JP2011521974A5 - - Google Patents
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- Publication number
- JP2011521974A5 JP2011521974A5 JP2011511876A JP2011511876A JP2011521974A5 JP 2011521974 A5 JP2011521974 A5 JP 2011521974A5 JP 2011511876 A JP2011511876 A JP 2011511876A JP 2011511876 A JP2011511876 A JP 2011511876A JP 2011521974 A5 JP2011521974 A5 JP 2011521974A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- amorphous form
- drug delivery
- delivery device
- glass transition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003381 stabilizer Substances 0.000 claims description 11
- 230000009477 glass transition Effects 0.000 claims description 9
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 6
- 229960003086 naltrexone Drugs 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 3
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 3
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 3
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims description 3
- 229960002646 scopolamine Drugs 0.000 claims description 3
- 239000007962 solid dispersion Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 25
- 229940124597 therapeutic agent Drugs 0.000 claims 25
- 239000002270 dispersing agent Substances 0.000 claims 11
- 238000012377 drug delivery Methods 0.000 claims 11
- 230000000087 stabilizing effect Effects 0.000 claims 8
- 238000013271 transdermal drug delivery Methods 0.000 claims 5
- 239000000853 adhesive Substances 0.000 claims 4
- 230000001070 adhesive effect Effects 0.000 claims 4
- 239000012790 adhesive layer Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000003860 storage Methods 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 230000037384 skin absorption Effects 0.000 claims 2
- 231100000274 skin absorption Toxicity 0.000 claims 2
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 239000003522 acrylic cement Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 238000010030 laminating Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 polysiloxane Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000004080 punching Methods 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5745508P | 2008-05-30 | 2008-05-30 | |
| US61/057,455 | 2008-05-30 | ||
| PCT/US2009/045739 WO2009158120A2 (en) | 2008-05-30 | 2009-05-29 | Stabilized transdermal drug delivery system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232586A Division JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521974A JP2011521974A (ja) | 2011-07-28 |
| JP2011521974A5 true JP2011521974A5 (https=) | 2015-01-15 |
| JP5695562B2 JP5695562B2 (ja) | 2015-04-08 |
Family
ID=41380695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511876A Active JP5695562B2 (ja) | 2008-05-30 | 2009-05-29 | 安定化された経皮薬物送達システム |
| JP2014232586A Pending JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232586A Pending JP2015083569A (ja) | 2008-05-30 | 2014-11-17 | 安定化された経皮薬物送達システム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20110182949A1 (https=) |
| EP (1) | EP2299989B1 (https=) |
| JP (2) | JP5695562B2 (https=) |
| KR (1) | KR101590209B1 (https=) |
| CN (1) | CN102099020B (https=) |
| AU (2) | AU2009262871B2 (https=) |
| BR (1) | BRPI0913214B1 (https=) |
| CA (1) | CA2726136C (https=) |
| MX (1) | MX2010012989A (https=) |
| NZ (1) | NZ589542A (https=) |
| WO (1) | WO2009158120A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009158120A2 (en) * | 2008-05-30 | 2009-12-30 | Mylan Laboratories Inc. | Stabilized transdermal drug delivery system |
| CN102630160B (zh) * | 2009-09-16 | 2014-05-07 | 株式会社三养生物制药 | 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法 |
