CA2728210A1 - Synthesis and use of heterocyclic antibacterial agents - Google Patents

Synthesis and use of heterocyclic antibacterial agents Download PDF

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Publication number
CA2728210A1
CA2728210A1 CA2728210A CA2728210A CA2728210A1 CA 2728210 A1 CA2728210 A1 CA 2728210A1 CA 2728210 A CA2728210 A CA 2728210A CA 2728210 A CA2728210 A CA 2728210A CA 2728210 A1 CA2728210 A1 CA 2728210A1
Authority
CA
Canada
Prior art keywords
alkynyl
aryl
alkyl
cycloalkyl
cycloalkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2728210A
Other languages
English (en)
French (fr)
Inventor
Panduranga Adulla P. Reddy
Umar Faruk Mansoor
M. Arshad Siddiqui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2728210A1 publication Critical patent/CA2728210A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2728210A 2008-06-25 2009-06-24 Synthesis and use of heterocyclic antibacterial agents Abandoned CA2728210A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7538308P 2008-06-25 2008-06-25
US61/075,383 2008-06-25
PCT/US2009/048368 WO2009158369A1 (en) 2008-06-25 2009-06-24 Synthesis and use of heterocyclic antibacterial agents

Publications (1)

Publication Number Publication Date
CA2728210A1 true CA2728210A1 (en) 2009-12-30

Family

ID=41059643

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728210A Abandoned CA2728210A1 (en) 2008-06-25 2009-06-24 Synthesis and use of heterocyclic antibacterial agents

Country Status (6)

Country Link
US (1) US20110212078A1 (enExample)
EP (1) EP2307365B1 (enExample)
JP (1) JP2011525927A (enExample)
CA (1) CA2728210A1 (enExample)
ES (1) ES2408932T3 (enExample)
WO (1) WO2009158369A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101765585B (zh) 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂
US9738604B2 (en) 2010-09-03 2017-08-22 Duke University Ethynylbenzene derivatives
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
AU2014306451B2 (en) 2013-08-16 2019-01-17 Duke University Substituted hydroxamic acid compounds
WO2015024021A2 (en) 2013-08-16 2015-02-19 Duke University Antibacterial compounds
US9908851B2 (en) 2013-08-16 2018-03-06 Duke University 2-piperidinyl substituted N,3-dihydroxybutanamides
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
WO2017030892A1 (en) 2015-08-14 2017-02-23 Reaction Biology Corp. Histone deacetylase inhibitors and methods for use thereof
TW201803847A (zh) 2016-06-23 2018-02-01 美商爾察禎有限公司 抗菌劑
GB2562777A (en) * 2017-05-25 2018-11-28 Taisho Pharmaceutical Co Ltd Novel alpha-amino amide derivatives
AR113299A1 (es) 2017-06-02 2020-04-08 Hoffmann La Roche Compuestos de isoindolina
ES2927480T3 (es) * 2017-06-02 2022-11-07 Hoffmann La Roche Compuestos de isoindolina-acetileno para el tratamiento del cáncer
EP3814351A1 (en) 2018-06-29 2021-05-05 F. Hoffmann-La Roche AG Compounds
MX2021015889A (es) 2019-06-21 2022-02-03 Hoffmann La Roche Nuevos inhibidores de egfr.
WO2020254572A1 (en) 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer
CN110498783A (zh) * 2019-08-02 2019-11-26 成都蓝蜻蜓生物技术有限公司 一种合成罗沙司他中间体的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1999041246A1 (en) 1998-02-11 1999-08-19 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
KR20010040939A (ko) * 1998-02-12 2001-05-15 몰레큐메틱스 리미티드 β-시트 미메틱 및 이의 사용과 관련된 방법
JP4020290B2 (ja) * 2000-09-14 2007-12-12 独立行政法人科学技術振興機構 光学活性ヒドロキサム酸
DE10227464A1 (de) 2002-06-20 2004-01-08 Technische Universität Braunschweig Glaszusammensetzung zur Herstellung von optischen Übertragungselementen
CA2512582C (en) 2003-01-08 2014-07-08 University Of Washington Antibacterial agents
US7553864B2 (en) 2005-12-01 2009-06-30 Schering Corporation Compounds for the treatment of inflammatory disorders and microbial diseases
CA2661605A1 (en) * 2006-08-31 2008-03-06 Schering Corporation Hydantoin derivatives useful as antibacterial agents
CN101765585B (zh) * 2007-06-12 2017-03-15 尔察祯有限公司 抗菌剂

Also Published As

Publication number Publication date
EP2307365A1 (en) 2011-04-13
ES2408932T3 (es) 2013-06-24
JP2011525927A (ja) 2011-09-29
US20110212078A1 (en) 2011-09-01
WO2009158369A1 (en) 2009-12-30
EP2307365B1 (en) 2013-03-27

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20150625