JP2011525899A - 磁性マイクロバブル、その作成方法及びその使用 - Google Patents

磁性マイクロバブル、その作成方法及びその使用 Download PDF

Info

Publication number
JP2011525899A
JP2011525899A JP2011515596A JP2011515596A JP2011525899A JP 2011525899 A JP2011525899 A JP 2011525899A JP 2011515596 A JP2011515596 A JP 2011515596A JP 2011515596 A JP2011515596 A JP 2011515596A JP 2011525899 A JP2011525899 A JP 2011525899A
Authority
JP
Japan
Prior art keywords
microbubbles
microbubble
shell
liquid
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2011515596A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011525899A5 (enExample
Inventor
クエンティン アンドルー パンクハースト、
エレノア フィービー ジェーン ストライド、
コリン デイヴィッド ポーター、
アナ ガルシア プリエト、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCL Business Ltd
Original Assignee
UCL Biomedica PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCL Biomedica PLC filed Critical UCL Biomedica PLC
Publication of JP2011525899A publication Critical patent/JP2011525899A/ja
Publication of JP2011525899A5 publication Critical patent/JP2011525899A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Soft Magnetic Materials (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
JP2011515596A 2008-06-27 2009-06-26 磁性マイクロバブル、その作成方法及びその使用 Abandoned JP2011525899A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0811856.4 2008-06-27
GBGB0811856.4A GB0811856D0 (en) 2008-06-27 2008-06-27 Magnetic microbubbles, methods of preparing them and their uses
PCT/GB2009/001614 WO2009156743A2 (en) 2008-06-27 2009-06-26 Magnetic microbubbles, methods of preparing them and their uses

Publications (2)

Publication Number Publication Date
JP2011525899A true JP2011525899A (ja) 2011-09-29
JP2011525899A5 JP2011525899A5 (enExample) 2012-12-06

Family

ID=39683315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011515596A Abandoned JP2011525899A (ja) 2008-06-27 2009-06-26 磁性マイクロバブル、その作成方法及びその使用

Country Status (5)

Country Link
US (1) US9427396B2 (enExample)
EP (1) EP2296620B1 (enExample)
JP (1) JP2011525899A (enExample)
GB (1) GB0811856D0 (enExample)
WO (1) WO2009156743A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021104036A (ja) * 2016-09-15 2021-07-26 ラブサイト インコーポレイテッド ソノポレーションを使用した生物学的細胞の高効率トランスフェクション

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322142B1 (de) * 2009-11-12 2016-07-27 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Biokompatible, magnetische Nanopartikel zur Behandlung von Glioblastomen
TWI491425B (zh) * 2010-11-26 2015-07-11 Univ Chang Gung Targeting drug administration system and its operation method
KR101292939B1 (ko) 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
DE102011000264B4 (de) 2011-01-21 2019-01-17 Surflay Nanotec Gmbh Mikrogasbläschen mit PVA-Wand, Herstellung und Verwendung von solchen Mikrogasbläschen
CZ2012646A3 (cs) * 2012-09-19 2014-02-19 Vysoké Učení Technické V Brně Způsob přípravy magneticky vodivých prášků s využitím kavitace a zařízení k provádění tohoto způsobu
WO2016115133A1 (en) * 2015-01-12 2016-07-21 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Polymer microbubbles as x-ray dark field contrast agents
GB201716237D0 (en) * 2017-10-05 2017-11-22 Univ Oxford Innovation Ltd Magnetic-acoustic device
GB201716239D0 (en) * 2017-10-05 2017-11-22 Univ Oxford Innovation Ltd Compositions and methods for treating pseudoaneurysm
CN109946966B (zh) * 2019-03-15 2022-04-15 宁波大学 基于参数不确定量化的磁流体运动控制方法
US11883679B2 (en) * 2019-10-11 2024-01-30 North Carolina State University Systems and methods for ultrasound induced thrombolysis with magnetic microbubbles, optional nanodroplets, and a rotational magnetic field
GB201918428D0 (en) 2019-12-13 2020-01-29 Univ Oxford Innovation Ltd Functionalised microbubbles
DE102024207013B4 (de) * 2024-07-25 2026-02-19 Volkswagen Aktiengesellschaft Batterie und Verfahren zum Betrieb einer Batterie

