|
US3674836A
(en)
*
|
1968-05-21 |
1972-07-04 |
Parke Davis & Co |
2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
|
|
US4027009A
(en)
*
|
1973-06-11 |
1977-05-31 |
Merck & Co., Inc. |
Compositions and methods for depressing blood serum cholesterol
|
|
JPS5612114B2
(enExample)
*
|
1974-06-07 |
1981-03-18 |
|
|
|
JPS5432794A
(en)
|
1977-08-18 |
1979-03-10 |
Omron Tateisi Electronics Co |
Manufacturing method of terminal rack
|
|
NO154918C
(no)
*
|
1977-08-27 |
1987-01-14 |
Bayer Ag |
Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
|
|
US4231938A
(en)
*
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
DE2951135A1
(de)
*
|
1979-12-19 |
1981-06-25 |
Hoechst Ag, 6230 Frankfurt |
Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
DK149080C
(da)
*
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
|
US4450171A
(en)
*
|
1980-08-05 |
1984-05-22 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
US4448784A
(en)
*
|
1982-04-12 |
1984-05-15 |
Hoechst-Roussel Pharmaceuticals, Inc. |
1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
|
|
US5354772A
(en)
*
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
US4499289A
(en)
*
|
1982-12-03 |
1985-02-12 |
G. D. Searle & Co. |
Octahydronapthalenes
|
|
CA1327360C
(en)
|
1983-11-14 |
1994-03-01 |
William F. Hoffman |
Oxo-analogs of mevinolin-like antihypercholesterolemic agents
|
|
US4613610A
(en)
*
|
1984-06-22 |
1986-09-23 |
Sandoz Pharmaceuticals Corp. |
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
|
|
US4686237A
(en)
*
|
1984-07-24 |
1987-08-11 |
Sandoz Pharmaceuticals Corp. |
Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
|
|
US4647576A
(en)
*
|
1984-09-24 |
1987-03-03 |
Warner-Lambert Company |
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
|
|
HU198005B
(en)
|
1984-12-04 |
1989-07-28 |
Sandoz Ag |
Process for producing mevqlolakton, derivatives, its indene-analogues and pharmaceutical compositions containing them
|
|
KR900001212B1
(ko)
|
1985-10-25 |
1990-02-28 |
산도즈 파마슈티칼스 코오포레이숀 |
메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
|
|
DE3543999A1
(de)
*
|
1985-12-13 |
1987-06-19 |
Bayer Ag |
Hochreine acarbose
|
|
FR2596393B1
(fr)
|
1986-04-01 |
1988-06-03 |
Sanofi Sa |
Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
|
|
US4681893A
(en)
*
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
PT87539B
(pt)
|
1987-05-22 |
1992-09-30 |
Squibb & Sons Inc |
Processo para a preparacao de inibidores da reductase de hmg-coa contendo fosforo e novos intermediarios
|
|
US4759923A
(en)
*
|
1987-06-25 |
1988-07-26 |
Hercules Incorporated |
Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
|
|
JP2569746B2
(ja)
*
|
1987-08-20 |
1997-01-08 |
日産化学工業株式会社 |
キノリン系メバロノラクトン類
|
|
US4871721A
(en)
*
|
1988-01-11 |
1989-10-03 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors
|
|
US4924024A
(en)
*
|
1988-01-11 |
1990-05-08 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
|
|
NO177005C
(no)
*
|
1988-01-20 |
1995-07-05 |
Bayer Ag |
Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
|
|
US5506219A
(en)
*
|
1988-08-29 |
1996-04-09 |
E. R. Squibb & Sons, Inc. |
Pyridine anchors for HMG-CoA reductase inhibitors
|
|
US5753675A
(en)
*
|
1989-03-03 |
1998-05-19 |
Novartis Pharmaceuticals Corporation |
Quinoline analogs of mevalonolactone and derivatives thereof
|
|
FI94339C
(fi)
*
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
US5177080A
(en)
*
|
1990-12-14 |
1993-01-05 |
Bayer Aktiengesellschaft |
