JP2011525927A - 複素環式抗菌剤の合成および使用 - Google Patents

複素環式抗菌剤の合成および使用 Download PDF

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Publication number
JP2011525927A
JP2011525927A JP2011516551A JP2011516551A JP2011525927A JP 2011525927 A JP2011525927 A JP 2011525927A JP 2011516551 A JP2011516551 A JP 2011516551A JP 2011516551 A JP2011516551 A JP 2011516551A JP 2011525927 A JP2011525927 A JP 2011525927A
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JP
Japan
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alkyl
alkynyl
aryl
cycloalkenyl
cycloalkyl
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Pending
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JP2011516551A
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English (en)
Japanese (ja)
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JP2011525927A5 (enExample
Inventor
パンデュランガ アデュラ ピー． レディー，
ウマール ファルク マンスール，
エム． アーシャド シディキ，
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2011525927A publication Critical patent/JP2011525927A/ja
Publication of JP2011525927A5 publication Critical patent/JP2011525927A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
JP2011516551A 2008-06-25 2009-06-24 複素環式抗菌剤の合成および使用 Pending JP2011525927A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7538308P 2008-06-25 2008-06-25
US61/075,383 2008-06-25
PCT/US2009/048368 WO2009158369A1 (en) 2008-06-25 2009-06-24 Synthesis and use of heterocyclic antibacterial agents

Publications (2)

Publication Number Publication Date
JP2011525927A true JP2011525927A (ja) 2011-09-29
JP2011525927A5 JP2011525927A5 (enExample) 2012-07-19

Family

ID=41059643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011516551A Pending JP2011525927A (ja) 2008-06-25 2009-06-24 複素環式抗菌剤の合成および使用

Country Status (6)

Country Link
US (1) US20110212078A1 (enExample)
EP (1) EP2307365B1 (enExample)
JP (1) JP2011525927A (enExample)
CA (1) CA2728210A1 (enExample)
ES (1) ES2408932T3 (enExample)
WO (1) WO2009158369A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201716375A (zh) 2007-06-12 2017-05-16 Achaogen Inc 抗菌劑
US9738604B2 (en) 2010-09-03 2017-08-22 Duke University Ethynylbenzene derivatives
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
WO2015024021A2 (en) 2013-08-16 2015-02-19 Duke University Antibacterial compounds
WO2015024016A2 (en) 2013-08-16 2015-02-19 Duke University 2-piperidinyl substituted n,3-dihydroxybutanamides
AU2014306451B2 (en) 2013-08-16 2019-01-17 Duke University Substituted hydroxamic acid compounds
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
GB2562777A (en) * 2017-05-25 2018-11-28 Taisho Pharmaceutical Co Ltd Novel alpha-amino amide derivatives
TWI774780B (zh) * 2017-06-02 2022-08-21 瑞士商赫孚孟拉羅股份公司 化合物
WO2018220149A1 (en) 2017-06-02 2018-12-06 F. Hoffmann-La Roche Ag Compounds
AU2019294414B2 (en) 2018-06-29 2023-06-29 F. Hoffmann-La Roche Ag Compounds
LT3986897T (lt) 2019-06-21 2023-11-10 F. Hoffmann-La Roche Ag Egfr inhibitorius, skirtas vėžiui gydyti
JP7530390B2 (ja) 2019-06-21 2024-08-07 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 新規ｅｇｆｒ阻害剤
CN110498783A (zh) * 2019-08-02 2019-11-26 成都蓝蜻蜓生物技术有限公司 一种合成罗沙司他中间体的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503674A (ja) * 1998-02-12 2002-02-05 モレキュメティックス リミテッド βシート模倣物およびその使用に関する方法
JP2002503657A (ja) * 1998-02-11 2002-02-05 デュポン ファーマシューティカルズ カンパニー メタロプロテイナーゼ阻害剤としての新規な環式スルホンアミド誘導体
JP2002088046A (ja) * 2000-09-14 2002-03-27 Japan Science & Technology Corp 光学活性ヒドロキサム酸
WO2008027466A1 (en) * 2006-08-31 2008-03-06 Schering Corporation Hydantoin derivatives useful as antibacterial agents
JP2010530372A (ja) * 2007-06-12 2010-09-09 アカオゲン，インコーポレーテッド 抗菌剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) * 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
DE10227464A1 (de) 2002-06-20 2004-01-08 Technische Universität Braunschweig Glaszusammensetzung zur Herstellung von optischen Übertragungselementen
SG2012000667A (en) 2003-01-08 2015-03-30 Univ Washington Antibacterial agents
US7553864B2 (en) 2005-12-01 2009-06-30 Schering Corporation Compounds for the treatment of inflammatory disorders and microbial diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002503657A (ja) * 1998-02-11 2002-02-05 デュポン ファーマシューティカルズ カンパニー メタロプロテイナーゼ阻害剤としての新規な環式スルホンアミド誘導体
JP2002503674A (ja) * 1998-02-12 2002-02-05 モレキュメティックス リミテッド βシート模倣物およびその使用に関する方法
JP2002088046A (ja) * 2000-09-14 2002-03-27 Japan Science & Technology Corp 光学活性ヒドロキサム酸
WO2008027466A1 (en) * 2006-08-31 2008-03-06 Schering Corporation Hydantoin derivatives useful as antibacterial agents
JP2010530372A (ja) * 2007-06-12 2010-09-09 アカオゲン，インコーポレーテッド 抗菌剤

Also Published As

Publication number Publication date
CA2728210A1 (en) 2009-12-30
EP2307365A1 (en) 2011-04-13
ES2408932T3 (es) 2013-06-24
EP2307365B1 (en) 2013-03-27
US20110212078A1 (en) 2011-09-01
WO2009158369A1 (en) 2009-12-30

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