JP2011522874A - 季節性および汎流行性の防御のための混合インフルエンザワクチン - Google Patents
季節性および汎流行性の防御のための混合インフルエンザワクチン Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
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| US13191808P | 2008-06-12 | 2008-06-12 | |
| US61/131,918 | 2008-06-12 | ||
| GB0905570.8 | 2009-03-31 | ||
| GBGB0905570.8A GB0905570D0 (en) | 2009-03-31 | 2009-03-31 | Combined vaccines |
| PCT/IB2009/006038 WO2009150532A1 (en) | 2008-06-12 | 2009-06-12 | Combined influenza vaccines for seasonal and pandemic protection |
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| JP2011522874A true JP2011522874A (ja) | 2011-08-04 |
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| EP (1) | EP2303321A1 (enExample) |
| JP (1) | JP2011522874A (enExample) |
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| AU (1) | AU2009259006A1 (enExample) |
| CA (1) | CA2727322A1 (enExample) |
| GB (1) | GB0905570D0 (enExample) |
| WO (1) | WO2009150532A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013048597A (ja) * | 2011-08-31 | 2013-03-14 | Tokyo Metropolitan Institute Of Medical Science | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| WO2016104584A1 (ja) * | 2014-12-25 | 2016-06-30 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2614802T3 (es) * | 2008-11-28 | 2017-06-02 | Statens Serum Institut | Vacunas contra la gripe optimizadas |
| AU2015203072B2 (en) * | 2009-02-10 | 2017-05-25 | Seqirus UK Limited | Influenza vaccine regimens for pandemic-associated strains |
| WO2010092476A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| CA2763816A1 (en) * | 2009-04-27 | 2010-11-04 | Novartis Ag | Adjuvanted vaccines for protecting against influenza |
| AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| WO2011044152A1 (en) * | 2009-10-05 | 2011-04-14 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer | Protection against pandemic and seasonal strains of influenza |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| KR20140068205A (ko) | 2011-09-20 | 2014-06-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
| RU2599496C2 (ru) * | 2012-03-06 | 2016-10-10 | Круселл Холланд Б.В. | Улучшенная вакцинация против гриппа |
| JP2016502995A (ja) | 2012-12-17 | 2016-02-01 | ユーロシネ ヴァクシンズ アクチエボラーグ | 鼻腔内予防接種投薬レジメン |
| KR20150104117A (ko) | 2012-12-18 | 2015-09-14 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 인플루엔자 바이러스 백신 및 그의 용도 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US10588957B2 (en) | 2013-10-25 | 2020-03-17 | Leukocare Ag | Method for the production of stabile vaccines |
| WO2016100926A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| AU2016281904B2 (en) | 2015-06-26 | 2022-08-11 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| WO2017218624A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| CN107151659B (zh) * | 2017-03-01 | 2021-04-02 | 苏州系统医学研究所 | 一种流感病毒株及其应用 |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| WO2019086463A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| CN111629751B (zh) * | 2018-01-22 | 2025-02-21 | 美国政府(由卫生和人类服务部的部长所代表) | 广泛保护性灭活流感病毒疫苗 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009023985A (ja) * | 2007-01-11 | 2009-02-05 | Osaka Prefecture Univ | インフルエンザウイルスに対する抗体の産生方法 |
| JP2011506264A (ja) * | 2006-12-06 | 2011-03-03 | ノバルティス アーゲー | インフルエンザウイルスの４つの株に由来する抗原を含むワクチン |
