JP2005533001A5 - - Google Patents
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- Publication number
- JP2005533001A5 JP2005533001A5 JP2003574230A JP2003574230A JP2005533001A5 JP 2005533001 A5 JP2005533001 A5 JP 2005533001A5 JP 2003574230 A JP2003574230 A JP 2003574230A JP 2003574230 A JP2003574230 A JP 2003574230A JP 2005533001 A5 JP2005533001 A5 JP 2005533001A5
- Authority
- JP
- Japan
- Prior art keywords
- vitaxin
- fragment
- binding
- integrin
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 35
- 230000027455 binding Effects 0.000 claims 32
- 102000006495 integrins Human genes 0.000 claims 26
- 108010044426 integrins Proteins 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 13
- 238000011275 oncology therapy Methods 0.000 claims 10
- 238000011282 treatment Methods 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 238000001959 radiotherapy Methods 0.000 claims 8
- 238000002512 chemotherapy Methods 0.000 claims 7
- 238000001794 hormone therapy Methods 0.000 claims 7
- 238000009169 immunotherapy Methods 0.000 claims 7
- 238000001356 surgical procedure Methods 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 238000001815 biotherapy Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- HGFOOLONGOBCMP-IBGZPJMESA-N (3s)-3-(6-methoxypyridin-3-yl)-3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazolidin-1-yl]propanoic acid Chemical compound C1=NC(OC)=CC=C1[C@H](CC(O)=O)N1C(=O)N(CCCC=2N=C3NCCCC3=CC=2)CC1 HGFOOLONGOBCMP-IBGZPJMESA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 230000003474 anti-emetic effect Effects 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 230000002141 anti-parasite Effects 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 239000002111 antiemetic agent Substances 0.000 claims 2
- -1 antifungal Substances 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 239000003096 antiparasitic agent Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36185902P | 2002-03-04 | 2002-03-04 | |
| US37039802P | 2002-04-05 | 2002-04-05 | |
| US44426503P | 2003-01-30 | 2003-01-30 | |
| PCT/US2003/006684 WO2003075957A1 (en) | 2002-03-04 | 2003-03-04 | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533001A JP2005533001A (ja) | 2005-11-04 |
| JP2005533001A5 true JP2005533001A5 (enExample) | 2006-01-12 |
Family
ID=27808630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003574230A Pending JP2005533001A (ja) | 2002-03-04 | 2003-03-04 | インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040001835A1 (enExample) |
| EP (1) | EP1487492A4 (enExample) |
| JP (1) | JP2005533001A (enExample) |
| AU (2) | AU2003217930A1 (enExample) |
| CA (1) | CA2478239A1 (enExample) |
| WO (1) | WO2003075957A1 (enExample) |
Families Citing this family (61)
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| US20110008327A1 (en) * | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| WO2005094322A2 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20100173864A1 (en) * | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| EP1755673B1 (en) | 2004-04-12 | 2014-07-23 | MedImmune, LLC | Anti-il-9 antibody formulations and uses thereof |
| US7329495B2 (en) | 2004-06-09 | 2008-02-12 | Board Of Regents, The University Of Texas System | Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors |
| AU2005277567A1 (en) * | 2004-08-16 | 2006-03-02 | Medimmune, Llc | Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
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| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| BR112013004776A2 (pt) | 2010-08-27 | 2017-09-19 | Stem Centrx Inc | moduladores de proteína notum e métodos de uso |
| CN103476429B (zh) | 2010-09-03 | 2016-08-24 | 施特姆森特克斯股份有限公司 | 新型调节剂及使用方法 |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| US20140302034A1 (en) | 2010-12-08 | 2014-10-09 | Stem Centrx, Inc. | Novel modulators and methods of use |
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| US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| RU2014103159A (ru) * | 2011-07-22 | 2015-08-27 | Павел КАЛИНСКИЙ | Опухолесективная модуляция хемокинов |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
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| US9220774B2 (en) | 2011-11-01 | 2015-12-29 | Bionomics Inc. | Methods of treating cancer by administering anti-GPR49 antibodies |
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| AU2012332587B2 (en) | 2011-11-01 | 2017-02-23 | Bionomics, Inc. | Antibodies and methods of treating cancer |
