JP2011521974A5 - - Google Patents
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- Publication number
- JP2011521974A5 JP2011521974A5 JP2011511876A JP2011511876A JP2011521974A5 JP 2011521974 A5 JP2011521974 A5 JP 2011521974A5 JP 2011511876 A JP2011511876 A JP 2011511876A JP 2011511876 A JP2011511876 A JP 2011511876A JP 2011521974 A5 JP2011521974 A5 JP 2011521974A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- amorphous form
- drug delivery
- delivery device
- glass transition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003381 stabilizer Substances 0.000 claims description 11
- 230000009477 glass transition Effects 0.000 claims description 9
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 6
- 229960003086 naltrexone Drugs 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 3
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 3
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 3
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims description 3
- 229960002646 scopolamine Drugs 0.000 claims description 3
- 239000007962 solid dispersion Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 25
- 229940124597 therapeutic agent Drugs 0.000 claims 25
- 239000002270 dispersing agent Substances 0.000 claims 11
- 238000012377 drug delivery Methods 0.000 claims 11
- 230000000087 stabilizing effect Effects 0.000 claims 8
- 238000013271 transdermal drug delivery Methods 0.000 claims 5
- 239000000853 adhesive Substances 0.000 claims 4
- 230000001070 adhesive effect Effects 0.000 claims 4
- 239000012790 adhesive layer Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000003860 storage Methods 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 230000037384 skin absorption Effects 0.000 claims 2
- 231100000274 skin absorption Toxicity 0.000 claims 2
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 239000003522 acrylic cement Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 238000010030 laminating Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 polysiloxane Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000004080 punching Methods 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5745508P | 2008-05-30 | 2008-05-30 | |
| US61/057,455 | 2008-05-30 | ||
| PCT/US2009/045739 WO2009158120A2 (en) | 2008-05-30 | 2009-05-29 | Stabilized transdermal drug delivery system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232586A Division JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521974A JP2011521974A (ja) | 2011-07-28 |
| JP2011521974A5 true JP2011521974A5 (https=) | 2015-01-15 |
| JP5695562B2 JP5695562B2 (ja) | 2015-04-08 |
Family
ID=41380695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511876A Active JP5695562B2 (ja) | 2008-05-30 | 2009-05-29 | 安定化された経皮薬物送達システム |
| JP2014232586A Pending JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232586A Pending JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20110182949A1 (https=) |
| EP (1) | EP2299989B1 (https=) |
| JP (2) | JP5695562B2 (https=) |
| KR (1) | KR101590209B1 (https=) |
| CN (1) | CN102099020B (https=) |
| AU (2) | AU2009262871B2 (https=) |
| BR (1) | BRPI0913214B1 (https=) |
| CA (1) | CA2726136C (https=) |
| MX (1) | MX2010012989A (https=) |
| NZ (1) | NZ589542A (https=) |
| WO (1) | WO2009158120A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2726136C (en) * | 2008-05-30 | 2016-11-01 | Mylan Laboratories, Inc. | Stabilized transdermal drug delivery system |
| KR101325104B1 (ko) * | 2009-09-16 | 2013-11-07 | 주식회사 삼양바이오팜 | 경피 투여 제형 및 그 제조 방법 |
| LT3257504T (lt) | 2009-12-22 | 2024-08-26 | UCB Biopharma SRL | Polivinilpirolidonas, skirtas nekristalinės formos kietos rotigotino dispersijos stabilizavimui |
| CN104582693A (zh) * | 2012-08-15 | 2015-04-29 | 道康宁公司 | 多层药物递送系统 |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| JP2016135744A (ja) * | 2013-05-08 | 2016-07-28 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| JP6726096B2 (ja) | 2013-07-03 | 2020-07-22 | エルテーエス ローマン テラピー−システメ アーゲー | 電子部品を有する経皮治療システム |
| WO2015025767A1 (ja) * | 2013-08-21 | 2015-02-26 | 久光製薬株式会社 | 貼付剤 |
| CN115444659A (zh) * | 2014-01-22 | 2022-12-09 | 4P治疗公司 | 滥用和误用制止透皮系统 |
| US11752110B2 (en) * | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
| CN106456566B (zh) | 2014-05-20 | 2020-06-16 | Lts勒曼治疗系统股份公司 | 含罗替戈汀的经皮递送系统 |
| CA2948219C (en) | 2014-05-20 | 2023-04-04 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
| WO2016049266A1 (en) * | 2014-09-24 | 2016-03-31 | Pain Therapeutics, Inc. | 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal |
| US10010543B1 (en) | 2014-12-23 | 2018-07-03 | Barr Laboratories, Inc. | Transdermal dosage form |
| US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
| EP3558276B1 (en) | 2016-12-20 | 2024-11-06 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| CN115813888A (zh) | 2016-12-20 | 2023-03-21 | 罗曼治疗系统股份公司 | 包含阿塞那平的透皮治疗系统 |
| KR102241892B1 (ko) | 2017-01-25 | 2021-04-20 | 한국전자기술연구원 | 백스캐터 통신을 위한 데이터 부호화 방법 및 이를 위한 장치 |
| EP3395336A1 (en) | 2017-04-28 | 2018-10-31 | Nitto Denko Corporation | Transdermal absorption preparation |
