JP2011518112A5 - - Google Patents
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- Publication number
- JP2011518112A5 JP2011518112A5 JP2010541634A JP2010541634A JP2011518112A5 JP 2011518112 A5 JP2011518112 A5 JP 2011518112A5 JP 2010541634 A JP2010541634 A JP 2010541634A JP 2010541634 A JP2010541634 A JP 2010541634A JP 2011518112 A5 JP2011518112 A5 JP 2011518112A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- bifidobacterium
- anaerobic
- therapeutic agent
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 35
- 201000010099 disease Diseases 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 26
- 239000013612 plasmid Substances 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 17
- 229940124597 therapeutic agent Drugs 0.000 claims description 17
- 230000000259 anti-tumor effect Effects 0.000 claims description 16
- 241000186000 Bifidobacterium Species 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 14
- 244000005700 microbiome Species 0.000 claims description 12
- 241000588724 Escherichia coli Species 0.000 claims description 10
- 230000010076 replication Effects 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 8
- 239000002243 precursor Substances 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical group NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 6
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 241001148471 unidentified anaerobic bacterium Species 0.000 claims 4
- 241001608472 Bifidobacterium longum Species 0.000 claims 3
- 229940009291 bifidobacterium longum Drugs 0.000 claims 3
- 125000003071 maltose group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000193403 Clostridium Species 0.000 claims 2
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 2
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 2
- QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 claims 2
- 241000194033 Enterococcus Species 0.000 claims 2
- 241000186660 Lactobacillus Species 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 2
- DLRVVLDZNNYCBX-ZZFZYMBESA-N beta-melibiose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 DLRVVLDZNNYCBX-ZZFZYMBESA-N 0.000 claims 2
- 229930182830 galactose Natural products 0.000 claims 2
- 239000007952 growth promoter Substances 0.000 claims 2
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims 2
- 229960000511 lactulose Drugs 0.000 claims 2
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims 2
- QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 claims 2
- 239000013600 plasmid vector Substances 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 241001134770 Bifidobacterium animalis Species 0.000 claims 1
- 241000186016 Bifidobacterium bifidum Species 0.000 claims 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims 1
- 241001468229 Bifidobacterium thermophilum Species 0.000 claims 1
- 102000053187 Glucuronidase Human genes 0.000 claims 1
- 108010060309 Glucuronidase Proteins 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 102000004459 Nitroreductase Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940118852 bifidobacterium animalis Drugs 0.000 claims 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims 1
- 229940004120 bifidobacterium infantis Drugs 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 229960004413 flucytosine Drugs 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 108020001162 nitroreductase Proteins 0.000 claims 1
- 239000003969 proliferation enhancer Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 108020004414 DNA Proteins 0.000 description 8
- 239000003550 marker Substances 0.000 description 8
- 239000013604 expression vector Substances 0.000 description 6
- 108020005091 Replication Origin Proteins 0.000 description 3
