JP2011530312A5 - - Google Patents
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- Publication number
- JP2011530312A5 JP2011530312A5 JP2011523071A JP2011523071A JP2011530312A5 JP 2011530312 A5 JP2011530312 A5 JP 2011530312A5 JP 2011523071 A JP2011523071 A JP 2011523071A JP 2011523071 A JP2011523071 A JP 2011523071A JP 2011530312 A5 JP2011530312 A5 JP 2011530312A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- locus
- nucleic acid
- polymorphism
- foxo3a
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700028369 Alleles Proteins 0.000 claims 18
- 101000877681 Homo sapiens Forkhead box protein O3 Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 210000000349 chromosome Anatomy 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108091034117 Oligonucleotide Proteins 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 102000054766 genetic haplotypes Human genes 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 102100035421 Forkhead box protein O3 Human genes 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 208000017667 Chronic Disease Diseases 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000005070 sampling Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000012807 PCR reagent Substances 0.000 claims 1
- 239000012445 acidic reagent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8772208P | 2008-08-10 | 2008-08-10 | |
| US61/087,722 | 2008-08-10 | ||
| PCT/US2009/053307 WO2010019519A2 (en) | 2008-08-10 | 2009-08-10 | Method of using foxo3a polymorphisms and haplotypes to predict and promote healthy aging and longevity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530312A JP2011530312A (ja) | 2011-12-22 |
| JP2011530312A5 true JP2011530312A5 (enExample) | 2015-06-18 |
| JP5814119B2 JP5814119B2 (ja) | 2015-11-17 |
Family
ID=41669598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011523071A Active JP5814119B2 (ja) | 2008-08-10 | 2009-08-10 | 健康的な老化および長寿を予測および促進するｆｏｘｏ３ａの多型およびハプロタイプを使用する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20110212447A1 (enExample) |
| EP (1) | EP2324127B1 (enExample) |
| JP (1) | JP5814119B2 (enExample) |
| KR (2) | KR101649541B1 (enExample) |
| CN (1) | CN102177255B (enExample) |
| AU (1) | AU2009282172B2 (enExample) |
| CA (1) | CA2733597C (enExample) |
| DK (1) | DK2324127T3 (enExample) |
| WO (1) | WO2010019519A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101649541B1 (ko) * | 2008-08-10 | 2016-08-19 | 쿠아키니 메디컬 센터 | 건강한 노화 및 장수를 예측하고 증진하기 위하여 ｆｏｘｏ３ａ 다형성 및 일배체형을 사용하는 방법 |
| US8990135B2 (en) * | 2010-06-15 | 2015-03-24 | The Regents Of The University Of Michigan | Personalized health risk assessment for critical care |
| CN103233001B (zh) * | 2012-06-25 | 2016-11-02 | 西北农林科技大学 | 秦川牛FoxO1基因单核苷酸多态性分子标记的检测方法与应用 |
| KR102017562B1 (ko) * | 2013-03-13 | 2019-09-03 | (주)아모레퍼시픽 | 미백 효능 물질의 스크리닝 방법 |
| US11413278B2 (en) | 2015-10-08 | 2022-08-16 | The Regents Of The University Of California | Compounds and methods for promoting stress resistance |
| WO2018183353A1 (en) * | 2017-03-27 | 2018-10-04 | Cardax Pharma, Inc. | Small molecule compounds to support healthy human aging |
| US11593512B2 (en) | 2017-05-12 | 2023-02-28 | Massachusetts Institute Of Technology | Systems and methods for crowdsourcing, analyzing, and/or matching personal data |
| WO2019156591A1 (en) * | 2018-02-12 | 2019-08-15 | Limited Liability Company "Gero" | Methods and systems for prediction of frailty background |
| CN111235250A (zh) * | 2020-03-31 | 2020-06-05 | 中国科学院昆明动物研究所 | 与健康老龄相关的关键通路及其外周血dna甲基化位点标志物和应用 |
| CN115466321B (zh) * | 2022-09-23 | 2024-03-22 | 南方医科大学珠江医院 | FOXO3a-DRI肽段、其药物组合物及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7932049B2 (en) | 2002-12-23 | 2011-04-26 | University Of Massachusetts | Methods of identifying longevity modulators and therapeutic methods of use thereof |
| WO2005004814A2 (en) | 2003-07-02 | 2005-01-20 | Elixir Pharmaceuticals, Inc. | Sirt1 and genetic disorders |
| US20060069049A1 (en) | 2003-12-29 | 2006-03-30 | President And Fellows Of Harvard College | Methods and reagents related to foxo |
| JP2008504018A (ja) * | 2004-06-03 | 2008-02-14 | ジョンズ ホプキンス ユニバーシティ | 細胞増殖または新生物性障害に関してスクリーニングする方法 |
| US7622271B2 (en) * | 2004-07-26 | 2009-11-24 | University Of Washington | Identification of aging genes through large-scale analysis |
| US20070118398A1 (en) * | 2005-11-18 | 2007-05-24 | Flicker Technologies, Llc | System and method for estimating life expectancy and providing customized advice for improving life expectancy |
| JP5292569B2 (ja) * | 2006-11-10 | 2013-09-18 | 国立大学法人名古屋大学 | 抗老化転写因子活性化剤及びその利用 |
| KR101649541B1 (ko) * | 2008-08-10 | 2016-08-19 | 쿠아키니 메디컬 센터 | 건강한 노화 및 장수를 예측하고 증진하기 위하여 ｆｏｘｏ３ａ 다형성 및 일배체형을 사용하는 방법 |
-
2009
- 2009-08-10 KR KR1020117005559A patent/KR101649541B1/ko active Active
- 2009-08-10 KR KR1020167022020A patent/KR20160102081A/ko not_active Abandoned
- 2009-08-10 CN CN200980140170.7A patent/CN102177255B/zh active Active
- 2009-08-10 WO PCT/US2009/053307 patent/WO2010019519A2/en not_active Ceased
- 2009-08-10 EP EP09807138.4A patent/EP2324127B1/en active Active
- 2009-08-10 US US13/058,179 patent/US20110212447A1/en not_active Abandoned
- 2009-08-10 CA CA2733597A patent/CA2733597C/en active Active
- 2009-08-10 JP JP2011523071A patent/JP5814119B2/ja active Active
- 2009-08-10 AU AU2009282172A patent/AU2009282172B2/en active Active
- 2009-08-10 DK DK09807138T patent/DK2324127T3/en active
-
2013
- 2013-03-15 US US13/831,775 patent/US20130295566A1/en not_active Abandoned
-
2015
- 2015-08-10 US US14/822,873 patent/US20150337383A1/en active Pending
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