Substituted pyridyl-dihydroxy-heptenoic acid and its salts
|
|
JP2648897B2
(ja)
*
|
1991-07-01 |
1997-09-03 |
塩野義製薬株式会社 |
ピリミジン誘導体
|
|
DE4129603A1
(de)
*
|
1991-09-06 |
1993-03-11 |
Thomae Gmbh Dr K |
Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
|
|
US5447954A
(en)
*
|
1992-05-05 |
1995-09-05 |
Smithkline Beecham P.L.C. |
Phenylderivate as inhibitors of ATP citrate lyase
|
|
US5712396A
(en)
*
|
1992-10-28 |
1998-01-27 |
Magnin; David R. |
α-phosphonosulfonate squalene synthetase inhibitors
|
|
LT3300B
(en)
|
1992-12-23 |
1995-06-26 |
Schering Corp |
Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor
|
|
US5594016A
(en)
*
|
1992-12-28 |
1997-01-14 |
Mitsubishi Chemical Corporation |
Naphthalene derivatives
|
|
US5662934A
(en)
|
1993-01-05 |
1997-09-02 |
Najarian; Thomas |
Compositions and methods for lowering cholesterol while maintaining antioxidant levels
|
|
SG45369A1
(en)
*
|
1993-01-19 |
1998-10-16 |
Warner Lambert Co |
Stable oral ci-981 formulation and process of preparing same
|
|
WO1995015954A1
(en)
|
1993-12-07 |
1995-06-15 |
Smithkline Beecham Plc |
Heterocyclic biphenylylamides useful as 5ht1d antagonists
|
|
US5776983A
(en)
*
|
1993-12-21 |
1998-07-07 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
US5488064A
(en)
*
|
1994-05-02 |
1996-01-30 |
Bristol-Myers Squibb Company |
Benzo 1,3 dioxole derivatives
|
|
US5385929A
(en)
*
|
1994-05-04 |
1995-01-31 |
Warner-Lambert Company |
[(Hydroxyphenylamino) carbonyl] pyrroles
|
|
US5612359A
(en)
*
|
1994-08-26 |
1997-03-18 |
Bristol-Myers Squibb Company |
Substituted biphenyl isoxazole sulfonamides
|
|
US5491134A
(en)
*
|
1994-09-16 |
1996-02-13 |
Bristol-Myers Squibb Company |
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
|
|
US5541204A
(en)
*
|
1994-12-02 |
1996-07-30 |
Bristol-Myers Squibb Company |
Aryloxypropanolamine β 3 adrenergic agonists
|
|
US5698527A
(en)
*
|
1995-08-08 |
1997-12-16 |
Merck & Co., Inc. |
Steroidal glycosides as antihyperlipidemic agents
|
|
EP0873361B1
(en)
|
1995-12-13 |
2006-11-02 |
The Regents Of The University Of California |
Crystals of the ligand-binding domain of the thyroid hormone receptor complexed to a ligand
|
|
IL117702A0
(en)
|
1996-03-28 |
1996-07-23 |
Tel Aviv Medical Center Resear |
Drug for hyperlipoproteinemia
|
|
US5770615A
(en)
*
|
1996-04-04 |
1998-06-23 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
DE19622222A1
(de)
|
1996-06-03 |
1997-12-04 |
Hoechst Ag |
Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide
|
|
AU2401697A
(en)
|
1996-06-20 |
1998-01-07 |
Pfizer Inc. |
4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors
|
|
HRP970330B1
(en)
|
1996-07-08 |
2004-06-30 |
Bayer Ag |
Cycloalkano pyridines
|
|
DE19653647A1
(de)
*
|
1996-12-20 |
1998-06-25 |
Hoechst Ag |
Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
|
|
DE19653645A1
(de)
*
|
1996-12-20 |
1998-06-25 |
Hoechst Ag |
Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
|
|
US6482821B2
(en)
*
|
1996-12-20 |
2002-11-19 |
Hoechst Aktiengellschaft |
Vitronectin receptor antagonists, their preparation and their use
|
|
TW536540B
(en)
*
|
1997-01-30 |
2003-06-11 |
Bristol Myers Squibb Co |
Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
|
|
EP0982992B1
(en)
|
1997-05-08 |
2002-09-25 |
Aventis CropScience UK Limited |
Use of thienopyrimidines as fungicides
|
|
GB9713739D0
(en)
|
1997-06-27 |
1997-09-03 |
Karobio Ab |
Thyroid receptor ligands
|
|
RU2196141C2
(ru)
|
