JP2009539841A5 - - Google Patents
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- Publication number
- JP2009539841A5 JP2009539841A5 JP2009514336A JP2009514336A JP2009539841A5 JP 2009539841 A5 JP2009539841 A5 JP 2009539841A5 JP 2009514336 A JP2009514336 A JP 2009514336A JP 2009514336 A JP2009514336 A JP 2009514336A JP 2009539841 A5 JP2009539841 A5 JP 2009539841A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- administered
- amount
- fragment
- intravenously
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 41
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 41
- 239000012634 fragment Substances 0.000 claims 11
- 238000001990 intravenous administration Methods 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 241000288906 Primates Species 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44762806A | 2006-06-06 | 2006-06-06 | |
| US92148506P | 2006-06-06 | 2006-06-06 | |
| PCT/US2007/013232 WO2007145941A2 (en) | 2006-06-06 | 2007-06-05 | Administration of anti-cd3 antibodies in the treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009539841A JP2009539841A (ja) | 2009-11-19 |
| JP2009539841A5 true JP2009539841A5 (enExample) | 2010-07-22 |
Family
ID=38832328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514336A Pending JP2009539841A (ja) | 2006-06-06 | 2007-06-05 | 自己免疫疾患の治療における抗cd3抗体の投与 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090258001A1 (enExample) |
| EP (2) | EP2023955A4 (enExample) |
| JP (1) | JP2009539841A (enExample) |
| AU (1) | AU2007258694B2 (enExample) |
| CA (1) | CA2653387A1 (enExample) |
| NZ (1) | NZ573132A (enExample) |
| WO (1) | WO2007145941A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2569509C (en) | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| CA2614640A1 (en) | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| WO2007114325A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 二重特異性抗体を精製するための抗体改変方法 |
| SG10201504662WA (en) | 2006-06-14 | 2015-07-30 | Macrogenics Inc | Methods For The Treatment Of Autoimmune Disorders Using Immunosuppressive Monoclonal Antibodies With Reduced Toxicity |
| WO2010027797A1 (en) * | 2008-08-26 | 2010-03-11 | Macrogenics Inc. | T-cell receptor antibodies and methods of use thereof |
| EA032828B1 (ru) * | 2008-10-10 | 2019-07-31 | Аптево Рисёрч Энд Девелопмент Ллс | Иммунотерапевтические средства против комплекса tcr |
| US8609364B2 (en) * | 2009-05-07 | 2013-12-17 | bioM{tilde over (e)}rieux, Inc. | Methods for antimicrobial resistance determination |
| WO2011050106A2 (en) * | 2009-10-20 | 2011-04-28 | Tolerx, Inc. | Anti-cd3 antibody dosing in autoimmune disease |
| WO2011050104A2 (en) * | 2009-10-20 | 2011-04-28 | Tolerx, Inc. | Methods of using anti-cd3 antibodies to prevent weight gain |
| MX2012006406A (es) | 2009-12-04 | 2012-07-25 | Genentech Inc | Anticuerpos multiespecificos, analogos de anticuerpo, composiciones y metodos. |
| PT3434767T (pt) | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| EP2787078B1 (en) | 2011-10-31 | 2019-05-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule having regulated conjugation between heavy-chain and light-chain |
| US10202452B2 (en) | 2012-04-20 | 2019-02-12 | Aptevo Research And Development Llc | CD3 binding polypeptides |
| CA2880880C (en) * | 2012-08-03 | 2021-01-26 | John Mckew | Cyclodextrin for the treatment of lysosomal storage diseases |
| ES2900898T3 (es) | 2014-04-07 | 2022-03-18 | Chugai Pharmaceutical Co Ltd | Anticuerpos biespecíficos inmunoactivadores |
| CA2947157A1 (en) | 2014-05-13 | 2015-11-19 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| MX2018003292A (es) | 2015-09-21 | 2018-08-01 | Aptevo Res & Development Llc | Polipéptidos de unión a cd3. |
| WO2017086367A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法 |
| JP6925278B2 (ja) | 2015-11-18 | 2021-08-25 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| CA3004288C (en) | 2015-12-28 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION |
| TW202214700A (zh) | 2016-03-14 | 2022-04-16 | 日商中外製藥股份有限公司 | 用於癌之治療的細胞傷害誘導治療劑 |
| US12569477B2 (en) * | 2017-06-28 | 2026-03-10 | Mitocholine Ltd | Compositions for synergistically enhancing mitochondrial function |