- 101100476566 Campylobacter jejuni aad9 gene Proteins 0.000 description 2
- 101100476567 Enterococcus faecalis spc gene Proteins 0.000 description 2
- 108050008922 Histone-like DNA-binding proteins Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010023191 Streptomycin 3''-adenylyltransferase Proteins 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12452808P | 2008-04-17 | 2008-04-17 | |
| US61/124,528 | 2008-04-17 | ||
| PCT/JP2009/001776 WO2009128275A1 (en) | 2008-04-17 | 2009-04-17 | Therapeutic agent for anaerobic diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518112A JP2011518112A (ja) | 2011-06-23 |
| JP2011518112A5 true JP2011518112A5 (enExample) | 2012-06-07 |
| JP5514735B2 JP5514735B2 (ja) | 2014-06-04 |
Family
ID=40792658
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541633A Active JP5735804B2 (ja) | 2008-04-17 | 2009-04-16 | 発現ベクター |
| JP2010541634A Active JP5514735B2 (ja) | 2008-04-17 | 2009-04-17 | 嫌気的疾患用治療薬 |
| JP2014248772A Active JP6089025B2 (ja) | 2008-04-17 | 2014-12-09 | 発現ベクター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541633A Active JP5735804B2 (ja) | 2008-04-17 | 2009-04-16 | 発現ベクター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014248772A Active JP6089025B2 (ja) | 2008-04-17 | 2014-12-09 | 発現ベクター |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8383398B2 (enExample) |
| EP (2) | EP2274422B1 (enExample) |
| JP (3) | JP5735804B2 (enExample) |
| KR (3) | KR101674977B1 (enExample) |
| CN (2) | CN102046791B (enExample) |
| CA (2) | CA2721653C (enExample) |
| DK (2) | DK2274422T3 (enExample) |
| ES (2) | ES2628378T3 (enExample) |
| HU (2) | HUE033561T2 (enExample) |
| PL (2) | PL2274422T3 (enExample) |
| PT (2) | PT2274422T (enExample) |
| WO (2) | WO2009128272A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535939B2 (en) | 2010-01-29 | 2013-09-17 | Anaeropharma Science, Inc. | Transfection vector |
| US20130095072A1 (en) * | 2010-01-29 | 2013-04-18 | Anaeropharma Science, Inc. | Therapeutic agent for ischemic diseases |
| EP2274422B1 (en) * | 2008-04-17 | 2017-03-15 | Anaeropharma Science, Inc. | Expression vector |
| US9730968B2 (en) | 2008-04-17 | 2017-08-15 | Anaeropharma Science, Inc. | Therapeutic agent for ischemic diseases |
| US8338162B2 (en) * | 2009-04-17 | 2012-12-25 | Anaeropharma Science, Inc. | Obligately anaerobic mutant lactic acid bacterium and preparation method therefor, and expression vector functioning in obligately anaerobic lactic acid bacterium |
| WO2013008881A1 (ja) * | 2011-07-13 | 2013-01-17 | 株式会社アネロファーマ・サイエンス | 虚血性疾患治療薬 |
| KR20170088866A (ko) | 2014-12-03 | 2017-08-02 | 가부시키가이샤 아네로파마·사이엔스 | 공발현 플라스미드 |
| KR101892722B1 (ko) * | 2015-01-19 | 2018-08-28 | 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 | 허혈성 질환 치료제 |
| LU100900B1 (de) * | 2018-08-10 | 2020-02-17 | Thomas Melchior Homann | Verbindungen zur modulation von a-ketoglutarsäure (2kg)-abhängigen oxygenasen |
| WO2021038975A1 (ja) | 2019-08-28 | 2021-03-04 | 株式会社アネロファーマ・サイエンス | ダイアボディ型ＢｓＡｂを発現・分泌するビフィドバクテリウム属細菌 |
| CN112999215B (zh) * | 2019-12-20 | 2024-06-21 | 复旦大学 | 呋喃酮糖苷类化合物的应用 |
| CN115400154A (zh) * | 2022-08-10 | 2022-11-29 | 深圳未知君生物科技有限公司 | 长双歧杆菌在制备治疗自闭症谱系障碍的药物中的应用 |
| WO2024187069A1 (en) * | 2023-03-08 | 2024-09-12 | University Of Florida Research Foundation, Incorporated | Engineering enterobacteria to site-specifically activate the anticancer prodrug 5-fluorocytosine for treating colon cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8713601D0 (en) * | 1987-06-10 | 1987-07-15 | Unilever Plc | Fermentation |
| WO1991009131A1 (en) * | 1989-12-20 | 1991-06-27 | Valio Finnish Cooperative Dairies Association | Cloning vector for use in lactic acid bacteria |
| US6984513B2 (en) | 1994-03-03 | 2006-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