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| EP1645283A1 (en) * | 2004-10-08 | 2006-04-12 | Chiron Behring GmbH & Co. KG | Combination vaccine |
| TW200700079A (en) * | 2005-03-23 | 2007-01-01 | Glaxosmithkline Biolog Sa | Composition |
| KR101211386B1 (ko) * | 2005-11-04 | 2012-12-13 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 알루미늄 보조제에 즉석 흡착되는 인플루엔자 백신 |
| US20090304742A1 (en) * | 2005-11-04 | 2009-12-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines with reduced amount of emulsion adjuvant |
| WO2007144772A2 (en) * | 2006-06-15 | 2007-12-21 | Novartis Ag | Adjuvant-sparing multi-dose influenza vaccination regimen |
| WO2008032219A2 (en) * | 2006-09-11 | 2008-03-20 | Novartis Ag | Making influenza virus vaccines without using eggs |
| TWI403518B (zh) * | 2007-01-23 | 2013-08-01 | Academia Sinica | 一種流感疫苗及其使用方法 |
| GB0810305D0 (en) * | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| US8668904B2 (en) * | 2007-12-06 | 2014-03-11 | Glaxosmithkline Biologicals S.A. | Influenza composition |
| ES2535101T3 (es) * | 2008-03-18 | 2015-05-05 | Novartis Ag | Mejoras en la preparación de antígenos en vacuna de virus de la gripe |
-
2009
- 2009-03-31 GB GBGB0905570.8A patent/GB0905570D0/en not_active Ceased
- 2009-06-12 WO PCT/IB2009/006038 patent/WO2009150532A1/en not_active Ceased
- 2009-06-12 CA CA2727322A patent/CA2727322A1/en not_active Abandoned
- 2009-06-12 CN CN2009801230987A patent/CN102245203A/zh active Pending
- 2009-06-12 JP JP2011513069A patent/JP2011522874A/ja active Pending
- 2009-06-12 KR KR1020117000394A patent/KR20110019417A/ko not_active Ceased
- 2009-06-12 US US12/997,577 patent/US20110200635A1/en not_active Abandoned
- 2009-06-12 EP EP09762060A patent/EP2303321A1/en not_active Withdrawn
- 2009-06-12 AU AU2009259006A patent/AU2009259006A1/en not_active Abandoned
-
2014
- 2014-08-18 US US14/461,852 patent/US20140363468A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506264A (ja) * | 2006-12-06 | 2011-03-03 | ノバルティス アーゲー | インフルエンザウイルスの４つの株に由来する抗原を含むワクチン |
| JP2009023985A (ja) * | 2007-01-11 | 2009-02-05 | Osaka Prefecture Univ | インフルエンザウイルスに対する抗体の産生方法 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6013048992; 三和護: ''【学会トピックス】ダチョウの卵から生まれた鳥インフルエンザ抗体マスク'' ［ｏｎｌｉｎｅ］日経メディカルオンライン , 20080118 * |
| JPN6013048993; Ｏｎｉｓｈｃｈｅｎｋｏ ｅｔ ａｌ．: ''Ｔｅｔｒａｖａｃｃｉｎｅ - ｎｅｗ ｆｕｎｄａｍｅｎｔａｌ ａｐｐｒｏａｃｈ ｔｏ ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｉｎｆｌｕｅｎｚａ ｐａｎｄｅｍｉｃ'' Ｚｈｕｒｎａｌ ｍｉｋｒｏｂｉｏｌｏｇｉｉ， ｅｐｉｄｅｍｉｏｌｏｇｉｉ， ｉ ｉｍｍｕｎｏｂｉｏｌｏｇｉｉ， Ｎｏ．４, 2007, ｐｐ．１５-１９ * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013048597A (ja) * | 2011-08-31 | 2013-03-14 | Tokyo Metropolitan Institute Of Medical Science | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| WO2016104584A1 (ja) * | 2014-12-25 | 2016-06-30 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
| JPWO2016104584A1 (ja) * | 2014-12-25 | 2017-10-05 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
| JP2020122003A (ja) * | 2014-12-25 | 2020-08-13 | テルモ株式会社 | 皮内投与インフルエンザワクチン組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009150532A1 (en) | 2009-12-17 |
| AU2009259006A1 (en) | 2009-12-17 |
| CN102245203A (zh) | 2011-11-16 |
| EP2303321A1 (en) | 2011-04-06 |
| US20140363468A1 (en) | 2014-12-11 |
| GB0905570D0 (en) | 2009-05-13 |
| US20110200635A1 (en) | 2011-08-18 |
| CA2727322A1 (en) | 2009-12-17 |
| KR20110019417A (ko) | 2011-02-25 |
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