for use in the treatment of dysregulation of mo and/or mn metabolism
CN109948371B (zh) * 2019-03-07 2021-06-25 深圳市智税链科技有限公司 为区块链节点发放身份证书的方法及相关装置
CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
WO2021231798A1 (en) 2020-05-13 2021-11-18 Disc Medicine, Inc. Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
EP4279924A4 (en) * 2021-01-18 2024-06-26 FUJIFILM Corporation ADSORPTION INHIBITOR FOR HEPCIDIN, ADSORPTION INHIBITOR METHOD, REFERENCE STANDARD, REAGENT, KIT AND MEASUREMENT METHODS

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE478145T1 (de) 1999-06-02 2010-09-15 Genentech Inc Sekretierte und transmembran polypeptide und dafür kodierende nukleinsäuren
US6262247B1 (en) 1999-08-30 2001-07-17 Incyte Genomics, Inc. Polycyclic aromatic hydrocarbon induced molecules
JP4944360B2 (ja) 2001-05-25 2012-05-30 アンスティテュ ナシオナル ド ラ サント エ ド ラ ルシュルシェ メディカル（アンセルム） 鉄ホメオスタシスの障害を治療するための医薬品を製造するためのヘプシジンの使用
CN1173737C (zh) 2002-10-21 2004-11-03 钱忠明 Hepcidin(海魄喜定)在制药中的应用
US7411048B2 (en) 2002-11-19 2008-08-12 Drg International, Inc. Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids
US8017737B2 (en) 2002-11-19 2011-09-13 Hasan Kulaksiz Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids; monoclonal antibodies specific to human hepcidin and associated uses therefor
CA2506668C (en) 2002-11-19 2014-08-19 Drg International, Inc. Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor
EP1644416A4 (en) 2003-06-30 2007-08-29 Centocor Inc ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
JP2007518062A (ja) 2003-09-29 2007-07-05 バイオサイト インコーポレイテッド 敗血症を診断する方法および診断するための組成物
AU2003271174A1 (en) * 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
US7723063B2 (en) * 2004-04-28 2010-05-25 Intrinsic Lifesciences Methods for measuring levels of bioactive human hepcidin
AU2006223374B2 (en) * 2005-03-11 2011-07-21 Aspira Women’s Health Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
TW201307390A (zh) * 2007-02-02 2013-02-16 Amgen Inc 海帕西啶（ｈｅｐｃｉｄｉｎ）、海帕西啶拮抗劑及使用方法
GR1006896B (el) * 2007-08-24 2010-07-20 Ελληνικο Ινστιτουτο Παστερ, Μεθοδος παραγωγης μιας πεπτιδικης ορμονης
WO2009044284A1 (en) 2007-10-02 2009-04-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antibodies specific for human hepcidin
PE20091261A1 (es) * 2007-11-02 2009-08-17 Lilly Co Eli Anticuerpos anti-hepcidina
CA2722600C (en) 2008-05-01 2014-01-21 Amgen Inc. Anti-hepcidin antibodies and methods of use

Also Published As

Publication number Publication date
JP5730200B2 (ja) 2015-06-03
AU2009279865A1 (en) 2010-02-11
ZA201100261B (en) 2012-06-27
MX2011001363A (es) 2011-04-26
EP2328931A1 (en) 2011-06-08
IL210643A0 (en) 2011-03-31
KR20110031963A (ko) 2011-03-29
IL210643A (en) 2015-09-24
HK1156326A1 (en) 2012-06-08
DK2328931T3 (da) 2013-09-30
CN102112489B (zh) 2014-05-14
BRPI0916624A2 (pt) 2015-12-01
KR101462307B1 (ko) 2014-11-17
PT2328931E (pt) 2013-11-07
WO2010017070A1 (en) 2010-02-11
JP2011530514A (ja) 2011-12-22
UA103032C2 (uk) 2013-09-10
US20110189190A1 (en) 2011-08-04
CA2733497C (en) 2015-06-02
NZ590863A (en) 2012-10-26
CA2733497A1 (en) 2010-02-11
CN102112489A (zh) 2011-06-29
EA201170312A1 (ru) 2012-03-30
AU2009279865B2 (en) 2013-10-10
ES2432018T3 (es) 2013-11-29
EP2328931B1 (en) 2013-08-14
US8609817B2 (en) 2013-12-17

Similar Documents

Publication Publication Date Title
ZA201100261B (en) Anti-hepcidin-25 selective antibodies and uses thereof
IL209309A0 (en) Anti-fn14 antibodies and uses thereof
IL216731A (en) And antibodies against p95 – her2 and their uses
ZA201003025B (en) Anti-hepcidin antibodies and uses thereof
IL250624B (en) Anti-fgfr3 antibodies and methods of using them
IL200012A0 (en) Anti-robo4 antibodies and uses therefor
LT2436696T (lt) Anti-beta-amiloido antikūnas ir jo panaudojimas
EP2494062A4 (en) ANTI-GLP-1R ANTIBODIES AND THEIR USES
ZA201107486B (en) Anti-tnf-x antibodies and their uses
PL2354161T3 (pl) Przeciwciało anty -NR10 i jego zastosowanie
EP2334330A4 (en) ANTI-CD147 ANTIBODIES, METHODS, AND USES
IL195658A0 (en) Anti-nkg2a antibodies and uses thereof
IL207129A0 (en) Ron antibodies and uses thereof
IL220536A0 (en) Anti - bv8 antibodies and uses thereof
PL2373675T3 (pl) Reagenty funkcjonalizujące tiole oraz ich zastosowania
SI2354161T1 (sl) Anti-NR10 protitelo in njegova uporaba
GB0903151D0 (en) Antibody uses and methods
IL219136A0 (en) Anti-hepsin antibodies and methods using same
IL214527A0 (en) Anti-mst1r antibodies and uses thereof
GB0812277D0 (en) Antibody and uses thereof
GB0822140D0 (en) Methods and reagents
GB0906115D0 (en) Antibody and uses thereof
ZA200905136B (en) Anti-robo4 antibodies and uses therefor
GB0816523D0 (en) Methods and uses
GB0810609D0 (en) Methods and uses