| KR102052774B1 (ko) | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Ｆｃ 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계 |
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| ES2812849T3 (es) | 2012-02-24 | 2021-03-18 | Abbvie Stemcentrx Llc | Anticuerpos anti-DLL3 y procedimientos de utilización de los mismos |
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| EP3338793A1 (en) | 2013-08-28 | 2018-06-27 | AbbVie Stemcentrx LLC | Novel sez6 modulators and methods of use |
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| EP3065780A1 (en) * | 2013-11-04 | 2016-09-14 | Pfizer Inc. | Anti-efna4 antibody-drug conjugates |
| EA201691683A1 (ru) | 2014-02-21 | 2017-04-28 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Антитела против dll3 и конъюгаты антитело-лекарственное средство для применения при меланоме |
| AU2015240599B2 (en) | 2014-04-04 | 2020-11-19 | Bionomics, Inc. | Humanized antibodies that bind LGR5 |
| PT3137114T (pt) | 2014-04-30 | 2021-02-26 | Pfizer | Conjugados anticorpo-fármaco anti-ptk7 |
| CN108697799A (zh) | 2016-03-22 | 2018-10-23 | 生态学有限公司 | 抗lgr5单克隆抗体的施用 |
| AU2018243670B2 (en) | 2017-03-31 | 2025-05-01 | The Regents Of The University Of California | Compositions and methods for targeting and killing ALPHA-V BETA-3-positive cancer stem cells (CSCs) and treating drug resistant cancers |
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| KR102304832B1 (ko) * | 2020-08-12 | 2021-09-24 | 영남대학교 산학협력단 | 암 세포의 증식을 억제하는 펩티드 fnin3 및 이의 용도 |
| JP7439808B2 (ja) * | 2021-09-17 | 2024-02-28 | 株式会社プロテリアル | 断線検知方法および断線検知装置 |
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| US6416964B2 (en) * | 1998-01-29 | 2002-07-09 | Merck & Co., Inc. | Methods of identifying modulators of kinases responsive to stress |
| AU3213799A (en) * | 1998-04-01 | 1999-10-18 | Du Pont Pharmaceuticals Company | Integrin antagonists |
| KR100335348B1 (ko) * | 1998-06-23 | 2002-05-06 | 김두식 | 종양 혈관신생 억제기능을 가지는 살모신을 유효성분으로 함유하는 항암제 |
| JP2002522540A (ja) * | 1998-08-13 | 2002-07-23 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| US6235877B1 (en) * | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| US6160099A (en) * | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
| US6204282B1 (en) * | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
| JP2002533404A (ja) * | 1998-12-23 | 2002-10-08 | ジー・ディー・サール・アンド・カンパニー | 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法 |
| WO2000046215A1 (en) * | 1999-02-03 | 2000-08-10 | Merck & Co., Inc. | Benzazepine derivatives as alpha-v integrin receptor antagonists |
| US6344484B1 (en) * | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| AU749351B2 (en) * | 1999-06-02 | 2002-06-27 | Merck & Co., Inc. | Alpha V integrin receptor antagonists |
| EP1187825A1 (en) * | 1999-06-07 | 2002-03-20 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| AU748949B2 (en) * | 1999-06-23 | 2002-06-13 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6531580B1 (en) * | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
| US6037176A (en) * | 1999-06-25 | 2000-03-14 | Isis Pharmaceuticals Inc. | Antisense inhibition of integrin beta 3 expression |
| US6849639B2 (en) * | 1999-12-14 | 2005-02-01 | Amgen Inc. | Integrin inhibitors and their methods of use |
| AU780364B2 (en) * | 2000-01-20 | 2005-03-17 | Merck Sharp & Dohme Corp. | Alpha V integrin receptor antagonists |
| CA2397665A1 (en) * | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| EP1268756A2 (en) * | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Company | Methods and compositions for modulating integrin-mediated cell-cell interactions |
| AU9259801A (en) * | 2000-09-14 | 2002-03-26 | Merck & Co Inc | Alpha v integrin receptor antagonists |
-
2003
- 2003-03-04 CA CA002478239A patent/CA2478239A1/en not_active Abandoned
- 2003-03-04 JP JP2003574230A patent/JP2005533001A/ja active Pending
- 2003-03-04 EP EP03713905A patent/EP1487492A4/en not_active Withdrawn
- 2003-03-04 AU AU2003217930A patent/AU2003217930A1/en not_active Abandoned
- 2003-03-04 WO PCT/US2003/006684 patent/WO2003075957A1/en not_active Ceased
- 2003-03-04 US US10/379,189 patent/US20040001835A1/en not_active Abandoned
-
2008
- 2008-01-09 US US11/971,675 patent/US20090148459A1/en not_active Abandoned
-
2009
- 2009-02-19 AU AU2009200666A patent/AU2009200666A1/en not_active Abandoned
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