| US6416754B1 (en) | 1994-03-03 | 2002-07-09 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
| TW357191B (en) * | 1996-06-04 | 1999-05-01 | Food Industry Development Res Institute | Bifidobacteria strains with acid, bile salt and oxygen tolerance and their culture method the invention relates to bifidobacteria strains with acid, bile salt and oxygen tolerance and their culture method |
| JP2000060541A (ja) * | 1998-08-27 | 2000-02-29 | Fuyuki Mitsuyama | ビフィズス菌増殖促進物質と整腸物質とビフィズス菌製剤 |
| JP3642755B2 (ja) | 2000-09-21 | 2005-04-27 | 純 天野 | 嫌気性菌を用いた遺伝子治療用医薬 |
| CA2342040C (en) * | 2000-09-21 | 2012-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anaerobic bacterium as a drug for cancer gene therapy |
| US7008633B2 (en) * | 2000-12-18 | 2006-03-07 | Board Of Regents, The University Of Texas System | Local regional chemotherapy and radiotherapy using in situ hydrogel |
| KR100457879B1 (ko) * | 2001-02-24 | 2004-11-18 | 주식회사 비피도 | 비피도박테리움 유래 신규 플라스미드, 이를 이용한 재조합 발현 벡터 및 형질전환 방법 |
| PT2088193E (pt) | 2004-11-24 | 2011-02-24 | Anaeropharma Science Inc | Novo vector vaivém |
| ES2548516T3 (es) * | 2005-01-21 | 2015-10-19 | The Research Foundation Of The State University Of New York | Métodos para el tratamiento de la capsulitis adhesiva |
| EP1867714B1 (en) | 2005-04-08 | 2013-09-18 | Anaeropharma Science Inc. | 5-fluorouracil-resistant bacteria and method for production thereof |
| CA2646244A1 (en) * | 2006-03-27 | 2007-10-04 | Government Of The United States Of Americas, As Represented By The Secre | Tetracycline compounds and methods of treatment |
| GB2439310A (en) * | 2006-04-13 | 2007-12-27 | Ambrozea Inc | Fermentation residuals from genetically-modified microorganisms |
| JP5048661B2 (ja) | 2006-05-24 | 2012-10-17 | 株式会社アネロファーマ・サイエンス | 遺伝子輸送担体作製方法 |
| EP2274422B1 (en) * | 2008-04-17 | 2017-03-15 | Anaeropharma Science, Inc. | Expression vector |
-
2009
- 2009-04-16 EP EP09733074.0A patent/EP2274422B1/en active Active
- 2009-04-16 CA CA2721653A patent/CA2721653C/en active Active
- 2009-04-16 JP JP2010541633A patent/JP5735804B2/ja active Active
- 2009-04-16 KR KR1020107025821A patent/KR101674977B1/ko not_active Expired - Fee Related
- 2009-04-16 WO PCT/JP2009/001768 patent/WO2009128272A1/en not_active Ceased
- 2009-04-16 PT PT97330740T patent/PT2274422T/pt unknown
- 2009-04-16 ES ES09733074.0T patent/ES2628378T3/es active Active
- 2009-04-16 DK DK09733074.0T patent/DK2274422T3/en active
- 2009-04-16 CN CN2009801205839A patent/CN102046791B/zh active Active
- 2009-04-16 PL PL09733074T patent/PL2274422T3/pl unknown
- 2009-04-16 HU HUE09733074A patent/HUE033561T2/hu unknown
- 2009-04-16 US US12/425,001 patent/US8383398B2/en not_active Expired - Fee Related
- 2009-04-17 WO PCT/JP2009/001776 patent/WO2009128275A1/en not_active Ceased
- 2009-04-17 KR KR1020107025820A patent/KR101671283B1/ko not_active Expired - Fee Related
- 2009-04-17 EP EP09733604.4A patent/EP2280717B1/en active Active
- 2009-04-17 PT PT09733604T patent/PT2280717T/pt unknown
- 2009-04-17 CA CA2721664A patent/CA2721664C/en active Active
- 2009-04-17 US US12/988,181 patent/US8470311B2/en active Active
- 2009-04-17 DK DK09733604.4T patent/DK2280717T3/en active
- 2009-04-17 KR KR1020167022911A patent/KR20160102584A/ko not_active Ceased
- 2009-04-17 ES ES09733604.4T patent/ES2686080T3/es active Active
- 2009-04-17 CN CN2009801205843A patent/CN102046190B/zh active Active
- 2009-04-17 JP JP2010541634A patent/JP5514735B2/ja active Active
- 2009-04-17 PL PL09733604T patent/PL2280717T3/pl unknown
- 2009-04-17 HU HUE09733604A patent/HUE039768T2/hu unknown
-
2013
- 2013-01-24 US US13/749,428 patent/US20130122582A1/en not_active Abandoned
-
2014
- 2014-12-09 JP JP2014248772A patent/JP6089025B2/ja active Active
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