JP2011525927A5 - - Google Patents
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- Publication number
- JP2011525927A5 JP2011525927A5 JP2011516551A JP2011516551A JP2011525927A5 JP 2011525927 A5 JP2011525927 A5 JP 2011525927A5 JP 2011516551 A JP2011516551 A JP 2011516551A JP 2011516551 A JP2011516551 A JP 2011516551A JP 2011525927 A5 JP2011525927 A5 JP 2011525927A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- substituted
- ethynyl
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 68
- 150000001875 compounds Chemical class 0.000 claims description 45
- 125000003118 aryl group Chemical group 0.000 claims description 28
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 25
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 25
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 24
- 125000000623 heterocyclic group Chemical group 0.000 claims description 22
- 125000001072 heteroaryl group Chemical group 0.000 claims description 18
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 208000035143 Bacterial infection Diseases 0.000 claims description 8
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 8
- 125000003386 piperidinyl group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000012453 solvate Substances 0.000 claims description 8
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 230000000813 microbial effect Effects 0.000 claims description 6
- 108010003026 UDP-3-O-acyl-N-acetylglucosamine deacetylase Proteins 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
- 125000001246 bromo group Chemical group Br* 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000192125 Firmicutes Species 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 102000005962 receptors Human genes 0.000 claims description 2
- 108020003175 receptors Proteins 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 description 28
- 125000003342 alkenyl group Chemical group 0.000 description 22
- 125000000217 alkyl group Chemical group 0.000 description 22
- -1 Heterocyclenyl Chemical group 0.000 description 17
- 125000003710 aryl alkyl group Chemical group 0.000 description 15
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 10
- 125000004475 heteroaralkyl group Chemical group 0.000 description 8
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 8
- 125000005843 halogen group Chemical group 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 125000004946 alkenylalkyl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000005018 aryl alkenyl group Chemical group 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7538308P | 2008-06-25 | 2008-06-25 | |
| US61/075,383 | 2008-06-25 | ||
| PCT/US2009/048368 WO2009158369A1 (en) | 2008-06-25 | 2009-06-24 | Synthesis and use of heterocyclic antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525927A JP2011525927A (ja) | 2011-09-29 |
| JP2011525927A5 true JP2011525927A5 (enExample) | 2012-07-19 |
Family
ID=41059643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516551A Pending JP2011525927A (ja) | 2008-06-25 | 2009-06-24 | 複素環式抗菌剤の合成および使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110212078A1 (enExample) |
| EP (1) | EP2307365B1 (enExample) |
| JP (1) | JP2011525927A (enExample) |
| CA (1) | CA2728210A1 (enExample) |
| ES (1) | ES2408932T3 (enExample) |
| WO (1) | WO2009158369A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2691987C (en) | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| WO2015024011A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| AU2014306451B2 (en) | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
| WO2015024016A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | 2-piperidinyl substituted n,3-dihydroxybutanamides |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| US10011611B2 (en) | 2015-08-14 | 2018-07-03 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
| WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
| GB2562777A (en) * | 2017-05-25 | 2018-11-28 | Taisho Pharmaceutical Co Ltd | Novel alpha-amino amide derivatives |
| ES2927480T3 (es) * | 2017-06-02 | 2022-11-07 | Hoffmann La Roche | Compuestos de isoindolina-acetileno para el tratamiento del cáncer |
| WO2018220149A1 (en) | 2017-06-02 | 2018-12-06 | F. Hoffmann-La Roche Ag | Compounds |
| IL279800B2 (en) | 2018-06-29 | 2024-02-01 | Hoffmann La Roche | Selective allosteric inhibitors of epidermal growth factor receptor mutants, pharmaceutical preparations containing them and their use |
| TW202115073A (zh) | 2019-06-21 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | 新穎的egfr抑制劑 |
| ES2961187T3 (es) | 2019-06-21 | 2024-03-08 | Hoffmann La Roche | Inhibidor de EGFR para el tratamiento del cáncer |
| CN110498783A (zh) * | 2019-08-02 | 2019-11-26 | 成都蓝蜻蜓生物技术有限公司 | 一种合成罗沙司他中间体的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925659A (en) * | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| AU2594799A (en) | 1998-02-11 | 1999-08-30 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| EP1053246B1 (en) * | 1998-02-12 | 2003-01-02 | Molecumetics, Ltd. | Beta-sheet mimetics and methods relating to the use thereof |
| JP4020290B2 (ja) | 2000-09-14 | 2007-12-12 | 独立行政法人科学技術振興機構 | 光学活性ヒドロキサム酸 |
| DE10227464A1 (de) | 2002-06-20 | 2004-01-08 | Technische Universität Braunschweig | Glaszusammensetzung zur Herstellung von optischen Übertragungselementen |
| ES2387803T3 (es) | 2003-01-08 | 2012-10-02 | Novartis Vaccines And Diagnostics, Inc. | Agentes antibacterianos |
| JP2009520689A (ja) | 2005-12-01 | 2009-05-28 | シェーリング コーポレイション | 炎症障害および微生物性疾患を処置するための化合物 |
| CN101528711A (zh) * | 2006-08-31 | 2009-09-09 | 先灵公司 | 可用作抗细菌剂的乙内酰脲衍生物 |
| CA2691987C (en) * | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
-
2009
- 2009-06-24 US US13/000,428 patent/US20110212078A1/en not_active Abandoned
- 2009-06-24 WO PCT/US2009/048368 patent/WO2009158369A1/en not_active Ceased
- 2009-06-24 EP EP09770902A patent/EP2307365B1/en not_active Not-in-force
- 2009-06-24 JP JP2011516551A patent/JP2011525927A/ja active Pending
- 2009-06-24 ES ES09770902T patent/ES2408932T3/es active Active
- 2009-06-24 CA CA2728210A patent/CA2728210A1/en not_active Abandoned