JP2011522808A - 相乗的な保存剤混合物 - Google Patents
相乗的な保存剤混合物 Download PDFInfo
- Publication number
- JP2011522808A JP2011522808A JP2011511999A JP2011511999A JP2011522808A JP 2011522808 A JP2011522808 A JP 2011522808A JP 2011511999 A JP2011511999 A JP 2011511999A JP 2011511999 A JP2011511999 A JP 2011511999A JP 2011522808 A JP2011522808 A JP 2011522808A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- bactericidal
- concentration
- present
- preservative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
【選択図】 なし
Description
全てのパーセンテージは、特に言及しない限り、重量%を意味する。
完成した化粧品における混合物の効能を評価するために、保存剤負荷試験を行った。試験は、ここに記載するように、シャンプーおよびローション基剤について行った。標準化された混合菌液を以下のように調製した。黄色ブドウ球菌(Staphylococcus aureus;ATCC 6538)、大腸菌(Escherichia coli;ATCC 8739)および緑膿菌(Pseudomonas aeruginosa;ATCC 9027)の3つの個々のトリプティックソイ寒天培地(Trypric soy agar)傾斜培養(slant)を、約35℃で24時間インキュベートした。その後、各傾斜培養を5 mLの無菌のリン酸緩衝希釈水 (PBDW)で洗浄した。その5 mLをさらに5 mLのBPDWと合わせ、全部で10 mLの個々の細菌懸濁液とした。PBDWのブランクを用いて機器の較正を行った後、個々の懸濁液のそれぞれの吸収を、530nmにおいて分光光度的に測定した。個々の懸濁液は、109 CFU/mL以内に標準化した。5 mLを個々の懸濁液から1つの無菌飼料カップへ無菌的に移し、「混合細菌」とした。その後、シャンプーおよびローションのサンプルそれぞれ40 gに、0.2 mLの標準化された細菌溶液を植え付け、各サンプルをよく混合した。
混合真菌−およそ等量のカンジダ・アルビカンスおよびアスペルギルス・ニガー;6.9×104〜1.2×105
実施例2
最小発育阻止濃度(MIC)を、個々の成分および二成分製剤について、以下に示すように測定した。黄色ブドウ球菌(グラム陽性)、大腸菌および緑膿菌(共にグラム陰性)のそれぞれの細菌懸濁液ならびにカンジダ・アルビカンスおよびアスペルギルス・ニガーのそれぞれの真菌懸濁液を、実施例1に記載したように調製した。各懸濁液は、細菌および真菌それぞれについて、108 CFU/mL以下または107cells/mL以下になるようにPBDWで標準化した。
Claims (9)
- 殺菌性および/または殺真菌性を有する少なくとも2つの化合物の組み合わせを含む保存剤であって、前記それぞれの組み合わせは、メチルイソチアゾリノン/ピロクトンオラミン;カプリリルグリコール/デヒドロ酢酸;ウンデカノール/デヒドロ酢酸およびラウリルアルコール/ソルビン酸からなる群より選択される保存剤。
- 請求項1に記載の化合物であって、前記殺菌性化合物がメチルイソチアゾリノンである場合は、前記殺菌性化合物は1%〜5%の濃度で存在し、前記殺菌性化合物がカプリリルグリコール、ウンデカノールおよびラウリルアルコールである場合は、前記殺菌性化合物は25%〜75%の濃度で存在する化合物。
- 請求項2に記載の化合物であって、前記殺菌性化合物がメチルイソチアゾリノンである場合は、前記殺菌性化合物は1.5%〜3%の濃度で存在し、前記殺菌性化合物がカプリリルグリコール、ウンデカノールおよびラウリルアルコールである場合は、前記殺菌性化合物は30%〜70%の濃度で存在する化合物。
- 請求項1〜3のいずれか1項に記載の化合物であって、前記殺真菌性化合物は、25%〜99%の濃度で存在する化合物。
- 請求項4に記載の化合物であって、前記殺真菌性化合物は、30%〜95%の濃度で存在する化合物。
- 請求項1〜5のいずれか1項に記載の保存剤を調製品に添加することを含む、前記調製品の細菌および真菌の負荷を減少させる方法。
- 請求項6に記載の方法であって、前記調製品は、個人用、家庭用および工業用の製品、製剤および調製品からなる群より選択される方法。
- 請求項7に記載の方法であって、前記調製品は、ローション、クリーム、膏薬(salve)および軟膏(ointment)のような化粧品、洗浄剤、界面活性剤、女性の衛生製品、拭き取り用の布(wipe)、ペットケアのための調製品、シャンプー、コンディショナー、ゲル、固定剤およびスプレーのようなヘア用調製品からなる群より選択される方法。
- 調製品の細菌および真菌の負荷を減少させるための、請求項1〜5のいずれか1項に記載の保存剤の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5836208P | 2008-06-03 | 2008-06-03 | |
US61/058,362 | 2008-06-03 | ||
EP08014560.0 | 2008-08-15 | ||
EP08014560A EP2153813A1 (en) | 2008-08-15 | 2008-08-15 | Synergistic preservative blends |
PCT/EP2009/003610 WO2009146800A2 (en) | 2008-06-03 | 2009-05-20 | Synergistic preservative blends |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2011522808A true JP2011522808A (ja) | 2011-08-04 |