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US20080063603A1 (en) * 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) * 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030185759A1 (en) * 1990-05-18 2003-10-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5420176A (en) * 1990-06-01 1995-05-30 Imarx Pharmaceutical Corp. Contrast media for ultrasonic imaging
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
US5310540A (en) * 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US20050053552A1 (en) 1993-01-25 2005-03-10 Quay Steven C. Phase shift colloids as ultrasound contrast agents
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
ES2231775T5 (es) * 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE4341478C2 (de) 1993-12-02 1998-10-08 Max Delbrueck Centrum Mittel zur Antitumortherapie
PL182223B1 (pl) * 1993-12-15 2001-11-30 Bracco Research Sa Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL
DE4412651A1 (de) 1994-04-13 1995-10-19 Mueller Schulte Detlef Dr Mittel zur selektiven AIDS Therapie sowie Verfahren zur Herstellung und Verwendung derselben
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US6132764A (en) 1994-08-05 2000-10-17 Targesome, Inc. Targeted polymerized liposome diagnostic and treatment agents
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) * 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
GB2313310B (en) * 1995-01-19 1999-03-17 Cate Folkert Jan Ten Local delivery and monitoring of drugs
US6540981B2 (en) * 1997-12-04 2003-04-01 Amersham Health As Light imaging contrast agents
US5558092A (en) * 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
GB2307414B (en) 1995-08-29 1998-03-11 Spectrx Inc Microporation of human skin for drug delivery and monitoring applications
US5876683A (en) * 1995-11-02 1999-03-02 Glumac; Nicholas Combustion flame synthesis of nanophase materials
DE69721235T2 (de) * 1996-02-19 2004-02-05 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
WO1998000193A1 (en) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
KR100593873B1 (ko) * 1996-08-02 2006-07-03 지이 헬스케어 에이에스 조영제
US6414139B1 (en) * 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
MXPA99003664A (es) * 1996-10-21 2002-06-11 Nycomed Imaging As Mejoras relacionadas con agentes de contraste.
ES2206689T3 (es) * 1996-10-28 2004-05-16 Amersham Health As Agentes de contraste.
EP1001816A4 (en) 1996-11-25 2002-07-17 Imarx Pharmaceutical Corp PERFLUORINATED ETHER COMPOSITIONS FOR USE AS DIAGNOSTIC CONTRAST AGENTS
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
GB9708240D0 (en) * 1997-04-23 1997-06-11 Nycomed Imaging As Improvements in or relating to contrast agents
US20020159951A1 (en) * 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) * 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
US20010053384A1 (en) * 1997-07-07 2001-12-20 James F. Greenleaf Site-directed transfection with ultrasound and cavitation nuclei
ATE252916T1 (de) * 1997-08-12 2003-11-15 Bracco Research Sa Verabreichbare formulierugen und ihre anwendung in mri
GB9717542D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
WO1999020312A1 (en) 1997-10-21 1999-04-29 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US6896659B2 (en) * 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
ATE276745T1 (de) 1998-04-09 2004-10-15 Amersham Health As Verwendung von teilchenförmigen kontrastmitteln in der diagnostischen bilderzeugung zur untersuchung physiologischer parameter
US20040170564A1 (en) 1998-04-22 2004-09-02 Roald Skurtveit Ultrasound contrast agent dispersions comprising gas and destabilising agent
WO1999055837A2 (en) * 1998-04-28 1999-11-04 Nycomed Imaging As Improvements in or relating to separation processes
US6548048B1 (en) * 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
