JP2011523405A5 - - Google Patents

Info

Publication number

JP2011523405A5

JP2011523405A5 JP2011508703A JP2011508703A JP2011523405A5 JP 2011523405 A5 JP2011523405 A5 JP 2011523405A5 JP 2011508703 A JP2011508703 A JP 2011508703A JP 2011508703 A JP2011508703 A JP 2011508703A JP 2011523405 A5 JP2011523405 A5 JP 2011523405A5

Authority

JP

Japan

Prior art keywords

igf

variable domain

drug

immunoglobulin variable

chain immunoglobulin

Prior art date

2009-05-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229940079593 drug Drugs 0.000 claims 17
• 239000003814 drug Substances 0.000 claims 17
• 108060003951 Immunoglobulin Proteins 0.000 claims 15
• 102000018358 immunoglobulin Human genes 0.000 claims 15
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 12
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 12
• 102000004169 proteins and genes Human genes 0.000 claims 11
• 108090000623 proteins and genes Proteins 0.000 claims 11
• 102000023732 binding proteins Human genes 0.000 claims 8
• 108091008324 binding proteins Proteins 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 108010051696 Growth Hormone Proteins 0.000 claims 6
• 102000018997 Growth Hormone Human genes 0.000 claims 6
• 239000000122 growth hormone Substances 0.000 claims 6
• 230000009001 hormonal pathway Effects 0.000 claims 6
• 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims 5
• 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 101710142969 Somatoliberin Proteins 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• 108091035707 Consensus sequence Proteins 0.000 claims 2
• 229940124013 Growth hormone receptor antagonist Drugs 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 206010071051 Soft tissue mass Diseases 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000006395 Globulins Human genes 0.000 claims 1
• 108010044091 Globulins Proteins 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 108700037519 pegvisomant Proteins 0.000 claims 1
• 239000003488 releasing hormone Substances 0.000 claims 1
• 229940099077 somavert Drugs 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1