Family
ID=40242591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011511999A Pending JP2011522808A (ja) | 2008-06-03 | 2009-05-20 | 相乗的な保存剤混合物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US9060952B2 (ja) |
EP (2) | EP2153813A1 (ja) |
JP (1) | JP2011522808A (ja) |
KR (1) | KR20110014636A (ja) |
CN (1) | CN102186453B (ja) |
AT (1) | ATE541554T1 (ja) |
AU (1) | AU2009254255B2 (ja) |
BR (1) | BRPI0913389B1 (ja) |
CA (1) | CA2726711A1 (ja) |
EA (1) | EA021050B1 (ja) |
ES (1) | ES2381165T3 (ja) |
HK (1) | HK1161970A1 (ja) |
MX (1) | MX2010013324A (ja) |
PL (1) | PL2296614T3 (ja) |
WO (1) | WO2009146800A2 (ja) |
ZA (1) | ZA201009047B (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060261312A1 (en) * | 2003-05-28 | 2006-11-23 | Lonza Inc. | Quaternary ammonium salts containing non-halogen anions as anticorrosive agents |
DE102010013274A1 (de) * | 2010-03-29 | 2011-11-17 | Beiersdorf Ag | Mikrobiologisch stabile anwendungsfreundliche Zubereitungen |
DE102010013272A1 (de) * | 2010-03-29 | 2011-09-29 | Beiersdorf Ag | Mikrobiologisch stabile anwendungsfreundliche Zubereitung mit Verdickern |
DE102010013275A1 (de) * | 2010-03-29 | 2011-09-29 | Beiersdorf Ag | Mikrobiologisch stabile anwendungsfreundliche W/O-Zubereitungen |
KR101189344B1 (ko) | 2010-06-23 | 2012-10-09 | 유한킴벌리 주식회사 | 자가-보존성 스킨케어 조성물 |
DE102012212281B3 (de) | 2012-07-13 | 2013-10-31 | Schülke & Mayr GmbH | Mischung von natürlichen bzw. naturidentischen Alkoholen mit verbesserter Wirksamkeit |
DE102013200819A1 (de) * | 2013-01-18 | 2014-07-24 | Beiersdorf Ag | Wirkstoffkombinationen aus Dehydracetsäure und einem oder mehrere Polyolen |
MX360413B (es) | 2013-06-27 | 2018-10-30 | Procter & Gamble | Composiciones conservantes para el cuidado personal. |
WO2016123308A1 (en) | 2015-01-28 | 2016-08-04 | Lonza, Inc. | Preservative compositions for formulations |
RU2704790C1 (ru) | 2015-12-31 | 2019-10-31 | Колгейт-Палмолив Компани | Очищающие бруски мыла |
CN105685202A (zh) * | 2016-02-25 | 2016-06-22 | 厦门理工学院 | 一种低乙醇保鲜剂及用途 |
US10271551B2 (en) | 2016-06-22 | 2019-04-30 | Lonza Inc. | Preservative composition for wet wipes |
FR3068216B1 (fr) * | 2017-06-30 | 2019-08-16 | L'oreal | Melange antimicrobien contenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one et de la piroctone olamine, et composition cosmetique le contenant |
CN109258648A (zh) * | 2018-10-25 | 2019-01-25 | 黑龙江工业学院 | 一种食品机械用杀菌剂组合物 |
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JP2000170077A (ja) * | 1998-10-02 | 2000-06-20 | Lion Corp | 繊維処理剤 |
