JP2011520433A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011520433A5 JP2011520433A5 JP2011507714A JP2011507714A JP2011520433A5 JP 2011520433 A5 JP2011520433 A5 JP 2011520433A5 JP 2011507714 A JP2011507714 A JP 2011507714A JP 2011507714 A JP2011507714 A JP 2011507714A JP 2011520433 A5 JP2011520433 A5 JP 2011520433A5
- Authority
- JP
- Japan
- Prior art keywords
- il1rn
- subject
- genotype
- osteoarthritis
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000008482 osteoarthritis Diseases 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 102220134620 rs9005 Human genes 0.000 claims description 25
- 206010061818 Disease progression Diseases 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 24
- 230000005750 disease progression Effects 0.000 claims description 24
- 102220133450 rs419598 Human genes 0.000 claims description 23
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 claims description 20
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 claims description 20
- 102000019034 Chemokines Human genes 0.000 claims description 18
- 108010012236 Chemokines Proteins 0.000 claims description 18
- 102000008186 Collagen Human genes 0.000 claims description 18
- 108010035532 Collagen Proteins 0.000 claims description 18
- 102000004127 Cytokines Human genes 0.000 claims description 18
- 108090000695 Cytokines Proteins 0.000 claims description 18
- 102000035195 Peptidases Human genes 0.000 claims description 18
- 108091005804 Peptidases Proteins 0.000 claims description 18
- 229920001436 collagen Polymers 0.000 claims description 18
- 239000012634 fragment Substances 0.000 claims description 18
- 235000019833 protease Nutrition 0.000 claims description 18
- 239000000090 biomarker Substances 0.000 claims description 17
- 102000054766 genetic haplotypes Human genes 0.000 claims description 13
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 150000007523 nucleic acids Chemical class 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 108700028369 Alleles Proteins 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 238000009396 hybridization Methods 0.000 claims description 6
- 102220134786 rs315952 Human genes 0.000 claims description 6
- 229940123922 Disease-modifying osteoarthritis drug Drugs 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000007717 exclusion Effects 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 238000013517 stratification Methods 0.000 claims description 2
- 238000011285 therapeutic regimen Methods 0.000 claims description 2
- 238000011269 treatment regimen Methods 0.000 claims description 2
- 208000012659 Joint disease Diseases 0.000 claims 1
- 230000003466 anti-cipated effect Effects 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4999208P | 2008-05-02 | 2008-05-02 | |
| US61/049,992 | 2008-05-02 | ||
| US11874408P | 2008-12-01 | 2008-12-01 | |
| US61/118,744 | 2008-12-01 | ||
| PCT/US2009/042746 WO2009135218A2 (en) | 2008-05-02 | 2009-05-04 | Detecting genetic predisposition to osteoarthritis associated conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015116397A Division JP6263499B2 (ja) | 2008-05-02 | 2015-06-09 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520433A JP2011520433A (ja) | 2011-07-21 |
| JP2011520433A5 true JP2011520433A5 (enExample) | 2013-04-18 |
| JP5762282B2 JP5762282B2 (ja) | 2015-08-12 |
Family
ID=41210581
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507714A Active JP5762282B2 (ja) | 2008-05-02 | 2009-05-04 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| JP2015116397A Active JP6263499B2 (ja) | 2008-05-02 | 2015-06-09 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| JP2017241315A Withdrawn JP2018038436A (ja) | 2008-05-02 | 2017-12-18 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015116397A Active JP6263499B2 (ja) | 2008-05-02 | 2015-06-09 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| JP2017241315A Withdrawn JP2018038436A (ja) | 2008-05-02 | 2017-12-18 | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100098775A1 (enExample) |
| EP (3) | EP2283156B1 (enExample) |
| JP (3) | JP5762282B2 (enExample) |
| AU (1) | AU2009242490B2 (enExample) |
| CA (1) | CA2723239C (enExample) |
| DK (2) | DK2283156T3 (enExample) |
| ES (2) | ES2708826T3 (enExample) |
| NZ (1) | NZ589034A (enExample) |
| WO (1) | WO2009135218A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2283156B1 (en) * | 2008-05-02 | 2015-11-11 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| US20120115137A1 (en) * | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| CA2881024C (en) * | 2012-08-06 | 2021-06-15 | Christoph Hubertus LADEL | Genetic markers for predicting responsiveness to fgf-18 compound |
| PL2880181T3 (pl) * | 2012-08-06 | 2019-03-29 | Merck Patent Gmbh | Biomarkery prognostyczne w zaburzeniach chrząstki |
| JP2019503176A (ja) | 2016-01-12 | 2019-02-07 | インターロイキン ジェネティクス， インコーポレイテッド | 処置に対する応答を予測するための方法 |