| EP3773911A2 (en) | 2018-04-04 | 2021-02-17 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| TW202546002A (zh) * | 2019-03-29 | 2025-12-01 | 荷蘭商美勒斯公司 | Cd3結合分子 |
| IL288024B2 (en) | 2019-05-14 | 2025-12-01 | Provention Bio Inc | Methods and compositions for preventing type |
| JP7774447B2 (ja) * | 2019-06-07 | 2025-11-21 | アディマブ・リミテッド・ライアビリティ・カンパニー | 高アフィニティ抗cd3抗体、ならびにその作製方法及び使用方法 |
| WO2020250940A1 (ja) * | 2019-06-11 | 2020-12-17 | 小野薬品工業株式会社 | 免疫抑制剤 |
| WO2021006328A1 (en) | 2019-07-10 | 2021-01-14 | Chugai Seiyaku Kabushiki Kaisha | Claudin-6 binding molecules and uses thereof |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
| MX2023013851A (es) | 2021-05-24 | 2023-12-08 | Provention Bio Inc | Metodos para el tratamiento de diabetes tipo 1. |
| IL315052A (en) | 2022-02-18 | 2024-10-01 | Beren Therapeutics P B C | Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same |
| US12122850B2 (en) | 2022-03-14 | 2024-10-22 | LamKap Bio gamma AG | Bispecific GPC3xCD28 and GPC3xCD3 antibodies and their combination for targeted killing of GPC3 positive malignant cells |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4658019A (en) | 1979-04-26 | 1987-04-14 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells |
| AU600575B2 (en) * | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| JP2546544B2 (ja) * | 1989-10-27 | 1996-10-23 | アーチ ディベラップメント コーポレイション | 免疫強化を促進するための方法と組成物 |
| US6406696B1 (en) * | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6750325B1 (en) * | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5968509A (en) | 1990-10-05 | 1999-10-19 | Btp International Limited | Antibodies with binding affinity for the CD3 antigen |
| EP0940468A1 (en) * | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6491916B1 (en) * | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| JP3111024B2 (ja) * | 1995-07-19 | 2000-11-20 | キヤノン株式会社 | カラーフィルタの製造装置及び製造方法及び表示装置の製造方法及び表示装置を備えた装置の製造方法 |
| US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US7041289B1 (en) | 1997-12-05 | 2006-05-09 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for treating established spontaneous auto-immune diseases in mammals |
| CA2224256C (en) | 1997-12-09 | 2013-04-30 | I.N.S.E.R.M. | Method for treating established spontaneous auto-immune diseases in mammals |
| GB9815909D0 (en) * | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| MXPA01007845A (es) * | 1999-02-05 | 2004-06-22 | Samsung Electronics Co Ltd | Metodo para la recuperacion de la textura de imagenes y aparato para el mismo. |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| EP1567192A4 (en) * | 2002-12-05 | 2006-02-08 | Protein Design Labs Inc | TECHNIQUES FOR TREATING ULCERO-HEMORRHAGIC RECTO-COLITIS WITH ANTI-CD3 ANTIBODIES |
| DE10336334B3 (de) * | 2003-08-08 | 2005-08-04 | Cnh Baumaschinen Gmbh | Hydraulisches Steuersystem für Baumaschinenen, insbesondere für Bagger |
| WO2005048935A2 (en) * | 2003-11-14 | 2005-06-02 | Brigham And Women's Hospital, Inc. | Methods of modulating immunity |
| WO2005077981A2 (en) * | 2003-12-22 | 2005-08-25 | Xencor, Inc. | Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES |
| WO2005076965A2 (en) * | 2004-02-04 | 2005-08-25 | The Trustees Of Columbia University In The City Of New York | Anti-cd3 and antigen-specific immunotherapy to treat autoimmunity |
| CA2569509C (en) * | 2004-06-03 | 2014-08-12 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| CA2614640A1 (en) * | 2005-07-11 | 2007-01-18 | Macrogenics, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
-
2007
- 2007-06-05 WO PCT/US2007/013232 patent/WO2007145941A2/en not_active Ceased
- 2007-06-05 JP JP2009514336A patent/JP2009539841A/ja active Pending
- 2007-06-05 EP EP07795754A patent/EP2023955A4/en not_active Withdrawn
- 2007-06-05 CA CA002653387A patent/CA2653387A1/en not_active Abandoned
- 2007-06-05 AU AU2007258694A patent/AU2007258694B2/en not_active Ceased
- 2007-06-05 NZ NZ573132A patent/NZ573132A/en not_active IP Right Cessation
- 2007-06-05 EP EP11190677A patent/EP2433650A3/en not_active Withdrawn
- 2007-06-05 US US11/810,235 patent/US20090258001A1/en not_active Abandoned
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