JP5762282B2 - 変形性関節症に関連する状態に対する遺伝的素因の検出 - Google Patents

変形性関節症に関連する状態に対する遺伝的素因の検出 Download PDF

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JP5762282B2
JP5762282B2 JP2011507714A JP2011507714A JP5762282B2 JP 5762282 B2 JP5762282 B2 JP 5762282B2 JP 2011507714 A JP2011507714 A JP 2011507714A JP 2011507714 A JP2011507714 A JP 2011507714A JP 5762282 B2 JP5762282 B2 JP 5762282B2
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osteoarthritis
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genotype
il1rn
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JP2011520433A (ja
JP2011520433A5 (enExample
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ジャック エフ． ブコウスキー，
ジャック エフ． ブコウスキー，
ナズニーン アジズ，
ナズニーン アジズ，
ファ−イン ワン，
ファ−イン ワン，
ケネス ハットナー，
ケネス ハットナー，
ムクンダン アッター
ムクンダン アッター
スティーブン ビー アブラムソン
スティーブン ビー アブラムソン
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インタールーキン ジェネティクス， インコーポレイテッド
インタールーキン ジェネティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2011507714A 2008-05-02 2009-05-04 変形性関節症に関連する状態に対する遺伝的素因の検出 Active JP5762282B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4999208P 2008-05-02 2008-05-02
US61/049,992 2008-05-02
US11874408P 2008-12-01 2008-12-01
US61/118,744 2008-12-01
PCT/US2009/042746 WO2009135218A2 (en) 2008-05-02 2009-05-04 Detecting genetic predisposition to osteoarthritis associated conditions

Related Child Applications (1)

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JP2015116397A Division JP6263499B2 (ja) 2008-05-02 2015-06-09 変形性関節症に関連する状態に対する遺伝的素因の検出

Publications (3)

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JP2011520433A JP2011520433A (ja) 2011-07-21
JP2011520433A5 JP2011520433A5 (enExample) 2013-04-18
JP5762282B2 true JP5762282B2 (ja) 2015-08-12

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JP2011507714A Active JP5762282B2 (ja) 2008-05-02 2009-05-04 変形性関節症に関連する状態に対する遺伝的素因の検出
JP2015116397A Active JP6263499B2 (ja) 2008-05-02 2015-06-09 変形性関節症に関連する状態に対する遺伝的素因の検出
JP2017241315A Withdrawn JP2018038436A (ja) 2008-05-02 2017-12-18 変形性関節症に関連する状態に対する遺伝的素因の検出

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JP2015116397A Active JP6263499B2 (ja) 2008-05-02 2015-06-09 変形性関節症に関連する状態に対する遺伝的素因の検出
JP2017241315A Withdrawn JP2018038436A (ja) 2008-05-02 2017-12-18 変形性関節症に関連する状態に対する遺伝的素因の検出

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US (2) US20100098775A1 (enExample)
EP (3) EP3467126A1 (enExample)
JP (3) JP5762282B2 (enExample)
AU (1) AU2009242490B2 (enExample)
CA (1) CA2723239C (enExample)
DK (2) DK2283156T3 (enExample)
ES (2) ES2708826T3 (enExample)
NZ (1) NZ589034A (enExample)
WO (1) WO2009135218A2 (enExample)

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ES2708826T3 (es) * 2008-05-02 2019-04-11 Orig3N Inc Detección de la predisposición genética a afecciones asociadas a la osteoartritis
US20120115137A1 (en) * 2010-08-31 2012-05-10 Kornman Kenneth S Methods of Predicting Osteoarthritis
US10221456B2 (en) * 2012-08-06 2019-03-05 Merck Patent Gmbh Genetic markers for predicting responsiveness to FPG-18 compound
CN104755629A (zh) * 2012-08-06 2015-07-01 默克专利有限公司 软骨疾病的预后生物标记
CA3011363A1 (en) 2016-01-12 2017-07-20 Interleukin Genetics, Inc. Methods for predicting response to treatment
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
HUE058848T2 (hu) 2017-09-29 2022-09-28 Merck Patent Gmbh FGF-18 vegyületre vonatkozó válaszkészség elõrejelzésére szolgáló gyulladásos biomarkerek
SI3687558T1 (sl) 2017-09-29 2022-08-31 Merck Patent Gmbh Presnovni biooznačevalci za napovedovanje odzivnosti na spojino FGF-18
EP3850113B1 (en) * 2018-09-10 2024-04-03 Merck Patent GmbH Markers useful in enrichment strategies for the treatment of osteoarthritis
US12370240B2 (en) 2018-11-28 2025-07-29 Genascence Corporation Methods and compositions for treating osteoarthritis
CA3142662A1 (en) 2019-06-06 2020-12-10 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
US20220265773A1 (en) * 2019-08-02 2022-08-25 New York University Methods and compositions for treating arthritis
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19

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GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4998617A (en) * 1986-09-15 1991-03-12 Laura Lupton Inc Facial cosmetic liquid make up kit
US4968607A (en) * 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
FR2650840B1 (fr) 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
US5593826A (en) 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
US5942390A (en) 1996-01-12 1999-08-24 Cedars-Sinai Medical Center Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism
US5698399A (en) * 1996-04-05 1997-12-16 Duff; Gordon W. Detecting genetic predisposition for osteoporosis
GB9621129D0 (en) * 1996-10-10 1996-11-27 Duff Gordon W Detecting genetic predisposition to sight-threatening diabetic retinopathy
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GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
WO2003064600A2 (en) * 2002-01-25 2003-08-07 Interleukin Genetics, Inc. The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes
EP2186913B1 (en) * 2003-11-26 2016-02-10 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
CA2631675A1 (en) * 2005-11-30 2007-06-21 The University Of North Carolina At Chapel Hill Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same
ES2708826T3 (es) * 2008-05-02 2019-04-11 Orig3N Inc Detección de la predisposición genética a afecciones asociadas a la osteoartritis
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Also Published As

Publication number Publication date
AU2009242490A1 (en) 2009-11-05
EP2283156A2 (en) 2011-02-16
US20160340734A1 (en) 2016-11-24
JP2011520433A (ja) 2011-07-21
JP2018038436A (ja) 2018-03-15
ES2708826T3 (es) 2019-04-11
AU2009242490B2 (en) 2015-01-22
NZ589034A (en) 2012-10-26
US20100098775A1 (en) 2010-04-22
EP3467126A1 (en) 2019-04-10
WO2009135218A3 (en) 2010-04-01
JP6263499B2 (ja) 2018-01-17
CA2723239C (en) 2020-07-21
EP3059323B1 (en) 2018-12-12
CA2723239A1 (en) 2009-11-05
DK3059323T3 (en) 2019-03-04
EP2283156B1 (en) 2015-11-11
EP3059323A1 (en) 2016-08-24
JP2015211677A (ja) 2015-11-26
ES2561316T3 (es) 2016-02-25
WO2009135218A2 (en) 2009-11-05
DK2283156T3 (en) 2016-02-15

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