JP2010524489A5 - - Google Patents
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- Publication number
- JP2010524489A5 JP2010524489A5 JP2010504835A JP2010504835A JP2010524489A5 JP 2010524489 A5 JP2010524489 A5 JP 2010524489A5 JP 2010504835 A JP2010504835 A JP 2010504835A JP 2010504835 A JP2010504835 A JP 2010504835A JP 2010524489 A5 JP2010524489 A5 JP 2010524489A5
- Authority
- JP
- Japan
- Prior art keywords
- binding domain
- amino acid
- acid sequence
- sequence shown
- domain consisting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 6
- 102100024654 Calcitonin gene-related peptide type 1 receptor Human genes 0.000 claims 5
- 101000760563 Homo sapiens Calcitonin gene-related peptide type 1 receptor Proteins 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 101000584593 Homo sapiens Receptor activity-modifying protein 3 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 102100030711 Receptor activity-modifying protein 3 Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- -1 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0708002.1A GB0708002D0 (en) | 2007-04-25 | 2007-04-25 | Antibodies |
| PCT/GB2008/001454 WO2008132453A1 (en) | 2007-04-25 | 2008-04-23 | Antibodies against ramp3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014102881A Division JP6086495B2 (ja) | 2007-04-25 | 2014-05-16 | Ｒａｍｐ３に対する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524489A JP2010524489A (ja) | 2010-07-22 |
| JP2010524489A5 true JP2010524489A5 (enExample) | 2011-06-16 |
Family
ID=38170659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504835A Pending JP2010524489A (ja) | 2007-04-25 | 2008-04-23 | Ｒａｍｐ３に対する抗体 |
| JP2014102881A Expired - Fee Related JP6086495B2 (ja) | 2007-04-25 | 2014-05-16 | Ｒａｍｐ３に対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014102881A Expired - Fee Related JP6086495B2 (ja) | 2007-04-25 | 2014-05-16 | Ｒａｍｐ３に対する抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8389237B2 (enExample) |
| EP (1) | EP2152753B1 (enExample) |
| JP (2) | JP2010524489A (enExample) |
| KR (1) | KR20100015915A (enExample) |
| CN (1) | CN101842390A (enExample) |
| AU (1) | AU2008244074B2 (enExample) |
| CA (1) | CA2685099A1 (enExample) |
| ES (1) | ES2393938T3 (enExample) |
| GB (1) | GB0708002D0 (enExample) |
| WO (1) | WO2008132453A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| GB0521139D0 (en) * | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| PE20080333A1 (es) | 2006-06-08 | 2008-06-15 | Chugai Pharmaceutical Co Ltd | Agentes para prevenir o tratar enfermedades inflamatorias |
| CN110372795A (zh) | 2007-08-02 | 2019-10-25 | 吉利德生物制剂公司 | Lox和loxl2抑制剂及其应用 |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| MX337081B (es) | 2007-12-05 | 2016-02-10 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-nr10 y su uso. |
| MY162546A (en) | 2007-12-05 | 2017-06-15 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for pruritus |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| CN102076355B (zh) * | 2008-04-29 | 2014-05-07 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| AU2009256246B2 (en) * | 2008-06-03 | 2013-07-18 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| AU2009268585C1 (en) * | 2008-07-08 | 2014-10-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
| KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| TWI646193B (zh) | 2009-03-19 | 2019-01-01 | 中外製藥股份有限公司 | 抗體恆定區域改變體 |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| JP2012525441A (ja) * | 2009-05-01 | 2012-10-22 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリンおよびこの使用 |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2012110585A (ru) | 2009-08-21 | 2013-09-27 | Джилид Байолоджикс, Инк. | Каталичические домены лизилоксидазы и loxl2 |