| US9925150B2 (en) * | 2009-12-22 | 2018-03-27 | Lts Lohmann Therapie-Systeme Ag | Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine |
| US20150196515A1 (en) * | 2012-08-15 | 2015-07-16 | Dow Coming Corporation | Multi-Layer Drug Delivery System |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| JP2016135744A (ja) * | 2013-05-08 | 2016-07-28 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| EP3016641B1 (de) | 2013-07-03 | 2018-09-05 | LTS Lohmann Therapie-Systeme AG | Transdermales therapeutisches system mit elektronischem bauteil |
| WO2015025767A1 (ja) * | 2013-08-21 | 2015-02-26 | 久光製薬株式会社 | 貼付剤 |
| CN115444659A (zh) * | 2014-01-22 | 2022-12-09 | 4P治疗公司 | 滥用和误用制止透皮系统 |
| WO2015177209A1 (en) | 2014-05-20 | 2015-11-26 | Lts Lohmann Therapie-Systeme Ag | Method for adjusting the release of active agent in a transdermal delivery system |
| US11752110B2 (en) * | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
| EP3145502B1 (en) * | 2014-05-20 | 2022-07-06 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system containing rotigotine |
| CA2962080A1 (en) | 2014-09-24 | 2016-03-31 | Pain Therapeutics, Inc. | 4:3 naltrexone: 5-methyl-2-furaldehyde cocrystal |
| US10010543B1 (en) | 2014-12-23 | 2018-07-03 | Barr Laboratories, Inc. | Transdermal dosage form |
| US9650338B1 (en) | 2016-07-29 | 2017-05-16 | VDM Biochemicals, Inc. | Opioid antagonist compounds and methods of making and using |
| WO2018115010A1 (en) | 2016-12-20 | 2018-06-28 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| ES2769286T3 (es) | 2016-12-20 | 2020-06-25 | Lts Lohmann Therapie Systeme Ag | Sistema terapéutico transdérmico que contiene asenapina |
| KR102241892B1 (ko) | 2017-01-25 | 2021-04-20 | 한국전자기술연구원 | 백스캐터 통신을 위한 데이터 부호화 방법 및 이를 위한 장치 |
| TWI741168B (zh) * | 2017-04-28 | 2021-10-01 | 日商日東電工股份有限公司 | 經皮吸收製劑 |
| ES2881783T3 (es) | 2017-06-26 | 2021-11-30 | Lts Lohmann Therapie Systeme Ag | Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona |
| CN112533593A (zh) | 2018-06-20 | 2021-03-19 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
| CA3101420A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| CN113453676B (zh) * | 2019-02-15 | 2025-08-05 | 久光制药株式会社 | 罗替戈汀稳定化方法 |
| CN113677343B (zh) * | 2019-03-19 | 2023-11-24 | 耐贝医药株式会社 | 生物体对药物的吸收性优异且化学稳定性也优异的医药组合物 |
| JP2022535003A (ja) * | 2019-05-31 | 2022-08-04 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | 接着促進剤を特徴とする除去可能なフィルム形成ゲル組成物 |
| DK3854388T3 (da) | 2020-01-24 | 2023-11-27 | Luye Pharma Switzerland Ag | Transdermalt terapeutisk system omfattende rotigotin og mindst et ikke-aminresistent silikoneklæbestof |
| CN115989025A (zh) * | 2020-08-31 | 2023-04-18 | 耐贝医药株式会社 | 用于缓解或治疗神经退行性疾病的症状的贴剂 |
| CN112891324A (zh) * | 2021-01-19 | 2021-06-04 | 北京亚宝生物药业有限公司 | 一种透皮贴剂 |
| KR102363479B1 (ko) * | 2021-03-12 | 2022-02-15 | 환인제약 주식회사 | 로티고틴 함유 경피 흡수 제제 |
| JP2024520271A (ja) * | 2021-06-06 | 2024-05-24 | スタートン セラピューティクス インコーポレイテッド | 治療上有効な量のレナリドミドまたは他の免疫調節剤を投与するための経皮薬物送達システム |
| CN116270575A (zh) * | 2021-08-16 | 2023-06-23 | 乐明药业(苏州)有限公司 | 一种含有氟比洛芬的药物组合物与贴剂 |
| CN120417892A (zh) * | 2022-12-26 | 2025-08-01 | 丸仁制药株式会社 | 透皮吸收制剂及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2920500A1 (de) | 1979-05-21 | 1980-11-27 | Boehringer Sohn Ingelheim | Pharmazeutische zubereitung in form eines polyacrylatfilmes |
| DE3204551A1 (de) * | 1982-02-10 | 1983-08-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung einer pharmazeutischen zubereitung in form eines polyacrylat-films |
| JPS60169414A (ja) * | 1984-02-14 | 1985-09-02 | Taisho Pharmaceut Co Ltd | 経皮吸収剤 |