GB9809776D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
ES2310938T3 (es) 1998-05-15 2009-01-16 Nasa/Johnson Space Center Microcapsulas de activacion externa.
GB2340225B (en) 1998-08-03 2002-11-13 Boris Zachar Gorbunov A detector and method for detecting ultra-low concentrations of molecules
AUPP899899A0 (en) * 1999-03-03 1999-03-25 Paragon Medical Limited Magnetic material
WO2000062818A1 (en) * 1999-04-20 2000-10-26 Richard Leslie Edelson Differentiation of monocytes into functional dendritic cells
JP3200704B2 (ja) 1999-05-13 2001-08-20 経済産業省産業技術総合研究所長 機能的に配置された磁気粒子・リポソーム粒子複合体
DE19924668A1 (de) * 1999-05-28 2000-11-30 Bayer Ag Substituierte alpha-Phenyl-beta-Ketosulfone
CN100402850C (zh) 1999-06-28 2008-07-16 加利福尼亚技术学院 微型制造的弹性体的阀和泵系统
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
EP1202671A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
GB9920392D0 (en) * 1999-08-27 1999-11-03 Nycomed Imaging As Improvemets in or relating to diagnostic imaging
US6395257B1 (en) * 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6180087B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
ATE331599T1 (de) * 2000-05-12 2006-07-15 Matregen Corp Verfahren zur herstellung von strukturen durch gebrauch von zentrifugalen kräften
JP5078212B2 (ja) * 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
DE10040380B4 (de) 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
EP1319423A3 (en) * 2001-12-11 2003-10-08 Dornier Medtech System GmbH Apparatus and method for initiating chemical reactions and for the targeted delivery of drugs or other agents
CA2759764C (en) 2002-02-14 2017-06-13 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
EP1720063B1 (en) 2002-02-15 2010-04-07 Nippon Soda Co., Ltd. Resin containing ketene-aldehyde copolymer
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
AU2003220353A1 (en) * 2002-03-19 2003-10-08 California Institute Of Technology A method for integrating microparticles into mems
AUPS220302A0 (en) 2002-05-08 2002-06-06 Chang, Chak Man Thomas A plasma formed within bubbles in an aqueous medium and uses therefore
CA2418229A1 (en) * 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
CA2428896A1 (en) 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
DE10224352A1 (de) 2002-06-01 2003-12-11 Mueller Schulte Detlef Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie
US20040086572A1 (en) 2002-07-17 2004-05-06 Dailey James P. Delivery of therapeutic agent affixed to magnetic particle
AU2003300043A1 (en) 2002-10-10 2004-05-04 Elizabeth Chambers Carriers attached to blood cells
EP1590006B1 (en) 2003-02-04 2010-09-08 Bracco Suisse SA Ultrasound contrast agents and process for the preparation thereof
US20060235296A1 (en) 2003-02-13 2006-10-19 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
JP4706003B2 (ja) 2003-06-12 2011-06-22 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影画像において補充曲線フィッティングを用いる血流評価法
US20060086834A1 (en) 2003-07-29 2006-04-27 Robert Pfeffer System and method for nanoparticle and nanoagglomerate fluidization
DE112004001663T5 (de) 2003-09-10 2006-07-27 Nahum Paransky Erzeugung von Nanopartikeln und Mikropartikeln
CN1215902C (zh) 2003-09-11 2005-08-24 复旦大学 一种具有核壳结构的磁性荧光双功能微球及其制备方法
WO2005025508A2 (en) 2003-09-12 2005-03-24 Bankruptcy Estate Of Ferx, Inc. Magnetically targetable particles comprising magnetic components and biocompatible polymers for site-specific delivery of biologically active agents
US20050074506A1 (en) 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
US20050089470A1 (en) 2003-10-24 2005-04-28 Johnson Bruce F. Labeled peptides for lectin-like oxidized low-density lipoprotein receptor (LOX-1)
US20050089471A1 (en) 2003-10-24 2005-04-28 Johnson Bruce F. Labeled ligands for lectin-like oxidized low-density lipoprotein receptor (LOX-1)
