JP2011528665A5 - - Google Patents

Info

Publication number

JP2011528665A5

JP2011528665A5 JP2011518930A JP2011518930A JP2011528665A5 JP 2011528665 A5 JP2011528665 A5 JP 2011528665A5 JP 2011518930 A JP2011518930 A JP 2011518930A JP 2011518930 A JP2011518930 A JP 2011518930A JP 2011528665 A5 JP2011528665 A5 JP 2011528665A5

Authority

JP

Japan

Prior art keywords

denv

polypeptide

composition

xaa

amino acid

Prior art date

2009-07-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims description 28
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 28
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
• 241000725619 Dengue virus Species 0.000 claims description 24
• 208000015181 infectious disease Diseases 0.000 claims description 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
• 208000009714 Severe Dengue Diseases 0.000 claims description 8
• 150000001413 amino acids Chemical class 0.000 claims description 8
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 8
• 206010012310 Dengue fever Diseases 0.000 claims description 6
• 206010053614 Type III immune complex mediated reaction Diseases 0.000 claims description 6
• 230000016178 immune complex formation Effects 0.000 claims description 6
• 230000000087 stabilizing effect Effects 0.000 claims description 6
• 108090000623 proteins and genes Proteins 0.000 claims description 5
• 102000004169 proteins and genes Human genes 0.000 claims description 5
• 108700028369 Alleles Proteins 0.000 claims description 4
• 201000002950 dengue hemorrhagic fever Diseases 0.000 claims description 4
• 201000009892 dengue shock syndrome Diseases 0.000 claims description 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
• 230000006872 improvement Effects 0.000 claims description 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
• LDCYZAJDBXYCGN-UHFFFAOYSA-N 5-hydroxytryptophan Chemical compound C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 claims description 2
• 208000001490 Dengue Diseases 0.000 claims description 2
• 108010021472 Fc gamma receptor IIB Proteins 0.000 claims description 2
• 108010021470 Fc gamma receptor IIC Proteins 0.000 claims description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
• 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 claims description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
• 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims description 2
• 102100029206 Low affinity immunoglobulin gamma Fc region receptor II-c Human genes 0.000 claims description 2
• 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims description 2
• 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims description 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
• 208000036142 Viral infection Diseases 0.000 claims description 2
• 150000003862 amino acid derivatives Chemical class 0.000 claims description 2
• 210000004899 c-terminal region Anatomy 0.000 claims description 2
• 208000025729 dengue disease Diseases 0.000 claims description 2
• 230000001419 dependent effect Effects 0.000 claims description 2
• 230000008935 histological improvement Effects 0.000 claims description 2
• 239000002245 particle Substances 0.000 claims description 2
• 230000009385 viral infection Effects 0.000 claims description 2
• 230000003612 virological effect Effects 0.000 claims description 2
• 230000005764 inhibitory process Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 25
• 206010061192 Haemorrhagic fever Diseases 0.000 description 2
• 206010018873 Haemoconcentration Diseases 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1