JP2006506333A5 - - Google Patents

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Publication number
JP2006506333A5
JP2006506333A5 JP2004522335A JP2004522335A JP2006506333A5 JP 2006506333 A5 JP2006506333 A5 JP 2006506333A5 JP 2004522335 A JP2004522335 A JP 2004522335A JP 2004522335 A JP2004522335 A JP 2004522335A JP 2006506333 A5 JP2006506333 A5 JP 2006506333A5
Authority
JP
Japan
Prior art keywords
antibody
compound
medicament
binding site
medicament according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004522335A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006506333A (ja
JP4583170B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2003/003156 external-priority patent/WO2004009638A1/en
Publication of JP2006506333A publication Critical patent/JP2006506333A/ja
Publication of JP2006506333A5 publication Critical patent/JP2006506333A5/ja
Application granted granted Critical
Publication of JP4583170B2 publication Critical patent/JP4583170B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2004522335A 2002-07-23 2003-07-23 副作用が軽減された治療抗体 Expired - Lifetime JP4583170B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39793402P 2002-07-23 2002-07-23
PCT/GB2003/003156 WO2004009638A1 (en) 2002-07-23 2003-07-23 Therapeutic antibodies with reduced side effects

Publications (3)

Publication Number Publication Date
JP2006506333A JP2006506333A (ja) 2006-02-23
JP2006506333A5 true JP2006506333A5 (enExample) 2006-09-07
JP4583170B2 JP4583170B2 (ja) 2010-11-17

Family

ID=30771146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004522335A Expired - Lifetime JP4583170B2 (ja) 2002-07-23 2003-07-23 副作用が軽減された治療抗体

Country Status (8)