1997-10-08 |
2003-01-10 |
Санкио Компани, Лимитед |
Замещенное конденсированное гетероциклическое соединение, способ фармакологического воздействия, способ ингибирования 5-липоксигеназы, ингибирования продукции липидных пероксидов или снижения уровня сахара в крови
|
|
IL140622A0
(en)
|
1998-07-06 |
2002-02-10 |
Bristol Myers Squibb Co |
Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
|
|
AU5612199A
(en)
|
1998-09-10 |
2000-04-03 |
Forbes Medi-Tech Inc. |
Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other
|
|
US6147089A
(en)
|
1998-09-17 |
2000-11-14 |
Pfizer Inc. |
Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
|
|
BR9915687A
(pt)
|
1998-11-25 |
2001-12-04 |
Nutri Pharma As |
Composição compreendendo proteìna de soja,fibras de dieta e um composto fitoestrogênio eseu uso na prevenção e/ou tratamento de doençascardiovasculares
|
|
WO2000038722A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
|
|
GB9828442D0
(en)
|
1998-12-24 |
1999-02-17 |
Karobio Ab |
Novel thyroid receptor ligands and method II
|
|
JP2002537407A
(ja)
|
1999-02-24 |
2002-11-05 |
ジョンズ・ホプキンス・ユニバーシティ |
血清コレステロールを調節するための組成物及び方法。
|
|
AU5031200A
(en)
|
1999-05-28 |
2000-12-18 |
Vertex Pharmaceuticals Incorporated |
Method for preparing 5-substituted oxazoles
|
|
US6414002B1
(en)
*
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
BR0112856A
(pt)
|
2000-07-31 |
2003-07-01 |
Smithkline Beecham Plc |
Método para o tratamento dos distúrbios, composto ou um sal ou solvato deste, processo para a preparação dos mesmos, composição farmacêutico, método de tratamento e/ou profilaxia de um ou mais dos distúrbios, uso de um composto, e, método para o tratamento de diabetes, grande depressão, depressão manìaca, ansiedade, esquizofrenia e distúrbios do sono, em mamìferos humanos e não humanos
|
|
JPWO2002101146A1
(ja)
|
2001-05-11 |
2004-10-14 |
阿里奈 中山 |
蓄光紙及びその製造方法並びにその利用方法
|
|
GB0124627D0
(en)
|
2001-10-15 |
2001-12-05 |
Smithkline Beecham Plc |
Novel compounds
|
|
SK2242004A3
(en)
|
2001-10-25 |
2004-11-03 |
Takeda Chemical Industries Ltd |
Quinoline compound
|
|
AU2003301226A1
(en)
|
2002-12-20 |
2004-07-22 |
Pharmacia Corp |
Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
|
|
WO2004092181A1
(en)
|
2003-04-11 |
2004-10-28 |
Smithkline Beecham Corporation |
Heterocyclic mchr1 antagonists
|
|
JP2006193426A
(ja)
|
2003-09-05 |
2006-07-27 |
Sankyo Co Ltd |
置換された縮環ピリミジン−4(3h)−オン化合物
|
|
CA2543122A1
(en)
|
2003-10-23 |
2005-05-12 |
Glaxo Group Limited |
3-(4-aminophenyl) thienopyrimid-4-one derivatives as mch r1 antagonists for the treatment of obesity, diabetes, depression and anxiety
|
|
WO2005047293A1
(en)
|
2003-11-07 |
2005-05-26 |
Neurocrine Biosciences, Inc. |
Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
|
|
US20050256124A1
(en)
|
2004-04-15 |
2005-11-17 |
Neurocrine Biosciences, Inc. |
Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
|
|
RU2266906C1
(ru)
|
2004-04-29 |
2005-12-27 |
Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") |
Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека
|
|
AR056155A1
(es)
*
|
2005-10-26 |
2007-09-19 |
Bristol Myers Squibb Co |
Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
|
|
US7745447B2
(en)
*
|
2005-10-26 |
2010-06-29 |
Bristol-Myers Squibb Company |
Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists
|
|
US7553836B2
(en)
*
|
2006-02-06 |
2009-06-30 |
Bristol-Myers Squibb Company |
Melanin concentrating hormone receptor-1 antagonists
|