JP2011528360A5 - - Google Patents
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- JP2011528360A5 JP2011528360A5 JP2011518840A JP2011518840A JP2011528360A5 JP 2011528360 A5 JP2011528360 A5 JP 2011528360A5 JP 2011518840 A JP2011518840 A JP 2011518840A JP 2011518840 A JP2011518840 A JP 2011518840A JP 2011528360 A5 JP2011528360 A5 JP 2011528360A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- methoxy
- drug conjugate
- anthracycline derivative
- conjugate compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 50
- -1 3-pyridylmethyl - Chemical class 0.000 claims description 47
- 150000001875 compounds Chemical class 0.000 claims description 42
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 27
- 239000000611 antibody drug conjugate Substances 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 22
- 239000000562 conjugate Substances 0.000 claims description 21
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 16
- 150000001413 amino acids Chemical group 0.000 claims description 15
- 125000005647 linker group Chemical group 0.000 claims description 15
- 125000002947 alkylene group Chemical group 0.000 claims description 14
- 238000010276 construction Methods 0.000 claims description 13
- 125000006850 spacer group Chemical group 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 10
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
- 230000008878 coupling Effects 0.000 claims description 9
- 238000010168 coupling process Methods 0.000 claims description 9
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- 125000000217 alkyl group Chemical group 0.000 claims description 8
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
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- 125000003118 aryl group Chemical group 0.000 claims description 5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
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- 101000846911 Homo sapiens Fc receptor-like protein 2 Proteins 0.000 claims 2
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- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- 102000052922 Large Neutral Amino Acid-Transporter 1 Human genes 0.000 claims 2
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- 102100038437 Sodium-dependent phosphate transport protein 2B Human genes 0.000 claims 2
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- 2009-07-14 CA CA2727915A patent/CA2727915C/en active Active
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- 2009-07-14 TW TW098123764A patent/TWI461428B/zh not_active IP Right Cessation
- 2009-07-14 JP JP2011518840A patent/JP6067222B2/ja not_active Expired - Fee Related
- 2009-07-14 EP EP09790394.2A patent/EP2303332B1/en active Active
- 2009-07-14 CN CN2009801359822A patent/CN102159248B/zh not_active Expired - Fee Related
- 2009-07-14 WO PCT/US2009/050537 patent/WO2010009124A2/en not_active Ceased
- 2009-07-14 RU RU2011105402/15A patent/RU2523419C2/ru active IP Right Revival
- 2009-07-14 ES ES09790394.2T patent/ES2532635T3/es active Active
- 2009-07-14 SG SG2013053939A patent/SG192517A1/en unknown
- 2009-07-14 KR KR1020117003368A patent/KR101667062B1/ko not_active Expired - Fee Related
- 2009-07-14 PE PE2011000027A patent/PE20110571A1/es not_active Application Discontinuation
- 2009-07-14 AR ARP090102664A patent/AR072804A1/es unknown
- 2009-07-14 BR BRPI0910810A patent/BRPI0910810A2/pt not_active IP Right Cessation
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2012
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2014
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