Country Link
US (2) US20040109855A1 (enExample)
EP (1) EP1523503B1 (enExample)
JP (1) JP4583170B2 (enExample)
AT (1) ATE428731T1 (enExample)
AU (1) AU2003260686B2 (enExample)
DE (1) DE60327205D1 (enExample)
ES (1) ES2323457T3 (enExample)
WO (1) WO2004009638A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4334866B2 (ja) 2000-10-09 2009-09-30 アイシス イノヴェイション リミテッド 治療用抗体
ES2628395T3 (es) 2007-08-15 2017-08-02 Bayer Pharma Aktiengesellschaft Anticuerpo regulado por proteasa
AU2013202755B2 (en) * 2007-08-22 2016-05-12 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
AU2016213702C1 (en) * 2007-08-22 2018-11-29 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
CN102482347B (zh) 2009-01-12 2017-04-26 希托马克斯医疗有限责任公司 修饰抗体组合物及其制备和使用方法
RU2011138951A (ru) 2009-02-23 2013-03-27 Сайтомкс Терапьютикс, Инк. Пропротеины и способы их применения
CA2871458C (en) 2012-04-27 2020-06-23 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
WO2013177596A2 (en) 2012-05-25 2013-11-28 Sloan Kettering Institute For Cancer Methods for treating gi syndrome and graft versus host disease
US9856314B2 (en) 2012-06-22 2018-01-02 Cytomx Therapeutics, Inc. Activatable antibodies having non-binding steric moieties and methods of using the same
EP2863948B1 (en) 2012-06-22 2018-10-24 Cytomx Therapeutics Inc. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
WO2014052462A2 (en) 2012-09-25 2014-04-03 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
AU2014204015A1 (en) 2013-01-04 2015-07-09 Cytomx Therapeutics, Inc. Compositions and methods for detecting protease activity in biological systems
US10633453B2 (en) 2013-05-28 2020-04-28 Kaohsiung Medical University Antibody locker for the inactivation of protein drug
US9517276B2 (en) 2013-06-04 2016-12-13 Cytomx Therapeutics, Inc. Compositions and methods for conjugating activatable antibodies
HRP20220553T1 (hr) 2013-07-25 2022-06-10 Cytomx Therapeutics Inc. Polispecifična protutijela, polispecifična protutijela koja se mogu aktivirati i postupci uporabe navedenih protutijela
US20150087810A1 (en) 2013-09-25 2015-03-26 Cytomx Therapeutics, Inc. Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
US9540440B2 (en) 2013-10-30 2017-01-10 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
WO2015089283A1 (en) 2013-12-11 2015-06-18 Cytomx Therapeutics, Inc. Antibodies that bind activatable antibodies and methods of use thereof
BR112016017649B1 (pt) 2014-01-31 2024-01-30 Cytomx Therapeutics, Inc Polipeptídeo isolado compreendendo substratos de matriptase e de ativador do plasminogênio u e outras porções cliváveis, composição farmacêutica compreendendo o dito polipeptídeo, bem como métodos para produzir e fabricar um polipeptídeo isolado compreendendo uma porção clivável e uso da composição farmacêutica e quantidade terapeuticamente eficaz da dita composição no tratamento de um distúrbio ou doença
WO2016014974A2 (en) 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
WO2016149201A2 (en) 2015-03-13 2016-09-22 Cytomx Therapeutics, Inc. Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
SG10201913762QA (en) 2015-05-04 2020-03-30 Cytomx Therapeutics Inc Anti-cd71 antibodies, activatable anti-cd71 antibodies, and methods of use thereof
CN107849133B (zh) 2015-05-04 2022-08-23 西托姆克斯治疗公司 抗cd166抗体、可活化抗cd166抗体及其使用方法
US10233244B2 (en) 2015-05-04 2019-03-19 Cytomx Therapeutics, Inc. Anti-ITGA3 antibodies, activatable anti-ITGA3 antibodies, and methods of use thereof
BR112018000768A2 (pt) 2015-07-13 2018-09-25 Cytomx Therapeutics Inc anticorpos anti-pd-1, anticorpos anti-pd-1 ativáveis e métodos de uso dos mesmos
CA3042679A1 (en) 2016-11-03 2018-05-11 Bristol-Myers Squibb Company Activatable anti-ctla-4 antibodies and uses thereof
EA201991353A1 (ru) 2016-12-09 2019-11-29 Двухвалентные антитела, маскированные спирализованными спиралями
CN110914302A (zh) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 可活化抗pdl1抗体及其使用方法
JP2020531045A (ja) 2017-07-14 2020-11-05 シートムエックス セラピューティクス,インコーポレイテッド 抗cd166抗体およびその使用
AU2018304711B2 (en) 2017-07-20 2025-04-10 Cytomx Therapeutics, Inc. Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof
EP3668545A2 (en) 2017-08-16 2020-06-24 Bristol-Myers Squibb Company Prodruggable antibodies, prodrugs thereof, and methods of use and making
IL321773A (en) 2017-10-14 2025-08-01 Cytomx Therapeutics Inc Activatable antibodies and methods for preparing them
CN120248140A (zh) 2018-12-06 2025-07-04 西托姆克斯治疗公司 基质金属蛋白酶可裂解的和丝氨酸或半胱氨酸蛋白酶可裂解的底物及其使用方法
WO2020247572A1 (en) 2019-06-05 2020-12-10 Seattle Genetics, Inc. Masked antibody formulations
AR119097A1 (es) 2019-06-05 2021-11-24 Seattle Genetics Inc Métodos de purificación de anticuerpos enmascarados
US20220251206A1 (en) 2019-06-11 2022-08-11 Bristol-Myers Squibb Company Anti-ctla4 antibody prodruggable (probody) at a cdr position
KR20220166814A (ko) 2020-04-09 2022-12-19 싸이톰스 테라퓨틱스, 인크. 활성화 가능한 항체를 함유하는 조성물
MX2022012592A (es) 2020-04-10 2022-12-07 Cytomx Therapeutics Inc Construcciones de citocinas activables y composiciones y metodos relacionados.
MX2023010840A (es) 2021-03-16 2023-10-26 Cytomx Therapeutics Inc Construcciones de citocinas activables enmascaradas y composiciones y métodos relacionados.
US20240352080A1 (en) 2021-07-14 2024-10-24 Seagen Inc. Antibody Masking Domains
EP4405387A1 (en) 2021-09-24 2024-07-31 Seagen Inc. Improved antibody masking domains
US20250136717A1 (en) 2022-05-16 2025-05-01 Byondis B.V. Novel masked antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9603507D0 (en) * 1996-02-20 1996-04-17 Isis Innovation Antibody variants
US5990286A (en) * 1996-12-18 1999-11-23 Techniclone, Inc. Antibodies with reduced net positive charge
JP4334866B2 (ja) * 2000-10-09 2009-09-30 アイシス イノヴェイション リミテッド 治療用抗体
EP1361893B1 (en) * 2001-02-19 2012-10-24 Merck Patent GmbH Modified anti-egfr antibodies with reduced immunogenicity

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