| US10337070B2 (en) | 2017-01-12 | 2019-07-02 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| DK3688468T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Inflammatoriske biomarkører til forudsigelse af modtageligheden for fgf-18 forbindelse |
| DK3687558T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Metaboliske biomarkører til forudsigelse af modtageligheden på fgf-18 forbindelse |
| IL281333B2 (en) * | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| US12370240B2 (en) | 2018-11-28 | 2025-07-29 | Genascence Corporation | Methods and compositions for treating osteoarthritis |
| CA3142662A1 (en) | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| US20220265773A1 (en) * | 2019-08-02 | 2022-08-25 | New York University | Methods and compositions for treating arthritis |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| US4998617A (en) | 1986-09-15 | 1991-03-12 | Laura Lupton Inc | Facial cosmetic liquid make up kit |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| CA2153387A1 (en) | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
| US5593826A (en) | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| US5686246A (en) | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
| US5942390A (en) | 1996-01-12 | 1999-08-24 | Cedars-Sinai Medical Center | Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism |
| US5698399A (en) | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| GB9621129D0 (en) * | 1996-10-10 | 1996-11-27 | Duff Gordon W | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| GB9706359D0 (en) * | 1997-03-27 | 1997-05-14 | Gemini International Holdings | Polymorphisms of an il-1 receptor antagonist gene |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| KR100924468B1 (ko) * | 2002-01-25 | 2009-11-03 | 인터레우킨 제네틱스, 인코포레이티드 | Ｉｌ-1 유전자 집단 및 관련된 염증성 다형성과 일배체형 |
| CA2921196C (en) * | 2003-11-26 | 2019-03-05 | Celera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
| US20090253585A1 (en) * | 2005-11-30 | 2009-10-08 | Luda Diatchenko | Identification of Genetic Polymorphic Variants Associated With Somatosensory Disorders and Methods of Using the Same |
| EP2283156B1 (en) * | 2008-05-02 | 2015-11-11 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| US9037472B2 (en) | 2012-04-20 | 2015-05-19 | Nuance Communications, Inc. | Method and system for facilitating communications for a user transaction |
-
2009
- 2009-05-04 EP EP09740020.4A patent/EP2283156B1/en not_active Not-in-force
- 2009-05-04 AU AU2009242490A patent/AU2009242490B2/en not_active Ceased
- 2009-05-04 CA CA2723239A patent/CA2723239C/en active Active
- 2009-05-04 DK DK09740020.4T patent/DK2283156T3/en active
- 2009-05-04 EP EP15193948.5A patent/EP3059323B1/en not_active Not-in-force
- 2009-05-04 EP EP18202413.3A patent/EP3467126A1/en not_active Withdrawn
- 2009-05-04 NZ NZ589034A patent/NZ589034A/xx not_active IP Right Cessation
- 2009-05-04 ES ES15193948T patent/ES2708826T3/es active Active
- 2009-05-04 ES ES09740020.4T patent/ES2561316T3/es active Active
- 2009-05-04 WO PCT/US2009/042746 patent/WO2009135218A2/en not_active Ceased
- 2009-05-04 DK DK15193948.5T patent/DK3059323T3/en active
- 2009-05-04 US US12/435,260 patent/US20100098775A1/en not_active Abandoned
- 2009-05-04 JP JP2011507714A patent/JP5762282B2/ja active Active
-
2015
- 2015-06-09 JP JP2015116397A patent/JP6263499B2/ja active Active
-
2016
- 2016-08-10 US US15/233,122 patent/US20160340734A1/en not_active Abandoned
-
2017
- 2017-12-18 JP JP2017241315A patent/JP2018038436A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018038436A5 (enExample) | ||
| DK2438193T3 (en) | Methods for assessing the risk of breast cancer | |
| JP2012503985A5 (enExample) | ||
| RU2009147281A (ru) | Способы и композиции для диагностики и лечения волчанки | |
| CA2881027C (en) | Prognosis biomarkers in cartilage disorders | |
| KR20170063977A (ko) | 유방암 발생 위험의 평가 방법 | |
| JP2013544536A5 (enExample) | ||
| RU2018122965A (ru) | Улучшенный способ и набор для определения тяжести и прогрессирования периодонтального заболевания | |
| US20100092959A1 (en) | Single nucleotide polymorphisms as genetic markers for childhood leukemia | |
| EP3332031A1 (en) | Snp rs12603226 as a predictive marker for nafld | |
| CN113646443A (zh) | 用于诊断神经胶质瘤或预测预后的组合物以及提供其相关信息的方法 | |
| JP2010510804A5 (enExample) | ||
| JP2020089370A (ja) | 抗精神病薬に基づく処置により誘導される錐体外路症状（ｅｐｓ）の発症を予測する方法 | |
| KR102063486B1 (ko) | Rnf213 단일염기다형성과 한국인 모야모야병 발병 위험도의 연관성 | |
| JPWO2011148715A1 (ja) | 正常眼圧緑内障疾患感受性遺伝子及びその利用 | |
| JP2013070660A (ja) | Ｃ型肝炎患者の経過予測方法 | |
| EP3938531A1 (en) | Methods for detecting or reducing the incidence of adverse drug reactions | |
| EP3315613B1 (en) | Methods and kits for diagnosing or assessing the risk of cervical cancer | |
| KR20230036504A (ko) | 근감소증 진단용 마커 및 이의 용도 | |
| WO2012056694A1 (ja) | 乳がん発症感受性の判定方法 | |
| EP3981001A1 (en) | Polymorphic markers for pharmacogenetic hla risk alleles | |
| JP2008505060A5 (enExample) | ||
| KR101598328B1 (ko) | Dna 복제수 변이를 이용한 강직성 척추염 발병 저위험도 예측용 조성물 및 이를 이용한 예측 방법 | |
| CN103695549B (zh) | 预测强直性脊柱炎易感性的试剂 | |
| CN103710447A (zh) | 一种预测强直性脊柱炎易感性的方法和试剂 |