JP5734180B2 - Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質 - Google Patents

Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質 Download PDF

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Publication number
JP5734180B2
JP5734180B2 JP2011508703A JP2011508703A JP5734180B2 JP 5734180 B2 JP5734180 B2 JP 5734180B2 JP 2011508703 A JP2011508703 A JP 2011508703A JP 2011508703 A JP2011508703 A JP 2011508703A JP 5734180 B2 JP5734180 B2 JP 5734180B2
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JP
Japan
Prior art keywords
igf
iie
growth hormone
antibody
protein
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JP2011508703A
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English (en)
Japanese (ja)
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JP2011523405A (ja
JP2011523405A5 (enExample
Inventor
ダニエル ドランスフィールド，
ダニエル ドランスフィールド，
エドワード コーエン，
エドワード コーエン，
ティモシー アダムス，
ティモシー アダムス，
リアー コスグローブ，
リアー コスグローブ，
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Commonwealth Scientific and Industrial Research Organisation
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Commonwealth Scientific and Industrial Research Organisation
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Publication of JP2011523405A publication Critical patent/JP2011523405A/ja
Publication of JP2011523405A5 publication Critical patent/JP2011523405A5/ja
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Publication of JP5734180B2 publication Critical patent/JP5734180B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2011508703A 2008-05-09 2009-05-08 Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質 Expired - Fee Related JP5734180B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5195608P 2008-05-09 2008-05-09
US61/051,956 2008-05-09
US5342708P 2008-05-15 2008-05-15
US61/053,427 2008-05-15
US16318009P 2009-03-25 2009-03-25
US61/163,180 2009-03-25
PCT/US2009/043273 WO2009137758A2 (en) 2008-05-09 2009-05-08 Igf-ii/gf-iie binding proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014016462A Division JP2014077020A (ja) 2008-05-09 2014-01-31 Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質

Publications (3)

Publication Number Publication Date
JP2011523405A JP2011523405A (ja) 2011-08-11
JP2011523405A5 JP2011523405A5 (enExample) 2013-04-11
JP5734180B2 true JP5734180B2 (ja) 2015-06-17

Family

ID=41265434

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011508703A Expired - Fee Related JP5734180B2 (ja) 2008-05-09 2009-05-08 Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質
JP2014016462A Pending JP2014077020A (ja) 2008-05-09 2014-01-31 Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014016462A Pending JP2014077020A (ja) 2008-05-09 2014-01-31 Ｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質

Country Status (6)

Country Link
US (1) US20110165145A1 (enExample)
EP (1) EP2296703A4 (enExample)
JP (2) JP5734180B2 (enExample)
AU (1) AU2009244091B2 (enExample)
CA (1) CA2723722A1 (enExample)
WO (1) WO2009137758A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012505900A (ja) * 2008-10-14 2012-03-08 ダイアクス コーポレーション 全身性強皮症に伴う肺線維症の治療および予防のためのｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質の使用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090368A1 (es) 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
UY32317A (es) 2008-12-12 2010-07-30 Boehringer Ingelheim Int Anticuerpos anti-igf
WO2012142164A1 (en) 2011-04-12 2012-10-18 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
KR101843248B1 (ko) * 2015-03-17 2018-03-29 고려대학교 세종산학협력단 흉선 기질 림프단백질 매개 신호전달을 제어하는 펩타이드 유도체 및 이를 포함하는 알러지 및 천식 질환 예방 및 치료용 약학 조성물
US10469309B1 (en) * 2016-04-28 2019-11-05 Servicenow, Inc. Management of computing system alerts

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2058041A1 (en) * 1990-06-27 1991-12-28 Katsuichi Sakano Anti-igf-ii monoclonal antibody
JP3213359B2 (ja) * 1990-12-21 2001-10-02 第一製薬株式会社 抗ｉｇｆ−ｉｉモノクローナル抗体
EP1505075B1 (en) * 2002-04-30 2009-10-07 Kyowa Hakko Kirin Co., Ltd. Antibody to human insulin-like growth factor
US20060263362A1 (en) * 2003-08-21 2006-11-23 Atsushi Ochiai Cancer metastasis inhibitor
EP1671647A1 (en) * 2003-09-24 2006-06-21 Kyowa Hakko Kogyo Co., Ltd. Medicament for treating cancer
WO2005028515A1 (ja) * 2003-09-24 2005-03-31 Kyowa Hakko Kogyo Co., Ltd. ヒトインスリン様成長因子に対する遺伝子組換え抗体
US7612179B2 (en) * 2003-11-28 2009-11-03 Astrazeneca Ab antibodies binding to a C-terminal fragment of apoliopoprotein E
CA2554965C (en) * 2004-02-19 2015-08-11 The Cbr Institute For Biomedical Research, Inc. Antibodies specific for activated conformation of lfa-1
CA2575791A1 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
CA2618920C (en) 2005-08-17 2015-03-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human monoclonal antibodies that specifically bind igf-ii
PL1979001T3 (pl) * 2005-12-13 2012-09-28 Medimmune Ltd Białka wiążące specyficzne dla insulinopodobnych czynników wzrostu i ich zastosowania
AU2007234733A1 (en) * 2006-04-07 2007-10-18 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antibody compositions and methods for treatment of neoplastic disease
WO2008144720A2 (en) * 2007-05-21 2008-11-27 University Of Washington Inhibitors of igf-1r signaling for the treatment of respiratory disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012505900A (ja) * 2008-10-14 2012-03-08 ダイアクス コーポレーション 全身性強皮症に伴う肺線維症の治療および予防のためのｉｇｆ−ｉｉ／ｉｇｆ−ｉｉｅ結合タンパク質の使用

Also Published As

Publication number Publication date
EP2296703A4 (en) 2012-09-05
AU2009244091B2 (en) 2014-11-27
JP2014077020A (ja) 2014-05-01
US20110165145A1 (en) 2011-07-07
JP2011523405A (ja) 2011-08-11
WO2009137758A2 (en) 2009-11-12
CA2723722A1 (en) 2009-11-12
AU2009244091A1 (en) 2009-11-12
EP2296703A2 (en) 2011-03-23
WO2009137758A3 (en) 2010-03-18

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