| UY32948A (es) * | 2009-10-15 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| UY32979A (es) * | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| TW201206473A (en) | 2010-08-03 | 2012-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN103260639A (zh) | 2010-08-26 | 2013-08-21 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| US9790280B2 (en) * | 2011-10-26 | 2017-10-17 | Elanco Tiergesundheit Ag | Monoclonal canine CD20 antibodies and methods of use |
| WO2013102042A2 (en) | 2011-12-30 | 2013-07-04 | Abbvie Inc. | Dual specific binding proteins directed against il-13 and/or il-17 |
| HK1212359A1 (en) | 2012-11-01 | 2016-06-10 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質 |
| US10379127B2 (en) | 2013-11-27 | 2019-08-13 | Welcome Receptor Antibodies Pty Ltd | Marker of cell death |
| WO2016044224A1 (en) | 2014-09-15 | 2016-03-24 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| WO2016167263A1 (ja) | 2015-04-14 | 2016-10-20 | 中外製薬株式会社 | Ｉｌ－３１アンタゴニストを有効成分として含有する、アトピー性皮膚炎の予防用及び／又は治療用医薬組成物 |
| ES3036076T3 (en) | 2015-04-14 | 2025-09-12 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing il-31 antagonist as active ingredient |
| JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
| GB201509907D0 (en) * | 2015-06-08 | 2015-07-22 | Urosens Ltd | Antibodies |
| ES2806498T3 (es) | 2015-06-08 | 2021-02-17 | Arquer Diagnostics Ltd | Métodos para el análisis de una muestra de orina |
| EP4060344A1 (en) | 2015-06-08 | 2022-09-21 | Arquer Diagnostics Limited | Methods and kits |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| JP2019522960A (ja) | 2016-04-21 | 2019-08-22 | アッヴィ・ステムセントルクス・エル・エル・シー | 新規の抗ｂｍｐｒ１ｂ抗体及び使用方法 |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| BR112020019882A2 (pt) | 2018-04-02 | 2021-01-05 | Amgen Inc. | Composições de erenumabe e seus usos |
| CN113272322A (zh) * | 2018-10-08 | 2021-08-17 | Uab 研究基金会 | 神经内分泌癌靶向治疗 |
| GB201818651D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| GB201818649D0 (en) | 2018-11-15 | 2019-01-02 | Univ Sheffield | Compounds |
| BR112022006590A2 (pt) | 2019-11-20 | 2022-06-28 | Chugai Pharmaceutical Co Ltd | Preparação contendo anticorpos |
| CN113512109B (zh) * | 2021-03-09 | 2022-03-25 | 北京康乐卫士生物技术股份有限公司 | 一种抗人乳头瘤病毒31型的单克隆中和抗体及其应用 |
| WO2024102912A1 (en) * | 2022-11-10 | 2024-05-16 | The Children's Medical Center Corporation | Cgrp/ramp1 blockade to treat endometriosis-associated pain and reduce endometriosis lesions |
| GB202303531D0 (en) * | 2023-03-10 | 2023-04-26 | Fusion Antibodies Plc | Antibodies and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030055231A1 (en) * | 1998-10-28 | 2003-03-20 | Jian Ni | 12 human secreted proteins |
| WO2004050834A2 (en) * | 2002-11-27 | 2004-06-17 | Genpath Pharmaceuticals, Incorporated | GPC99 AND GPC99a: METHODS AND COMPOSITIONS FOR TREATING CANCER |
| GB0521139D0 (en) | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
-
2007
- 2007-04-25 GB GBGB0708002.1A patent/GB0708002D0/en not_active Ceased
-
2008
- 2008-04-23 WO PCT/GB2008/001454 patent/WO2008132453A1/en not_active Ceased
- 2008-04-23 US US12/597,269 patent/US8389237B2/en not_active Expired - Fee Related
- 2008-04-23 CA CA002685099A patent/CA2685099A1/en not_active Abandoned
- 2008-04-23 AU AU2008244074A patent/AU2008244074B2/en not_active Ceased
- 2008-04-23 KR KR1020097022348A patent/KR20100015915A/ko not_active Withdrawn
- 2008-04-23 CN CN200880013626A patent/CN101842390A/zh active Pending
- 2008-04-23 EP EP08750480A patent/EP2152753B1/en not_active Not-in-force
- 2008-04-23 ES ES08750480T patent/ES2393938T3/es active Active
- 2008-04-23 JP JP2010504835A patent/JP2010524489A/ja active Pending
-
2013
- 2013-02-07 US US13/762,266 patent/US20130189285A1/en not_active Abandoned
-
2014
- 2014-05-16 JP JP2014102881A patent/JP6086495B2/ja not_active Expired - Fee Related
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