| US4797284A (en) | 1986-03-12 | 1989-01-10 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4880633A (en) * | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| IT1253265B (it) * | 1991-11-25 | 1995-07-14 | Rotta Research Lab | Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. |
| US5494680A (en) * | 1993-12-08 | 1996-02-27 | Minnesota Mining And Manufacturing Company | Transdermal delivery device |
| WO1996008229A2 (en) * | 1994-09-14 | 1996-03-21 | Minnesota Mining And Manufacturing Company | Matrix for transdermal drug delivery |
| US5662928A (en) | 1995-04-21 | 1997-09-02 | Ciba-Geigy Corporation | Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system |
| KR970009795A (ko) * | 1995-08-30 | 1997-03-27 | 이웅열 | 경피투여용 첩부제 조성물 |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US6238700B1 (en) | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| ATE207348T1 (de) * | 1995-12-01 | 2001-11-15 | Alza Corp | Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix |
| DE19548332A1 (de) * | 1995-12-22 | 1997-07-10 | Rotta Res Bv | Hormonpflaster |
| US6623763B2 (en) * | 1996-01-08 | 2003-09-23 | Lts Lohmann Therape-System Ag | Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism |
| US5869089A (en) * | 1996-03-21 | 1999-02-09 | China-America Technology Corp. (Ctc) | Manufacturing method of programmable transdermal therapeutic system |
| DE19629468A1 (de) * | 1996-07-11 | 1998-01-15 | Schering Ag | Transdermale therapeutische Systeme |
| US20040018241A1 (en) * | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| DE10060550C1 (de) | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| WO2003034961A1 (en) * | 2001-10-23 | 2003-05-01 | Euro-Celtique, S.A. | Terazosin transdermal device and methods |
| US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
| DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| KR100682729B1 (ko) * | 2004-06-15 | 2007-02-15 | (주)아모레퍼시픽 | 신규 경피흡수제제 및 그 제조방법 |
| DE102004062182B4 (de) * | 2004-12-20 | 2007-06-06 | Bayer Schering Pharma Ag | Transdermales Pflaster mit Progesteron A-Spezifische Liganden (PRASL) als Wirkstoff |
| US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
| WO2007077741A1 (ja) * | 2005-12-28 | 2007-07-12 | Hisamitsu Pharmaceutical Co., Inc. | 経皮吸収型製剤 |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| EP3788877B1 (en) * | 2007-04-11 | 2024-08-07 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| WO2009158120A2 (en) * | 2008-05-30 | 2009-12-30 | Mylan Laboratories Inc. | Stabilized transdermal drug delivery system |
| RU2013139701A (ru) | 2011-02-17 | 2015-03-27 | Ф. Хоффманн-Ля Рош Аг | Способ контролируемой кристаллизации активного фармацевтического ингредиента из состояния переохлажденной жидкости экструзией горячего распада |
-
2009
- 2009-05-29 WO PCT/US2009/045739 patent/WO2009158120A2/en not_active Ceased
- 2009-05-29 MX MX2010012989A patent/MX2010012989A/es active IP Right Grant
- 2009-05-29 AU AU2009262871A patent/AU2009262871B2/en active Active
- 2009-05-29 BR BRPI0913214-7A patent/BRPI0913214B1/pt active IP Right Grant
- 2009-05-29 US US12/994,918 patent/US20110182949A1/en not_active Abandoned
- 2009-05-29 EP EP09770655.0A patent/EP2299989B1/en active Active
- 2009-05-29 JP JP2011511876A patent/JP5695562B2/ja active Active
- 2009-05-29 CN CN2009801289266A patent/CN102099020B/zh active Active
- 2009-05-29 US US12/475,390 patent/US9226902B2/en active Active
- 2009-05-29 NZ NZ589542A patent/NZ589542A/xx not_active IP Right Cessation
- 2009-05-29 CA CA2726136A patent/CA2726136C/en active Active
- 2009-05-29 KR KR1020107029551A patent/KR101590209B1/ko active Active
-
2014
- 2014-11-17 JP JP2014232586A patent/JP2015083569A/ja active Pending
-
2016
- 2016-04-08 AU AU2016202212A patent/AU2016202212B2/en active Active
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