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JP2006143719A (ja) * | 2004-11-16 | 2006-06-08 | Rohm & Haas Co | 殺菌性組成物 |
JP2007532542A (ja) * | 2004-04-08 | 2007-11-15 | アイエスピー インヴェストメンツ インコーポレイテッド | 抗菌性組成物 |
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2008
- 2008-08-15 EP EP08014560A patent/EP2153813A1/en not_active Ceased
-
2009
- 2009-05-20 EP EP09757183.0A patent/EP2296614B2/en not_active Not-in-force
- 2009-05-20 PL PL09757183T patent/PL2296614T3/pl unknown
- 2009-05-20 MX MX2010013324A patent/MX2010013324A/es active IP Right Grant
- 2009-05-20 EA EA201001846A patent/EA021050B1/ru not_active IP Right Cessation
- 2009-05-20 AU AU2009254255A patent/AU2009254255B2/en not_active Ceased
- 2009-05-20 CA CA2726711A patent/CA2726711A1/en not_active Abandoned
- 2009-05-20 JP JP2011511999A patent/JP2011522808A/ja active Pending
- 2009-05-20 ES ES09757183T patent/ES2381165T3/es active Active
- 2009-05-20 WO PCT/EP2009/003610 patent/WO2009146800A2/en active Application Filing
- 2009-05-20 CN CN2009801291529A patent/CN102186453B/zh not_active Expired - Fee Related
- 2009-05-20 AT AT09757183T patent/ATE541554T1/de active
- 2009-05-20 KR KR1020107027291A patent/KR20110014636A/ko not_active Application Discontinuation
- 2009-05-20 BR BRPI0913389-5A patent/BRPI0913389B1/pt not_active IP Right Cessation
- 2009-05-20 US US12/996,044 patent/US9060952B2/en not_active Expired - Fee Related
-
2010
- 2010-12-15 ZA ZA2010/09047A patent/ZA201009047B/en unknown
-
2012
- 2012-03-06 HK HK12102271.2A patent/HK1161970A1/xx not_active IP Right Cessation
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WO2004028519A1 (ja) * | 2002-09-26 | 2004-04-08 | Mandom Corporation | 防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品 |
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Also Published As
Publication number | Publication date |
---|---|
US9060952B2 (en) | 2015-06-23 |
BRPI0913389A2 (pt) | 2015-11-24 |
EA201001846A1 (ru) | 2011-08-30 |
EA021050B1 (ru) | 2015-03-31 |
KR20110014636A (ko) | 2011-02-11 |
AU2009254255A1 (en) | 2009-12-10 |
PL2296614T3 (pl) | 2013-03-29 |
HK1161970A1 (en) | 2012-08-17 |
EP2296614B2 (en) | 2019-08-28 |
AU2009254255B2 (en) | 2014-02-27 |
CN102186453B (zh) | 2013-11-13 |
ATE541554T1 (de) | 2012-02-15 |
MX2010013324A (es) | 2011-03-25 |
CA2726711A1 (en) | 2009-12-10 |
BRPI0913389B1 (pt) | 2017-07-04 |
CN102186453A (zh) | 2011-09-14 |
ES2381165T3 (es) | 2012-05-23 |
EP2153813A1 (en) | 2010-02-17 |
WO2009146800A2 (en) | 2009-12-10 |
EP2296614A2 (en) | 2011-03-23 |
EP2296614B1 (en) | 2012-01-18 |
ZA201009047B (en) | 2011-09-28 |
US20110301206A1 (en) | 2011-12-08 |
WO2009146800A3 (en) | 2010-07-22 |
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