US7329391B2 (en) 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
US20050175709A1 (en) * 2003-12-11 2005-08-11 Baty Ace M.Iii Therapeutic microparticles
ES2531751T3 (es) 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste
WO2005070299A1 (en) 2004-01-16 2005-08-04 The University Of Houston System Methods and apparatus for medical imaging
WO2005086639A2 (en) 2004-02-10 2005-09-22 Barnes-Jewish Hospital Improved efficacy and safety of targeted particulate agents with decoy systems
WO2005079843A1 (ja) 2004-02-25 2005-09-01 Ttc Co., Ltd. 新規リポソーム
CN1667413A (zh) 2004-03-09 2005-09-14 中国科学院过程工程研究所 一种免疫磁性微球及其制备方法和用途
US20060024232A1 (en) 2004-06-02 2006-02-02 Sidney Kimmel Cancer Center Imaging and therapeutic agents targeting proteins expressed on endothelial cell surface
DE102004036780A1 (de) 2004-07-29 2006-03-23 Dr. Kübler GmbH Verfahren zur In-vitro-Herstellung eines Stoffgemisches für ein tumorkrankes Individuum sowie Stoffgemisch für ein tumorkrankes Individuum
JP2006045132A (ja) 2004-08-05 2006-02-16 Konica Minolta Medical & Graphic Inc リポソーム含有磁気共鳴造影剤
CN101389273B (zh) 2004-08-05 2012-09-05 贝勒研究院 基因或药物递送系统
US7575738B2 (en) 2004-08-13 2009-08-18 General Electric Company Heat shock protein as a targeting agent for endothelium-specific in vivo transduction
WO2006018433A1 (en) 2004-08-18 2006-02-23 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
US20060049116A1 (en) 2004-09-03 2006-03-09 Subramanian Krupakar M Method and apparatus for bubble glow discharge plasma treatment of fluids
EP1655040A1 (en) 2004-10-08 2006-05-10 Bracco Imaging, S.P.A. Contrast agent formulations for the visualization of the lymphatic system
EP1810688A1 (en) 2004-11-10 2007-07-25 Konica Minolta Medical & Graphic, Inc. Pharmaceutical preparation containing coated magnetic particles and method for production thereof, and diagnosis therapy system
RU2007127314A (ru) 2004-12-17 2009-01-27 Конинклейке Филипс Электроникс Н.В. (Nl) Контрастные средства или терапевтические средства направленной доставки для молекулярной визуализации и терапии
US20090246127A1 (en) 2004-12-17 2009-10-01 Koninklijke Philips Electronics, N.V. Targeting agents for molecular imaging
EP1830902A2 (en) 2004-12-30 2007-09-12 Cinvention Ag Combination comprising an agent providing a signal, an implant material and a drug
WO2006080243A1 (ja) 2005-01-28 2006-08-03 Konica Minolta Medical & Graphic, Inc. 被覆磁性粒子含有製剤およびその製造方法、並びに診断治療システム
EP1866663A1 (en) 2005-03-03 2007-12-19 Bracco Research S.A. Medical imaging system based on a targeted contrast agent
WO2006102395A2 (en) 2005-03-22 2006-09-28 Medstar Health Inc Delivery systems and methods for diagnosing and treating cardiovascular diseases
WO2006122414A1 (en) 2005-05-17 2006-11-23 Matregen Corp. Depot for sustained and controlled delivery of methotrexate
JP2009502266A (ja) 2005-07-28 2009-01-29 パスクワーレ モサイコ， 系及び物質の状態を改善するための手段を製造する方法並びにそれらの使用
JP2009502395A (ja) 2005-08-03 2009-01-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁気温熱療法のための超音波モニタリングおよびフィードバック
CN1315920C (zh) 2005-08-08 2007-05-16 北京师范大学 具有无机/有机核壳结构的磁性复合微球及其制备方法
WO2007028981A1 (en) 2005-09-08 2007-03-15 University Of Dundee Apparatus and method for sonoporation
GB0518273D0 (en) 2005-09-08 2005-10-19 Univ Dundee Apparatus and method for sonoporation
WO2007081410A2 (en) * 2005-09-13 2007-07-19 True Materials Incorporated Encoded microparticles
US8427160B2 (en) 2005-10-12 2013-04-23 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
CN100560133C (zh) 2006-03-14 2009-11-18 中国人民解放军第二军医大学 磁性聚乳酸-羟基乙酸氧化酚砷纳米微球及其制药用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021104036A (ja) * 2016-09-15 2021-07-26 ラブサイト インコーポレイテッド ソノポレーションを使用した生物学的細胞の高効率トランスフェクション
JP7155318B2 (ja) 2016-09-15 2022-10-18 ラブサイト インコーポレイテッド ソノポレーションを使用した生物学的細胞の高効率トランスフェクション

