CA2721653C - Expression vector - Google Patents
Expression vector Download PDFInfo
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- CA2721653C CA2721653C CA2721653A CA2721653A CA2721653C CA 2721653 C CA2721653 C CA 2721653C CA 2721653 A CA2721653 A CA 2721653A CA 2721653 A CA2721653 A CA 2721653A CA 2721653 C CA2721653 C CA 2721653C
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- plasmid
- microliter
- dna
- bifidobacterium
- gene
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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| US61/124,528 | 2008-04-17 | ||
| PCT/JP2009/001768 WO2009128272A1 (en) | 2008-04-17 | 2009-04-16 | Expression vector |
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| CA2721653A1 CA2721653A1 (en) | 2009-10-22 |
| CA2721653C true CA2721653C (en) | 2018-03-20 |
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| EP (2) | EP2274422B1 (enExample) |
| JP (3) | JP5735804B2 (enExample) |
| KR (3) | KR101674977B1 (enExample) |
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| US8535939B2 (en) | 2010-01-29 | 2013-09-17 | Anaeropharma Science, Inc. | Transfection vector |
| US20130095072A1 (en) * | 2010-01-29 | 2013-04-18 | Anaeropharma Science, Inc. | Therapeutic agent for ischemic diseases |
| EP2274422B1 (en) * | 2008-04-17 | 2017-03-15 | Anaeropharma Science, Inc. | Expression vector |
| US9730968B2 (en) | 2008-04-17 | 2017-08-15 | Anaeropharma Science, Inc. | Therapeutic agent for ischemic diseases |
| US8338162B2 (en) * | 2009-04-17 | 2012-12-25 | Anaeropharma Science, Inc. | Obligately anaerobic mutant lactic acid bacterium and preparation method therefor, and expression vector functioning in obligately anaerobic lactic acid bacterium |
| WO2013008881A1 (ja) * | 2011-07-13 | 2013-01-17 | 株式会社アネロファーマ・サイエンス | 虚血性疾患治療薬 |
| KR20170088866A (ko) | 2014-12-03 | 2017-08-02 | 가부시키가이샤 아네로파마·사이엔스 | 공발현 플라스미드 |
| KR101892722B1 (ko) * | 2015-01-19 | 2018-08-28 | 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 | 허혈성 질환 치료제 |
| LU100900B1 (de) * | 2018-08-10 | 2020-02-17 | Thomas Melchior Homann | Verbindungen zur modulation von a-ketoglutarsäure (2kg)-abhängigen oxygenasen |
| WO2021038975A1 (ja) | 2019-08-28 | 2021-03-04 | 株式会社アネロファーマ・サイエンス | ダイアボディ型ＢｓＡｂを発現・分泌するビフィドバクテリウム属細菌 |
| CN112999215B (zh) * | 2019-12-20 | 2024-06-21 | 复旦大学 | 呋喃酮糖苷类化合物的应用 |
| CN115400154A (zh) * | 2022-08-10 | 2022-11-29 | 深圳未知君生物科技有限公司 | 长双歧杆菌在制备治疗自闭症谱系障碍的药物中的应用 |
| WO2024187069A1 (en) * | 2023-03-08 | 2024-09-12 | University Of Florida Research Foundation, Incorporated | Engineering enterobacteria to site-specifically activate the anticancer prodrug 5-fluorocytosine for treating colon cancer |
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| GB8713601D0 (en) * | 1987-06-10 | 1987-07-15 | Unilever Plc | Fermentation |
| WO1991009131A1 (en) * | 1989-12-20 | 1991-06-27 | Valio Finnish Cooperative Dairies Association | Cloning vector for use in lactic acid bacteria |
| US6984513B2 (en) | 1994-03-03 | 2006-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
| US6416754B1 (en) | 1994-03-03 | 2002-07-09 | The Board Of Trustees Of The Leland Stanford Junior University | Anaerobe targeted enzyme-mediated prodrug therapy |
| TW357191B (en) * | 1996-06-04 | 1999-05-01 | Food Industry Development Res Institute | Bifidobacteria strains with acid, bile salt and oxygen tolerance and their culture method the invention relates to bifidobacteria strains with acid, bile salt and oxygen tolerance and their culture method |
| JP2000060541A (ja) * | 1998-08-27 | 2000-02-29 | Fuyuki Mitsuyama | ビフィズス菌増殖促進物質と整腸物質とビフィズス菌製剤 |
| JP3642755B2 (ja) | 2000-09-21 | 2005-04-27 | 純 天野 | 嫌気性菌を用いた遺伝子治療用医薬 |
| CA2342040C (en) * | 2000-09-21 | 2012-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anaerobic bacterium as a drug for cancer gene therapy |
| US7008633B2 (en) * | 2000-12-18 | 2006-03-07 | Board Of Regents, The University Of Texas System | Local regional chemotherapy and radiotherapy using in situ hydrogel |
| KR100457879B1 (ko) * | 2001-02-24 | 2004-11-18 | 주식회사 비피도 | 비피도박테리움 유래 신규 플라스미드, 이를 이용한 재조합 발현 벡터 및 형질전환 방법 |
| PT2088193E (pt) | 2004-11-24 | 2011-02-24 | Anaeropharma Science Inc | Novo vector vaivém |
| ES2548516T3 (es) * | 2005-01-21 | 2015-10-19 | The Research Foundation Of The State University Of New York | Métodos para el tratamiento de la capsulitis adhesiva |
| EP1867714B1 (en) | 2005-04-08 | 2013-09-18 | Anaeropharma Science Inc. | 5-fluorouracil-resistant bacteria and method for production thereof |
| CA2646244A1 (en) * | 2006-03-27 | 2007-10-04 | Government Of The United States Of Americas, As Represented By The Secre | Tetracycline compounds and methods of treatment |
| GB2439310A (en) * | 2006-04-13 | 2007-12-27 | Ambrozea Inc | Fermentation residuals from genetically-modified microorganisms |
| JP5048661B2 (ja) | 2006-05-24 | 2012-10-17 | 株式会社アネロファーマ・サイエンス | 遺伝子輸送担体作製方法 |
| EP2274422B1 (en) * | 2008-04-17 | 2017-03-15 | Anaeropharma Science, Inc. | Expression vector |
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- 2009-04-17 EP EP09733604.4A patent/EP2280717B1/en active Active
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2013
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2014
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| CA2721653C (en) | Expression vector | |
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