| WO2019002204A1 (en) | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER |
| US12329862B2 (en) | 2018-06-20 | 2025-06-17 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| AU2019291060B2 (en) | 2018-06-20 | 2024-09-05 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| US20220117934A1 (en) * | 2019-02-15 | 2022-04-21 | Hisamitsu Pharmaceutical Co., Inc. | Rotigotine stabilization method |
| US20220160697A1 (en) | 2019-03-19 | 2022-05-26 | Nobelpharma Co., Ltd. | Pharmaceutical composition having excellent drug absorption into the living body and excellent chemical stability |
| WO2020243506A1 (en) * | 2019-05-31 | 2020-12-03 | Kindeva Drug Delivery | Removable film-forming gel compositions featuring adhesion promoters |
| ES2966170T3 (es) | 2020-01-24 | 2024-04-18 | Luye Pharma Switzerland Ag | Sistema terapéutico transdérmico que comprende rotigotina y al menos un adhesivo de silicona no resistente a las aminas |
| TW202228688A (zh) * | 2020-08-31 | 2022-08-01 | 日商耐貝醫藥股份有限公司 | 用於神經退化性疾病之症狀緩解或治療之貼附劑 |
| CN112891324A (zh) * | 2021-01-19 | 2021-06-04 | 北京亚宝生物药业有限公司 | 一种透皮贴剂 |
| KR102363479B1 (ko) * | 2021-03-12 | 2022-02-15 | 환인제약 주식회사 | 로티고틴 함유 경피 흡수 제제 |
| US20220395468A1 (en) * | 2021-06-06 | 2022-12-15 | Starton Therapeutics, Inc. | Transdermal Drug Delivery Systems for Administration of a Therapeutically Effective Amount of Lenalidomide and Other Immunomodulatory Agents |
| CN116270575A (zh) * | 2021-08-16 | 2023-06-23 | 乐明药业(苏州)有限公司 | 一种含有氟比洛芬的药物组合物与贴剂 |
| CN120417892A (zh) * | 2022-12-26 | 2025-08-01 | 丸仁制药株式会社 | 透皮吸收制剂及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2920500A1 (de) * | 1979-05-21 | 1980-11-27 | Boehringer Sohn Ingelheim | Pharmazeutische zubereitung in form eines polyacrylatfilmes |
| DE3204551A1 (de) * | 1982-02-10 | 1983-08-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films |
| JPS60169414A (ja) * | 1984-02-14 | 1985-09-02 | Taisho Pharmaceut Co Ltd | 経皮吸収剤 |
| US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4797284A (en) * | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| IT1253265B (it) * | 1991-11-25 | 1995-07-14 | Rotta Research Lab | Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. |
| US5494680A (en) * | 1993-12-08 | 1996-02-27 | Minnesota Mining And Manufacturing Company | Transdermal delivery device |
| CA2198390C (en) | 1994-09-14 | 2009-08-11 | James E. Garbe | Matrix for transdermal drug delivery |
| US5662928A (en) * | 1995-04-21 | 1997-09-02 | Ciba-Geigy Corporation | Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system |
| KR970009795A (ko) * | 1995-08-30 | 1997-03-27 | 이웅열 | 경피투여용 첩부제 조성물 |
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| US6238700B1 (en) * | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| AU1120097A (en) * | 1995-12-01 | 1997-06-27 | Alza Corporation | Improved method for preventing crystal formation in a dispersion of a liquid in a matrix |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
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| DE19629468A1 (de) | 1996-07-11 | 1998-01-15 | Schering Ag | Transdermale therapeutische Systeme |
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| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| US8496960B2 (en) * | 2001-10-23 | 2013-07-30 | Purdue Pharma L.P. | Terazosin transdermal device and methods |
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| DE102004062182B4 (de) | 2004-12-20 | 2007-06-06 | Bayer Schering Pharma Ag | Transdermales Pflaster mit Progesteron A-Spezifische Liganden (PRASL) als Wirkstoff |
| US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
| JP5285279B2 (ja) * | 2005-12-28 | 2013-09-11 | 久光製薬株式会社 | 経皮吸収型製剤 |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| EP3053440B1 (en) * | 2007-04-11 | 2020-08-12 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| CA2726136C (en) * | 2008-05-30 | 2016-11-01 | Mylan Laboratories, Inc. | Stabilized transdermal drug delivery system |
| CA2824639A1 (en) | 2011-02-17 | 2012-08-23 | Ashish Chatterji | A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion |
-
2009
- 2009-05-29 CA CA2726136A patent/CA2726136C/en active Active
- 2009-05-29 KR KR1020107029551A patent/KR101590209B1/ko active Active
- 2009-05-29 US US12/994,918 patent/US20110182949A1/en not_active Abandoned
- 2009-05-29 AU AU2009262871A patent/AU2009262871B2/en active Active
- 2009-05-29 NZ NZ589542A patent/NZ589542A/xx not_active IP Right Cessation
- 2009-05-29 JP JP2011511876A patent/JP5695562B2/ja active Active
- 2009-05-29 US US12/475,390 patent/US9226902B2/en active Active
- 2009-05-29 CN CN2009801289266A patent/CN102099020B/zh active Active
- 2009-05-29 EP EP09770655.0A patent/EP2299989B1/en active Active
- 2009-05-29 MX MX2010012989A patent/MX2010012989A/es active IP Right Grant
- 2009-05-29 WO PCT/US2009/045739 patent/WO2009158120A2/en not_active Ceased
- 2009-05-29 BR BRPI0913214-7A patent/BRPI0913214B1/pt active IP Right Grant
-
2014
- 2014-11-17 JP JP2014232586A patent/JP2015083569A/ja active Pending
-
2016
- 2016-04-08 AU AU2016202212A patent/AU2016202212B2/en active Active
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