Also Published As

Publication number Publication date
WO2009156743A3 (en) 2010-07-15
EP2296620A2 (en) 2011-03-23
GB0811856D0 (en) 2008-07-30
US9427396B2 (en) 2016-08-30
EP2296620B1 (en) 2015-05-13
WO2009156743A2 (en) 2009-12-30
US20110172486A1 (en) 2011-07-14

Similar Documents

Publication Publication Date Title
US9427396B2 (en) Magnetic microbubbles, methods of preparing them and their uses
US9750821B2 (en) Gas-filled microvesicle assembly for contrast imaging
Sirsi et al. State-of-the-art materials for ultrasound-triggered drug delivery
CA2545362C (en) Assembly of gas-filled microvesicle with active component for contrast imaging
Crowder et al. Sonic activation of molecularly-targeted nanoparticles accelerates transmembrane lipid delivery to cancer cells through contact-mediated mechanisms: implications for enhanced local drug delivery
Reznik et al. Optical studies of vaporization and stability of fluorescently labelled perfluorocarbon droplets
AU2005273865B2 (en) Gas-filled microvesicles composition for contrast imaging
TWI476005B (zh) 具有超音波觸發釋藥功能以及造影功能的奈米級與微米級氣泡
Song et al. High efficiency molecular delivery with sequential low-energy sonoporation bursts
TWI432227B (zh) 具有超音波觸發釋藥功能之磁振影像引導藥物載體
Bettinger et al. Design of microbubbles for gene/drug delivery
Goldenstedt et al. Delivery by shock waves of active principle embedded in gelatin-based capsules
Vlaskou et al. Magnetic Microbubbles: Magnetically Targeted and Ultrasound‐Triggered Vectors for Gene Delivery in Vitro
Palekar-Shanbhag et al. Microbubbles and their applications in pharmaceutical targeting
Li et al. Multifunctionalized microbubbles for cancer diagnosis and therapy
Chen et al. Acoustically active red blood cell carriers for ultrasound-triggered drug delivery with photoacoustic tracking
Becker et al. Ultrasound active nanoscaled lipid formulations for thrombus lysis
US20200237878A1 (en) Compositions and methods for treating pseudoaneurysm
Ameta et al. Ultrasound Contrast Agents: Sonochemical Preparation
Zullino Acoustic Vaporization of Polymer-Lipid Coated Droplets
Mullin et al. Ultrasound and microbubble parameter optimization for maximizing sonoporation
Song Microbubble size and dose effects on sonoporation in vitro and in vivo
DRUG SONOPORATION, GENE TRANSFECTION
Smith In vitro Characterization of Echogenic Liposomes (ELIP) for Ultrasonic Delivery of Recombinant Tissue-type Plasminogen Activator (rt-PA)
Benchimol Ultrasound-responsive particles for cancer diagnostics and therapeutics

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120607

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121011

A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20130301